Findings of magnetic resonance and neurological outcome in newborns with Hypoxic Ischemic En-cephalopathy: integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i11.19736

Keywords:

Asphyxia Neonatorum; Hypoxia-Ischemia, Brain; Infant, Newborn; Diagnostic Imaging; Neurodevelopmental disorders.

Abstract

The aim of the study was to analyze the main findings in neuroimaging exams and neurodevelopmental outcomes in children with hypoxic-ischemic encephalopathy. This is an integrative review in which searches were performed on the CINAHL and PubMed databases, with the following inclusion criteria: cohort studies, clinical trials, publications from the last 5 years in the languages of Portuguese, English and Spanish. Infant: birth-23 months, Infant: 1-23 months, human, diagnosis by magnetic resonance, tomography and electroencephalogram. Of the 2,248 articles that were identified, 11 were selected to compose the study. Imaging tests showed the prevalence of lesions in the basal ganglia and thalamus and in white matter. The main neurological results identified were characterized as motor, cognitive and language delay. There was a higher frequency of lesions in Basal Ganglia, Thalamus and in the White Matter was discovered by means of magnetic resonance imaging. Regarding child development, the main outcomes identified were motor, cognitive and language delay. This study points out the disadvantages caused by the limited access to neuroimaging techniques in developing countries, as well as the lack of standardized instruments for assessing child development.

References

Abreu, A. J. P. (2018). Encefalopatia Neonatal: etiologia e morbilidade [Dissertação de Mestrado, Faculdade de Medicina da Universidade de Coimbra]. Repositório científico da Universidade de Coimbra. http://hdl.handle.net/10316/82130

Adhikari, S., & Rao, K. S. (2017). Neurodevelopmental outcome of term infants with perinatal asphyxia with hypoxic ischemic encephalopathy stage II. Brain & development, 39(2), 107-111. https://doi.org/10.1016/j.braindev.2016.09.005

Al Amrani, F., Kwan, S., Gilbert, G., Saint-Martin, C., Shevell, M., & Wintermark P. (2017). Early Imaging and Adverse Neurodevelopmental Outcome in Asphyxiated Newborns Treated With Hypothermia. Pediatric neurology, 73, 20-27. https://doi.org/10.1016/j.pediatrneurol.2017.04.025

Albuquerque, K. A. de., & Cunha, A. C. B. da. (2020). Novas tendências em instrumentos para triagem do desenvolvimento infantil no Brasil: uma revisão sistemática. Journal of Human Growth and Development, 30(2), 188-196. https://doi.org/10.7322/jhgd.v30.10366

Alves, S. C. C. (2012). Fisiopatologia dos gânglios da base na Doença de Parkinson [Dissertação de Mestrado, Faculdade de Medicina da Universidade de Coimbra]. Repositório científico da Universidade de Coimbra. http://hdl.handle.net/10316/84946

American Academy of Pediatrics. (2007). Bright futures: Guidelines for health supervision of infants, children, and adolescents (3ª ed.). American Academy of Pediatrics.

Araújo, A. T. C., Eickmann, S. H., & Coutinho, S. B. (2013). Fatores associados ao atraso do desenvolvimento motor de crianças prematuras internadas em unidade de neonatologia. Revista Brasileira de Saúde Materno Infantil, 13(2), 119-128. https://doi.org/10.1590/S1519-38292013000200005

Araújo, B. C., Gerzson, L. R., & Almeida, C. S. de. (2020). Aspectos avaliativos do desenvolvimento infantil na atenção básica: uma revisão integrativa. Archives of Health Sciences, 27(1), 56-60. https://doi.org/10.17696/2318-3691.27.1.2020.1462

Azhari, A., Truzzi, A., Neoh, M. J.-Y., Balagtas, J. P. M., Tan, H. H., Goh, P. P., Ang, X. A., Setoh, P., Rigo, P., Bornstein, M. H., & Esposito, G. (2020). A decade of infant neuroimaging research: What have we learned and where are we going?. Infant Behavior and Development, 58, 1-15. https://doi.org/10.1016/j.infbeh.2019.101389

