Relation between genetic variant of vitamin D receptor and fibromyalgia
DOI:
https://doi.org/10.33448/rsd-v11i8.30984Keywords:
Fibromyalgia; Polymorphism; Vitamin D.Abstract
Objective: Understand the relationship between fibromyalgia and a genetic variant of the VDR gene, called Cdx2 that encodes the vitamin D receptor, besides evaluating the association of clinical characteristics from the study participants with genotypic and allelic variants of the VDR gene. Methods: This is a case-control, cross-sectional, quantitative, and experimental study, that recruited 65 individuals, however, due to the exclusion factors applied, only 62 participated effectively, 33 with FM and 29 in the control group. 5 questionnaires were applied to those with disease and only 1 to those without. The polymorphism of Cdx2, promotes a G/A exchange, in 12q13.11, found through the qPCR. Results: By analyzing the genotypes, 54.8% (34/62) of the participants were GG, 32.3% (20/62) GA and the AA genotype was present in 12.9% (8/62). Among the participants, 83.9% (52/62) were female and 74.2% (46/62) were white. The genetic variant, Cdx2, was statistically correlated with FM (p=0.004), where 66.7% of patients with FM had the GG genotype, moreover the GG/GA genotype had 12,6 chances of developing FM (OR = 12,57; IC95%: 1,465-107,889; P=0.001) if compare with the genotype AA. Conclusion: The polymorphism of Cdx2 (AA) increases the expression of the receptor, inhibits the Th1 response and activates the Th2, also improves the response to vitamin D and acts as a protective factor for the individual without the disease.
References
Anunciação, L., Caregnato, M. & Silva, C. S. F. (2019). Aspectos psicométricos do Inventário Beck de Depressão-II e do Beck Atenção Primária em usuários do Facebook. J Bras Psiquiatr. https://doi.org/10.1590/0047- 2085000000231
Haussler, R. M., Jurutka, W. P., Mizwicki, M. & Norman, W. A. (2011). Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)2vitamin D3: Genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab. doi: 10.1016/j.beem.2011.05.010. PMID: 21872797.
Heymann, R. E; et al. (2017). Novas diretrizes para o diagnóstico da fibromialgia. Revista brasileira de reumatologia. https://www.scielo.br/j/rbr/a/kCdwgDXPSXQMSXn5VKMFB3x/?lang=pt&f ormat=pdf.
Hou, W., Wan, X. & Fan, J. (2015). Variants Fok1 and Bsm1 on VDR are associated with the melanoma risk: evidence from the published epidemiological studies. BMC Genet. doi: 10.1186/s12863-0150163-6
Iqbal, N. M. & Khan, A. T. (2017). Association between Vitamin D receptor (Cdx2, FokI, BsmI, ApaI, BglI, TaqI, and Poly (A)) gene polymorphism and breast cancer: A systematic review and meta-analysis. Tumour Biol. doi: 10.1177/1010428317731280
Janssen, L.P., Medeiros, L.F., Souza, A. & Silva, J. (2021). Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance. An Acad Bras Cienc 93: e20210618. doi:10.1590/0001-3765202120210618.
Karras, S., Rapti, E., Matsoukas, S. & Kotsa, K. (2016). Vitamin D in Fibromyalgia: A Causative or Confounding Biological Interplay. Nutrients. 2016 Jun 4;8(6):343.doi:10.3390/nu8060343.PMID:27271665;PMCID:PMC4924184.
Maffei, E. M. (2020). Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative Remedies. Int J Mol Sci.2020;21(21):7877. doi:10.3390/ijms21217877
Marasli, E., Ozdolap, S. & Sarikaya, S. (2016). Relationship between FokI polymorphism in the vitamin D receptor gene and fibromyalgia syndrome. Int J Rheum Dis. doi: 10.1111/1756185X.12878
Martinez, E. J., Grassi, C. D. & Marques, G. L. (2010). Análise da aplicabilidade de três instrumentos de avaliação de dor em distintas unidades de atendimento: ambulatório, enfermaria e urgência. Rev Bras Reumatol. https:// www.scielo.br/j/rbr/a/NLCV93zyjfqB6btxpNRfBzJ/?lang=pt&format =pdf
Oono, F., Sukamoto, Y., Tachi, Y., Mabashi-Asazuma, H. et al. (2020). Effect of Cdx2 Polyorphism on the Relationship between Dietary Calcium Intake and Peak Bone Mass in Young Japanese Women. Nutrients. doi: 10.3390/nu1201019
Paiva, S. E., Heymann, E. R., Rezende, C. M. et al. (2013). A Brazilian Portuguese version of the Revised Fibromyalgia Impact Questionnaire (FIQR): a validation study. Clin Rheumatol. doi: 10.1007/s10067013-2259-6
Pulito, C., Terrenato, I., Benedetto, A., Korita, E. et al. (2015). Cdx2 Polymorphism Affects the Activities of Vitamin D Receptor in Human Breast Cancer Cell Lines and Human Breast Carcinomas. Plos One. doi: 10.1371/journal.pone.0124894
Saxena, V., Pradhan, P. & Tyagi, K. (2020). Diagnostic Accuracy of ACR 2010 Preliminary Diagnostic Criteria in the Diagnosis of Fibromyalgia Among Chronic Backache Patients. Indian J Orthop. 2020 Jul 30;54(Suppl 1):150157. doi: 10.1007/s43465-020-00211-6. PMID: 32952923; PMCID: PMC7474007.
Simmons, J.D., Mullighan, C., Welsh, K.I. & Jewell, D.P. (2000) Vitamin D receptor gene polymorphism: association with Crohn’s disease susceptibility. Gut. doi: 10.1136/gut.47.2.211.
Siracusa, R., Paola, R.D., Cuzzocrea, S. & Impellizzeri, D. (2021). Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update. Int J Mol Sci. 2021 Abr 9;22(8):3891. doi: 10.3390/ijms22083891. PMID:33918736; PMCID: PMC8068842.
Triantos, C., Aggeletopoulou, I., Kalafateli, M., Spantidea, P.I. et al. (2018). Prognostic significance of vitamin D receptor (VDR) gene polymorphisms in liver cirrhosis. Scientific Reports. https://www.nature.com/articles/s41598-018-32482-3
Valdivielso, M. J. & Fernandez, E. (2006). Vitamin D receptor polymorphisms and diseases. Clinic Chimica Acta Vol 371, Issues 1-2, Pág 1-12. Doi: https://doi.org/10.1016/j.cca.2006.02.016
Wepner, F., Scheuer, R., Schuetz-Wiese,r B., Machacek, P., Pieler-Bruha, E., Cross, H.S., Hahne, J. & Friedrich, M. (2014). Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial. Pain. 2014 Fev;155(2):261-268. doi: 10.1016/j.pain.2013.10.002. PMID: 24438771.
Wolfe, F., Clauw, D.J., Fittzcharles, M.A. et al. (2010). The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res. 2010; 62 (5): 600-610.
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