Variability of Heart Rate as a biomarker of stress: integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v9i12.11125

Keywords:

Heart Rate; Autonomous nervous system; Parasympathetic nervous system.

Abstract

Objective: to identify the applicability of Heart Rate Variability (HRV) as a biomarker of stress through an integrative literature review. Method: for this purpose, a search was conducted in the Web of Science ® and Medical Literature Analysis and Retrieval System Online (MEDLINE) databases. The descriptors Heart Rate Variability, HRV, Autonomous Nervous System (ANS), RR Intervals and stress were combined in different ways in order to allow greater capture of studies. Inclusion criteria were studies involving humans, association between HRV and stress or ANS, and HRV analysis using linear and non-linear measurements. Eighteen publications were identified that met the inclusion and exclusion criteria. A descriptive analysis of these works was carried out. Results: the results showed that HRV characteristics were altered in response to stress. HRV indices obtained by linear methods (time domain and frequency domain) and non-linear methods were cited in some studies as a clinical diagnostic tool to investigate cardiovascular interactions, evaluate physiological mechanisms and trace their changes in different physiological states. Conclusion: it is concluded that HRV can be used to evaluate stress because it reflects cardiac activity and ANS activities. It was observed that the different methods used to induce stress were able to stimulate an ANS response through the changes in HRV parameters.

References

Borchini, R., Bertù, L., Ferrario, M. F., Veronesi., Bonzini, M., Dorso, M., & Cesana, G. (2015). Prolonged job strain reduces time-domain heart rate variability on both working and resting days among cardiovascular-susceptible nurses. International Journal of Occupational Medicine and Environmental Health, 28(1), 42-51. doi:10.2478/s13382-014-0289-1

Catai, A. M., Pastre, C. M., Godoy, M. F., Silva, E., Takahashi, A. C. M., & Vanderlei, L. C. M. (2020). Heart rate variability: are you using it properly? Standardisation checklist of procedures. Brazilian Journal of Physical Therapy, 24(2), 91-102. doi:10.1016/j.bjpt.2019.02.006

Cruvinel Júnior, R. H., Pfister, A. P. L., Ferreira, E. K., & Guimarães, J. C. (2019). Níveis de estresse e variabilidade da frequência cardíaca em professores universitários. Revista Interdisciplinar de Estudos em Saúde, 9(2), 73-82.

Fadaee, S. B., Beetham, K. S., Howden, E. J., Stanton, T., Isbel, N. M., & Coombes, J. S. (2017). Oxidative stress is associated with decreased heart rate variability in patients with chronic kidney disease. Redox Report, 22(5), 197-204. doi:10.1080/13510002.2016.1173326

Farah, B. Q., Barros M. V. G., Balagopal, B., & Ritti-Dias, R. M. (2014). Heart rate variability and cardiovascular risk factors in adolescent boys. The Journal of Pediatric, 165(5), 945-950. doi:10.1016 / j.jpeds.2014.06.065

Figueiredo, T., Willardson, J. M., Miranda, H., Bentes, C. M., Reis, V. M., Salles, B. F., & Simão, R. (2016). Influence of rest interval length between sets on blood pressure and heart rate variability after a strength training session performed by prehypertensive men, Journal of Strength and Conditioning Research, 30(7), 1813-1824. doi:10.1519/JSC.0000000000001302

Galvão, C. M., Mendes, K. D. S., & Silveira, R. C. C. P. (2010). Integrative re¬view: review method to synthesize evidence available in the literature. In: M. M. Brevidelli, & S. C. M. Sertório (2010). Trabalho de conclusão de curso: guia prático para docentes e alunos da área da saúde (pp. 105-126). São Paulo: Iátrica

Grantcharov, P. D., Boillat, T., Elkabany, S., Wac, K., & Rivas, H. (2018). Acute mental stress and surgical performance. BJS Open, 3(1), 119-125. doi:10.1002/bjs5.104

