Influence of micronutrient supplementation in patients with COVID-19
DOI:
https://doi.org/10.33448/rsd-v11i4.27601Keywords:
2019 Novel Coronavirus Disease; Micronutrients; Recommended dietary allowances.Abstract
The aim of this study was to present the possible effects of micronutrient supplementation on the immune response of patients with COVID-19 and its relationship to protection against the coronavirus and its severity. Thus, it is an integrative review, in which searches were carried out in the PubMed, Virtual Health Library (BVS) and ScienceDirect databases, including only scientific articles published in the years 2020 to 2021. For the search key, the terms were considered: “Dietary supplements AND Micronutrients AND Coronavirus infections” and correspondents in Portuguese, where 63 studies were found, of which 12 were selected for review. The analyzed articles presented different types of studies and a diversity of micronutrients involved in the management of COVID-19, thus it was concluded that these nutrients can bring several health benefits and adequate levels of vitamins and minerals suggest less susceptibility to any infection process, including COVID-19.
References
Abioye, A. I., Bromage, S., & Fawzi, W. (2021). Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Global Health, 6(1), e003176. http://dx.doi.org/10.1136/bmjgh-2020-003176
Aslam, M. F., Majeed, S., Aslam, S. & Irfan, J. A. (2017). Vitamins: Key Role Players in Boosting Up Immune Response-A Mini Review. Vitamins & Mineirals, 6(1), 153-161. https://doi:10.4172/2376-1318.1000153
Bellmann-Weiler, R., Lanser, L., Barket, R., Rangger, L., Schapfl, A., Schaber, M., Fritsche, G., Wöll, E., & Weiss, G. (2020). Prevalence and predictive value of anemia and dysregulated iron homeostasis in patients with COVID-19 infection. Journal of Clinical Medicine, 9(8), 2429. https://doi.org/10.3390/jcm9082429
Bassatne, A., Basbous, M., Chakhtoura, M., El Zein, O., Rahme, M., & El-Hajj Fuleihan, G. (2021). The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis. Metabolism: clinical and experimental, 119, 154753. https://doi.org/10.1016/j.metabol.2021.154753
Botelho, L. L. R., Cunha, C. C. A. & Macedo, M. (2014). O método da revisão integrativa nos estudos organizacionais. Gestão e Sociedade, 5(11), ISSN: 1980-5756. http://www.gestaoesociedade.org/gestaoesociedade/article/view/1220/906.
Calder, P. C. (2013). Feeding the immune system. Proceedings of the Nutrition Society, 72(3), 299-309. https://doi.org/10.1017/S0029665113001286
Calder, P. C., Carr, A. C., Gombart, A. F., & Eggersdorfer, M. (2020). Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients, 12(4), 1181. https://doi.org/10.3390/nu12041181
Elham, A. S., Azam, K., Azam, J., Mostafa, L., Nasrin, B., & Marzieh, N. (2021). Serum vitamin D, calcium, and zinc levels in patients with COVID-19. Clinical Nutrition ESPEN, 43, 276-282. https://doi.org/10.1016/j.clnesp.2021.03.040
Gammoh, N. Z. & Rink, L. (2017). Zinc in infection and inflammation. Nutrients, 9(6), 624. https://doi.org/10.3390/nu9060624
Ganz T. (2013). Systemic iron homeostasis. Physiological reviews, 93(4), 1721–1741. https://doi.org/10.1152/physrev.00008.2013
Gombart, A. F., Pierre, A., & Maggini, S. (2020). A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients, 12(1), 236. https://doi.org/10.3390/nu12010236
Haryanto, B., Suksmasari, T., Wintergerst, E., & Maggini, S. (2015). Multivitamin supplementation supports immune function and improves conditions triggered by reduced air quality. Vitamins & Mineirals, 4, 1-15. http://dx.doi.org/10.4172/2376-1318.1000128
