Chitosan-clay nanocomposite as a drug delivery system of ibuprofen
DOI:
https://doi.org/10.33448/rsd-v11i1.24684Keywords:
Nanocompósitos; Ibuprofeno; Liberação controlada de fármacos.Abstract
Chitosan/montmorillonite nanocomposite films were prepared by the solvent evaporation method to immobilize the drug ibuprofen (IBU) and delay its release in a medium that simulates the environment of the gastrointestinal tract. The effects of montmorillonite, at different mass proportions (10, 20, and 50%), on the morphological and physical properties of the films were studied. The samples were characterized by X-ray diffraction (XRD), Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), degree of swelling, drug encapsulation, and drug release efficiency. According to the XRD it was evidenced that the incorporation of montmorillonite to chitosan led to the formation of nanocomposites of ordered morphology. The infrared spectra confirmed the good interaction between montmorillonite and chitosan by the formation of nanocomposites. This fact, which favored the imprisonment of the IBU, reduced the diffusion coefficient in the studied systems. The micrographs comproved the formation of dense and uniform films. The controlled release profile, especially for the nanocomposite with 10% clay mass, showed a slow drug release rate. The incorporation of montmorillonite at different proportions produced different morphologies, with good encapsulation efficiency and an adequate profile for the controlled release of the drug.
References
Abdeen, R. & Salahuddin, N. (2013). Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen. Journal of Chemistry, 1, 1-9.
Ambrogi, V., Perioli, L., Ricci, M., Pulcini, L., Nocchetti, M., Giovagnoli S. & Rossi, C. (2018). Eudragit® and hydrotalcite-like anionic clay composite system for diclofenac colonic delivery. Microporous and Mesoporous Materials. 115 (3), 405-412.
Azhar, F. F. & Olad, A. (2014). A study on sustained release formulations for oral delivery of 5-fluorouracil based on alginate–chitosan/montmorillonite nanocomposite systems. Applied Clay Science, 101, 288-296.
Barbosa, H. D. C., Santos, B. F. F., Tavares, A. A., Barbosa, R. C., Fook, M. V. L., Canedo, E. L. & Silva, S. M. L. (2018). Inexpensive apparatus for fabricating microspheres for 5-fluorouracil controlled release systems. International Journal of Chemical Engineering, 2018, 1-8.
Baskar, D. & Kumar, T. S. S. (2009). Effect of deacetylation time on the preparation, properties and swelling behavior of chitosan films. Carbohydrate Polymers, 78 (4), 767-772.
Braga, C. R. C., Barbosa, R. C., Lima, R. S. C., Fook, M. V. L. & Silva, S. M. L. (2012, July). Nanocompósitos Quitosana/Montmorilonita para Aplicação em Liberação Controlada de Fármacos. Poster presented at the 10th Congresso Brasileiro de Polímeros, Maringá, PR.
Choi, C., Nam, J. P. & Nah, J. W. (2016). Application of chitosan and chitosan derivatives as biomaterials. Journal of Industrial and Engineering Chemistry, 33, 1-10.
Darder, M., Colilla, M. & Ruiz-Hitzky, E. (2003). Biopolymer-clay nanocomposites based on chitosan intercalated in montmorillonite. Chemistry of Materials, 15 (20), 3774-3480.
Dziadkowiec, J., Mansa, R., Quintela, A., Rocha, F. & Detellier, C. (2017). Preparation, characterization and application in controlled release of Ibuprofen-loaded Guar Gum/Montmorillonite Bionanocomposites. Applied Clay Science, 135, 52-63.
Hua, S., Yang, H., Wang, W. & Wang, A. (2010). Controlled release of ofloxacin from chitosan–montmorillonite hydrogel. Applied Clay Science, 50 (1), 112-117.
Kolhe, P. & Kannan, R. M. Improvement in ductility of chitosan through blending and copolymerization with PEG: FTIR investigation of molecular interactions. Biomacromolecules, 4 (1), 173-180.
Korsmeyer, R. W., Gurny, R., Doelker, E., Buri, P. & Peppas, N. A. (1983). Mechanisms of solute release from porous hydrophilic polymers. International Journal of Pharmaceutics, 15 (1), 25-35.
Lopes, C. M., Lobo, J. M. S. & Costa, P. (2005). Formas farmacêuticas de liberação modificada: polímeros hidrifílicos. Revista Brasileira de Ciências Farmacêuticas, 41 (2), 143-154.
