Azithromycin: characteristics and clinical indications for bacterial and virus infections, including SARS-CoV-2 infections
DOI:
https://doi.org/10.33448/rsd-v10i12.19864Keywords:
COVID-19; SARS-CoV-2; Clinical trial; Hydroxychloroquine; Azithromycin.Abstract
Objective: to accomplish a literature review to research the clinical characteristics of azythromycin, and its indications and associations for SARS-CoV-2 infections. Methodology: Electronic searches were carried out on PUBMED Central, BVS/BIREME, Web of Science and The Cochrane Library with the aid of key-words. Results: Azithromycin is a secure antibiotic belonging to the macrolide class, effective for a vast number of infections, especially respiratory diseases. It seems to have viral indirect activity due to its being capable of altering the cell machinery, including mitochondrias, for changing the normal functioning of mitochondrial ribosomes. Conclusion: It is uncertain whether azithromycin is eligible for the treatment of virus infections in general and especially for COVID-19. Its combination with hydroxychloroquine, however, should be better researched in order to answer if it can be applied as a clinical approach for this matter.
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Copyright (c) 2021 Gabriel Henrique Queiroz Oliveira; Guilherme Marinho Sampaio; Hadassa Fonsêca Silva; Douglas José Abreu da Silva Cristovam; Rodolfo Scavuzzi Carneiro Cunha; Sandra Sayão Maia; Paulo Melo Júnior; Felipe Leonardo de Melo Almeida Fonseca; Alexandrino Pereira dos Santos Neto; Ailton Coelho de Ataíde Filho; Luciano Barreto Silva
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