Ballantyne, M., Stevens, B., Guttmann, A., Willan, A. R., & Rosenbaum, P. (2014). Maternal and infant predictors of attendance at Neonatal Follow-Up programmes. Child: care, health and development, 40(2), 250-258. https://doi.org/10.1111/cch.12015

Ballot, D. E., Rakotsoane, D., Cooper, P. A., Ramdin, T. D., Chirwa, T., & Pepper, M. S. (2020). A prospective observational study of developmental outcomes in survivors of neonatal hypoxic ischaemic encephalopathy in South Africa. The South African Medical Journal, 110(4), 308-312. https://doi.org/10.7196/SAMJ.2020.v110i4.14311

Barta, H., Jermendy, A., Kolossvary, M., Kozak, L. R., Lakatos, A., Meder, U., Szabo, M., & Rudas, G. (2018). Prognostic value of early, conventional proton magnetic resonance spectroscopy in cooled asphyxiated infants. BMC Pediatrics, 18(302), 1-11. https://doi.org/10.1186/s12887-018-1269-6

Bayley, N. (2006). Bayley scales of Infant and Toddler Development (3ª ed.). Harcourt Assessment.

Binkowski, R. T. K., & Weinmann, A. R. M. (2015). Hipotermia terapêutica em recém-nascidos com diagnóstico de encefalopatia hipóxico isquêmica: Revisão de Literatura. Revista Saúde (Santa Maria), 41(1), 37-48. http://dx.doi.org/10.5902/2236583410649

Botelho, L. L. R., Cunha, C. C. A., & Macedo, M. (2011). O método da revisão integrativa nos estudos organizacionais. Gestão E Sociedade, 5(11), 121-136. https://doi.org/10.21171/ges.v5i11.1220

Cardoso, F. G. C., Formiga, C. K. M. R., Bizinotto, T., Tessler, R. B., & Rosa Neto, F. (2017). Validade concorrente da escala Brunet-Lézine com a escala bayley para avaliação do desenvolvimento de bebês pré-termo até dois anos. Revista Paulista de Pediatria, 35(2), 144-150. https://doi.org/10.1590/1984-0462/;2017;35;2;00005

Charon, V., Proisy, M., Bretaudeau, G., Bruneau, B., Pladys, P., Beuchée, A., Burnouf-Rose, G., Ferré, J.-C., & Rozel, C. (2016). Early MRI in neonatal hypoxic-ischaemic encephalopathy treated with hypothermia: Prognostic role at 2-year follow-up. European journal of radiology, 85(8), 1366-1374. https://doi.org/10.1016/j.ejrad.2016.05.005

Dunne, J. M., Wertheim, D., Clarke, P., Kapellou, O., Chisholm, P., Boardman, J. P., & Shah, D. K. (2017). Automated electroencephalographic discontinuity in cooled newborns predicts cerebral MRI and neurodevelopmental outcome. Archives of Disease in Childhood - Fetal and Neonatal Edition, 102(1), 58-64. https://doi.org/10.1136/archdischild-2015-309697

Edwards, A. D., Brocklehurst, P., Gunn, A. J., Halliday, H., Juszczak, E., Levene, M., Strohm, B., Thoresen, M., Whitelaw, A., & Azzopardi, D. (2010). Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ, 340(c363), 1-7. https://doi.org/10.1136/bmj.c363

Ferreira, L. S. (2019). Alterações de neuroimagem estrutural em crianças com encefalopatia epiléptica de causa desconhecida. [Dissertação de Mestrado, Faculdade de Ciências Médicas da Universidade Estadual de Campinas]. Repositório da Produção Científica e Intelectual da Unicamp. http://repositorio.unicamp.br/jspui/handle/REPOSIP/334047

França, E. B., Lansky, S., Rego, M. A. S., Malta, D. C., França, J. S., Teixeira, R., Porto, D., Almeida, M. F. de., Souza, M. F. M. de., Szwarcwald, C. L., Mooney, M., Naghavi, M., & Vasconcelos, A. M. N. (2017). Principais causas da mortalidade na infância no Brasil, em 1990 e 2015: estimativas do estudo de Carga Global de Doença. Revista Brasileira de Epidemiologia, 20(1), 46-60. https://doi.org/10.1590/1980-5497201700050005

