Auditive Mismatch Negativity Evoked Potential in musicians and non – musicians: Systematic review




Auditory evoked potential; Musicians; No musicians; MMN.


The evoked potential of long latency Mismatch Negativity (MMN) refers objectively as an electrophysiological method to the abilities of sound discrimination, auditory processing, auditory memory and involuntary attention at central level. Such skills are found differently between musicians and non-musicians and MMN is used in an objective way to detect them. Objective: to carry out a systematic review to check if there are differences in latency and amplitude presented by MMN in musicians and non-musicians. Method: The research was carried out between September and November 2020, in the electronic databases Pubmed, ScienceDirect, BVS (Lilacs), Scopus, Circumpolar Health Bibliographic Database, SciELO, Embase, Web of science and Cochrane Central Register of Controlled Trials (CENTRAL), as well as the gray literature bases, DissOnline, The New York Academy of Medicine, Clinical Evidence and Clinical Trials, using the descriptors as follows Music OR musician OR musicians AND potential mismatch negavitity OR MMN OR evoked potentials auditory OR Long Latency . Results: 9 articles were found, of which 7 addressed that musicians outperformed non-musicians in their latencies and amplitudes of MMN, in contrast 2 articles did not differentiate the latencies and amplitudes between musicians and non-musicians. Conclusion: In a large majority of studies, musicians showed a superiority to non-musicians in amplitude, which means that the neural abilities of auditory and behavioral discrimination of musicians surpass those of non-musicians, musicians presented lower latency of MMN, even exceeding not musicians.


Arndt, C., Schlemmer, K., & van der Meer, E. (2020). Same or different pitch? Effects of musical expertise, pitch difference, and auditory task on the pitch discrimination ability of musicians and non-musicians. Experimental Brain Research, 238(1), 247–258. Springer Berlin Heidelberg. Retrieved from

Crespo-Bojorque, P., Monte-Ordoño, J., & Toro, J. M. (2018). Early neural responses underlie advantages for consonance over dissonance. Neuropsychologia, 117(November 2017), 188–198. Elsevier Ltd. Retrieved from

Ferreira, D. A., Bueno, C. D., Costa, S. S. da, & Sleifer, P. (2017). Aplicabilidade do Mismatch Negativity na população infantil: revisão sistemática de literatura. Audiology - Communication Research, 22(0), 1–10.

Nikjeh, D. A., Lister, J. J., & Frisch, S. A. (2009). Preattentive cortical-evoked responses to pure tones, harmonic tones, and speech: Influence of music training. Ear and Hearing, 30(4), 432–446.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Método Qualitativo, Quantitativo ou Quali-Quanti. Metodologia da Pesquisa Científica. Retrieved from Acesso em: 28 março 2020.

Rodrigues, A. C., Loureiro, M., & Caramelli, P. (2013). Efeitos do treinamento musical no cérebro: aspectos neurais e cognitivos. Neuropsicologia Latinoamericana, 5(4), 15–31.

Sanju, H. K., & Kumar, P. (2016). Pre-attentive auditory discrimination skill in Indian classical vocal musicians and non-musicians. Journal of Otology, 11(3), 102–110. Elsevier Ltd. Retrieved from

Tervaniemi, M., Ilvonen, T., Karma, K., Alho, K., & Näätänen, R. (1997). The musical brain: Brain waves reveal the neurophysiological basis of musicality in human subjects. Neuroscience Letters, 226(1), 1–4.

Tervaniemi, M., Kruck, S., De Baene, W., Schröger, E., Alter, K., & Friederici, A. D. (2009). Top-down modulation of auditory processing: Effects of sound context, musical expertise and attentional focus. European Journal of Neuroscience, 30(8), 1636–1642.

Tervaniemi, Mari, Just, V., Koelsch, S., Widmann, A., & Schröger, E. (2005). Pitch discrimination accuracy in musicians vs nonmusicians: An event-related potential and behavioral study. Experimental Brain Research, 161(1), 1–10.

Virtala, P., Huotilainen, M., Partanen, E., & Tervaniemi, M. (2014). Musicianship facilitates the processing of Western music chords-An ERP and behavioral study. Neuropsychologia, 61(1), 247–258. Elsevier. Retrieved from

Vuust, P., Brattico, E., Seppänen, M., Näätänen, R., & Tervaniemi, M. (2012). The sound of music: Differentiating musicians using a fast, musical multi-feature mismatch negativity paradigm. Neuropsychologia, 50(7), 1432–1443. Elsevier Ltd. Retrieved from



How to Cite

VERAS, A. R. F. S.; MACAMBIRA, Y. K. S. .; FARIAS , R. R. S. de . Auditive Mismatch Negativity Evoked Potential in musicians and non – musicians: Systematic review. Research, Society and Development, [S. l.], v. 10, n. 1, p. e59610112170, 2021. DOI: 10.33448/rsd-v10i1.12170. Disponível em: Acesso em: 2 feb. 2023.



Review Article