Pharmaceutical care in improving adherence to drug treatment

Authors

DOI:

https://doi.org/10.33448/rsd-v10i16.23753

Keywords:

Medication adherence; Pharmaceutical services; Pharmacy.

Abstract

Adherence to drug treatment depends on a set of associated factors, and is characterized as crucial for the proper execution of the treatment. Poor adherence can aggravate health conditions and lead to an increase in mortality. One of the activities that make up pharmaceutical care is the promotion and maintenance of treatment adherence. Therefore, this work aims to highlight the importance of the pharmacist and pharmacist care in the adherence process,. A literature review was carried out, based on a search in the PubMed, Google Scholar and Latin American and Caribbean Literature in Health Sciences databases, with a time frame from 2010 to 2021. After screening and applying the inclusion and exclusion criteria, 16 papers were selected.. From these, it was evidenced that pharmaceutical care was applied to different health conditions, from different types of pharmaceutical interventions. Studies have shown improved adherence to drug treatment when associated with pharmaceutical care, in different health contexts, and from a variety of types of interventions. Therefore, it is possible to conclude that pharmaceutical care is shown as a strategic and extremely important practice to promote medication adherence.

References

Agostini, C. P. (2018). Cuidado farmacêutico no Brasil: uma revisão bibliográfica. [Trabalho de conclusão de curso, Universidade Regional Integrada do Alto Uruguai e das Missões]. http://repositorio.uricer.edu.br/handle/35974/180

Araujo, N. C. F., Palhão, D. M. R., Silva, V. C., Ávila, J. O. L., Cardoso, K. F., Santos, E. R. F., Lomba, F. C. M. S., Carvalho, I. R. A., Souza, B. Q., & Polisel, C.G. (2017). Avaliação da adesão ao tratamento em condições crônicas de saúde por meio do cuidado farmacêutico. Revista Brasileira de Farmácia Hospitalar e Serviços de saúde, 08 (03), 37-41. http://rbfhss.saude.ws/revista/arquivos/2017080306001194BR.pdf

Azevedo, M. G. B., Pedrosa, R. S., Aoqui, C. M., Martins, R. R., & Junior, T. N. (2017). Effectiveness of home pharmaceutical interventions in metabolic syndrome: a randomized controlled trial. Brazilian Journal of Pharmaceutical Sciences, 53 (02), 01-09. https://doi.org/10.1590/s2175-97902017000216089

Bastos-barbosa, R. G., Ferriolli, E., Moriguti, J. C., Nogueira, C. B., Nobre, F., Ueta, J., & Lima, N. K.C. (2012). Adesão ao tratamento e controle da pressão arterial em idosos com hipertensão. Arquivos Brasileiros de Cardiologia, 99 (01), 636-641. https://doi.org/10.1590/S0066-782X2012005000054

Chambela, M. C., Mediano, M. F. F., Carneiro, F. M., Ferreira, R. R., Waghabi, M. C., Mendes, V. G., Oliveira, L.S., Holanda, M.T., Souza, A. S., Costa, A. R., Xavier, S. S., Silva, G. M. S., & Saraiva, R. M. (2019). Impact of pharmaceutical care on the quality of life of patients with heart failure due to chronic Chagas disease: Randomized clinical trial. British Journal of Clinical Pharmacology, 01 (86), 143-154. https://doi.org/10.1111/bcp.14152

Chung, W. W., Chua, S. S., Lai, P. S. M., & Chan, S. P. (2014). Effects of a pharmaceutical care model on medication adherence and glycemic control of people with type 2 diabetes. Patient Preference and Adherence, 03 (08), 85-94. https://doi.org/10.2147/PPA.S66619

Cruz, W. M., Queiroz, L. M. D., & Soler, O. (2020). Cuidado farmacêutico para utentes de farmácia comunitária privada: Revisão sistemática. Brazilian Journal of Development, 06 (10), 78682-78702. https://www.brazilianjournals.com/index.php/BRJD/article/view/18343

