Allergic bronchopulmonary aspergillosis in patients with Cystic Fibrosis
Keywords:Cystic fibrosis; Aspergillus fumigatus; Allergic bronchopulmonary aspergillosis.
Cystic fibrosis (CF) is a genetic disease of autosomal recessive profile and is characterized by dysfunction of the CFTR gene, which will affect some organs such as the lungs, pancreas, liver, intestines, and testes, with the lungs being the most characteristic. Such changes are capable of causing consistent obstructions due to the viscous mucus produced. Infections are a recurrent factor in carriers of this disease due to the presence of secretion, becoming an ideal environment for the propagation of microorganisms, such as fungi and bacteria, which can colonize the airways of patients and bring about an aggravation, worsening the patient's clinical picture. This is the case of the fungus Aspergillus fumigattus, the cause of allergic bronchopulmonary aspergillosis (ABPA), which can lead to relevant complications, especially in lung function. Analyzing the factors that make CF patients more likely to contract ABPA and how this can worsen their clinical condition, searching for materials from the PUBMED and SCIELO platforms, using the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), the results obtained in this study show that the presence of ABPA in cystic fibrosis patients brings increased microbial colonization, lung deterioration, poorer nutritional status, and greater respiratory obstruction by mucus that causes a greater increase in hospitalization.
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