COVID long syndrome: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i13.35990

Keywords:

COVID-19; Clinical manifestations; Chronic condition.

Abstract

Objective: To carry out an integrative review about the clinical manifestations and impact of the long COVID syndrome in adults. Methodology: This is a study with a qualitative approach, integrative review, whose article data collection was carried out by the “Publish or Perish” software, with a search with the title and keywords “long COVID” and “post COVID” and selected articles that have H-index, a citation metric. Results and Discussion: 3999 articles were searched, 567 with H-index and 29 selected for article. Grouped by themes: epidemiology of long COVID: most affected groups; risk factors or predictors; clinical manifestations; symptom progression; relationship between the severity of the acute condition and long-term COVID; specific situation after hospital discharge and socioeconomic impact. The study showed a higher prevalence in females, a higher age group, with a relevance of data for the persistence of symptoms, with many or specific symptoms at the beginning of the condition as a risk factor, whose most frequent clinical manifestations were fatigue, dyspnea and neuropsychological condition, with variable progression and significant impact on health and life. Conclusion: Due to the size of affected patients and the proportion of the long COVID syndrome presented in the studies, it is necessary to be able to identify the aspects related to long COVID and the impact on the quality of life and livelihood of individuals in order to encourage scientific production on the subject. of topics not yet well clarified and providing updates to health professionals.

Author Biography

Oscar Nunes Alves, Hospital Geral de Palmas

Graduado em Medicina pela Universidade Federal do Espírito Santo, Neurocirurgião pela Sociedade Brasileira de Neurocirurgia e Associação Médica Brasileira. Médico Neurocirurgião concursado do Serviço de Neurocirurgia do Hospital Geral de Palmas, atendendo também a hospitais privados e sócio proprietário do Instituto de Neurociências do Tocantins.

References

Ahmed, H., Patel, K., Greenwood, D. C., Halpin, S., Lewthwaite, P., Salawu, A., & Sivan, M. (2020). Long-term clinical outcomes in survivors of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome coronavirus (MERS) outbreaks after hospitalisation or ICU admission: a systematic review and meta-analysis. Journal of rehabilitation medicine, 52(5), 1-11.

Al-Aly, Z., Xie, Y., & Bowe, B. (2021). High-dimensional characterization of post-acute sequelae of COVID-19. Nature, 594(7862), 259-264.

Augustin, M., Schommers, P., Stecher, M., Dewald, F., Gieselmann, L., Gruell, H., ... & Lehmann, C. (2021). Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study. The Lancet Regional Health-Europe, 6, 100122.

Ayoubkhani, D., Khunti, K., Nafilyan, V., Maddox, T., Humberstone, B., Diamond, I., & Banerjee, A. (2021). Post-COVID syndrome in individuals admitted to hospital with COVID-19: retrospective cohort study. BMJ, 372.

Blomberg, B., Mohn, K. G. I., Brokstad, K. A., Zhou, F., Linchausen, D. W., Hansen, B. A., ... & Langeland, N. (2021). Long COVID in a prospective cohort of home-isolated patients. Nature medicine, 27(9), 1607-1613.

Broome, M. E. (2000). Integrative literature reviews for the development of concepts. Concept development in nursing: foundations, techniques and applications, 231, 250.

Carvalho-Schneider, C., Laurent, E., Lemaignen, A., Beaufils, E., Bourbao-Tournois, C., Laribi, S., ... & Bernard, L. (2021). Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clinical Microbiology and Infection, 27(2), 258-263.

Davis, H. E., Assaf, G. S., McCorkell, L., Wei, H., Low, R. J., Re'em, Y., ... & Akrami, A. (2021). Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine, 38, 101019.

Dennis, A., Wamil, M., Alberts, J., Oben, J., Cuthbertson, D. J., Wootton, D., ... & Banerjee, A. (2021). Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study. BMJ open, 11(3), e048391.

Dubey, S., Biswas, P., Ghosh, R., Chatterjee, S., Dubey, M. J., Chatterjee, S., ... & Lavie, C. J. (2020). Psychosocial impact of COVID-19. Diabetes & Metabolic Syndrome: clinical research & reviews, 14(5), 779-788.

Fernández-de-Las-Peñas, C., Palacios-Ceña, D., Gómez-Mayordomo, V., Florencio, L. L., Cuadrado, M. L., Plaza-Manzano, G., & Navarro-Santana, M. (2021). Prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis. European journal of internal medicine, 92, 55-70.

Goërtz, Y. M., Van Herck, M., Delbressine, J. M., Vaes, A. W., Meys, R., Machado, F. V., ... & Spruit, M. A. (2020). Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome?. ERJ open research, 6(4).

Graham, E. L., Clark, J. R., Orban, Z. S., Lim, P. H., Szymanski, A. L., Taylor, C., ... & Koralnik, I. J. (2021). Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized COVID‐19 “long haulers”. Annals of clinical and translational neurology, 8(5), 1073-1085.

Halpin, S. J., McIvor, C., Whyatt, G., Adams, A., Harvey, O., McLean, L., ... & Sivan, M. (2021). Postdischarge symptoms and rehabilitation needs in survivors of COVID‐19 infection: a cross‐sectional evaluation. Journal of medical virology, 93(2), 1013-1022.

Hampshire, A., Trender, W., Chamberlain, S. R., Jolly, A. E., Grant, J. E., Patrick, F., ... & Mehta, M. A. (2021). Cognitive deficits in people who have recovered from COVID-19. EClinicalMedicine, 39, 101044.

Harzing, A.W. (2007). Publish or Perish, Disponível em: https://harzing.com/resources/publish-or-perish

Huang, C., Huang, L., Wang, Y., Li, X., Ren, L., Gu, X., ... & Cao, B. (2021). 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. The Lancet, 397(10270), 220-232.

