Epidemiological situation of TB – HIV co-infection in Baixada Santista between 2006 and 2016
DOI:
https://doi.org/10.33448/rsd-v11i1.25285Keywords:
Tuberculosis; VIH; Epidemiology; Coinfection.Abstract
To perform an analysis of HIV as a risk factor for the outcome of death in patients co-infected with Tuberculosis in the city of Santos – SP between 2006 and 2016. Study with a retrospective design comprising 18850 cases of Tuberculosis reported in Baixada Santista between 2006 and 2016. To perform an analysis of HIV as a risk factor for the outcome of death in patients co-infected with Tuberculosis in the city of Santos – SP between 2006 and 2016. The database was obtained from the Center for Epidemiological Surveillance of the State of São Paulo (CVE -SP). During the study period, 1984 cases of TB/HIV co-infection were reported, representing 12.8% of the total sample (15488). Of the co-infection cases, 35.3% were female and 64.7% male, and the gender variable did not show a statistically significant association with the HIV variable (p=0.097). We had a predominance of HIV/TB co-infection cases in patients aged between 30 – 50 years, these account for 65.9% of patients with co-infection. we observed that 17.4% of patients abandoned treatment before completion and that the cure rate was 55.6% for this population; The outcome and HIV variables showed a statistically significant association (p < 0.001). We conclude that there was no statistically significant association between TB/HIV co-infection and gender. The variables age, treatment dropout and cure were statistically significant when evaluated using statistical tests. The mortality rate, as well as the treatment dropout rate were proportionally higher in those patients co-infected with TB/HIV when compared to patients infected only with Tuberculosis.
References
Arakaki-Sanchez, D., & Brito, R. C. (2011), Brazil, organizadores. Manual de recomendações para o controle da tuberculose no Brasil. 1a edição. Brasília, DF: Ministério da Saúde, Secretaria de Vigilância em Saúde, Departamento de Vigilância Epidemiológica. 284 p. (Série A. Normas e Manuais Técnicos).
Barcellos, C., & Santos, S. M. (1997) Colocando dados no mapa: a escolha da unidade espacial de agregação e integração de base de dados em saúde e ambiente através do geoprocessamento. Inf Epidemiol SUS. 1997;5(1):21-9.
Barr, D. A., Lewis, J. M., Feasey, N., Schutz, C., Kerkhoff, A. D., Jacob, S. T., et al. (2020) Mycobacterium tuberculosis bloodstream infection prevalence, diagnosis, and mortality risk in seriously ill adults with HIV: a systematic review and meta-analysis of individual patient data. Lancet Infect Dis. 20(6):742–52.
Bastos, S. H., Tamitano. M., Tancredi. M. V., Luppi. C. G., & Hino. P. (2020) Coinfecção Tuberculose/HIV: perfil sociodemográfico e saúde de usuários de um Centro especializado. Acta Paul Enferm. 33:1-7.
Bell, L. C. K., & Noursadeghi, M. (2020) Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection. Nat Rev Microbiol. 16(2):80–90.
Getahun H, Gunneberg C, Granich R, & Nunn P. (2010) HIV Infection–Associated Tuberculosis: The Epidemiology and the Response. Clin Infect Dis. (s3):S201–7.
Jamal, L. F., & Moherdaui, F. (2007) Tuberculose e infecção pelo HIV no Brasil: magnitude do problema e estratégias para o controle. Rev Saúde Pública. 41(suppl 1):104–10.
Kingkaew N, Sangtong B, Amnuaiphon W, Jongpaibulpatana J, Mankatittham W, Akksilp S, et al. (2009) HIV-associated extrapulmonary tuberculosis in Thailand: epidemiology and risk factors for death. Int J Infect Dis. 13(6):722–9.
Ministério da Saúde (BR). Programa Nacional de Controle da tuberculose. manual técnico para controle da tuberculose. (6a ed.), 2002.
Mendes, A. M., & Fensterseifer, L. M. Tuberculose: porque os pacientes abandonam o tratamento? (2004) Bol Pneum Sanitária. 12(1):7-38
Pawlowski, A., Jansson, M., Sköld, M., Rottenberg, M. E., & Källenius, G. (2012) Tuberculosis and HIV co-infection. PLoS Pathog. 8(2): e1002464.
Regional Office for South-East Asia WHO. SEA-RC69/2: Introduction to the Regional Director’s Annual Report on the Work of WHO in the South-East Asia Region covering the period 1 January 2015-31 December 2015 [Internet]. New Delhi: WHO Regional Office for South-East Asia (2016); 978-92-9022-515–7. https://apps.who.int/iris/handle/10665/249521
Reiners, A. A. O., Azevedo, C. R., Vieira, M. A., & Gawlinski, A. L. (2006) Produção bibliográfica sobre adesão/não-adesão de pessoas ao tratamento de saúde. Ciên Saúde Coletiva. 13(2):2294-305.
Ribeiro, S. A., Amado, V. M., Camalier, A. A., Fernandes, M. A. A., & Schenkman, S (2000). Estudo caso-controle de indicadores de abandono em doentes com tuberculose. J Pneum; 26(6):291-6.
Oliveira, H. B. de, Marín-León, L., & Cardoso, J. C. (2004). Perfil de mortalidade de pacientes com tuberculose relacionada à comorbidade tuberculose-Aids. Rev Saúde Pública.;38:503–10.
Tornheim, J. A., & Dooley, K. E. (2018). Challenges of TB and HIV co-treatment: updates and insights. Curr Opin HIV AIDS. 13(6):486–91.
Vendramini, S. H. F., Santos, N. S. G. M. dos, Santos, M. de L. S. G., Chiaravalloti-Neto, F., Ponce, M. A. Z., Gazetta, C. E., et al. (2010) Análise espacial da tuberculose/HIV: relação com níveis socioeconômicos em município do sudeste do Brasil. Rev Soc Bras Med Trop. 43:536–41.
Vieira, A. G et al (2009). Características da tuberculose pulmonar em área hiper epidêmica – município de Santos (SP). Jornal Brasileiro de Pneumologia, Artigo original, volume 35.
Vicentin, G; & Santo, A. H., & Carvalho, M. S (2002). mortalidade por tuberculose e indicadores sociais no município do rio de janeiro. Ciência & Saúde Coletiva.
Ximenes, R. A. A., Martelli, C. M. T., Souza, W. V. et al, (1999) Vigilância de doenças endêmicas em áreas urbanas: a interface entre mapas de setores censitários e indicadores de morbidade. Cad Saúde Pública 15:53-61.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Matheus Budahazi Jardine; João Guilherme Saenz Carneiro; Lucca Moreira Lopes; Hugo Garcia Fortunato; Marcos Montani Caseiro
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
