Prevalence and factors associated with mortality in fets and newborns with diagnosis of gastroschisis

Authors

DOI:

https://doi.org/10.33448/rsd-v11i8.30489

Keywords:

Gastroschisis; Mortality; Ultrasonography; Fetal surgery.

Abstract

Objective: To analyze the prevalence of mortality and the possible factors associated with this outcome in fetuses and newborns diagnosed with gastroschisis.

Methods: This is a cross-sectional and retrospective study with data from neonates born with simple and complex gastroschisis. The outcome variable was mortality (yes/no) from gastroschisis. Independent variables included maternal and neonatal characteristics in fetuses and newborns diagnosed with gastroschisis. The variables were analyzed using multiple Poisson regression. Results: The prevalence of mortality in neonates with gastroschisis was 30.23%. Complex gastroschisis (p=0.002), not performing surgery to close the gastroschisis (p=0.000), performing five surgeries (p=0.000), performing surgery after the second day of birth (p=0.000), were the most important factors associated with increased risk of mortality. Hospitalization in a neonatal ICU (p=0.000) was associated, indicating a protective factor for neonatal mortality. Conclusions: There was a high prevalence of mortality in neonates with gastroschisis. The associated factors highlight the importance of early diagnosis of complex gastroschisis, as well as the early performance of surgery to close the gastroschisis.

References

Behram, M., Oğlak, S.C., Özaydın, S., Çaypınar, S.S., Gönen, İ., Tunç ,Ş., Başkıran Y., & Özdemir, İ. (2021). What is the main factor in predicting the morbidity and mortality in patients with gastroschisis: delivery time, delivery mode, closure method, or the type of gastroschisis (simple or complex)? Turk J Med Sci.; 51(3):1587-95. 10.3906 / sag-2011-166.

Bhat, V., Moront, M. & Bhandari, V. (2020). Gastroschisis: A State-of-the-Art Review. Children (Basel); 7(12):302. 10.3390/children7120302.

Bugge, M., Drachmann, G., Kern, P, Budtz-Jørgensen, E., Eiberg, H., Olsen, B., Tommerup, N., & Nielsen, I.M. (2017). Abdominal Wall Defects in Greenland 1989-2015. Birth Defects Res.; 109 (11):836-842. 10.1002/bdr2.1025.

Calganotto, H., Muller, A.L.L & Leite, J.C.L., Sanseverino, M.T.V. Gomes, K.W. & Magalhães, J.A.A (2013). Fatores associados à mortalidade em recém-nascidos com gastrosquise. Rev. Bras. Ginecol. Obstet. 35 (12) https://doi.org/10.1590/S0100-72032013001200004

Castilla, E.E., Mastroiacovo, P. & Orioli, I.M. (2008). Gastroschisis: international epidemiology and public health perspectives. Am J Med Genet C Semin Med Genet., 15; 148C (3):162-79. 10.1002/ajmg.c.30181.

Clark, R.H., Walker, M.W. & Gauderer, M.W (2011). Factors associated with mortality in neonates with gastroschisis. Eur J Pediatr Surg.; 21(1):21-4. 10.1055/s-0030-1262791.

De Moraes, C.L., Tacon, F.S.A., Carvalho, V.P., Barreto, M. & Amaral, W.N. (2019). Diagnóstico e evolução dos fetos com defeitos na parede abdominal. Revista Goiana de Medicina. N 56, p. 6-11.

Egger, P.A., de Souza, M.P., Riedo, C.O., Dutra, A.C., da Silva, M.T., Pelloso, S.M., & Carvalho, M.D.B. (2021). Gastroschisis annual incidence, mortality, and trends in extreme Southern Brazil. J Pediatr (Rio J): S0021-7557(21)00079-6. 10.1016/j.jped.2021.04.007.

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas. (3a ed.). Scientific Methodology: Science, Teaching and Research. Editora Artes Médicas.

Eggink, B.H., Richardson, C.J., Malloy, M.H. & Angel, C.A. (2006). Outcome of gastroschisis: a 20-year case review of infants with gastroschisis born in Galveston, Texas. J Pediatr Surg.; 41(6):1103-08. 10.1016/j.jpedsurg.2006.02.008.

