Epidemiological and spatio-temporal characteristics of new leprosy cases in municipalities in the state of Alagoas, Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v10i5.14962

Keywords:

Leprosy; Epidemiology; Spatio-temporal analysis.

Abstract

Introduction: The difficulties in coping with leprosy reaffirm the importance of epidemiological studies in different locations to better assess the magnitude of its endemicity. Objective: to analyze the distribution of new cases and leprosy detection coefficients in the state of Alagoas. Method: This is an ecological study. Leprosy cases reported in the municipalities of Alagoas were included. The study was based on records obtained in the National Notification System, from State Department of Health (2010-2019) and demographic data from the population census (2010). Association, spatial and trend temporal analysis were used. Results: 4,343 cases of leprosy were reported in the municipalities. The average rate of detection of new cases for the total population was estimated at 10.85, ranging from 12.57 (2010) to 11.63 (2019). The highest rate was estimated for the municipality of Santana do Ipanema (58.2), considered to be hyper-endemic. Rates with very high endemic values were observed in 13 municipalities. There was a downward trend in the mean number of cases in 2010-2014 (APC = -4.34, CI95%: -10.5-2.3) and an increase in 2015-2019 (APC = 3.04, CI95%: -15.1-25). The gross and Bayesian rates showed many municipalities with a high endemic characteristic, in the west, northwest, northeast and south regions. Conclusion: This study showed clusters in areas of greater socioeconomic vulnerability. It is recommended to plan preventive actions, to actively search for cases and to evaluate contacts in the identified areas.

References

Aagaard‐Hansen, J., Nombela, N., & Alvar, J. (2010). Population movement: a key factor in the epidemiology of neglected tropical diseases. Tropical Medicine & International Health, 15(11), 1281-1288.

Almeida, E. (2012). Econometria espacial. Campinas–SP. Alínea.

Anselin, L. (2005). Exploring spatial data with GeoDaTM: a workbook. Center for spatially integrated social science.

Bailey, T. C., & Gatrell, A. C. (1995). Interactive spatial data analysis (Vol. 413, No. 8). Essex: Longman Scientific & Technical.

Barbosa, C. C., Bonfim, C. V. D., de Brito, C. M. G., Ferreira, A. T., Gregório, V. R. D. N., de Oliveira, A. L. S., ... & de Medeiros, Z. M. (2018). Spatial analysis of reported new cases and local risk of leprosy in hyper‐endemic situation in Northeastern Brazil. Tropical Medicine & International Health, 23(7), 748-757.

Brasil. (2019). Ministério da Saúde. Departamento de Informátoca do SUS. Informações de Saúde. Epidemiológicas e de Morbidade. Hanseníase. Acessado em 12 de fevereiro de 2021 em: http://www2.datasus.gov.br/DATASUS/index.php?area=0203&id=31032752. Brasília, DF. 2019.

Brasil. (2021). Ministério da Saúde. Sala de Apoio à Gestão Estratégica. Situação de Saúde. Indicadores de Morbidade. Hanseníase. Acessado em 12 de fevereiro de 2021 em: https://sage.saude.gov.br/# (accessed Feb 12, 2021).

Brasil. (2016). Ministério da Saúde. Secretaria de Vigilância em Saúde. Diretrizes para vigilância, atenção e eliminacao da hanseníase como problema de saúde pública: manual técnico-operacional.

Ferreira, F. R., & Nascimento, L. F. C. (2019). Spatial approach of leprosy in the State of São Paulo, 2009-2012. Anais brasileiros de dermatologia, 94(1), 37-41.

Freitas, L. R. S. D., Duarte, E. C., & Garcia, L. P. (2017). Análise da situação epidemiológica da hanseníase em uma área endêmica no Brasil: distribuição espacial dos períodos 2001-2003 e 2010-2012. Revista Brasileira de Epidemiologia, 20, 702-713.

Gaschignard, J., Grant, A. V., Thuc, N. V., Orlova, M., Cobat, A., Huong, N. T., & Alcais, A. (2016). Pauci-and multibacillary leprosy: two distinct, genetically neglected diseases. PLoS neglected tropical diseases, 10(5), e0004345.

Kerr-Pontes, L. R., Barreto, M. L., Evangelista, C. M., Rodrigues, L. C., Heukelbach, J., & Feldmeier, H. (2006). Socioeconomic, environmental, and behavioural risk factors for leprosy in North-east Brazil: results of a case–control study. International journal of epidemiology, 35(4), 994-1000.

Leon, K. E., Jacob, J. T., Franco-Paredes, C., Kozarsky, P. E., Wu, H. M., & Fairley, J. K. (2016, April). Delayed diagnosis, leprosy reactions, and nerve injury among individuals with Hansen's disease seen at a United States clinic. In Open Forum Infectious Diseases (Vol. 3, No. 2, p. ofw063). Oxford University Press.

Lie, H. P. (1929). Why is leprosy decreasing in Norway?. Transactions of The Royal Society of Tropical Medicine and Hygiene, 22(4).

Lockwood, D. N., & Saunderson, P. R. (2012). Nerve damage in leprosy: a continuing challenge to scientists, clinicians and service providers. International health, 4(2), 77-85.

Monteiro, L. D., Martins-Melo, F. R., Brito, A. L., Alencar, C. H., & Heukelbach, J. (2015). Spatial patterns of leprosy in a hyperendemic state in Northern Brazil, 2001-2012. Revista de Saúde Pública, 49, 84.