Heller, R. A., Sun, Q., Hackler, J., Seelig, J., Seibert, L., Cherkezov, A., ... & Schomburg, L. (2021). Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker. Redox biology, 38, 101764. https://doi.org/10.1016/j.redox.2020.101764
Hemilä H. (2003). Vitamin C, respiratory infections and the immune system. Trends in immunology, 24(11), 579-580. https://doi.org/10.1016/j.it.2003.09.004
Hiedra, R., Lo, K. B., Elbashabsheh, M., Gul, F., Wright, R. M., Albano, J., Azmaiparashvili, Z., & Patarroyo Aponte, G. (2020). The use of IV vitamin C for patients with COVID-19: a case series. Expert review of anti-infective therapy, 18(12), 1259-1261. https://doi.org/10.1080/14787210.2020.1794819
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., ... & Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet, 395(10223), 497-506. https://doi.org/10.1016/S0140-6736(20)30183-5
Huang, Z., Liu, Y., Qi, G., Brand, D., & Zheng, S. G. (2018). Role of Vitamin A in the Immune System. Journal of clinical medicine, 7(9), 258. https://doi.org/10.3390/jcm7090258
Im, J. H., Je, Y. S., Baek, J., Chung, M. H., Kwon, H. Y., & Lee, J. S. (2020). Nutritional status of patients with COVID-19. International Journal of Infectious Diseases, 100, 390-393. https://doi.org/10.1016/j.ijid.2020.08.018
INSTITUTE OF MEDICINE - IOM. (2011). Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Washington, DC: The National Academies Press.
Kalantar-Zadeh, K., & Moore, L.W. (2020). Impact of Nutrition and Diet on COVID-19 Infection and Implications for Kidney Health and Kidney Disease Control. Journal of Renal Nutrition: the Official Journal of Renal Nutrition of the National Kidney Foundation, 30 (3), 179-181. https://doi.org/10.1053/j.jrn.2020.03.006
Liu, N., Sun, J., Wang, X., Zhang, T., Zhao, M., & Li, H. (2021). Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis. International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases, 104, 58–64. https://doi.org/10.1016/j.ijid.2020.12.077
Lichtenstein, A., Ferreira-Júnior, M., Sales, M. M., Aguiar, F. B., Fonseca, L. A. M., Sumita, N. M., ... & do Hospital, R. D. L. C. (2013). Vitamina D: ações extraósseas e uso racional. Revista da Associação Médica Brasileira, 59(5), 495-506. https://doi.org/10.1016/j.ramb.2013.05.002
Maggini, S., Pierre, A. & Calder, P.C. (2018). Immune function and micronutrient requirements change over the life course. Nutrients, 10(10), 1531. https://doi.org/10.3390/nu10101531
Majeed, M., Nagabhushanam, K., Gowda, S., & Mundkur, L. (2021). An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: The case for adequate selenium status. Nutrition, 82, 111053. https://doi.org/10.1016/j.nut.2020.111053
Mayor-Ibarguren, A., Busca-Arenzana, C., & Robles-Marhuenda, Á. (2020). A Hypothesis for the Possible Role of Zinc in the Immunological Pathways Related to COVID-19 Infection. Frontiers in immunology, 11, 1736. https://doi.org/10.3389/fimmu.2020.01736
Molla, G. K., Uzun, Ö. Ü., Koç, N., Yeşil, B. Ö., & Bayhan, G. İ. (2021). Evaluation of nutritional status in pediatric patients diagnosed with COVID-19 infection. Clinical Nutrition ESPEN, 44, 424-428. https://doi.org/10.1016/j.clnesp.2021.04.022
Oz, H. S. (2017). Nutrients, infectious and inflammatory diseases. Nutrients, 9(10), 1085. https://doi.org/10.3390/nu9101085
Petrelli, F., Luciani, A., Perego, G., Dognini, G., Colombelli, P. L., & Ghidini, A. (2021). Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies. The Journal of steroid biochemistry and molecular biology, 211, 105883. https://doi.org/10.1016/j.jsbmb.2021.105883
Sabico, S., Enani, M. A., Sheshah, E., Aljohani, N. J., Aldisi, D. A., Alotaibi, N. H., Alshingetti, N., Alomar, S. Y., Alnaami, A. M., Amer, O. E., Hussain, S. D., & Al-Daghri, N. M. (2021). Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate COVID-19: A Randomized Clinical Trial. Nutrients, 13(7), 2170. https://doi.org/10.3390/nu13072170
