Pretreatment neutrophil-lymphocyte ratio has prognosis value in breast cancer patients

Authors

DOI:

https://doi.org/10.33448/rsd-v11i9.31783

Keywords:

Breast cancer; Prognosis; Inflammation; Biomarkers; Survival.

Abstract

Objectives: This study aimed to determine the prognostic value of the pretreatment inflammatory indexes neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, and platelet-lymphocyte ratio in breast cancer. Methods: A retrospective cohort of patients with breast cancer receiving treatment at a specialized cancer hospital were collected from 2016. Pretreatment complete blood cell counts were evaluated to assess inflammatory indexes. The outcome variable was 5-year overall survival. Kaplan-Meier curves, log-rank test, and Cox regression (hazard ratio; 95% confidence interval) were used. Results: A total of 312 women (mean age 51.9 years; histopathological grade II 61.6%; tumor stage III 50.0%) were included in the study. Of these, 169 (54.2%) died within 5 years, the majority of whom had neutrophil-lymphocyte ratio ≥ 2.5 (62.5%; p= 0.002), histopathological grades II and III (60.4%; p= 0.024), more advanced tumor stages (87.7%; p<0.001), and significantly lower overall survival. Neutrophil-lymphocyte ratio ≥ 2.5 (hazard ratio, 1.53; 95% CI, 1.11-2.11) was an independent prognostic factor for overall survival. In addition, histopathological grades II (hazard ratio, 3.53; 95% confidence interval, 1.29-9.68) and III stage (hazard ratio, 2.50; 95% confidence interval, 1.45-4.34) and stage IV (hazard ratio, 6.07; 95% confidence interval, 3.43-10.73) demonstrated predictive power. Conclusion: Pretreatment neutrophil-lymphocyte ratio was considered a useful predictor of overall survival in breast cancer.

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Published

06/07/2022

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SILVA, S. H. K. da; OLIVEIRA, L. C. de; PERES, W. A. F. .; WIEGERT, E. V. M. .; MOTTA, R. S. T.; SILVA, N. . F. da .; LOPES, M. S. da M. e S. . Pretreatment neutrophil-lymphocyte ratio has prognosis value in breast cancer patients . Research, Society and Development, [S. l.], v. 11, n. 9, p. e17611931783, 2022. DOI: 10.33448/rsd-v11i9.31783. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/31783. Acesso em: 24 apr. 2024.

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Vol. 11 No. 9

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Health Sciences

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Copyright (c) 2022 Sandra Helena Kaznowski da Silva; Livia Costa de Oliveira; Wilza Arantes Ferreira Peres; Emanuelly Varea Maria Wiegert; Rachel Souza Thompson Motta; Naira Freire da Silva; Márcia Soares da Mota e Silva Lopes

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