Treatment of Cerebrovascular Accident (CVA) sequelae with botulinum toxin: A literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i8.17880

Keywords:

Botulinum toxin; Paralysis; Stroke; Rehabilitation; Muscle spasticity.

Abstract

Introduction: The cerebrovascular accident (CVA) is a very prevalent event in the world population, and among its sequelae, muscle spasticity and paralysis stand out. Botulinum toxin is a pharmacological technique that brings beneficial effects to patients with spasticity, such as gain in range of motion and improvement in the function of affected limbs. Objective: to identify the evidence regarding the use of this toxin in these patients, especially in the face of muscle spasticity, an event strongly related to a stroke. Methodology: This is a descriptive research of the integrative literature review type, which seeks evidence on the use of botulinum toxin for the treatment of stroke sequelae. The search was conducted using PubMed, MEDLINE, Scielo, CDSR, Google Scholar, BVS and EBSCO databases, from 2003 to 2021. Thus, 26 scientific productions were totaled for the integrative literature review. Results: the treatment of spasticity with botulinum toxin is more successful when the administration follows some                 criteria such as: dose adjustment according to age, weight, degree of spasticity and musculature administered. Conclusion: the application of this toxin, combined with continued physical therapy, is the treatment of first choice for muscle spasticity, particularly in patients with sequelae after stroke, in order to increase mobility, range of motion, facilitate the performance of hygiene and other functional activities, improve immobilization wear and pain, and, thus, improve the quality of life of these patients.

References

Almeida, S. R. M. (2012). Análise epidemiológica do acidente vascular no Brasil. Revista Neurociências, 20 (4), 481-482. https://doi.org/10.34024/rnc.2012.v20.8219

Anjos, A. A., Moura, B. A., Lima, J. M. C. S. R & Lima, P. C. S. R. (2020). Toxina botulínica para correção de assimetria facial pós AVE: relato de caso clínico. Research, Society and Development, 9 (10), 1-17. https://doi.org/10.33448/rsd-v9i10.9214

Barbosa, A. C., Ribeiro, I. M & Medeiros, L. (2020). Paresia do membro superior contralateral após infiltração de toxina botulínica A para espasticidade pós-AVE. Revista Científica da Ordem dos Médicos, 33 (11), 761-764. https://doi.org/10.20344/amp.11503

Barbosa, C. M. R. & Barbosa, J. R. A. (2017). Toxina botulínica em Odontologia. Elsevier.

Calil, A. M. & Paranhos, W. Y. (2007). O enfermeiro e as situações de emergência. Atheneu.

Cardoso, E., Pedreira, G., Prazeres, A., Nildo, R. & Melo, A. (2007). Does Botulinum Toxin improve the function of the patient with spasticity after stroke? Arq Neuropsiquiatr, 63(3), 592-595. https://doi.org/10.1016/j.rehab.2018.05.1320

Casaca, I. (2006). Fisioterapia e Toxina Botulínica do Tipo A. Arq Fisioter, 1(2), 46-53.

Demetrios, M., Khan F., Stokes, L. T. M., Brand, C. & McSweeney, S. (2013). Multidisciplinary rehabilitation following botulinum toxin and other focal intramuscular treatment for post-stroke spasticity. Cochrane Database of Systematic Reviews, 5 (6). https://doi.org/10.1002/14651858.CD009689

Elovic, E. P., Brashear, A., Kaelin D., Liu, J., Millis, R. S., Barron, R. & Turkel, C. (2008). Repeated Treatments With Botulinum Toxin Type A Produce Sustained Decreases in the Limitations Associated With Focal Upper-Limb Poststroke Spasticity for Caregivers and Patients. Arch Phys Med Rehabil, 89 (1), 799-806. https://doi.org/10.1016/j.apmr.2008.01.007

Ênia, J. R. N., Fernandes, J. G. A, Nascimento, F., Silva, L. A. M., Reis, T. & Dietrich, L. (2021). Toxina botulínica no tratamento da paralisia facial: um tratamento reabilitador minimamente invasivo. Research, Society and Development, 10 (5), 1-11. http://dx.doi.org/10.33448/rsd-v10i5.15204

