Effectiveness and safety of inhaled corticosteroid therapy in asthmatic children and adolescents
DOI:
https://doi.org/10.33448/rsd-v10i8.16918Keywords:
Asthma; Corticosteroids; Pharmacotherapy.Abstract
The aim of this study was to investigate the use of inhaled corticosteroids (IC) for the treatment of asthma in order to provide relevant information and ensure a safer and more effective treatment for children and teenagers. An systematic review of the literature available on PubMed, Scielo and ScienceDirect was carried out using the following the descriptors: asthma, corticosteroids, drug therapy and children.The selected works were: open access; published in either Portuguese, English or Spanish; ranging from the year 2016 to 2021. Of the 233 compiled studies, 14 were selected. In the research, it was noticed that the particle size has an influence in the effectiveness and safety of the treatment, changing the availability of the drug in its target and the dosage administered to promote the desired effect. Furthermore, the particularities of ICs available on the market, which can be used alone or in combination with β2-adrenergic agonists, allow for a reduction in the IC dosage, thus reducing the incidence of possible adverse drug reactions (ADRs). It is important to emphasize that fluticasone proved to be one of the safest medications when its influence in the growth of children and adolescents was considered. Finally, despite the range of studies in the area, further research on this topic is necessary, especially those involving the influence of particle size on the effectiveness and safety of treatment, as well as the main ADRs on the proposed topic.
References
Axelsson, I., Naumburg, E., Prietsch, S. O., & Zhang, L. (2019). Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth. Cochrane Database of Systematic Reviews, (6).
De Assis, E. V., Santana, M. D., do NA Feitosa, A., & de Sousa, M. N. A. (2019). Prevalência de sintomas de asma e fatores de risco em adolescentes. J Hum Growth Dev, 29(1), 110-116.
De-la-Torre-Ugarte, M. C., Takahashi, R. F., & Bertolozzi, M. R. (2011). Revisão sistemática: noções gerais. Revista da Escola de Enfermagem da USP, 45(5), 1260-1266.
El Baou, C., Di Santostefano, R. L., Alfonso-Cristancho, R., Suarez, E. A., Stempel, D., Everard, M. L., & Barnes, N. (2017). Effect of inhaled corticosteroid particle size on asthma efficacy and safety outcomes: a systematic literature review and meta-analysis. BMC pulmonary medicine, 17(1), 1-16.
Fernandes, S. D. S. C., Solé, D., Camargos, P., Andrade, C. R. D., & Ibiapina, C. D. C. (2018). Fatores associados à expressão da asma em adolescentes. Jornal Brasileiro de Pneumologia, 44(1), 12-17.
Global Initiative for Asthma. Global for Asthma Management and prevention (2019). Retrieved april 7, 2021, from Gina Asthma: https://ginasthma.org/wp-content/uploads/2019/06/GINA-2019-main-report-June-2019-wms.pdf
Jenkins, C. R., Eriksson, G., Bateman, E. D., Reddel, H. K., Sears, M. R., Lindberg, M., & O’Byrne, P. M. (2017). Efficacy of budesonide/formoterol maintenance and reliever therapy compared with higher-dose budesonide as step-up from low-dose inhaled corticosteroid treatment. BMC pulmonary medicine, 17(1), 1-8.
Kew, K. M., Quinn, M., Quon, B. S., & Ducharme, F. M. (2016). Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children. Cochrane Database of Systematic Reviews, (6).
Kuschnir, F. C., Gurgel, R. Q., Solé, D., Costa, E., Felix, M. M. R., Oliveira, C. L. D., Vasconcellos, M. T. L., & Kuschnir, M. C. C. (2016). ERICA: prevalência de asma em adolescentes brasileiros. Revista de Saúde Pública, 50, 13s.
Leung, J. S., Johnson, D. W., Sperou, A. J., Crotts, J., Saude, E., Hartling, L., & Stang, A. (2017). A systematic review of adverse drug events associated with administration of common asthma medications in children. PLoS One, 12(8), e0182738.
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ, 339, b2700.
