Carbamazepine and carbamazepine-10, 11-epoxide therapeutic drug monitoring and biochemical and hematological evaluation in bipolar disorder outpatients

Authors

DOI:

https://doi.org/10.33448/rsd-v10i11.19640

Keywords:

Therapeutic monitoring of drugs; Carbamazepine; Carbamazepine-10; 11-Epoxide; Hematological and biochemical parameters; HPLC-PDA validation; Bipolar disorder.

Abstract

The objective of this study was to validate an analytical technique with HPLC-PDA for plasma measurement of carbamazepine (CBZ) and its metabolite carbamazepine-10, 11-epoxide (CBZ-E) for therapeutic monitoring (TM) of patients diagnosed with bipolar disorder (BD), as well as evaluating hematological and biochemical parameters of patients using CBZ. Sixteen patients registered with the Public Service of Psychiatry were selected. CBZ and CBZ-E measurements were performed with HPLC-PDA shimadzu LC-20 AT Prominence, under concentration gradient. Validation criteria: selectivity, linearity, precision, accuracy, recovery, stability. Hematological and biochemical tests were performed using conventional methods. As a result, it was obtained: accuracy >85% and precision <15%, good selectivity, robustness and stability, LOQ = 250 ng.mL-1 and HQL = 60,000 ng.mL-1. Among patients, 25% and 6.25% had CBZ and CBZ-E levels within the therapeutic range, respectively. There were hematological and biochemical changes related to the drug. The validated method is reliable for its intended purpose. TM proved to be extremely useful for detecting therapeutic failure.

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Published

04/09/2021

How to Cite

CUNHA, L. C. da .; FREIRE, R. V. C. .; SILVA, C. M. de S. .; SALAZAR, V. C. R. .; CRUZ, A. de C. .; OLIVEIRA NETO, J. R. de .; ALMEIDA, R. F. de .; PEREIRA, I. B. . Carbamazepine and carbamazepine-10, 11-epoxide therapeutic drug monitoring and biochemical and hematological evaluation in bipolar disorder outpatients. Research, Society and Development, [S. l.], v. 10, n. 11, p. e377101119640, 2021. DOI: 10.33448/rsd-v10i11.19640. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/19640. Acesso em: 25 apr. 2024.

Issue

Vol. 10 No. 11

Section

Health Sciences

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Copyright (c) 2021 Luiz Carlos da Cunha; Ramias Vieira Calixto Freire; Carla Maria de Sousa Silva; Vania Cristina Rodriguez Salazar; Alessandro de Carvalho Cruz; Jerônimo Raimundo de Oliveira Neto; Renzo Freire de Almeida; Iuri Barbosa Pereira

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