Gerenutti, M., Martinez, A. M. V., & Bergamaschi, C. C. (2017). The effectiveness of a pharmaceutical care model on adherence to antiretroviral therapy: as AME-based cohort study in brazil. Advanced Pharmaceutical Bulletin, 07 (03), 469-472. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651069/

Gewehr, D. M., Bandeira, V. A. C., Gelatti, G. T., Colet, C. F., & Oliveira, K. R. (2018). Adesão ao tratamento farmacológico da hipertensão arterial na Atenção Primária à Saúde. Saúde Debate, 42 (116), 179-190. https://www.scielo.br/j/sdeb/a/4Dh4vDYyPWvKHSxHzT9X7zf/?lang=pt&format=pdf

Haramiova, Z., Stasko, M., Hulin, M., Tesar, T., Kuzelova, M., & Morisky, D. M. (2017). The effectiveness of daily SMS reminders in pharmaceutical care of older adults on improving patients’ adherence to antihypertensive medication (SPPA): study protocol for a randomized controlled trial. BioMed Central, 18 (334), 01-15. https://trialsjournal.biomedcentral.com/track/pdf/10.1186/s13063-017-2063-8.pdf

Heisler, M., Hofer, T. P., Schmittdiel, J. A., Selby, J.V., Klamerus, M. L., Bosworth, H. B., Bermann, M., & Kerr, E. A. (2012). Improving blood pressure control through a clinical pharmacist outreach program in patients with diabetes mellitus in 2 high-performing health systems: the adher-ence and intensification of medications cluster randomized, controlled pragmatic trial. Circulation, 125 (23), 2863–2872. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999872/

Hernández, C. M. L., Rodríguez, J. A. L., Fernández, F. L., Larrañaga, A. C., Cortes, J. B., Feliu, L. A. G., Plou, B. P., & González, I. D. C. (2020). Social support, social context and nonadherence to treatment in young senior patients with multimorbidity and polypharmacy followed-up in primary care. Plos One, 15 (06), 01-15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314051/

Ho, M. P., Bryson, C. L., & Rumsfeld, J. S. (2009). Medication adherence: its importance in cardiovascular outcomes. Circulation, 119 (23), 3028-3035. https://pubmed.ncbi.nlm.nih.gov/19528344/

Holt, E. W., Muntner, P, Joyce, C. J., Webber, L., & Wood, M. (2010). Health-related quality of life and antihypertensive medication adherence among older adults. Age Ageing, 39 (04), 481-487. https://doi.org/10.1093/ageing/afq040

Khdour, M. R., Elyan, S. O., Hallak, H. O., Jarab, A. S., Mukattash, T. L., & Astal, A. (2019). Pharmaceutical care for adult asthma patients: A controlled intervention one‐year follow‐up study. Basic & Clinal Pharmacology & Toxicology, 01 (126), 332-340. https://doi.org/10.1111/bcpt.13344

Lavielle, M., Puyraimond-zemmour, D., Romand, X., Gossec, L., Senbel, E., Pouplin, S., Beauvais, C., Gutermann, L., Mezieres, M., Dougados, M., & Molto, A. (2018). Methods to improve medication adherence in patients with chronic inflammatory rheumatic diseases: a systematic literature. Rheumatic and Musculoskeletal diseases, 04 (02), 01-08. http://dx.doi.org/10.1136/rmdopen-2018-000684

Li, H., Zheng, S., Liu, F., & Zhao, R. (2021). Fighting against COVID-19: Innovative strategies for clinical pharmacists. Research in Social and Administrative Pharmacy, 01 (17), 1813–1818. https://doi.org/10.1016/j.sapharm.2020.04.003

Lu, M., Zhou, Y., Wang, B., Hu, Z., Du, Y., Liu, S., Lin, X., Cui, Y., & Jin, H. (2018). Impact of multidisciplinary collaborative pharmaceutical care on knowledge, adherence, and efficacy of hormone therapy in climacteric women. Patient Preference and Adherence, 01 (12), 1273-1278. https://doi.org/10.2147/PPA.S165238

Marfo, A. F. A., & Daaku, F. T. O. (2017). Exploring the extended role of the community pharmacist in improving blood pressure control among hypertensive patients in a developing setting. Journal of Pharmaceutical Policy and Practice, 10 (39), 01-09. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740879/

