Identification of the change in the profile of renal markers associated with SARS-CoV-2 infection
DOI:
https://doi.org/10.33448/rsd-v11i7.30541Keywords:
SARS-CoV-2 virus; Rim Insufficiency; Biochemical markers; Health teaching.Abstract
Kidney injury is a syndrome characterized by reduced kidney function and is an important finding in hospitalized patients. Studies have shown significantly elevated levels of renal biomarkers in patients infected with COVID-19. Therefore, the objective of this literature review was to describe changes in renal markers in laboratory tests of hospitalized patients with COVID-19, reporting on the problems caused to the human organism related to infection, the effects of infection on the renal system of hospitalized patients and changes in renal markers in infected patients. It is a theoretical framework developed through the search of publications obtained in the databases: PubMed and SciELO, published in the last 3 years. The descriptors SARS-CoV-2, Renal Failure and Renal Markers were used. Through the analysis of the survey of all the material, it was possible to demonstrate that 25% of hospitalized patients with COVID-19 develop renal failure, presenting an increase in urea and creatine levels, a decrease in the rate of GFR, and the presence of proteinuria and hematuria in the exams. of urine. Regarding complications resulting from SARS-CoV-2 infection, the respiratory, cardiovascular, renal, hepatic, gastrointestinal and neurological systems were the most reported. Given the importance of maintaining kidney integrity and screening through biochemical markers, more research on this topic is needed to improve understanding of kidney damage in COVID-19 cases and its health impact.
References
Adapa, S., Aeddula, N. R., Konala, V. M., Chenna, A., Naramala, S., Madhira, B. R., Gayam, V., Balla, M., Muppidi, V., & Bose, S. (2020). COVID-19 and renal failure: Challenges in the delivery of renal replacement therapy. Journal of Clinical Medicine Research, 12(5), 276–285. https://doi.org/10.14740/jocmr4160
Alfadda, A. A., AlKhowaiter, M., Alotaibi, N., Alayed, K., Alzahrani, M., Binkhamis, K., Siddiqui, K., Youssef, A., Altalhi, H., Almaghlouth, I., Alarifi, M., Albanyan, S., Alosaimi, M. F., Hasanato, R., Isnani, A., Dekhil, H., & Rafiullah, M. (2021). Características clínicas e bioquímicas e resultados de pacientes hospitalizados com suspeita de COVID-19: comparação positiva e negativa do swab de RT-PCR. Journal of Infection and Public Health , 14 (11), 1623–1629. https://doi.org/10.1016/j.jiph.2021.09.014
Almeida, A. B., Abrão, J. S., Luz, T. N., Delmoro, A. C. L., Camilo, F. F., Oliveira, C. H. S., Souza, F., Terra, M. C., Oliveira, C. M., & Salles, B. C. C. (2021). Marcadores bioquímicos na COVID-19: Uma revisão na literatura. Pesquisa, Sociedade e Desenvolvimento, 10 (3), e6310313045. https://doi.org/10.33448/rsd-v10i3.13045
Bonetti, G., Manelli, F., Bettinardi, A., Borrelli, G., Fiordalisi, G., Marino, A., Menolfi, A., Saggini, S., Volpi, R., Adamini, R., & Lippi, G. (2020). Urinalysis parameters for predicting severity in coronavirus disease 2019 (COVID-19). Clinical Chemistry and Laboratory Medicine, 58(9), e163–e165. https://doi.org/10.1515/cclm-2020-0576
Borges, M. A., & Paiva, M. J. M. (2021). Exames laboratoriais para diagnóstico da covid-19 / Laboratory tests for covid-19 diagnosis. Brazilian Journal of Development, 7(12), 110872–110879. https://doi.org/10.34117/bjdv7n12-052
Carvalho, L. F., Paula, T. C. G. Q., & Peixoto, V. S. (2021). Lesão renal aguda em pacientes diagnosticados com COVID-19 em uma UTI do sudoeste goiano. Research, Society and Development, 10(17), e157101724492. https://doi.org/10.33448/rsd-v10i17.24492
Chan, L., Chaudhary, K., Saha, A., Chauhan, K., Vaid, A., Zhao, S., Paranjpe, I., Somani, S., Richter, F., Miotto, R., Lala, A., Kia, A., Timsina, P., Li, L., Freeman, R., Chen, R., Narula, J., Just, A. C., Horowitz, C. (2021). AKI in hospitalized patients with COVID-19. Journal of the American Society of Nephrology: JASN, 32(1), 151–160. https://doi.org/10.1681/ASN.2020050615
Cheng, Y., Luo, R., Wang, K., Zhang, M., Wang, Z., Dong, L., Li, J., Yao, Y., Ge, S., & Xu, G. (2020). Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney International, 97(5), 829–838. https://doi.org/10.1016/j.kint.2020.03.005
Diao, B., Wang, C., Wang, R., Feng, Z., Zhang, J., Yang, H., Tan, Y., Wang, H., Wang, C., Liu, L., Liu, Y., Liu, Y., Wang, G., Yuan, Z., Hou, X., Ren, L., Wu, Y., & Chen, Y. (2021). Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection. Nature Communications, 12(1), 2506. https://doi.org/10.1038/s41467-021-22781-1
Dusse, L. M. S., Rios, D. R. A., Sousa, L. P. N., Moraes, R. M. M. S., Domingueti, C. P., & Gomes, K. B. (2017). Biomarkers of renal function: What is currently available? RBAC, 49(1). https://doi.org/10.21877/2448-3877.201600427
