Influence of storage and expiry date on stability and occurrences of adverse events in the use of medicines
DOI:
https://doi.org/10.33448/rsd-v10i15.22341Keywords:
Expiration date; Highly surveillance medicines; Term of use of medicines.Abstract
The consumption of inappropriate medications can be important in the occurrence of adverse events and cause harm to patients' health. It is perceived that internal and external factors, physical and chemical, have the ability to influence the stability of the constituents and can change the nature of clinical outcomes through the use of these drugs. This work aims to survey the literature on changes in the constitution of drugs over the period of validity. This is a literature review where searches were performed for scientific articles in SciELO, LILACS and MEDLINE electronic databases with keywords in agreement with the DECs. The shelf life of medicines is determined through technical evaluations and compliance with health regulations where it is ensured that the drug is suitable for human consumption. After this period or disrespecting these guidelines, it is possible that changes occur in their constitutions that can cause intoxication or lead to intoxication such as NET and Syndrome and Steven Jhonson. The consumption of medications in improper conditions, or expired, has the capacity to increase health risks and can promote sequelae and lethal outcomes. Therefore, measures and surveillance are needed to control the quality, validity, storage and consumption conditions of medicines.
References
Ahmad, S., Ahmed, Z., Anwar, M. A. & Sheraz, M. S. (2016). Photostability and photostabilization of drugs and drug products, Int. J. Photoenergy 1–19
Amaral, A. T. D., Andrade, C. H., Kümmerle, A. E., & Guido, R. V. (2017). A evolução da Química Medicinal no Brasil: Avanços nos 40 anos da Sociedade Brasileira de Química. Química Nova, 40, 694-700.
Barata-Silva, C., Hauser-Davis, R. A., Silva, A. L. O. D., & Moreira, J. C. (2017). Desafios ao controle da qualidade de medicamentos no Brasil. Cadernos Saúde Coletiva, 25, 362-370.
Brade, W. P., Herdrich, K., Kachel-Fischer, U. & Araújo, C. E. (1991). Dosing and side-effects of ifosfamide plus mesna. Journal of Cancer Research and Clinical Oncology, 117(S4), S164–S186. doi:10.1007/bf01613224
de Oliveira, J. P. B., Gonzalez, B. L., Chierrito, D., Teston, A. P. M., de Mello, J. C. P., Romanichen, F. M. D. F., & de Medeiros Araújo, D. C. (2020). Análise do peso médio, resistência mecânica e desintegração de comprimidos genéricos de varfarina sódica. Brazilian Journal of Development, 6(9), 69865-69875.
de Araujo Silva, J. G., Neto, J. G. P., & de Araujo Freire, R. (2020). Correlação entre estabilidade e condições de armazenamento de medicamentos no interior das ambulâncias do Serviço Móvel de Urgência (SAMU). Brazilian Journal of Development, 6(12), 94622-94632.
de Oliveira, R. X., Silva, C. H., do Carmo Cupertino, M., da Silva, E. F., da Silva, M. C., Miguel, P. S. B., & Moreira, T. R. (2021). O uso de antimicrobianos na Atenção Primária à Saúde. Brazilian Journal of Health Review, 4(1), 3048-3056.
Facci, J., Diniz, L. F., Reis, N. F., & Fernandes, C. (2020). Evolução da legislação e das técnicas analíticas aplicadas a estudos de estudos de estabilidades de insumos e produtos farmacêuticos. Química Nova, 43, 959-73
Gil, E. D. S. (2010). Controle físico-químico de qualidade de medicamentos. In Controle físico-químico de qualidade de medicamentos (pp. 511-511).
Iserson, K. V. (2021). Should We Use Expired Drugs When Necessary? The Journal of Emergency Medicine, 60(5), 669–73. doi:10.1016/j.jemermed.2021.02.002
Klaassen, C. D., & Watkins III, J. B. (2009). Fundamentos em Toxicologia de Casarett e Doull (Lange). AMGH Editora.
Martins, M. A. F., & Galato, D. (2018). Irregularidades dos medicamentos comercializados no Brasil: uma análise das notificações e das medidas sanitárias de 2012 a 2017. Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia (Health Surveillance under Debate: Society, Science & Technology)–Visa em Debate, 6(4), 23-33.
Souza, J. N. D. (2014). Estudo de estabilidade: fatores que influenciam na estabilidade do medicamento.
McCullough, M., Burg, M., Lin, E., Peng, D., & Garner, W. (2017). Steven Johnson Syndrome and Toxic Epidermal Necrolysis in a burn unit: A 15-year experience. Burns, 43(1), 200-205.
Moro A.; Invernizzi, N. (2017). A tragédia da talidomida: a luta pelos direitos das vítimas e por melhor regulação de medicamentos. História, Ciências, Saúde- Manguinhos. 24(3). https://doi.org/10.1590/S0104-59702017000300004.
Neto, H. C., Chagas, B. F., Soares, M. Z., Lachinski, R. E., & Linartevichi, V. F. (2019). Síndrome de Stevens-Johnson associada a fenitoína em pós-operatório de hemorragia intraparenquimatosa cerebral: relato de caso. Fag Journal Of Health (FJH), 1(4), 169-184.
Olson K. R., Anderson I. B., Rodrigues D. C., & Benowitz N. L. et al. (2014). Manual de toxicologia clínica. AMGH Editora.
Pereira, G. C., Barbosa, N. A., de Souza, V. O., de Lima, R. Q., & da Silva, M. T. (2020). Avaliação da qualidade dos comprimidos de ibuprofeno vendidos irregularmente no centro de Manaus em comparação aos medicamentos comercializados em drogarias. Brazilian Journal of Technology, 3(4), 160-168.
Pinto, V. B. (2016). Armazenamento e distribuição: o medicamento também merece cuidados. Uso Racional de Medicamentos: fundamentação em condutas terapêuticas e nos macroprocessos da Assistência Farmacêutica, 1(12), 1-7.
Randhawa G. K., Sharma R., Singh N. R., & Sharma N. (2017). A Qualitative and Quantitative Comparison of Adverse Drug Reaction Data in Different Drug Information Sources. Int J Appl Basic Med Res.;7(4): 223-22710.4103/ijabmr.IJABMR_18_17.
Souza, M. T. de, Silva, M. Dias da & Carvalho, R Integrative review: what is it? How to do it?. Einstein (São Paulo) 8, (1)102-106. <https://doi.org/10.1590/S1679-45082010RW1134>. https://doi.org/10.1590/S1679-45082010RW1134.
Stark G. J. P., Fawcett I. G., & Tucker. (1997). A study of the stability of some commercial solid dosage forms beyond their expiration dates, Pharm. J. 258. 637–640.
Zhang, J., Lei, Z., Xu, C., Zhao, J., & Kang, X. (2021). Current Perspectives on Severe Drug Eruption. Clinical Reviews in Allergy & Immunology, 1-17.
Zilker M., Sorgel F., & Holzgrabe U. (2019). A systematic review of the stability of finished pharmaceutical products and drug substances beyond their labeled expiry dates. Journal of Pharmaceutical and Biomedical Analysis. 10.1016/j.jpba.2019.01.016
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