Freitas, Z. M. P. (2016). Influência da avaliação neurológica seriada e seus reflexos no prognóstico funcional de recém-nascidos a termo com asfixia perinatal [Tese de Doutorado, Universidade Federal de Sergipe]. Biblioteca Digital de Teses e Dissertações (BDTD) da UFS. https://ri.ufs.br/jspui/handle/riufs/3634

Freitas, Z. M. P., Pereira, C. U., & Oliveira, D. M. P. (2018). Influência da avaliação neurológica seriada durante período de internamento hospitalar e seus reflexos no prognóstico funcional de recém-nascidos a termo com asfixia perinatal. Revista Brasileira de Neurologia e Psiquiatria, 22(2), 142-156. https://www.revneuropsiq.com.br/rbnp/article/view/409

Goenka, A., & Yozawitz, E. (2018). Prognostic Markers in Term Infants with Hypoxic–Ischemic Encephalopathy: Comparative Analysis of MRI, EEG, and Apgar Scores. Journal of Pediatric Neurology, 16(1), 8-14. https://doi.org/10.1055/s-0037-1606367

Green, E., Stroud, L., Bloomfield, S., Cronje, J., Foxcroft, C., Hurter, K., Lane, H., Marais, R., Marx, C., McAlinden, P., O'Connell, R., Paradice, R., & Venter, D. (2018). Manual Griffiths III - Griffiths Scales of Child Development (3ª ed.). Hogrefe Editora.

Guimarães, M. D., Schuch, A., Hochhegger, B., Gross, J. L., Chojniak, R., & Marchiori, E. (2014). Ressonância magnética funcional na oncologia: estado da arte. Radiologia Brasileira, 47(2), 101-111. https://doi.org/10.1590/S0100-39842014000200013

Gunn, A. J., & Thoresen, M. (2019). Neonatal encephalopathy and hypoxic–ischemic encephalopathy. In L. S. de Vries, & H. C. Glass (Eds.) Handbook of Clinical Neurology (Vol. 162, Cap.10, pp. 217-237). Elsevier. https://doi.org/10.1016/B978-0-444-64029-1.00010-2

Iwata, O., Iwata, S., Thornton, J. S., Vita, E. de., Bainbridge, A., Herbert, L., Scaravilli, F., Peebles, D., Wyatt, J. S., Candy, E. B., & Robertson, N. J. (2007). “Therapeutic time window” duration decreases with increasing severity of cerebral hypoxia–ischaemia under normothermia and delayed hypothermia in newborn piglets. Brain Research, 1154, 173-180. https://doi.org/10.1016/j.brainres.2007.03.083

Lakatos, A., Kolossváry, M., Szabó, M., Jermendy, Á., Barta, H., Gyebnár, G., Rudas, G., & Kozák, L.R. (2019). Neurodevelopmental effect of intracranial hemorrhage observed in hypoxic ischemic brain injury in hypothermia-treated asphyxiated neonates - an MRI study. BMC Pediatrics, 19(430), 1-11. https://doi.org/10.1186/s12887-019-1777-z

Madaschi, V. (2012). Tradução, adaptação transcultural e evidências de validade das Escalas Bayley III de Desenvolvimento Infantil em uma população do Município de Barueri, São Paulo [Dissertação de Mestrado, Universidade Presbiteriana Mackenzie]. Biblioteca Digital de Teses e Dissertações da Universidade Presbiteriana Mackenzie. http://tede.mackenzie.br/jspui/handle/tede/1591

Mastrangelo, M., Di Marzo, G., Chiarotti, F., Andreoli, C., Colajacomo, M. C., Ruggieri, A., & Papoff, P. (2019). Early Post-cooling Brain Magnetic Resonance for the Prediction of Neurodevelopmental Outcome in Newborns with Hypoxic–Ischemic Encephalopathy. Journal of Pediatric Neurosciences, 14(4), 191-202. https://doi.org/10.4103/jpn.jpn_25_19