Figueiredo, S. A., & Paula, F. B. A. (2022). Diagnóstico da COVID-19 em laboratórios de análises clínicas. Research, Society and Development, 11(1), e49511125286. https://doi.org/10.33448/rsd-v11i1.25286
Gabarre, P., Dumas, G., Dupont, T., Darmon, M., Azoulay, E., & Zafrani, L. (2020). Acute kidney injury in critically ill patients with COVID-19. Intensive Care Medicine, 46(7), 1339–1348. https://doi.org/10.1007/s00134-020-06153-9
Generoso, G. M. (2021). Análise de internações por Covid-19 em unidade de terapia intensiva adulto. Repositório institucional da UFCS. https://repositorio.ufsc.br/handle/123456789/230732
Girardi, J. (2022). Alterações laboratoriais no exame qualitativo de urina (EQU) de pacientes com covid-19. Repositório digital da UFRGS. https://www.lume.ufrgs.br/handle/10183/235000
Gonzales, P. L. V., & Souza, E. S. (2020). Principais complicações relacionadas à infecção por Sars-CoV-2. Repositório institucional da FPS. https://tcc.fps.edu.br/handle/fpsrepo/893
Guedin, A. M., Duarte, A. M., Corrêa, A. L. J., Júnior, D. G. D., Della, K. P., Borges, L. P., Pinna, P. M., & Corrêa, M. I. (2021). Occurrence and management of acute kidney injury in patients with COVID-19 in intensive care. Brazilian Journal of Health Review, 4(6), 27058–27067. https://doi.org/10.34119/bjhrv4n6-274
Li, Z., Wu, M., Yao, J., Guo, J., Liao, X., Song, S., Li, J., Duan, G., Zhou, Y., Wu, X., Zhou, Z., Wang, T., Hu, M., Chen, X., Fu, Y., Lei, C., Dong, H., Xu, C., Hu, Y., Yan, J. (2020). Kidney dysfunctions of COVID-19 patients: A multi-centered, retrospective, observational study. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3556634
Matos, A. C. G., Andrade, T. V., Noronha, N. C. M., Lima, T. B., Nascimento, C. I. S., Santos, A. C. M., Santana, V. S. J., Maynard, L. G., & Jesus, C. V. F. (2021). Lesão renal aguda na COVID-19 e abordagem multiprofissional. Research, Society and Development, 10(3), e53310313436. https://doi.org/10.33448/rsd-v10i3.13436
Nepomuceno Morais, V., Carvalho Barros Dias, F., Borges Aguiar Santana, T., Guimarães Maciel, L., Cabral de Souza, Y., Andrade Mescoloti, A., De Pádua Milagres, F. A., & Sanzio Pimenta, R. (2021). Doença pelo coronavírus 2019: uma revisão sistemática. Revista Interdisciplinar da Universidade Federal do Tocantins, 8(1), 1–17. https://doi.org/10.20873/uftv8-9354
Pecly, I. M. D., Azevedo, R. B., Muxfeldt, E. S., Botelho, B. G., Albuquerque, G. G., Diniz, P. H. P., Silva, R., & Rodrigues, C. I. S. (2021). A review of Covid-19 and acute kidney injury: from pathophysiology to clinical results. Jornal Brasileiro de Nefrologia: Orgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia, 43(4), 551–571. https://doi.org/10.1590/2175-8239-JBN-2020-0204
Perico, L., Benigni, A., Casiraghi, F., Ng, L. F. P., Renia, L., & Remuzzi, G. (2021). Immunity, endothelial injury and complement-induced coagulopathy in COVID-19. Nature Reviews. Nephrology, 17(1), 46–64. https://doi.org/10.1038/s41581-020-00357-4
Ribeiro, E. H. S. (2022). Biomarcadores laboratoriais como preditores de gravidade em pacientes COVID-19: uma revisão de literatura. Repositório institucional da UFRG. https://repositorio.ufrn.br/handle/123456789/46271
Rodrigues, C. M. B., Costa, N. B., Vieira, V. R., Gabriel, E. A., & Gabriel, S. A. (2020). COVID-19: sistema renal e cardíaco. ULAKES JOURNAL OF MEDICINE, 1. http://revistas.unilago.edu.br/index.php/ulakes/article/view/257
Roghani, A. (2021). The influence of covid-19 vaccine on daily cases, hospitalization, and death rate in Tennessee: A case study in the United States. In bioRxiv (p. 2021.03.16.21253767). https://doi.org/10.1101/2021.03.16.21253767
Ronco, C., & Reis, T. (2020). Kidney involvement in COVID-19 and rationale for extracorporeal therapies. Nature Reviews Nephrology, 16(6), 308–310. https://doi.org/10.1038/s41581-020-0284-7
SILVA, W. Z. R. (2021) Aspectos gerais da COVID-19 e suas consequências. Repositório Institucional UNIFESP. https://repositorio.unifesp.br/handle/11600/61555
World Health Organization. (2022). WHO Coronavirus (COVID-19) Dashboard. Disponível em: https://covid19.who.int/
Xiang, J., Wen, J., Yuan, X., Xiong, S., Zhou, X., Liu, C., & Min, X. (2020). Potential biochemical markers to identify severe cases among COVID-19 patients. In bioRxiv (p. 2020.03.19.20034447). https://doi.org/10.1101/2020.03.19.20034447
Zermiani, K. (2021). Lesão renal aguda na infecção por SARS-CoV-2: revisão narrativa da literatura. Repositório institucional da UFSC. https://repositorio.ufsc.br/handle/123456789/223440
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Letícia Paiva de Carvalho Santos; Moisés Thiago de Souza Freitas
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
