Cardiovascular changes in patients with SARS-CoV-2 submitted to intensive care: Scope review
DOI:
https://doi.org/10.33448/rsd-v10i2.12689Keywords:
Scope review; SARS-CoV-2; Intensive care unit; Cardiovascular changes.Abstract
Objective: to map the scientific literature on cardiovascular alterations with the highest incidence in patients with SARS-CoV-2 submitted to intensive care units. Method: scoping review following the design of the Joanna Briggs Institute. Contemplated the bases of white and gray literature, without temporal and idiomatic restriction. Three stages of study selection were performed: selection by title and abstract; reading in full the selected studies and reading the references of the included studies. The included studies were presented in narrative synthesis and tables. Results: a total of 2269 publications were obtained, obtaining eight studies after the selection steps. The most relevant findings were: leukocytopenia, increase in cardiac necrosis markers, alteration of the ST segments, thickening of the left ventricle and reduction in left ventricular ejection flow. Conclusion: the cardiac alterations with the highest incidence found in these patients were those caused by the inflammatory response in the heart and the overload of the cardiac pump.
References
Acr Recommendations for the use of Chest Radiography and Computed Tomography (CT) for Suspected COVID-19 Infection. & Harrison X. Bai e cols, Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT Disponível em: https://www.acr.org/Advocacy-and-Economics/ACR-Position-tatements/Recommendations-for-Chest-Radiography-and-CT-for-Suspected-COVID19 Infection/https://pubs.rsna.org/doi/10.1148/radiol.2020200823."
Arentz, M., Yim, E., Klaff, L., Lokhandwala, S., Riedo, F. X., Chong, M., & Lee, M. (2020). Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State. JAMA, 323(16), 1612–1614. https://doi.org/10.1001/jama.2020.4326
Babapoor-Farrokhran, S., Gill, D., Walker, J., Rasekhi, R. T., Bozorgnia, B., & Amanullah, A. (2020). Myocardial injury and COVID-19: Possible mechanisms. Life sciences, 253, 117723. https://doi.org/10.1016/j.lfs.2020.117723
Bhatraju, P. K., Ghassemieh, B. J., Nichols, M., Kim, R., Jerome, K. R., Nalla, A. K., Greninger, A. L., Pipavath, S., Wurfel, M. M., Evans, L., Kritek, P. A., West, T. E., Luks, A., Gerbino, A., Dale, C. R., Goldman, J. D., O'Mahony, S., & Mikacenic, C. (2020). Covid-19 in Critically Ill Patients in the Seattle Region - Case Series. The New England journal of medicine, 382(21), 2012–2022. https://doi.org/10.1056/NEJMoa2004500
China, Chinese Center for Disease Control and Prevention.JAMA. 10.1001/jama.2020.2648
Chinas NHCo. New coronavirus pneumonia prevention and control program (5a ed.). http://www.nhc.gov.cn/yzygj/s7653p/202002/ 3b09b894ac9b4204a79db5b8912d4440"
Chu, H., Zhou, J., Wong, B. H., Li, C., Chan, J. F., Cheng, Z. S., Yang, D., Wang, D., Lee, A. C., Li, C., Yeung, M. L., Cai, J. P., Chan, I. H., Ho, W. K., To, K. K., Zheng, B. J., Yao, Y., Qin, C., & Yuen, K. Y. (2016). Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways. The Journal of infectious diseases, 213(6), 904–914. https://doi.org/10.1093/infdis/jiv380
Creswell J. W. Projeto de pesquisa: métodos qualitativo, quantitativo e misto. 3ª ed. Porto Alegre (RS): Artmed; 2010