Luo, D., Sang, L., Wang, X., Xu, S. & Li, X. (2011). Low temperature, pH-triggered synthesis of collagen–chitosan–hydroxyapatite nanocomposites as potential bone grafting substitutes. Materials Letters,65 (15), 2395-2397.
Masood, S. (2007). Application of fused deposition modelling in controlled drug delivery devices. Assembly automation, 27 (3), 215-221.
Manzoor, K., Ahmad, S., Soundarajan, A., Ikram, S. & Ahmed, S. (2018). Chitosan Based Nanomaterials for Biomedical Applications. Handbook of Nanomaterials for Industrial Applications, 543-562.
Marchessault, R. H., Ravenelle, F. & Zhu, X. X. (2006). Polysaccharides for drug delivery and pharmaceutical applications. ACS Publications, Washington.
Marreco, P. R., Moreira, P. L., Genari, S. C. & Moraes, A. M. (2004). Effects of different sterilization methods on the morphology, mechanical properties, and cytotoxicity of chitosan membranes used as wound dressings. Journal of Biomedical Materials Research - Part B, 71 (2), 268-277.
Martino, A., Kucharczyk, P., Capakova, Z., Humpolicek, P. & Sedlarik, V. (2017). Chitosan-based nanocomplexes for simultaneous loading, burst reduction and controlled release of doxorubicin and 5-fluorouracil. International Journal of Biological Macromolecules, 102, 613-624.
Mincheva, R., Manolova, N., Sabov, R., Kjurkchiev, G & Rashkov, I. (2004). Hydrogels from chitosan crosslinked with poly (ethylene glycol) diacid as bone regeneration materials. e-Polymers, 4 (1), 1-5.
Mukhopadhyay, R., Bhaduri, D., Sarkar, B., Rusmin, R., Hou, D., Khanam, R., Sarkar, S., Biswas, J. K., Vithanage, M. & Bhatnagar, A. (2020). Clay–polymer nanocomposites: Progress and challenges for use in sustainable water treatment. Journal of Hazardous Materials, 383, 121125.
Paiva, L., Morales, A. & Díaz, F. (2008). Argilas organofílicas: características, metodologias de preparação, compostos de intercalação e técnicas de caracterização. Cerâmica, 54 (330), 213-226.
Santos, B. F. F., Maciel, M. A., Tavares, A. A., Fernandes, C. Q. B. A., Sousa, W. J. B, Fook, M. V. L., Leite, I. F. & Silva, S. M. L. (2018). Synthesis and preparation of chitosan/clay microspheres: Effect of process parameters and clay type. Materials, 11 (12), 2523.
Silva, S. M., Braga, C. R., Fook, M. V. L., Raposo, C. M., Carvalho, L. H. & Canedo, E. L. (2012). Application of infrared spectroscopy to analysis of chitosan/clay nanocomposites. Infrared Spectroscopy - Materials Science, Engineering and Technology.
Tan, W., Zhang, Y., Szeto, Y. & Liao, L. (2008). A novel method to prepare chitosan/montmorillonite nanocomposites in the presence of hydroxy-aluminum oligomeric cátions. Composites Science and Technology, 68 (14), 2917-2921.
Vieira, A. P., Badshah, S. & Airoldi, C. (2013). Ibuprofen-loaded chitosan and chemically modified chitosans-release features from tablet and film forms. International Journal of Biological Macromolecules, 52, 107-115.
Vukajlovic, D., Parker, J., Bretcanu, O. & Novakovic, K. (2019). Chitosan based polymer/bioglass composites for tissue engineering applications. Materials Science and Engineering: C, 96, 955-967.
Wang, S., Shen, L., Tong, Y., Chen, L., Phang, I., Lim, P. & Liu, T. (2005). Biopolymer chitosan/montmorillonite nanocomposites: preparation and characterization. Polymer Degradation and Stability, 90 (1), 123-131.
Zheng, J., Luan, L., Wang, H., Xi, L. & Yao, K. (2007). Study on ibuprofen/montmorillonite intercalation composites as drug release system. Applied Clay Science, 36 (4), 297-301.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Albaniza Alves Tavares; Maria Dennise Medeiros Macêdo; Pedro Henrique Correia de Lima; Rossemberg Cardoso Barbosa; Wladymyr Jefferson Bacalhau Sousa; Cristiano José de Farias Braz; Matheus Ferreira de Souza; Camila Melo Gadelha Pereira Diniz; Marcus Vinícius Lia Fook; Suédina Maria de Lima Silva
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