Mitra, S., Kendall, G. S., Bainbridge, A., Sokolska, M., Dinan, M., Uria-Avellanal, C., Price D., Mckinnon, K., Gunny, R., Huertas-Ceballos, A., Golay, X., & Robertson, N. J. (2019). Proton magnetic resonance spectroscopy lactate/N-acetylaspartate within 2 weeks of birth accurately predicts 2-year motor, cognitive and language outcomes in neonatal encephalopathy after therapeutic hypothermia. Archives of Disease in Childhood. Fetal and Neonatal Edition, 104(4), 424-432. https://doi.org/10.1136/archdischild-2018-315478

Moher, D., Liberati, A., Tetzlaff, J., & Altman. D. G. (2009). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Medicine, 6(7). https://doi.org/10.1371/journal.pmed.1000097

Montaldo, P., Lally, P. J., Oliveira, V., Swamy, R., Mendoza, J., Atreja, G., Kariholu, U., Shivamurthappa, V., Liow, N., Teiserskas, J., Pryce, R., Soe, A., Shankaran, S., & Thayyil, S. (2019). Therapeutic hypothermia initiated within 6 hours of birth is associated with reduced brain injury on MR biomarkers in mild hypoxic-ischaemic encephalopathy: a non-randomised cohort study. Archives of Disease in Childhood. Fetal and Neonatal Edition, 104(5),515-520. doi: 10.1136 / archdischild-2018-316040

Montanha, S. U. S. de., Silva Filho, W. S. da., & Frazão, D. W. P. (2020). A importância da ressonância magnética fetal no estudo de doenças do sistema nervoso central: revisão integrativa da literatura. Brazilian Journal of Development, 6(10), 74326-74344. https://doi.org/10.34117/bjdv6n10-019

Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid, A. (2016). Rayyan-a web and mobile app for systematic reviews. Systematic Reviews, 5(210), 1-10. https://doi.org/10.1186/s13643-016-0384-4

Palisano, R., Rosenbaum, P., Walter, S., Russell, D., Wood, E., & Galuppi, B. (1977). Development and reliability of a system to classify gross motor function in children with cerebral palsy. Development Medicine & Child Neurology, 39(4), 214-223. https://doi.org/10.1111/j.1469-8749.1997.tb07414.x

Papazian, O. (2018). Encefalopatía Hipóxica-Isquémica Neonatal. Medicina (Buenos Aires), 78(Suppl 2), 36-41. http://www.medicinabuenosaires.com/PMID/30199363.pdf

Perez, J. M., Golombek, S. G., & Sola, A. (2017) Clinical hypoxic-ischemic encephalopathy score of the Iberoamerican Society of Neonatology (Siben): A new proposal for diagnosis and management. Revista da Associação Médica Brasileira, 63(1), 64-69. https://doi.org/10.1590/1806-9282.63.01.64

Piper, M. C., & Darrah, J. (1994). Motor assessment of the developing infant (1ª ed.). Saunders.

Procianoy, R. S., & Silveira, R. C. (2017). Encefalopatia Hipóxico-Isquêmica. In D. A. Burns, D. Campos Júnior., L. R. Silva, W. G. Borges, & D. Blank (Org), Tratado de Pediatria: Sociedade Brasileira de Pediatria. (4ª ed., Vol. 2, pp. 1677-1682). Manole.

Procianoy, R. S., Corso, A. L., Longo, M. G., Vedolin, L., & Silveira, R.C. (2019). Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy: magnetic resonance imaging findings and neurological outcomes in a Brazilian cohort. The Journal of Maternal-Fetal & Neonatal Medicine, 32(16), 2727-2734. https://doi.org/10.1080/14767058.2018.1448773

Procianoy, R. S., Corso, A. L., Schoenardie, B. O., De Oliveira, G. P., Longo M. G., & Silveira R. C. (2020). Outcome and Feasibility after 7 Years of Therapeutic Hypothermia in Southern Brazil. American Journal of Perinatology, 37(9), 955-961. https://doi.org/10.1055/s-0039-1692388

Rao, R., Trivedi, S., Distler, A., Liao, S., Vesoulis, Z., Smyser, C., & Mathur, A. M. (2019). Neurodevelopmental Outcomes in Neonates with Mild Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia. American Journal of Perinatology, 36(13), 1337–1343. https://doi.org/10.1055/s-0038-1676973