Järvelin-Pasanen, S., Sinikallio, S, & Tarvainen, M. P. (2018). Heart rate variability and occupational stress-systematic review. Industrial Health, 56(6), 500-511. doi:10.2486

Javorka, M., Krohova, J., Czippelova, B., Turianikova, Z., Lazarova, Z., Javorka, K., & Faes, L. (2017). Basic cardiovascular variability signals: mutual directed interactions explored in the information domain. Clinical Physics and Physiological Measurement, 38(5), 877-894. doi:10.1088/1361-6579/aa5b77

Kim, H. G., Cheon, E.-J., Bai, D.-S., Lee, Y. H., & Koo, B.-H. (2018). Stress and heart rate variability: a meta-analysis and review of the literature. Psychiatry Investigation, 15(3), 235-245. doi:10.30773/pi

Leme, L. C., Oliveira, R., Ramos, S. P., Milanez, V. F., Nakamura, F. Y., & Leicht, L. (2015). The influence of a weekend with passive rest on the psychological and autonomic recovery in professional handball players. Kinesiology, 47(1), 44-52.

Markov, A., Isolonin, I., & Bojko, E. (2016). Heart rate variability in workers of various professions in contrasting seasons of the year. International Journal of Occupational Medicine and Environmental Health, 29(5), 793-780. doi:10.13075/ijomeh.1896.00276

Martins, C. C. F., Tourinho, F., & Santos, V. (2016). Estresse-normal ou patológico? Saúde & Transformação Social/Health & Social Change, 7(1), 1-8.

Mestanikova, A., Mestanik, M., Ondrejka, I., Hrtanek, I., Cesnekova, D., Júnior, A. J., Visnovcova, Z., Sekaninova, N., & Tonhajzerova, I. (2019). Complex cardiac vagal regulation to mental and physiological stress in adolescent major depression. Journal of Affective Disorders, 249, 234-241. doi:10.1016/j.jad.2019.01.043.

Naranjo, J., De la Cruz, B., Sarabia, E., Hoyo, M., & Domínguez-Cobo, S. (2015). Heart rate variability: a follow-up in elite soccer players throughout the season. International Journal of Sports of Medicine, 36(11), 881-886. doi:10.1055/s-0035-1550047

Oxford Centre for Evidence-based Medicine. (2020). Levels of evidence and grades of recommendations. Oxford: CEBM. https://www.cebm.net/

Peçanha, T., Forjaz, C. L. M., & Low, D. A. (2017). Additive effects of heating and exercise on baroreflex control of heart rate in healthy males. The Journal of Applied Physiology, 123(6), 1555-1562. doi:10.1152/japplphysiol.00502.2017

Peçanha, T., Forjaz, C. L. M., & Low, D. A. (2017). Passive heating attenuates post-exercise cardiac autonomic recovery in healthy young males. Frontiers in Neuroscience, 11, 727. doi:10.3389/fnins.2017.00727

Proietti, R., di Fronso, S., Pereira, L. A., Bortoli, L., Robazza, C., Nakamura, F. Y., & Bertollo, M. (2017). Heart rate variability discriminates competitive levels in professional soccer players. The Journal of Strength and Conditioning Research, 31(6), 1719-1725. doi: 10.1519/JSC.0000000000001795

Reinertsen, E., Nemati, S., Vest, A. N., Vaccarino, V., Lampert, R., Shah, A. J., & Clifford, G. D. (2017). Heart rate-based window segmentation improves accuracy of classifying posttraumatic stress disorder using heart rate variability measures. Physiological Measurement, 38(6), 1061-1076. doi:10.1088/1361-6579

Reis, H. J. L., Guimarães, H. P., Zazula, A. D., Vasques, R. G., & Lopes, R. D. (2013). ECG: manual prático de eletrocardiograma. São Paulo: Atheneu.