Santiago, M. B. & Souza, M. L. R. (2020). Uma revisão sobre a deficiência de selênio e a suscetibilidade às infecções virais com ênfase particular no novo coronavírus. Brazilian Journal of Health Review, 3(5), 11509-11520. https://doi.org/10.34119/bjhrv3n5-012
Segal A. W. (2005). How neutrophils kill microbes. Annual review of immunology, 23, 197–223. https://doi.org/10.1146/annurev.immunol.23.021704.115653
Sies, H., & Jones, D. P. (2020). Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nature reviews Molecular cell biology, 21(7), 363–383. https://doi.org/10.1038/s41580-020-0230-3
Teymoori‐Rad, M., Shokri, F., Salimi, V. & Marashi, S. M. (2019). The interplay between vitamin D and viral infections. Reviews in medical virology, 29(2), e2032. https://doi.org/10.1002/rmv.2032
Theurl, I., Aigner, E., Theurl, M., Nairz, M., Seifert, M., Schroll, A., Sonnweber, T., Eberwein, L., Witcher, D. R., Murphy, A. T., Wroblewski, V. J., Wurz, E., Datz, C., & Weiss, G. (2009). Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications. Blood, 113(21), 5277–5286. https://doi.org/10.1182/blood-2008-12-195651
Thomas, S., Patel, D., Bittel, B., Wolski, K., Wang, Q., Kumar, A., ... & Desai, M. Y. (2021). Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection: the COVID A to Z randomized clinical trial. JAMA network open, 4(2), e210369-e210369. https://doi.org/10.1001/jamanetworkopen.2021.0369
Velthuis, A. J., van den Worm, S. H., Sims, A. C., Baric, R. S., Snijder, E. J., & van Hemert, M. J. (2010). Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS pathogens, 6(11), e1001176. https://doi.org/10.1371/journal.ppat.1001176
Wang, M. X., Gwee, S. X. W., & Pang, J. (2021). Micronutrients deficiency, supplementation and novel coronavirus infections - a systematic review and meta-analysis. Nutrients, 13(5), 1589. https://doi.org/10.3390/nu13051589
Wessling-Resnick M. (2010). Iron homeostasis and the inflammatory response. Annual review of nutrition, 30, 105–122. https://doi.org/10.1146/annurev.nutr.012809.104804
Wishart, K. (2017). Increased micronutrient requirements during physiologically demanding situations: review of current evidence. Vitamins & Minerals, 6(166), 2376-1318. https://doi.org/10.4172/2376-1318.1000166
Xing, Y., Zhao, B., Yin, L., Guo, M., Shi, H., Zhu, Z., Zhang, L., He, J., Ling, Y., Gao, M., Lu, H., Mao, E., & Zhang, L. (2021). Vitamin C supplementation is necessary for patients with coronavirus disease: An ultra-high-performance liquid chromatography-tandem mass spectrometry finding. Journal of pharmaceutical and biomedical analysis, 196, 113927. https://doi.org/10.1016/j.jpba.2021.113927
Zhang, L., & Liu, Y. (2020). Potential interventions for novel coronavirus in China: A systematic review. Journal of medical virology, 92(5), 479–490. https://doi.org/10.1002/jmv.25707
Zhao, B., Ling, Y., Li, J., Peng, Y., Huang, J., Wang, Y., Qu, H., Gao, Y., Li, Y., Hu, B., Lu, S., Lu, H., Zhang, W., & Mao, E. (2021). Beneficial aspects of high dose intravenous vitamin C on patients with COVID-19 pneumonia in severe condition: a retrospective case series study. Annals of palliative medicine, 10(2), 1599–1609. https://doi.org/10.21037/apm-20-1387
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Lisandra Mikaely Barboza da Silva; Mayara Gabriela Cândido de Oliveira; Ana Caroline da Fonseca Nunes; Roseane Morais da Silva; Rayssa da Silva Felinto; Brenda Kelly Pontes Soares; Flaviane Dantas de Araújo; Albenize de Azevêdo Soares; Jayara Mikarla de Lira; José Adailton da Silva; Heleni Aires Clemente
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