Iqbal, F. M., Lam, K., Sounderajah, V., Clarke, J. M., Ashrafian, H., & Darzi, A. (2021). Characteristics and predictors of acute and chronic post-COVID syndrome: A systematic review and meta-analysis. EClinicalMedicine, 36, 100899.

Kamal, M., Abo Omirah, M., Hussein, A., & Saeed, H. (2021). Assessment and characterisation of post‐COVID‐19 manifestations. International journal of clinical practice, 75(3), e13746.

Kniffin, K. M., Narayanan, J., Anseel, F., Antonakis, J., Ashford, S. P., Bakker, A. B., ... & Vugt, M. V. (2021). COVID-19 and the workplace: Implications, issues, and insights for future research and action. American Psychologist, 76(1), 63.

Ladds, E., Rushforth, A., Wieringa, S., Taylor, S., Rayner, C., Husain, L., & Greenhalgh, T. (2020). Persistent symptoms after COVID-19: qualitative study of 114 “long COVID” patients and draft quality principles for services. BMC health services research, 20(1), 1-13.

Lopez-Leon, S., Wegman-Ostrosky, T., Perelman, C., Sepulveda, R., Rebolledo, P. A., Cuapio, A., & Villapol, S. (2021). More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. Scientific reports, 11(1), 1-12.

Mahmud, R., Rahman, M. M., Rassel, M. A., Monayem, F. B., Sayeed, S. J. B., Islam, M. S., & Islam, M. M. (2021). Post-COVID-19 syndrome among symptomatic COVID-19 patients: A prospective cohort study in a tertiary care center of Bangladesh. PLoS One, 16(4), e0249644.

Moreno-Pérez, O., Merino, E., Leon-Ramirez, J. M., Andres, M., Ramos, J. M., Arenas-Jiménez, J., ... & COVID19-ALC research group. (2021). Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study. Journal of Infection, 82(3), 378-383.

OPAS. (2020). Manejo Clínico da COVID-19. Orientação provisória. Institucional Repository for Information Sharing. Disponível em: https://iris.paho.org/handle/10665.2/52285. Acesso em: 29 set 2022.

Peghin, M., Palese, A., Venturini, M., De Martino, M., Gerussi, V., Graziano, E., ... & Tascini, C. (2021). Post-COVID-19 symptoms 6 months after acute infection among hospitalized and non-hospitalized patients. Clinical Microbiology and Infection, 27(10), 1507-1513.

Petersen, M. S., Kristiansen, M. F., Hanusson, K. D., Danielsen, M. E., á Steig, B., Gaini, S., ... & Weihe, P. (2021). Long COVID in the Faroe Islands: a longitudinal study among nonhospitalized patients. Clinical Infectious Diseases, 73(11), e4058-e4063.

Seeßle, J., Waterboer, T., Hippchen, T., Simon, J., Kirchner, M., Lim, A., ... & Merle, U. (2022). Persistent symptoms in adult patients 1 year after coronavirus disease 2019 (COVID-19): a prospective cohort study. Clinical infectious diseases, 74(7), 1191-1198.

Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8, 102-106.

Sudre, C. H., Murray, B., Varsavsky, T., Graham, M. S., Penfold, R. S., Bowyer, R. C., ... & Steves, C. J. (2021). Attributes and predictors of long COVID. Nature medicine, 27(4), 626-631.

Sykes, D. L., Holdsworth, L., Jawad, N., Gunasekera, P., Morice, A. H., & Crooks, M. G. (2021). Post-COVID-19 symptom burden: what is long-COVID and how should we manage it?. Lung, 199(2), 113-119.

Taquet, M., Dercon, Q., Luciano, S., Geddes, J. R., Husain, M., & Harrison, P. J. (2021). Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19. PLoS medicine, 18(9), e1003773.

Townsend, L., Dowds, J., O’Brien, K., Sheill, G., Dyer, A. H., O’Kelly, B., ... & Bannan, C. (2021). Persistent poor health after COVID-19 is not associated with respiratory complications or initial disease severity. Annals of the American Thoracic Society, 18(6), 997-1003.

Townsend, L., Dyer, A. H., Jones, K., Dunne, J., Mooney, A., Gaffney, F., ... & Conlon, N. (2020). Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. PloS one, 15(11), e0240784.

Whittemore, R., & Knafl, K. (2005). The integrative review: updated methodology. Journal of advanced nursing, 52(5), 546-553.

World Health Organization (2021). A clinical case definition of post COVID-19 condition by a Delphi consensus, 6 October 2021”. Disponível em: https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1. Acesso em: 29 set 2022

World Health Organization. (2022, September 26). Painel da OMS Coronavírus (COVID-19). WHO. Retrieved September 29, 2022, from https://COVID19.who.int/

Xie, Y., Xu, E., Bowe, B., & Al-Aly, Z. (2022). Long-term cardiovascular outcomes of COVID-19. Nature medicine, 28(3), 583-590.

Zhang, Y., Li, Y. X., Zhong, D. L., Liu, X. B., Zhu, Y. Y., Jin, R. J., & Li, J. (2022). Clinical practice guidelines and expert consensus statements on rehabilitation for patients with COVID-19: protocol for a systematic review. BMJ open, 12(8), e060767.

Published

15/10/2022

How to Cite

NUNES, M. de C.; ALVES, O. N.; SANTANA, L. C. de; NUNES, L. T. D. . COVID long syndrome: an integrative review. Research, Society and Development, [S. l.], v. 11, n. 13, p. e572111335990, 2022. DOI: 10.33448/rsd-v11i13.35990. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/35990. Acesso em: 18 apr. 2024.

Issue

Section

Health Sciences