Figallo, M. A. S., Hernández, G. R. L., Lagares, D. T., Araya, A. C., Ferrerosa, O. T., Pacheco, E. H. & Perez, J. L. G. (2020). Use of Botulinum Toxin in Orofacial Clinical Practice. Toxins, 12(2), 1-16. https://doi.org/10.3390/toxins12020112

Foley, N., Pereira S., Salter, K., Fernandez, M. M., Speechley, M., Sequeira, K., Miller, T. & Teasell, R. (2013). Treatment with botulinum toxin improves upper-extremity function post stroke: a systematic review and meta-analysis. Archives of Physical Medicine and Rehabilitation, 94 (5), 977-989. https://doi.org/10.1016/j.apmr.2012.12.006

Fujimura, O. T. R. K. (2017). Improvement in Disability Assessment Scale after Botulinum toxin A treatment for upper limb spasticity. Japanese Journal of Comprehensive Rehabilitation Science, 8 (1), 4-9. https://doi.org/10.11336/jjcrs.8.4

Gouvêa, D., Gomes, C. S. P., Melo, S. C., Abrahão, P. N. & Barbieri, G. (2015). Acidente Vascular Encefálico: uma revisão da literatura. Ciência Atual: Revista Científica Multidisciplinar da Universidade São José, 6 (2), 2-6.

Kaji, R., Osako, Y., Suyama, K., Maeda, T., Uechi, Y. & Iwasaki, M. (2010). Botulinum toxin type A in post-stroke upper limb spasticity. Current Medical Research & Opinion, 36 (8), 1983-1992. https://doi.org/10.1185/03007995.2010.497103

Lauaté, J., Landrault, E., Courtois, S. J., Mertens, P. & Boisson, D. G. (2004). Traitement de la spasticité focale du membre supérieur par toxine botulinique après accident vasculaire cérébral (AVE). Intérêt d’une approche au cas par cas. Annales de Réadaptation et de Médecine Physique, 47 (1), 555-562. https://doi.org/0.1016/j.annrmp.2004.02.01

Lima, L. S. R. & Guedes, J. L. S. (2020). Botulinum toxin in dentistry: a literature. Review. Rev. Brá, 77 (1), 1-8. tp://dx.doi.org/10.18363/rbo.v77.2020.e1798

Lundstrom, E., Terént, A. & Borg, L. (2008). Prevalence of disabling spasticity 1 year after first-ever stroke. European Journal of Neurology, 15 (6), 533-539. https://doi.org/10.1111/j.1468-1331.2008.02114.x

Mukai, Y. & Kaji, R. (2011). Use of botulinum neurotoxin therapy. Brain and Nerve 63 (7), 775-784. https://doi.org/10.11477/mf.1416100959

Oliveira, D. R. N, Paiva, I. M. B. & Anomal, R. F (2017). O uso da toxina botulínica no tratamento da espasticidade após acidente vascular encefálico: uma revisão de literatura. Journals Bahiana School of Medicine and Public Health, 7 (12), 289-297. http://dx.doi.org/10.17267/2238-2704rpf.v7i2.1242

Piassaroli, C. A. P, Almeida, G. C., Luvizotto, C. & Suzan, A. B. B. M. (2012). Physical Therapy Rehabilitation Models in Adult Patients with Ischemic Stroke Sequel. Revista Neurociências, 20 (1), 128-137. https://doi.org/10.34024/rnc.2012.v20.10341

Pierson, S. H., Katz, D. L. & Tarsy, D. (1996). Botulinum toxin A in the treatment of spasticity: functional implications and patient selection. Archives of Physical Medicine and Rehabilitation, 77 (7), 717-721. https://doi.org/10.1016 / s0003-9993 (96) 90015-5.