Dec, G. W., Jr, Palacios, I. F., Fallon, J. T., Aretz, H. T., Mills, J., Lee, D. C., & Johnson, R. A. (1985). Active myocarditis in the spectrum of acute dilated cardiomyopathies. Clinical features, histologic correlates, and clinical outcome. The New England journal of medicine, 312(14), 885–890. https://doi.org/10.1056/NEJM198504043121404
Dec, G. W., Jr, Waldman, H., Southern, J., Fallon, J. T., Hutter, A. M., Jr, & Palacios, I. (1992). Viral myocarditis mimicking acute myocardial infarction. Journal of the American College of Cardiology, 20(1), 85–89. https://doi.org/10.1016/0735-1097(92)90141-9
Deng, Q., Hu, B., Zhang, Y., Wang, H., Zhou, X., Hu, W., Cheng, Y., Yan, J., Ping, H., & Zhou, Q. (2020). Suspected myocardial injury in patients with COVID-19: Evidence from front-line clinical observation in Wuhan, China. International journal of cardiology, 311, 116–121. https://doi.org/10.1016/j.ijcard.2020.03.087
Dhawan et al COVID-19 and cardiovascular disease: What we know, what we think we know, and what we need to know, Journal of Molecular and Cellular Cardiology, 2019, DOI: 10.1016/j.yjmcc.2020.04.026
Esfandiarei, M., & McManus, B. M. (2008). Molecular biology and pathogenesis of viral myocarditis. Annual review of pathology, 3, 127–155. https://doi.org/10.1146/annurev.pathmechdis.3.121806.151534
G Guo, T., Fan, Y., Chen, M., Wu, X., Zhang, L., He, T., Wang, H., Wan, J., Wang, X., & Lu, Z. (2020). Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19). JAMA cardiology, 5(7), 811–818. https://doi.org/10.1001/jamacardio.2020.1017
Grasselli, G., Pesenti, A., & Cecconi, M. (2020). Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response. JAMA, 323(16), 1545–1546. https://doi.org/10.1001/jama.2020.4031
Guan W, Ni Z, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 10.1056/NEJMoa2002032.
Hu, Y., Sun, J., Dai, Z., Deng, H., Li, X., Huang, Q., Wu, Y., Sun, L., & Xu, Y. (2020). Prevalence and severity of corona virus disease 2019 (COVID-19): A systematic review and meta-analysis. Journal of clinical virology: the official publication of the Pan American Society for Clinical Virology, 127, 104371. https://doi.org/10.1016/j.jcv.2020.104371.
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., Xiao, Y., Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet (London, England), 395(10223), 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5
Inciardi, R. M., Lupi, L., Zaccone, G., Italia, L., Raffo, M., Tomasoni, D., Cani, D. S., Cerini, M., Farina, D., Gavazzi, E., Maroldi, R., Adamo, M., Ammirati, E., Sinagra, G., Lombardi, C. M., & Metra, M. (2020). Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19). JAMA cardiology, 5(7), 819–824. https://doi.org/10.1001/jamacardio.2020.1096
Juusela, A., Nazir, M., & Gimovsky, M. (2020). Two cases of coronavirus 2019-related cardiomyopathy in pregnancy. American journal of obstetrics & gynecology MFM, 2(2), 100113. https://doi.org/10.1016/j.ajogmf.2020.100113
Li, J. W., Han, T. W., Woodward, M., Anderson, C. S., Zhou, H., Chen, Y. D., & Neal, B. (2020). The impact of 2019 novel coronavirus on heart injury: A Systematic review and Meta-analysis. Progress in cardiovascular diseases, 63(4), 518–524. https://doi.org/10.1016/j.pcad.2020.04.008
Li, S. S., Cheng, C. W., Fu, C. L., Chan, Y. H., Lee, M. P., Chan, J. W., & Yiu, S. F. (2003). Left ventricular performance in patients with severe acute respiratory syndrome: a 30-day echocardiographic follow-up study. Circulation, 108(15), 1798–1803. https://doi.org/10.1161/01.CIR.0000094737.21775.32.