Kumar, T., Vaughan, R. & Polak, M. (2013). A proposed classification for the spectrum of vanishing gastroschisis. European Journal of Pediatric Surgery.; 23(1):72–75. 10.1055/s-0032-1330841.

Lap, C.C., Brizot, M.L., Pistorius, L.R., Kramer, W.L., Teeuwen, I.B., Eijkemans, M.J., Brouwers, H.A, Pajkrt, E., van Kaam, A.H., van Scheltema, P.N., Eggink, A.J., van Heijst, A.F., Haak, M.C., van Weissenbruch, M.M., Sleeboom, C., Willekes, C., van der Hoeven, M.A., van Heurn, E.L., Bilardo, C.M., Dijk, P.H., van Baren, R., Francisco, R.P., Tannuri, A.C., Visser, G.H., & Manten, G.T. (2016). Outcome of isolated gastroschisis; an international study, systematic review and meta-analysis. Early Hum Dev.; 103:209-218. 10.1016/j.earlhumdev.2016.10.002.

Materna-kiryluk, A., Więckowska, B., Wiśniewska, K. & Czyżewska, M. (2016). Geospatial Clustering Of Gastroschisis In Poland: Data From The Polish Registry Of Congenital Malformations (PRCM); Int J Ocupa Med Environ Health; 29 (3):461–70. 10.13075/ijomeh.1896.00624.

Melov, S.J., Tsang, I., Cohen, R., Badawi, N., Walker, K., Soundappan, S.S.V., & Alahakoon, T.I. (2018). Complexity of gastroschisis predicts outcome: epidemiology and experience in an Australian tertiary centre. BMC Pregnancy Childbirth.; 18(1):222. 10.1186/s12884-018-1867-1.

Pimentel, G.M., Nascimento, J.T. & Leitão, A.M. (2021). Assistência de enfermagem no diagnóstico de gastrosquise: uma revisão integrativa de literatura. Research, Society and Development, v. 10, n. 15, e553101523829. http://dx.doi.org/10.33448/rsd-v10i15.23829.

Rentea, R.M. & Gupta, V. (2021). Gastroschisis. 2021. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021. PMID: 32491817.

South, A., Wessel, J., Sberna, A., Patel, M. & Morrow, A. L. (2011). Hospital readmission among infants with gastroschisis. J Perinatol.; 31: 546–50. https://doi.org/10.1038/jp.2010.206.

Stallings, E.B., Isenburg, J.L., Short, T.D., Heinke, D., Kirby, R.S., Romitti, P.A., Canfield, M.A., O'Leary, L.A., Liberman, R.F., Forestieri, N.E., Nembhard, W.N., Sandidge, T., Nestoridi, E., Salemi, J.L., Nance, A.E., Duckett, K., Ramirez, G.M., Shan, X., Shi, J., & Lupo, P.J. (2019). Population-based birth defects data in the United States, 2012-2016: A focus on abdominal wall defects. Birth Defects Res.;111(18):1436-47. 10.1002/bdr2.1607.

Tauriainen, A., Sankilampi, U., Raitio, A., Tauriainen, T., Helenius, I., Vanamo, K., & Hyvärinen, A. (2021). The association of perinatal and clinical factors with outcomes in infants with gastroschisis-a retrospective multicenter study in Finland. Eur J Pediatr.; 180(6):1875-83. 10.1007/s00431-021-03964-w.

Thomas, K. (2021). Gastroschisis. Global Gastroschisis Foundation. Available from: https://averysangels.org/gastroschisis/

Wright, N.J., Sekabira, J. & Ade-Ajayi, N (2018). Care of infants with gastroschisis in low-resource settings. Semin Pediatr Surg.; 27(5):321-26. 10.1053/j.sempedsurg.2018.08.004

Published

12/06/2022

How to Cite

FERREIRA, R. G. .; MENDONÇA , C. R. .; TACON, F. S. de A.; RAMOS, L. L. G. .; ESTEVES, E. .; AFIUNE, A. P. .; RUANO, R. .; AMARAL, W. N. do . Prevalence and factors associated with mortality in fets and newborns with diagnosis of gastroschisis . Research, Society and Development, [S. l.], v. 11, n. 8, p. e12711830489, 2022. DOI: 10.33448/rsd-v11i8.30489. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/30489. Acesso em: 20 apr. 2024.

Issue

Section

Health Sciences