Hypoglycemic effect of Anacardium occidentale L.: scientific and technological prospecting
Keywords:
Anacardium; Hypoglycemic agents; Diabetes mellitus; Prospection.Abstract
The Anacardium occidentale L. belongs to the family Anacardiaceae, which has approximately 76 genera and 6000 species of pan-tropical distribution. Popularly known as cashew tree is a plant native to the Brazilian Northeast, having as edible parts the cashew nuts and the cashew nut, much found in the coastal sedimentary trays. In Brazil it occurs very frequently in the states of Piauí, Ceará, Pernambuco and Bahia. The objective of the present study was to carry out a scientific and technological prospection of the A. occidentale plant focused on hypoglycemic and antidiabetic activities of the plant. In the scientific prospection the articles published in the period 1951 - November/2020 were searched in the databases Pubmed, ScienceDirect, Scielo and LILACS using the following descriptors: A. occidentale, hypoglycemiant agents, diabetes mellitus and their correspondents in Portuguese: A. occidentale, hypoglycemic agents and diabetes mellitus. In the technological prospection, the patent applications filed in four databases: INPI, EPO, USPTO and WIPO using as descriptor only A. occidentale. The various articles and patents found report several pharmacological activities, among which the hypoglycemic effect demonstrated by 6 articles and 3 patents on this plant stands out. Therefore, A. occidentale has a potential hypoglycemic and antidiabetic effect to be better explored.
References
Araújo, S., Sousa, I. J. O., Gonçalves, R. L. G., França, A. R. S., Negreiros, O. S., Brito, A. K. S., Oliveira, A. P. & Lima, E. B. S. (2018). Aplicações farmacológicas e tecnológicas da goma do cajueiro (Anacardium occidentale L.) – Um produto obtido da flora brasileira. Revista Geintec, 8(1), 4292-4305.
Arya, R., Babu, V., Liyas, M. & Nasim, K.T. (1989). Phytochemical examination of the leaves of Anacardium occidentale. Journal of the Indian Chemical Society, 66(1), 67-68.
Attri, B. L. (2009). Effect of initial sugar concentration on the physicochemical characteristics and sensory qualities of cashew apple wine. Natural Product Radiance, 8(4), 374-379.
Behravan, E., Heidari, M. R., Heidari, M., Fatemi, G., Etemad, L., Taghipour, G. & Abbasifard, M. (2012). Comparison of gastric ulcerogenicity of percolated extract of Anacardium occidentale (cashew nut) with indomethacin in rats. Pakistan Journal of Pharmaceutical Sciences, 25(1), 111-115.
Bettega, P. V. C., Czlusniak, G. R., Piva, R., Namba, E. L., Ribas, C. R., Grégio, A. M. T. & Rosa, E. A. R. (2011). Fitoterapia: dos canteiros ao balcão da farmácia. Archives of Oral Research, 7(1), 89-97.
Cansian, R. L., Mossi, A. J., Oliveira, D., Toniazzo, G., Treichel, H., Paroul, N., Astolfi, V. & Serafini, L. A. (2010). Atividade antimicrobiana e antioxidante do óleo essencial de ho-sho (Cinnamomum camphora Ness e Eberm Var. Linaloolifera fujita). Ciência e Tecnologia de Alimentos, 30(2), 378-384;
Carvalho, N. S., Silva, M. M., Silva, R. O., Nicolau, L. A. D., Sousa, F. B. M., Damasceno, S. R. B., Silva, D. A., Barbosa, A. L. R., Leite, J. R. S. A. & Medeiros, J. V. R. (2015). Gastroprotective properties of cashew gum, a complex heteropolysaccharide of Anacardium occidentale, in naproxen-induced gastrointestinal damage in rats. Drug Development Research, 76(3), 143–151.
Fagbohun, T. R. & Odufunwa, K. T. (2010). Hypoglycemic effect of methanolic extract of Anacardium occidentale leaves in alloxan-induced diabetic rats. Nigerian Journal of Physiological Sciences, 25(1), 87-90.
Flatt, S. K. S., Day, C., Bailey, C. J. & Flatt, P. R. (1989). Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice. Acta Diabetologica, 26(1), 51-55.
