Analysis of the behavior of a biomaterial based on wollastonite/TCP in the implant process of an experimental model of critical bone defects

Authors

DOI:

https://doi.org/10.33448/rsd-v10i7.16800

Keywords:

Biomaterials; Bone regeneration; Calcium Silicate; Calcium phosphates.

Abstract

This study analyzes the clinical, macroscopic and radiographic characteristics of a biomaterial with different proportions of wolastonite (W) and tricalcium phosphate (TCP) on bone tissue regeneration during the implantation process of an experimental model of critical bone defects. Fifteen Wistar rats were used, randomly distributed in 5 groups (n = 3), with a bone defect created on an 8.0 mm diameter calvaria. 4 groups received implants with different proportions of W%/TCP%, referred to as W20/TCP80, W40/TCP60, W60/TCP40 and W80/TCP20. The fifth control group (GC) was filled with blood clot only. Clinical evaluation was performed every 24 hours, and after 7 days, the animals were euthanized. The calvaria were dissected and analyzed macroscopically and by radiography. All study groups showed a satisfactory clinical evolution. The macroscopic analysis showed filling of the bone defect with granules surrounded by newly formed tissue, and the radiographic analysis showed different patterns of displacement of the biomaterial. The study concluded that the different proportions of W%/TCP% were well tolerated by the study groups and demonstrated biocompatibility. The enhanced hydrophilic behavior of the W40/TCP60, W60/TCP40 and W80/TCP20 groups favored the application in the experimental model in vivo.

Author Biographies

Mauricio Mitsuo Monção, Instituto Federal de educação, Ciência e Tecnologia da Bahia

Master in Health Sciences, Specialization in Medical Imagenology, Graduation in Technology in Radiology. Professor at the Federal Institute of Education, Science and Technology of Bahia - IFBA, in the department of health and biology technology. Regular student of the doctoral program in Interactive Processes of Organs and Systems at the Institute of Health Sciences at UFBA.

Raísa Cavalcante Dourado, Universidade Federal da Bahia

Doctoral student in Interactive Processes of Organs and Systems at the Institute of Health Sciences - UFBA. Master's Degree in Dentistry from UFBA (2016) in the area of ​​Oral Pathology, Post-Graduation in Oral Surgery from the Brazilian Dental Association (2014) and Graduation in Dentistry from the State University of Feira de Santana (2013). Currently a substitute professor at the Federal University of Bahia, at the Institute of Health Sciences. Currently a doctoral student at PPgPIOS/ICS/UFBA

Luísa Queiroz Vasconcelos, Universidade Federal da Bahia

Graduated in Dentistry from the Federal University of Bahia (2012), Master in Interactive Processes of Organs and Systems from the Federal University of Bahia (2015), Specialization in Dental Prosthesis from Instituto Prime Centro de Ensino Pessoal - Faculdade Avantis (2017), Doctorate in Interactive Processes of Organs and Systems by the Federal University of Bahia (2019).

Isabela Cerqueira Barreto, Universidade Federal da Bahia

Graduated in Dentistry from the Federal University of Bahia (UFBA), Improvement in Periodontics from the Center for Dental Studies (CENO), Specialization in Periodontics from the Bahia Center for Dental Studies (CEBEO-UFBA), Masters in Morphological Sciences - concentration area in Bioengineering Tissue - from the Federal University of Rio de Janeiro (UFRJ) and Doctorate in Interactive Processes of Organs and Systems (UFBA). She is a professor of Biochemistry at the Institute of Health Sciences at UFBA and coordinator of the Laboratory of Tissue Bioengineering and Biomaterials. Has experience in Dentistry, develops studies in the area of ​​Morphology, with an emphasis on Tissue Bioengineering and Periodontics, and works mainly on the following topics: Biology and Biochemistry of Bone Tissue, Tissue Bioengineering, Biomaterials and Bone Grafts, Bone Regeneration.

Roberto Paulo Correia de Araújo, Universidade Federal da Bahia

Professor of Oral Biochemistry at the Institute of Health Sciences, Federal University of Bahia. Graduated in Dentistry at UFBA, Specialization, and Doctorate in Dentistry. He was Professor of Biochemistry at the Institute of Biological Sciences and the Faculty of Nursing at the Catholic University of Salvador until 2008. He has scientific articles published in specialized journals, scientific communications carried out in events, books and published chapters. In 2002 he launched the Journal of Medical and Biological Sciences, ISSN 1677-5090 and 2236-5222 (electronic) of which he is its Scientific Editor. Member of the Chamber of Health Sciences of the Foundation for Research Support of the State of Bahia - FAPESB

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Published

02/07/2021

How to Cite

MONÇÃO, M. M.; DOURADO, R. C. .; VASCONCELOS, L. Q. .; BARRETO, I. C.; ARAÚJO, R. P. C. de. Analysis of the behavior of a biomaterial based on wollastonite/TCP in the implant process of an experimental model of critical bone defects. Research, Society and Development, [S. l.], v. 10, n. 7, p. e55110716800, 2021. DOI: 10.33448/rsd-v10i7.16800. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/16800. Acesso em: 26 apr. 2024.

Issue

Vol. 10 No. 7

Section

Health Sciences

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Copyright (c) 2021 Mauricio Mitsuo Monção; Raísa Cavalcante Dourado; Luísa Queiroz Vasconcelos; Isabela Cerqueira Barreto; Roberto Paulo Correia de Araújo

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