Clinical evolution of patients with COVID-19: anticoagulation impact

Authors

DOI:

https://doi.org/10.33448/rsd-v11i9.31423

Keywords:

COVID-19; Evolution; Anticoagulation; Intensive Care Unit.

Abstract

A doença do coronavírus 19 (COVID-19) tem como alvo principal o sistema respiratório e evolui para forma grave em até 16% dos casos hospitalizados, com a instalação de transtornos tromboembólicos, sepse e morte. O objetivo deste estudo foi avaliar a evolução de pacientes com COVID-19, internados em unidade de terapia intensiva (UTI), observando os impactos da anticoagulação naqueles com parâmetros críticos. O objetivo deste estudo foi avaliar a evolução de pacientes com COVID-19, internados em unidade de terapia intensiva (UTI), observando os impactos da anticoagulação naqueles com parâmetros críticos. Estudo transversal, realizado com a revisão de prontuários de pacientes internados em UTI, com diagnóstico confirmado de COVID-19, no período compreendido entre março e dezembro de 2020, em um hospital geral no sul do Brasil. Dentre os 231 pacientes analisados, observou-se letalidade de 66,2%. Dentre os achados mais relevantes associados à óbito estão a presença de cardiopatia e hipertensão arterial sistêmica (HAS) prévia, evolução clínica com insuficiência renal e clearance <30 e hiperbilirrubinemia. Dos 103 pacientes internados que estavam com anticoagulação sob parâmetros críticos, 88 evoluíram com óbito. Foram associados à mortalidade a idade avançada (≥ 60 anos), presença de comorbidades, complicações durante a internação, alterações laboratoriais e evolução com hepatite transinfecciosa. Anticoagulação sob parâmetros críticos foi associada à maior taxa de óbito, com evolução clínica entre admissão em UTI e desfecho fatal após duas semanas de infecção.

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15/07/2022

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OLIVEIRA, L. H. R. T. de .; REIS JUNIOR, N. A. dos .; GOMES, J. S.; SPÁRTALIS JUNIOR, P. B. .; MELLO, R. S. de .; SCHUELTER TREVISOL, F. Clinical evolution of patients with COVID-19: anticoagulation impact. Research, Society and Development, [S. l.], v. 11, n. 9, p. e46611931423, 2022. DOI: 10.33448/rsd-v11i9.31423. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/31423. Acesso em: 20 apr. 2024.

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Vol. 11 No. 9

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Health Sciences

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Copyright (c) 2022 Laylla Hanna Rocha Torres de Oliveira; Nilton Almeida dos Reis Junior; José Sávio Gomes; Péricles Brasil Spártalis Junior; Rogério Sobroza de Mello; Fabiana Schuelter Trevisol

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