Rêgo, M. G. S., Vilela, M. B. R., & De Oliveira, C. M. (2018). Óbitos perinatais evitáveis por intervenções do Sistema Único de Saúde do Brasil. Revista Gaúcha de Enfermagem, 39, e2017-0084. https://doi.org/10.1590/1983-1447.2018.2017-0084

Rodrigues, O. M. P. R. (2012). Escalas de desenvolvimento infantil e o uso com bebês. Educar em Revista, 43, 81-100. https://doi.org/10.1590/S0104-40602012000100007

Sarnat, H. B., & Sarnat, M. S. (1976). Neonatal Encephalopathy Following Fetal Distress: A Clinical and Electroencephalographic Study. Archives of Neurology, 33, 696-705. https://doi.org/10.1001/archneur.1976.00500100030012

Silva, N. D. S. H., Lamy Filho, F., Gama, M. E. A., Lamy, Z. C., Pinheiro, A. L., & Silva, D. N. (2011). Instrumentos de avaliação do desenvolvimento infantil de recém-nascidos prematuros. Revista Brasileira Crescimento Desenvolvimento Humano, 21(1), 85-98. http://pepsic.bvsalud.org/scielo.php?script=sci_arttext&pid=S0104-12822011000100009

Sociedade Brasileira De Pediatria. (2019-2021). Hipotermia Terapêutica: Documento Científico (4ª ed.). Departamento Científico de Neonatologia. https://www.sbp.com.br/imprensa/detalhe/nid/hipotermia-terapeutica/#:~:text=A técnica de hipotermia vem,diagnóstico de encefalopatia hipóxico-isquêmica

Souza, R. G., Menezes, M. S. D., Castro, P. S., Carneiro, J. A., De Pinho, L., & Caldeira, A. P. (2020). Atraso do desenvolvimento neuropsicomotor entre recém-nascidos de alto risco acompanhados em um ambulatório de seguimento. Revista Norte Mineira de Enfermagem, 9(1), 57–66. https://doi.org/10.46551/rnm23173092202090107

Stillwell, S. B., Fineout-Overholt, E., Melnyk, B. M., & Williamson, K. M. (2010). Evidence-based pratice, step by step: searching for the evidence. The American Journal of Nursing, 110(5), 41-47. https://doi.org/10.1097/01.naj.0000372071.24134.7e

Tagin, M. A., Woolcott, C. G., Vincer, M. J., Whyte, R. K., & Stinson, D. A. (2012). Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy: An Updated Systematic Review and Meta-analysis. Archives of Pediatrics & Adolescent Medicine, 166(6), 558-566. https://doi.org/10.1001/archpediatrics.2011.1772

Takazono, P. S., & Golin, M. O. (2013). Asfixia Perinatal: Repercussões Neurológicas e Detecção Precoce. Revista Neurociências, 21(1), 108–117. https://doi.org/10.34024/rnc.2013.v21.8210

World Health Organization (2021). Number of neonatal deaths from birth asphyxia and birth trauma in the world. https://www.who.int/data/maternal-newborn-child-adolescent-ageing/indicator-explorer-new/mca/number-of-neonatal-deaths---by-cause

Zhong, G., Zhang, R., Jiaerken, Y., Yu, X., Zhou, Y., Liu, C., Lin, L., Tong, L. & Lou, M. (2017). Better Correlation of Cognitive Function to White Matter Integrity than to Blood Supply in Subjects with Leukoaraiosis. Frontiers in Aging Neuroscience, 9(185), 1-7. https://doi.org/10.3389/fnagi.2017.00185

Published

04/09/2021

How to Cite

FERREIRA, B. C.; CARDOSO, A.; RESENDE, L. T. de; ANDRADE, A. da S. A.; OLIVEIRA, H. F. .; VAEZ, A. C. . Findings of magnetic resonance and neurological outcome in newborns with Hypoxic Ischemic En-cephalopathy: integrative review. Research, Society and Development, [S. l.], v. 10, n. 11, p. e356101119736, 2021. DOI: 10.33448/rsd-v10i11.19736. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/19736. Acesso em: 16 apr. 2024.

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Review Article