Monteiro, L. D., Mota, R. M. S., Martins-Melo, F. R., Alencar, C. H., & Heukelbach, J. (2017). Determinantes sociais da hanseníase em um estado hiperendêmico da região Norte do Brasil. Revista de Saúde Pública, 51, 70.

Murto, C., Chammartin, F., Schwarz, K., da Costa, L. M. M., Kaplan, C., & Heukelbach, J. (2013). Patterns of migration and risks associated with leprosy among migrants in Maranhao, Brazil. PLoS neglected tropical diseases, 7(9), e2422.

Lencucha, R., Drope, J., Bialous, S. A., & Richter, A. P. (2017). Institutions and the implementation of tobacco control in Brazil. Cadernos de Saúde Pública, 33, e00168315.

Nery, J. S., Ramond, A., Pescarini, J. M., Alves, A., Strina, A., Ichihara, M. Y., Penna, M. L. F., Smeeth L., Rodrigues, L. C., Barreto, M. L., Brickley, E. B., Penna, G. O. (2019). Socioeconomic determinants of leprosy new case detection in the 100 Million Brazilian Cohort: a population-based linkage study. The Lancet Global Health, 7(9), e1226-e1236.

Penna, M. L. F., Reydeoliveira, M. V., & Penna, G. O. (2009). The epidemiological behaviour of leprosy in Brazil. Leprosy review, 80(3), 332-345.

Pescarini, J. M., Strina, A., Nery, J. S., Skalinski, L. M., Andrade, K. V. F., Penna, M. L. F., Brickley, E. B., Rodrigues, L. C., Barreto, M. L., Penna, G. O. (2018). Socioeconomic risk markers of leprosy in high-burden countries: A systematic review and meta-analysis. PLoS neglected tropical diseases, 12(7), e0006622.

Pescarini, J. M., Williamson, E., Nery, J. S., Ramond, A., Ichihara, M. Y. Fiaccone, R. L., Yuri, M., Penna, M. L. F., Smeeth, L., Rodrigues, L. C., Penna, G. O., Brickley, E. B., Barreto, M. L. (2020). Effect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 Million Brazilian Cohort: a quasi-experimental study. The Lancet Infectious Diseases, 20(5), 618-627.

Rao, P. N. (2017). Global leprosy strategy 2016-2020: Issues and concerns. Indian J Dermatol Venereol Leprol; 83, 4-6.

Raposo, M. T., Reis, M. C., de Queiroz Caminha, A. V., Heukelbach, J., Parker, L. A., Pastor-Valero, M., & Nemes, M. I. B. (2018). Grade 2 disabilities in leprosy patients from Brazil: Need for follow-up after completion of multidrug therapy. PLoS neglected tropical diseases, 12(7), e0006645.

Schneider, P. B., & Freitas, B. H. B. M. D. (2018). Leprosy trends in children under 15 years of age in Brazil, 2001-2016. Cadernos de Saúde Pública, 34(3).

Talhari, C., Talhari, S., Penna, G. O. (2015). Clinical aspects of leprosy. Clin Dermatol, 33: 26-37.

Teixeira, K. H. (2020). Uma análise espacial da pobreza no Estado de Alagoas. Redes; 25: 2668–2692.

WHO. (2010). First WHO report on neglected tropical diseases: working to overcome the global impact of neglected tropical diseases. World Heal Organ 2010. DOI:10.1177/1757913912449575.

WHO. (2020). Global leprosy (Hansen disease) update, 2019: time to step-up prevention initiatives. Wkly Epidemiol Rec; 95: 417–40.

WHO. (2021). Global Leprosy (Hansen’s Disease) Strategy 2021–2030: Towards Zero Leprosy. ISBN: 978-92-9022-850-9

WHO. (2013). Leprosy elimination. Cluster analysis of the overall detection rate of leprosy in Brazil for the triennium 2011-2013. Disponível em: https://www.who.int/lep/resources/Cluster_analysis/en/.

Wilder-Smith EP, Van Brakel WH. (2008). Nerve damage in leprosy and its management. Nat Clin Pract Neurol, 4: 656–63.

Withington, S. G., Joha, S., Baird, D., Brink, M., Brink, J. (2003). Assessing socio-economic factors in relation to stigmatization, impairment status, and selection for socio-economic rehabilitation: a 1-year cohort of new leprosy cases in north Bangladesh. Leprosy Review, 74: 120–32.

Van Brakel, W. H., Sihombing, B., Djarir, H., Beise, K., Kusumawardhani, L., Yulihane, R. & Wilder-Smith, A. (2012). Disability in people affected by leprosy: the role of impairment, activity, social participation, stigma and discrimination. Global health action, 5(1), 18394.

Visschedijk, J., Borek, J. V. de, Eggens, H., Lever, P., Beers, S. V., Klatser, P. (2000). Review: Mycobacterium leprae – millennium resistant! Leprosy control on the threshold of a new era. Tropical Medicine International Health, 5: 388–99.

Published

14/05/2021

How to Cite

ALVES, G. M. G.; MELO, G. C. de .; TEIXEIRA, C. S. S.; CARVALHO, L. W. T. de .; TAVARES, C. M.; ARAÚJO, K. C. G. M. de . Epidemiological and spatio-temporal characteristics of new leprosy cases in municipalities in the state of Alagoas, Brazil. Research, Society and Development, [S. l.], v. 10, n. 5, p. e48510514962, 2021. DOI: 10.33448/rsd-v10i5.14962. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/14962. Acesso em: 25 apr. 2024.

Issue

Section

Health Sciences