Factors associated with Leishmania/Human Immunodeficiency Virus co-infection: a cohort study (2007-2018)
DOI:
https://doi.org/10.33448/rsd-v10i17.24545Keywords:
Visceral Leishmaniasis; HIV; Coinfection; Epidemiological methods.Abstract
Introduction: Visceral leishmaniasis (VL) and human immunodeficiency virus (HIV) infection are public health problems, with high numbers of cases and fatality worldwide. Objective: To assess factors associated with leishmania/HIV co-infection in Brazil. Methodology: Retrospective cohort study with univariate and multivariate analysis of 28,265 individuals, notified and with confirmed diagnosis of VL, in the National System of Notifiable Diseases (SINAN), from 2007 to 2018, in Brazil. Results: Most of the co-infected individuals were young, male, non-white, living in urban areas, with up to eight years of schooling, and who entered this study as a new case. Greater chances of coinfection were observed for individuals aged from eleven to nineteen years (OR=1.74), twenty to thirty-nine years (OR=13.06) and over forty years (OR=6.96), who used N-methylglucamine antimoniate (OR=4.36), amphotericin B deoxycholate (OR=6.21) and liposomal amphotericin B (OR=1.60), who had recurrence (OR=3.99), whose cases evolved to treatment dropout (OR=2.00), and deaths from causes other than VL (OR=4.00) and transfer (OR=1.50). Lower chances of co-infection were observed in women (OR=0.80), living in rural areas (OR=0.54), who had five to six symptoms (OR=0.82). Conclusion: The results point to the need for improvement in the follow-up of individuals co-infected with VL/HIV, in order to reduce relapses, transfers and treatment abandonment. Special attention should be given to the timely diagnosis of HIV infection in individuals with VL, especially in young men living in urban areas.
References
Abreu, M. S., Siqueira, J. M. M. T., Maia, J. C. S., Nepomuceno, D. B., Luz, E. B. A. L., & Mendes-Sousa, A. F. (2021). Aspectos epidemiológicos e distribuição espacial da leishmaniose visceral em Picos, Piauí, Brasil. Saúde Coletiva (Barueri), 11(65), 5846-5857. https://doi.org/10.36489/saudecoletiva.2021vl1i65p5 846-5857
Alvarenga, D. G., Escalda, P. M. F., Costa, A. S. V., & Monreal, M. T. F. D. (2010). Leishmaniose visceral: estudo retrospectivo de fatores associados à letalidade. Revista da Sociedade Brasileira de Medicina Tropical, 43(2), 194-197. https://doi.org/10.1590/S0037-86822010000200017
Batista, R. M., Andrade, S. S., & Souza, T. F. M. P. (2021). Prevalence of HIV / AIDS cases in the last 10 years in Brazil. Research, Society and Development, 10(14), 01-08 https://doi.org/10.33448/rsd-v10i14.22149
Brasil. (2009) Ministério da Saúde. Guia de Vigilância Epidemiológica. 7. ed. Brasília: Ministério da Saúde; 2009.
Brasil. (2012). Ministério da Saúde. Resolução nº 466, de 12 de dezembro de 2012. Aprova diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Diário Oficial da União, 12(1), 59-63. https://conselho.saude.gov.br/resolucoes/2012/Reso466.pdf
Brasil. (2018). Ministério da Saúde. SINAN – Sistema de Agravo de Notificação. Ministério da Saúde, Brasília. http://sinan.saude.gov.br/sinan/login/login.jsf
Carvalho, F. L., Aires, D. L. S., Segunda, Z. F., Azevedo, C. M. P. S., Corrêa, R. G. C. F., Aquino, D. M. C., & Caldas, A. J. M. (2013). Perfil epidemiológico dos indivíduos HIV positivo e coinfecção HIV-Leishmania em um serviço de referência em São Luís, MA, Brasil. Ciência & Saúde Coletiva, 18(5), 1305-1312. https://doi.org/10.1590/S1413-81232013000500015.
Costa, R. K. E., Holanda, E. C., Andrade, S. M., Nascimento, M. S. V., Soares, L. F., & Oliveira, E. H. (2021). Visceral Leishmaniasis and Human Immunodeficiency Virus Coinfection: epidemiological profile of cases reported in São Luís-Maranhão, Brazil. Research, Society and Development, 10(4), 01-10. https://doi.org/1 0.33448/rsd-v10i4.13317.
Cota, G. F., Sousa, M. R., Demarqui, F. N., & Rabello, A. (2012). The diagnostic accuracy of serologic and molecular methods for detecting visceral leishmaniasis in HIV infected patients: meta-analysis. PLoS Neglectd Tropical Diseases, 6(5), 01-11. https://doi.org/10.1371/journal.pntd.0001665.
Couto, F. M., Santos, A. B., Domiciano, L. S., Reis, L. E. S. (2021). Vínculo fatal -Leishmania infantum e HIV: uma revisão sistemática de literatura. Revista da Semana Acadêmica do Curso de Medicina da UFFS, 4(4), 01-13.