Li, T.-W. Han, M. Woodward, et al., The impact of 2019 novel coronavirus on heart injury: A systematic review and Meta-analysis, Progress in Cardiovascular Diseases (2020), https://doi.org/10.1016/j.pcad.2020.04.008
Liu, W. J., Zhao, M., Liu, K., Xu, K., Wong, G., Tan, W., & Gao, G. F. (2017). T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV. Antiviral research, 137, 82–92. https://doi.org/10.1016/j.antiviral.2016.11.006
Long, W.J. Brady, A. Koyfman, et al., Cardiovascular complications in COVID-19, American Journal of Emergency Medicine, https://doi.org/10.1016/j.ajem.2020.04.04845.
Lopes A.C., Liberatori Filho A. W. Tratamento da insuficiência cardíaca -- aspectos atuais. Rev. Assoc. Med. Bras. [Internet]. 1998 June [cited 2020 May 16] ; 44( 2 ): 75-76. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42301998000200001&lng=en.https://doi.org/10.1590/S0104-42301998000200001.
Ma et al, COVID-19 Myocarditis and Severity Factors: An Adult Cohort Study medRxiv 2020. 03. 19. 20034124; doi: https://doi.org/10.1101/2020.03.19.20034124"
Ma, L., Song, K., & Huang, Y. (2020). Coronavirus Disease-2019 (COVID-19) and Cardiovascular Complications. Journal of cardiothoracic and vascular anesthesia, S1053-0770(20)30400-6. Advance online publication. https://doi.org/10.1053/j.jvca.2020.04.041
Madjid, M., Safavi-Naeini, P., Solomon, S. D., & Vardeny, O. (2020). Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA cardiology, 5(7), 831–840. https://doi.org/10.1001/jamacardio.2020.1286
Mahmud, E., Dauerman, H. L., Welt, F. G., Messenger, J. C., Rao, S. V., Grines, C., Mattu, A., Kirtane, A. J., Jauhar, R., Meraj, P., Rokos, I. C., Rumsfeld, J. S., & Henry, T. D. Management of Acute Myocardial Infarction During the COVID-19 Pandemic, Journal of the American College of Cardiology (2020), https://doi.org/10.1016/j.jacc.2020.04.039.
Mehra, M. R., Desai, S. S., Kuy, S., Henry, T. D., & Patel, A. N. (2020). Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19. The New England journal of medicine, 382(25), e102. https://doi.org/10.1056/NEJMoa2007621
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & PRISMA Group (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS medicine, 6(7), e1000097. https://doi.org/10.1371/journal.pmed.1000097
Parry J. (2020). Wuhan: Britons to be evacuated as scientists estimate 44 000 cases of 2019-nCOV in the city. BMJ (Clinical research ed.), 368, m351. https://doi.org/10.1136/bmj.m351.
Peiris, J. S., Chu, C. M., Cheng, V. C., Chan, K. S., Hung, I. F., Poon, L. L., Law, K. I., Tang, B. S., Hon, T. Y., Chan, C. S., Chan, K. H., Ng, J. S., Zheng, B. J., Ng, W. L., Lai, R. W., Guan, Y., Yuen, K. Y., & HKU/UCH SARS Study Group (2003). Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet (London, England), 361(9371), 1767–1772. https://doi.org/10.1016/s0140-6736(03)13412-5
Peters, M. D., Godfrey, C. M., Khalil, H., McInerney, P., Parker, D., & Soares, C. B. (2015). Guidance for conducting systematic scoping reviews. International journal of evidence-based healthcare, 13(3), 141–146. https://doi.org/10.1097/XEB.0000000000000050.
Ruan, Q., Yang, K., Wang, W., Jiang, L., & Song, J. (2020). Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive care medicine, 46(5), 846–848. https://doi.org/10.1007/s00134-020-05991-x.
Santos et al – Radiol. Brasil.36(6) (2003).
Shi, S., Qin, M., Shen, B., Cai, Y., Liu, T., Yang, F., Gong, W., Liu, X., Liang, J., Zhao, Q., Huang, H., Yang, B., & Huang, C. (2020). Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA cardiology, 5(7), 802–810. https://doi.org/10.1001/jamacardio.2020.0950.
