Use of azelaic acid in the treatment of acne vulgaris in adolescents

Authors

DOI:

https://doi.org/10.33448/rsd-v11i7.30594

Keywords:

Azelaic acid; Acne vulgaris; Adolescents; Health teaching.

Abstract

The pathogenesis of acne is an involvement of some multifaceted processes within the pilosebaceous unit, giving room for bacterial overgrowth and inflammation. This usually happens in the pubertal transition period, when hormonal changes in the body alter the function of the pilosebaceous gland, with this, studies have shown that, in clinical cases, azelaic acid is effective and safe when applied to the specific location where acne is found. , and in the proper concentration. The aim of this study is to identify the benefits of azelaic acid in the treatment of acne vulgaris in adolescents, through data from the literature. It is an integrative literature review, which allows the summary of several published studies, allowing new knowledge and results of other research. The analysis of the data obtained was performed after organizing the selected articles in a table containing: author, theme, objective, methods, results, and year of publication. It can be concluded that azelaic acid has a positive effect in the treatment of acne vulgaris, when applied in the correct way, ideal amount and in a timely manner. It is very important to follow up with a professional, because the acid, despite promoting tolerable side effects, can cause greater dysfunctions if the type of acne, skin or lifestyle of the teenager is not analyzed.

References

Baccoli, B. C., Sciani, M. D., & Carvalho, A. A. (2015). Os benefícios do óleo de melaleuca na acne grau II e III: uma revisão de literatura. Revista da Universidade Vale do Rio Verde, 13(1), 536-547.

Bagatin, E., Timpano, D. L., Guadanhim, L. R. D. S., Nogueira, V. M. A., Terzian, L. R., Steiner, D., & Florez, M. (2014). Acne vulgaris: prevalence and clinical forms in adolescents from São Paulo, Brazil. Anais brasileiros de dermatologia, 89, 428-435.

Botelho, L. L. R., de Almeida Cunha, C. C., & Macedo, M. (2011). O método da revisão integrativa nos estudos organizacionais. Gestão e sociedade, 5(11), 121-136.

Chilicka, K., Rogowska, A. M, Szyguła, R., Dzieńdziora-Urbińska, I., & Taradaj, J. (2020). Uma comparação da eficácia dos peelings de ácido azelaico e pirúvico no tratamento da acne adulta feminina: um estudo controlado randomizado. Relatórios científicos, 10 (1), 12612. https://doi.org/10.1038/s41598-020-69530-w

Costa, C. S., & Bagatin, E. (2013). Evidências sobre o tratamento da acne. Sao Paulo Medical Journal, 131(3), 193-197.

Fluhr, J. W., & Degitz, K. (2010). Antibiotics, azelaic acid and benzoyl peroxide in topical acne therapy. Journal der Deutschen Dermatologischen Gesellschaft= Journal of the German Society of Dermatology: JDDG, 8, S24-30.

Fox, L., Csongradi, C., Aucamp, M., Du Plessis, J., & Gerber, M. (2016). Treatment modalities for acne. Molecules, 21(8), 1063.

Gieler, U., Gieler, T., & Kupfer, J. P. (2015). Acne and quality of life–impact and management. Journal of the European Academy of Dermatology and Venereology, 29, 12-14.

Gregoriou, S., Chalikias, J., Lazarou, D., Danopoulou, I., Katsambas, A., Rigopoulos, D., & Attikon–Xaidari, G. O impacto da acne vulgar na qualidade de vida e saúde psíquica em jovens adolescentes na Grécia. Resultados de uma pesquisa populacional.

Hazarika, N. (2021). Acne vulgaris: new evidence in pathogenesis and future modalities of treatment. Journal of dermatological treatment, 32(3), 277-285.

II, J. C. X., Sousa, L. A. F. de, Almeida, M., Silva, M. M., Oliveira, M. de J. M. G. de, Sodré, M. T. C., Amaral, C. A., Galvão, L. C. de C., & Sousa, E. M. de. (2021). Analysis of the understanding about the care necessary for the treatment of acne in adolescents in a church in the City of São Luís. Research, Society and Development, 10(13).

Kosmadaki, M., & Katsambas, A. (2017). Topical treatments for acne. Clinics in dermatology, 35(2), 173-178.

Knutsen-Larson, S., Dawson, A. L., Dunnick, C. A., & Dellavalle, R. P. (2012). Acne vulgaris: pathogenesis, treatment, and needs assessment. Dermatologic Clinics, 30(1), 99-106.

Leccia, M. T., Auffret, N., Poli, F., Claudel, J. P., Corvec, S., & Dreno, B. (2015). Topical acne treatments in Europe and the issue of antimicrobial resistance. Journal of the European Academy of Dermatology and Venereology, 29(8), 1485-1492.

Liu, H., Yu, H., Xia, J., Liu, L., Liu, G., Sang, H., & Peinemann, F. (2020). Tratamentos tópicos baseados em evidências (ácido azelaico, ácido salicílico, nicotinamida, enxofre, zinco e ácido de frutas) para acne: uma versão resumida de uma revisão sistemática Cochrane. Journal of Evidence-Based Medicine, 13 (4), 275-283.

Mwanthi, M., & Zaenglein, A. L. (2018). Update in the management of acne in adolescence. Current opinion in pediatrics, 30(4), 492-498.

Ogé, L. K., Broussard, A., & Marshall, M. D. (2019). Acne vulgaris: diagnosis and treatment. American family physician, 100(8), 475-484.

Ramanathan, S., & Hebert, AA (2011). Manejo da acne vulgar. Journal of Pediatric Health Care, 25 (5), 332-337.

Searle, T., Ali, F. R., & Al-Niaimi, F. (2022). The versatility of azelaic acid in dermatology. Journal of Dermatological Treatment, 33(2), 722-732.

Sieber, M. A., & Hegel, J. K. E. (2014). Azelaic acid: properties and mode of action. Skin pharmacology and physiology, 27(Suppl. 1), 9-17.

Szymańska, A., Budzisz, E., & Erkiert-Polguj, A. (2019). Efficacy of 30% azelaic acid peel in the nonpharmacological treatment of facial acne. Journal of Dermatological Treatment, 32(3), 291-296.

Szymańska, A., Budzisz, E., & Erkiert‐Polguj, A. (2022). Long‐term effect of azelaic acid peel on sebum production in acne. Dermatologic therapy, 35(1), e15186.

Zaenglein, A. L. (2018). Acne vulgaris. New England Journal of Medicine, 379(14), 1343-1352.

Published

05/06/2022

How to Cite

PENA, L. S. C. .; SANTOS, J. R.; CAETITÉ, A. R. M. Use of azelaic acid in the treatment of acne vulgaris in adolescents . Research, Society and Development, [S. l.], v. 11, n. 7, p. e58711730594, 2022. DOI: 10.33448/rsd-v11i7.30594. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/30594. Acesso em: 20 apr. 2024.

Issue

Section

Review Article