Mary, A., Boursier, A., Henry, I. D., Grados, F., Séjourné, A., Salomon, S., Fardellone, P., Brazier, M., & Goeb, V. (2018). Mobile phone text messages improve treatment adherence in patients taking methotrexate for rheumatoid arthritis: a randomized pilot study. Arthritis Care & Research, 01 (01), 01-26. https://doi.org/10.1002/acr.23750

Martin, D., Luz, P.M., Lake, J. E., Clark, J. L., Campos, D. P., Veloso, V. G., Moreira, R. I., Cardoso, S. W., Klausner, J. D., & Grinsztejn, B. (2017). Pharmacy refill data can be used to predict virologic failure for patients on antiretroviral therapy in Brazil.Journal of the International AIDS Society, 20 (01), 01-05. https://www.arca.fiocruz.br/handle/icict/25689

Menditto, E., Orlando, V., Rosa, G., Minghetti, P., Musazzi, U. M., Cahir, C., Kurczewska-Michalak, M., Kardas, P., Costa, E., Lobo, J. M. S., & Almeida, I. F. (2020). Patient centric pharmaceutical drug product design – the impact on medication adherence. Pharmaceutics, 44 (12), 01-33. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023035/

Milosavljevic, A., Aspden, T., & Harrison, Jeff. (2018). Community pharmacist-led interventions and their impact on patients’ medication adherence and other health outcomes: a systematic review. International Journal of Pharmacy Practice, 01 (26), 387-397. https://doi.org/10.1111/ijpp.12462

Modé, C. L., Lima, M. M., Carnavalli, F., Trindade, A. B., Almeida, A. E., Chin, C. M., & Santos, J. L. (2015). Atenção farmacêutica em pacientes hipertensos: estudo piloto. Revista de Ciências Farmacêuticas Básica e Aplicada, 36 (01), 35-41. https://rcfba.fcfar.unesp.br/index.php/ojs/article/view/65/63

Naqvi, A. A., Hassali, M.A., Naqvi, S. B. S., & Aftab, M. T. (2019). Impact of pharmacist educational intervention on disease knowledge,rehabilitation and medication adherence,treatment-induced direct cost, health related quality of life and satisfaction inpatients with rheumatoid arthritis: study protocol for a randomized controlled trial. BMC research in progress, 20 (488),01-11. https://pubmed.ncbi.nlm.nih.gov/31399128/

Nicoletti, M., A. & Ito, R. K. (2018). Formação do farmacêutico: novo cenário de atuação profissional com o empoderamento de atribuições clínicas. Revista Saúde, 11 (03-04), 01-14. http://revistas.ung.br/index.php/saude/article/view/2536/2395

Oliveira, R. E. M., Filipin, M. D. V., & Giardini, M. H. (2015). Intervenções farmacêuticas destinadas à otimização da adesão ao tratamento medicamentoso de um paciente. Revista Eletrônica de Farmácia, 12 (02), 39-51. https://doi.org/10.5216/ref.v12i2.34346

Plaster, C. P., Melo, D. T., Boldt, V., Cassaro, K. O. S., Lessa, F.C. R., Boechat, G. A. P., Bissoli, N. S., & Andarade, T. U. (2012). Reduction of cardiovascular risk in patients with metabolic syndrome in a community health center after a pharmaceutical care program of pharmacotherapy follow-up. Brazilian Journal of Pharmaceutical Sciences, 48 (03), 435-446. https://www.scielo.br/j/bjps/a/KRHFrqQ5hrHh7q4Lfw6LYVy/?format=pdf&lang=en

Rigoni, C. C., Brito, E. S., Alano, G. M., & Galato, D. (2015). Pharmacotherapy review: a proposal to improve medication adherence among hypertensive patients. Brazilian Journal of Pharmaceutical Sciences, 51 (04), 763-773. https://doi.org/10.1590/S1984-82502015000400002