Dembelu, M., & Woseneleh, T. (2021). Prevalence of and Factors Associated with Reoccurrence of Opportunistic Infections Among Adult HIV/AIDS Patients Attending the ART Clinic at Public Health Facilities in Arba Minch Town, Southern Ethiopia. HIV/AIDS (Auckland, N.Z.), 13(1), 867-876. https://doi.org/10.2147/HIV.S328362
Gomes MP, Barbosa D, Gomes AMT, Silva G, Souza FA, & Silva ALB. (2021). A vivência do preconceito após a revelação da soropositividadae para HIV. Revista Rede de Cuidados em Saúde, 15(1), 47-56.
Hosmer, D. W., Jovanovic, B., & Lemeshow, S. (1989). Best Subsets Logistic Regression. Biometrics, 45(4), 1265-1270. https://doi.org/10.2307/2531779
Leite, A. I., & Araújo, L. B. (2013). Leishmaniose visceral: aspectos epidemiológicos relacionados aos óbitos em Mossoró-RN. Revista de Patologia Tropical, 42(3), 301-308. https://doi.org/10.5216/rpt.v42i3.2 6928
Leite, N. C., Garcia, J. L., & Gonçalves, I. M. (2021). Perfil epidemiológico da leishmaniose visceral no Brasil no período de 2007 a 2017. Revista de Patologia do Tocantins, 7(4), 29-33. https://doi.org/10.20873/ uft.2446-6492.2020v7n4p29
Lindoso, J. A. L., Moreira, C. H. V., Cunha, M. A.; & Queiroz, I. T. (2018). Visceral leishmaniasis and HIV coinfection: current perspectives. HIV/AIDS – Research and Palliative Care, 10(1), 193-201. https://d oi.org/10.2147/HIV.S143929
Mazon-Silva, S. L., Oliveira, N. A., Aguiar, A. S., Guimarães, N. S., & Figueiredo, S. M. (2021). Consumo alcoólico de homens soropositivos para o HIV. Health and Biosciences, 2(1), 05-15. https://doi.org/10.4745 6/hb.v2i1.32459
Monteiro, I. O. P., Leite, E. H. C. A. M., Costa, M. S. S., Souza, L. S., Pinto, E. O., Almeida, G. S., & Cordeiro, P. M. (2021). The Human Immunodeficiency Virus in rural areas: reflections from the perspective of access to health services. Research, Society and Development, 10(11), 01-16. https://doi.org/10.33448/rs d-v10i11.19620
Nunes BEBR, Leal TC, Paiva JPS, Silva LF, Carmo RF, Machado MF, Araújo MDP, Santos VS, & Souza CDF. (2020). Social determinants of mortality due to visceral leishmaniasis in Brazil (2001-2015): an ecological study. Revista da Sociedade Brasileira de Medicina Tropical, 53(1): e20190262. https://doi.org/10.1590/0037-8682-0262-2019
Oliveira, L. C. (2021). Aspectos epidemiológicos da leishmaniose visceral humana no Brasil e estados e cidades gêmeas do país, com enfoque no estado e na cidade gêmea com maior número de casos. [Dissertação de mestrado, Universidade Estadual do Oeste do Paraná]. http://tede.unioeste.br/handle/tede/5 540
Silva, B. B. L., Alves, A. K. R., Almeida, B. C., Pereira, R. B., Castro, M. R., Santos, V. A. P. P., Fontenele, M. J. A., Silva, L. S., Oliveira, A. C., Nogueira, F. D., Alves, F. R. O., Veras, I. L., Silveira, E. M. Q. F. B., Mello, G. W. S., & Farias, D. R. (2021). Análise dos perfis epidemiológicos da leishmaniose visceral e da coinfecção leishmaniose visceral-HIV no Piauí, 2007 a 2019. Research, Society and Development, 10(12), 01-08. http://dx.doi.org/10.33448/rsd-v10i12.20247
Sousa-Gomes, M. L., Maia-Elkhoury, A. N. S., Pelissari, D. M.; Lima Júnior, F. E. F., Sena, J. M., Chechinel, M. P. (2011). Coinfecção Leishmania-HIV no Brasil: aspectos epidemiológicos, clínicos e laboratoriais. Epidemiologia e Serviços de Saúde, 20(4), 519-526.http://dx.doi.org/10.5123/S1679-49742011000400011
Sousa-Gomes, M. L., Romero, G. A. S., & Werneck, G. L. (2017). Visceral leishmaniasis and HIV/AIDS in Brazil: Are we aware enough? PLoS Neglected Tropical Diseases, 11(9), 01-12. http://dx.doi.org/10.137 1/journal.pntd.0005772
Souza, E. C., Braga, K. L., Silva, T. K., Silva, M. L. (2020). Apresentação clínica da leishmaniose visceral em pacientes portadores do HIV: Análise dos Fatores Relacionados ao Aparecimento da Doença. Brazilian Journal of health Review, 3(2), 1766-1777. DOI:10.34119/bjhrv3n2-037
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