Pimentel, L. H. C., Alencar, F. J., Rodrigues, L. R. S., Sousa, F. C. F. & Teles, J. B. M. (2014). Effects of botulinum toxin type A for spastic foot in post-stroke patients enrolled in a rehabilitation program. Arq Neuropsiquiatr, 22 (1), 28-32. https://doi.org/10.1590/0004-282x20130189

Portella, L. V., Santiago, F. L. D., Maia, P. A. & Mancini, M. C. (2004). Os efeitos da toxina botulínica no tratamento da espasticidade: uma revisão da literatura. Revista da Fisioterapia da Universidade de São Paulo, 11 (1), 47-55. https://doi.org/10.1590/fpusp.v11i1.76883

Schuster, R. C., Sant, C. R. & Dalbosco, V. (2007). Efeitos da estimulação elétrica funcional (FES) sobre o padrão de marcha de um paciente hemiparético. Acta Fisiátrica, 14 (2), 82-86. https://doi.org/10.11606/issn.2317-0190.v14i2a102794

Serrano S., Constantino, J., Januário, F. & Amaral, C. (2014). Espasticidade do Membro Superior: Avaliação da Eficácia e Segurança da Toxina Botulínica e Utilidade da Escala GAS - Estudo Retrospetivo. Rev Soc Port Med Fis Reabil, 25 (1), 11-19. http://dx.doi.org/10.25759/spmfr.127

Slawek J., Bogucki, U. & Reclawowicz, D. (2005). Botulinum toxin type A for upper limb spasticity following stroke: an open-label study with individualised, flexible injection regimens. Neurol Sci, 26 (1), 32-39. https://doi.org/ 10.1007 / s10072-005-0379-8.

Souza, A. O. & Cavalcanti, D. S. P. (2016). Toxina Botulínica Tipo A: aplicação e particularidades no tratamento da espasticidade, do estrabismo, do blefaroespasmo e de rugas faciais. Saúde & Ciência em Ação, 3 (1), 58-70.

Sposito, M. M. M. (2004). Toxina botulínica tipo A: propriedades farmacológicas e uso clínico. Acta Fisiátrica, 11 (1), 7-44. https://doi.org/ 10.11606/issn.2317-0190.v11isupl.1a102495

Sposito, M. M. M. (2009). Botulinic Toxin Type A: action mechanism. Acta Fisiátrica, 16 (1), 25-37.

Teles, M. S. & Gusmão, C. (2012). Fugl-Meyer Functional Evaluation of Patients patients with Stroke using the protocol of Fugl-Meyer. Revista Neurociências, 20 (1), 42-49.

Thompson, A. J., Jarrett, L., Lockley, J., Marsden, J. & Stevenson VL (2005). Clinical Management of spasticity. Journal of Neurology, Neurosurgery, and Psychiatry, 76 (4), 459-463. https://doi.org/10.1136 / jnnp.2004.035972

Veverka, T., Hluštík, P., Hok, P., Otruba, P., Zapletalová, J., Zapletalová, J., Tüdös, Z., Alois, K. A. & Kaňovský, P. (2016). Sensorimotor modulation by botulinum toxin A in post -stroke arm spasticity: Passive hand movement. J Neurol Sci, Czech Republic, 362 (3), 14-20.

Ward, A. B., Wissel, J., Borg, J., Ertzgaard, P., Herrmann, C., Kulkarni, J., Lindgren, K., Reuter, I., Sakel, M., Satero, P., Sharma, S., Wein, T., Wright, N. & Smith, A. F. (2014). Functional goal achievement in post-stroke spasticity patients: the BOTOX Economic Spasticity Trial (BEST). J Rehabil Med. 46 (6), 504–513. https://doi.org/ 10.2340 / 16501977-1817

Wolfgang, J. H., Hefter, H., Reissig, A., Kollewe, K. & Wissel, J. (2014). Efficacy and safety of botulinum toxin type A (Dysport) for the treatment of post-stroke armspasticity: Results of the German–Austrian open-label post-marketing surveillance prospective study. J Neurol Sci, 337 (1), 86-90. https://doi.org/10.1016 / j.jns.2013.11.022

Published

18/07/2021

How to Cite

FIGUEIREDO, B. Q. de; RICARDO NETO, A. .; NOGUEIRA, C. F. R.; FERNANDES, R. A.; ALMEIDA, M. G. . Treatment of Cerebrovascular Accident (CVA) sequelae with botulinum toxin: A literature review . Research, Society and Development, [S. l.], v. 10, n. 8, p. e56610817880, 2021. DOI: 10.33448/rsd-v10i8.17880. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/17880. Acesso em: 24 sep. 2023.

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Section

Health Sciences