Rimes, K. A., Lievesley, K., & Chalder, T. (2017). Stress vulnerability in adolescents with chronic fatigue syndrome: experimental study investigating heart rate variability and skin conductance responses. Journal of Child Psychology and Psychiatry, 58(7), 851-858. doi:10.1111/jcpp.12711

Rodrigues, P. H., Oliveira, M. B., Cazelato, L., Chagas, E. F. B., & Quitério, R. J. (2016). A influência dos fatores de risco para doenças cardiovasculares sobre a modulação autonômica cardíaca. Revista de Atenção à Saúde, 14(49), 34-40. doi: 10.13037/ras.vol14n49.3712

Sánchez-Hechavarría, M. E., Ghiya, S., Carrazana-Escalona, R., Cortina-Reyna, S., Andreu-Heredia, A., Acosta-Batista, C., & Saá-Muñoz, N. A. (2019). Introduction of application of gini coefficient to heart rate variability spectrum for mental stress evaluation. Arquivos Brasileiros de Cardiologia. 113(4), 725-733. doi: 10.5935/abc.20190185

Santos, L., Barroso, J. J., Macau, E. E. N., & Godoy, M. F. (2015). Assessment of heart rate variability by application of central tendency measure. Medical & Biological Engineering & Computing, 53(11), 1231-1237. doi: 10.1007/s11517-015-1390-8

Šapina, M., Karmakar, C. K., Kramarić, K., Garcin, M., Adelson, P. D., Milas, K., Pirić, M., Brdarić, D., & Yearwood, J. (2018). Entropia de tom multi-lag no estresse neonatal. Journal of the Royal Society, Interface, 15(146), 20180420. doi: 10.1098/rsif.2018.0420

Task Force of the European Society of Cardiology of the North American Society of Pacing

Electrophysiology. Heart rate variavility: standards of measurement, physiological interpretation, and clinical use. (1996). Circulation, 93(5), 1043-1065. doi:10.1161/01.

Tonhajzerova, I., Visnovcova, Z., Mestanikova, A., Jurko, A., & Mestanik, M. (2016). Cardiac vagal control and depressive symptoms in response to negative emotional stress. Advances in Experimental Medicine and Biology. 934, 23-30. doi:10.1007/5584_2016_17

Vanderlei, L. C. M., Pastre, C. M., Freitas Júnior, I. F., & Godoy, M. F. (2010). Índices geométricos de variabilidade da frequência cardíaca em crianças obesas e eutróficas. Arquivos Brasileiros de Cardiologia, 95(1), 35-40. doi:10.1590/S0066-782X2010005000082

Vanderlei, L. C. M., Pastre, C. M., Hoshi, R. A., Carvalho, T. D., & Godoy, M. F. (2009). Noções básicas de variabilidade da frequência cardíaca e sua aplicabilidade clínica. Revista Brasileira de Cirurgia Cardiovascular, 24(2), 205-217. doi:10.1590/S0102-76382009000200018

Visnovcova, Z., Monkra, D., Mikolka, P., Mestanik, M., Jurko, A., Javorka, M., Calkovska, & Tonhajzerova, I. (2015). Alterations in vagal-immune pathway in long-lasting mental stress. Advances in Experimental Medicine and Biology, 832, 45-50. doi: 10.1007/5584_2014_10

Zanetti, M., Faes, L., Nollo, G., Cecco, M., Pernice, R., Maule, L., Pertile, M., & Fornaser, A. (2019). Information dynamics of the brain, cardiovascular and respiratory network during different levels of mental stress. Entropy, 21(3), 275. doi:10.3390/e21030275

Published

22/12/2020

How to Cite

ARAÚJO, L. M. de; CARVALHO, C. M. S. de; AMARAL, M. M.; SANTOS, L. dos. Variability of Heart Rate as a biomarker of stress: integrative review. Research, Society and Development, [S. l.], v. 9, n. 12, p. e34991211125, 2020. DOI: 10.33448/rsd-v9i12.11125. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/11125. Acesso em: 20 apr. 2024.

Issue

Section

Review Article