Singh, S., & Desai, R. (2020). COVID-19 and new-onset arrhythmia. Journal of arrhythmia, 36(3), 547–548. https://doi.org/10.1002/joa3.12354
Sociedade Brasileira de Cardiologia. Como tratar. Barueri, SP: Manole; 2008. 2, 424-39.
South, A. M., Diz, D. I., & Chappell, M. C. (2020). COVID-19, ACE2, and the cardiovascular consequences. American journal of physiology. Heart and circulatory physiology, 318(5), H1084–H1090. https://doi.org/10.1152/ajpheart.00217.2020
Stefanini, G. G., Montorfano, M., Trabattoni, D., Andreini, D., Ferrante, G., Ancona, M., Metra, M., Curello, S., Maffeo, D., Pero, G., Cacucci, M., Assanelli, E., Bellini, B., Russo, F., Ielasi, A., Tespili, M., Danzi, G. B., Vandoni, P., Bollati, M., Barbieri, L., Chieffo, A. (2020). ST-Elevation Myocardial Infarction in Patients With COVID-19: Clinical and Angiographic Outcomes. Circulation, 141(25), 2113–2116. https://doi.org/10.1161/CIRCULATIONAHA.120.047525
Tersalvi, G., Vicenzi, M., Calabretta, D., Biasco, L., Pedrazzini, G., & Winterton, D. (2020). Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms. Journal of cardiac failure, 26(6), 470–475. https://doi.org/10.1016/j.cardfail.2020.04.009
Tricco, A. C., Lillie, E., Zarin, W., O'Brien, K. K., Colquhoun, H., Levac, D., Moher, D., Peters, M., Horsley, T., Weeks, L., Hempel, S., Akl, E. A., Chang, C., McGowan, J., Stewart, L., Hartling, L., Aldcroft, A., Wilson, M. G., Garritty, C., Lewin, S., … Straus, S. E. (2018). PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Annals of internal medicine, 169(7), 467–473. https://doi.org/10.7326/M18-0850
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., Zhao, Y., Li, Y., Wang, X., & Peng, Z. (2020). Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA, 323(11), 1061–1069. https://doi.org/10.1001/jama.2020.1585
"Who, World Health Organization. Coronavirus disease 2019 (COVID-19): situation report 114. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200513-covid-19-sitrep-114.pdf?sfvrsn=17ebbbe_4"
Who, World Health Organization. Coronavirus disease 2019 (COVID-19): situation report 114. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200513-covid-19-sitrep-114.pdf?sfvrsn=17ebbbe_4
Wu, Z., & McGoogan, J. M. (2020). Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA, 323(13), 1239–1242. https://doi.org/10.1001/jama.2020.2648.
Xiao, Z., Xu, C., Wang, D., & Zeng, H. (2020). The experience of treating patients with acute myocardial infarction under the COVID-19 epidemic. Catheterization and cardiovascular interventions: official journal of the Society for Cardiac Angiography & Interventions, 10.1002/ccd.28951. Advance online publication. https://doi.org/10.1002/ccd.28951
Yang et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. Published online February 24, 2020. 10.1016/S2213-2600(20)30079-5
Yu, C. M., Wong, R. S., Wu, E. B., Kong, S. L., Wong, J., Yip, G. W., Soo, Y. O., Chiu, M. L., Chan, Y. S., Hui, D., Lee, N., Wu, A., Leung, C. B., & Sung, J. J. (2006). Cardiovascular complications of severe acute respiratory syndrome. Postgraduate medical journal, 82(964), 140–144. https://doi.org/10.1136/pgmj.2005.037515.
Zeng, J. H., Liu, Y. X., Yuan, J., Wang, F. X., Wu, W. B., Li, J. X., Wang, L. F., Gao, H., Wang, Y., Dong, C. F., Li, Y. J., Xie, X. J., Feng, C., & Liu, L. (2020). First case of COVID-19 complicated with fulminant myocarditis: a case report and insights. Infection, 48(5), 773–777. https://doi.org/10.1007/s15010-020-01424-5.
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