Saleem, F., Hassali, M. A., Shafie, A. A., Haq, N. U., Faraooqui, M., Aljadhay, H., & Ahmad, F. U. D. (2013). Pharmacist intervention in improving hypertension related knowledge, treatment medication adherence and health-related quality of life: a non-clinical randomized controlled trial. Health Expectations, 01 (18), 1270-1281. https://doi.org/10.1111/hex.12101

Saturnino, L. T. M., Perine, E., Luz, Z. M. P., & Modena, C. M. (2012). Farmacêutico: um profissional em busca de sua identidade. Revista Brasileira de Farmácia, 93 (01),10-16. https://www.arca.fiocruz.br/handle/icict/7860

Silva, L. C. A., Brito, P. O. L., Melo, C. D., Falcai, A., & Pereira, I. C.P. (2017). Contribuições da atenção farmacêutica a pacientes em tratamento oncológico. Revista de Investigação Biomédica, 09 (02), 216-222. http://www.ceuma.br/portalderevistas/index.php/RIB/article/view/164/pdf

Soares, A. L. P. P. P., Costa, M. A., & Teixeira, J. J. V. (2016). Nível de entendimento sobre prescrição farmacêutica. Estamos preparados para essa nova realidade? Infarma Ciências Farmacêuticas, 28 (03), 149-156. http://dx.doi.org/10.14450/2318-9312.v28.e3.a2016.pp149-156

Song, Z., Hu, Y., Zheng, S., Yang, L., & Zhao, R. (2021). Hospital pharmacists’ pharmaceutical care for hospitalized patients with COVID-19: Recommendations and guidance from clinical experience. Research in Social and Administrative Pharmacy, 01 (17), 2027–2031. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129111/

Stockl, K. M., Shin, J. S., Lew, H. C., Zakharyan, A., Harada, A. S. M., Solow, B. K., & Curtis, B. S. (2010). Outcomes of a rheumatoid arthritis disease therapy management program focusing on medication adherence. Journal of Managed Care & Specialty Pharmacy, 16 (08), 593-604. https://doi.org/10.18553/jmcp.2010.16.8.593

.

Tommelein, E., Mehuys, E., Van Hees, T., Adriaens, E., Van Bortel, L., Christiaens, T., Van Tongelen, I., Remon, J. P., Boussery, k., & Brusselleet, G. (2013). Effectiveness of pharmaceutical care for patients with chronic obstructive pulmonar disease (PHARMACOP): a randomized controlled trial. British Journal of Clinical Pharmacology, 77 (05), 756-766. https://doi.org/10.1111/bcp.12242

Tritany, R. F., & Tritany, E. F. (2020). Serviços Farmacêuticos no Enfrentamento à COVID-19: Uma Revisão Integrativa da Literatura. Revista Saúde em Redes, 06 (02), 07-24. http://revista.redeunida.org.br/ojs/index.php/rede-unida/article/viewFile/3301/536

Organização Mundial da Saúde. (2003). Adherence to Long-term Therapies: Evidence for Action. https://apps.who.int/iris/handle/10665/42682

Wuyts, J., Maesschalck., J., Wulf, I., Foubert, K., Boussery, K., Lepeleire, J., & Foulon, V. (2018). Studying the impact of a medication use evaluation for polymedicated older patients by the community pharmacist (SIMENON):study protocol. BMC Health Services Research, 18, (623), 01-08. https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-018-3440-z

Xin, C., Xia, Z., Jiang, C., Lin, M., & Li, G. (2015). Effect of pharmaceutical care on medication adherence of patients newly prescribed insulin therapy: a randomized controlled study. Patient Preference and Adherence, 01 (09), 797-802. https://doi.org/10.2147/PPA.S84411

Published

12/12/2021

How to Cite

RODRIGUES , J. F. B. .; MELO, D. F. dos S. .; BASTOS, W. D. G. .; RANDAU, K. P. . Pharmaceutical care in improving adherence to drug treatment. Research, Society and Development, [S. l.], v. 10, n. 16, p. e316101623753, 2021. DOI: 10.33448/rsd-v10i16.23753. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/23753. Acesso em: 23 apr. 2024.

Issue

Section

Health Sciences