O’Byrne, P. M., FitzGerald, J. M., Bateman, E. D., Barnes, P. J., Zhong, N., Keen, C., Jorup, C., Lamarca, R., Inavov, S., & Reddel, H. K. (2018). Inhaled combined budesonide–formoterol as needed in mild asthma. New England Journal of Medicine, 378(20), 1865-1876.
Oliver, A. J., Covar, R. A., Goldfrad, C. H., Klein, R. M., Pedersen, S. E., Sorkness, C. A., Tomkins, S. A., Villarán, C., & Grigg, J. (2016). Randomized trial of once-daily fluticasone furoate in children with inadequately controlled asthma. The Journal of pediatrics, 178, 246-253.
Pearlman, D. S., Eckerwall, G., McLaren, J., Lamarca, R., Puu, M., Gilbert, I., Jorup, C., Sandin, K., & Lanz, M. J. (2017). Efficacy and safety of budesonide/formoterol pMDI vs budesonide pMDI in asthmatic children (6–< 12 years). Annals of Allergy, Asthma & Immunology, 118(4), 489-499.
Peters, S. P., Bleecker, E. R., Canonica, G. W., Park, Y. B., Ramirez, R., Hollis, S., Fjallbrant, H., Jorup, C., & Martin, U. J. (2016). Serious asthma events with budesonide plus formoterol vs. budesonide alone. New England Journal of Medicine, 375(9), 850-860.
Pizzichini, M. M. M., Carvalho-Pinto, R. M. D., Cançado, J. E. D., Rubin, A. S., Cerci Neto, A., Cardoso, A. P., Cruz, A. A., Fernandes, A. L. G., Blanco, D. C., Vianna, E. O., Junior, G. C., Rizzo, J. A., Fritscher, L. G., Caetano, L. S. B., Pereira, L. F. F., Rabahi, M. F., Oliveira, M. A.., Lima, M. A., Almeida, M. B., Stelmach, R., Pitrez, P.M., & Cukier, A. (2020). Recomendações para o manejo da asma da Sociedade Brasileira de Pneumologia e Tisiologia-2020. Jornal Brasileiro de Pneumologia, 46(1).
Płoszczuk, A., Bosheva, M., Spooner, K., McIver, T., & Dissanayake, S. (2018). Efficacy and safety of fluticasone propionate/formoterol fumarate in pediatric asthma patients: a randomized controlled trial. Therapeutic advances in respiratory disease, 12, 1753466618777924.
Prishtina, L. N. (2014). The Global Asthama Report 2014: https://rsdjournal.org/index.php/rsd/about/submissions
Singh, A., Nandan, D., Dewan, V., & Sankar, J. (2016). Comparison of clinical effects of beclomethasone dipropionate & budesonide in treatment of children with mild persistent asthma: A double-blind, randomized, controlled study. The Indian journal of medical research, 144(2), 250.
Sonnappa, S., McQueen, B., Postma, D. S., Martin, R. J., Roche, N., Grigg, J., Guilbert, T., Gouder, C., Pizzichini, E., Niimi, A., Phipatanakul, W., Chisholm, A., Dandurand, R. J., Kaplan, A., Israel, E., Papi, A., Aalderen, W. M. C., Usmani, O. S.,& Price, D. B. (2018). Extrafine versus fine inhaled corticosteroids in relation to asthma control: a systematic review and meta-analysis of observational real-life studies. The Journal of Allergy and Clinical Immunology: In Practice, 6(3), 907-915.
Wang, G., Zhang, X., Zhang, H. P., Wang, L., Kang, D. Y., & Barnes, P. J. (2017). Corticosteroid plus β 2-agonist in a single inhaler as reliever therapy in intermittent and mild asthma: a proof-of-concept systematic review and meta-analysis. Respiratory research, 18(1), 1-18.
Wolthers, O. D., Stone, S., Bareille, P., Tomkins, S., & Khindri, S. (2017). Knemometry assessment of short-term growth in children with asthma receiving fluticasone furoate for 2 weeks: a randomized, placebo-controlled, crossover trial. Clinical therapeutics, 39(6), 1191-1199.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Lucas Nobrega de Oliveira; Aline Kely Felício de Sousa; Richard Morrinson Couras de Carvalho; Bruno Wesley Ramalho Cirilo Ferreira; Cibério Landim Macedo
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