Ivorra, M. D., D’Ocon, M. P., Paya, M. & Villar, A. (1988). Antihyperglycemic and insulin release effects of â-sitosterol 3-â-D glucoside and its aglucone â-sitosterol. Archives Internationales de Pharmacodynamie et de Therapie, 296(1), 224-231.
Jaiswal, Y. S., Tatke, P. A., Gabhe, S. Y. & Vaidya, A. B. (2017). Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n-streptozotocin diabetic rats. Journal of Traditional and Complementary Medicine, 7(4), 421-427.
Marques, T. H. C., Santos, O. S., Melo, C. H. S., Carvalho, R. B. F., Lima, L. S., David, J. M., David, J. P. L. & Freitas, R. M. (2013). Atividade anticolinesterásica e perfil químico de uma fração cromatográfica ativa do extrato etanólico das flores Bellis perennis L. (Asteraceae). Química Nova, 36(4), 549-553.
Melo-Cavalcante, A. A., Dantas, S. M., Leite, A. D. E. S., Matos, L. A., Sousa, J. M., Picada, J. N. & Silva, J. (2011). In vivo antigenotoxic and anticlastogenic effects of fresh and processed cashew (Anacardium occidentale) apple juices. Journal of Medicinal Food, 14(1), 792-798.
Melo-Cavalcante, A. A., Rubensam, G., Picada, J. N., Silva, E. G., Fonseca, M. J. C. F. & Henriques, J. A. (2003). Mutagenicity, antioxidante potential, and antimutagenic activity against hydrogen peroxide of cashew (Anacardium occidentale) apple juice and cajuina. Environmental and Molecular Mutagenesis, 41(5), 360-369.
Ojewole, J. A. (2003) Laboratory evaluation of the hypoglycemic effect of Anacardium occidentale Linn. (Anacardiaceae) stem-bark extracts in rats. Methods and Findigs in Experimental and Clinical Pharmacology, 25(3), 199-204.
Olajide, O. A., Aderogba, M. A., Adedapo, A. D. & Makinde, J. M. (2004) Effects of Anacardium occidentale stem bark extract on in vivo inflammatory models. Journal of Ethnopharmacology, 95(2/3), 139-142.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J. & Shitsuka, R. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed. UAB/NTE/UFSM. Recuperado em 24 novembro, 2020, de: https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_MetodologiaPesquisa-Cientifica.pdf?sequence=1
Schirato, G. V., Monteiro, F. M. F., Silva, F. O., Lima Filho, J. L., Leão, A. M. A. C. & Porto, A. L. F. (2006). O polissacarídeo do Anacardium occidentale L. na fase inflamatória do processo cicatricial de lesões cutâneas. Ciência Rural, 36(1), 149–154.
Sokeng, S. D., Lontsi, D., Moundipa, P. F., Jatsa, H. B., Watcho, P. & Kamtchouing, P. (2007). Hypoglycemic effect of Anacardium occidentale L. methanol extract and fractions on streptozotocin-induced diabetic rats. International Journal of Medical Sciences, 2(2), 133-137.
Sousa, F. C. F., Melo, C. T. V., Citó, C. O. M., Félix, F.H. C., Vasconcelos, S. M. M., Fonteles, M. M. F., Barbosa Filho, J. M. & Viana, G. S. B. (2008). Plantas medicinais e seus constituintes bioativos: Uma revisão da bioatividade e potenciais benefícios nos distúrbios da ansiedade em modelos animais. Revista Brasileira de Farmacognosia, 18(4), 642-654.
Swarnalakshmi, T., Gomathi, K., Sulochana, N., Baskar, E. A. & Parmar, N. S. (1981). Anti-inflammatory activity of (-)-epicatechin, a biflavonoid isolated from Anacardium occidentale Linn. Indian Journal of Pharmaceutical Sciences, 43(1), 205-208.
Zackiewicz, M. & Salles Filho, S. (2001). Technological Foresight – um instrumento para política científica e tecnológica. Revista Parcerias Estratégicas, 6(10), 144-161.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Thais Cruz Ramalho; Cid Rangel de Sousa Vieira; Mateus Almeida Macêdo; Lina Clara Gayoso e Almendra Ibiapina Moreno; Hercília Maria Lins Rolim
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
