Management and prognosis of gastroschisis in a public maternity hospital in the state of Sergipe

Authors

DOI:

https://doi.org/10.33448/rsd-v11i16.38455

Keywords:

Gastroschisis; Congenital Abnormalities; Prenatal Care; Prognosis.

Abstract

Gastroschisis is the most common congenital anomaly of the abdominal wall, defined as a defect in its closure, resulting in evisceration of intra-abdominal structures. It often appears isolated, without association with other anomalies. In different regions of Brazil and the world, there has been an increase in the incidence of this pathology - currently between 2 and 5 per 10,000 live births - configuring a public health problem to be equated. The present study aimed to analyze the profile of births and deaths due to gastroschisis, to identify the causes of in-hospital mortality and the occurrences of postoperative complications of newborns with gastroschisis, in a public maternity hospital in the state of Sergipe. This is a prospective observational cohort study, aligned with the multicenter study 'PAEDSURG' in which all Brazilian hospitals would be eligible to participate. Data were collected between 11/15/2021 and 11/15/2022, from all consecutively eligible cases, under the supervision of the pediatric surgeon coordinating the research site, Drª Marcia Montalvão. Five cases of newborns with gastroschisis were described, all born by cesarean section, prematurity was seen in 4 cases (median GA 35 weeks), with low birth weight observed in 75% of cases (median 2180g). All mothers were primiparous, all had prenatal care and underwent an ultrasound examination, showing gastroschisis in 4 NBs, 3 mothers had low maternal age (median of 18 years), none with higher education. The mortality rate was low (of the 5 NBs, only 1 died) and socioeconomic factors were associated with the occurrence of gastroschisis.

Author Biographies

Fernanda Lodysllen Costa Silva, Universidade Federal de Sergipe

Acadêmica do 12º período de Medicina pela Universidade Federal de Sergipe, Brasil.

Técnica em enfermagem da Unidade de Terapia Intensiva Neonatal da Maternidade Nossa Senhora de Lourdes, Aracaju-SE, Brasil.

Instrumentadora cirúrgica do Hospital Regional de Propriá-SE, Brasil.

Márcia Virgínia Pereira Montalvão , Universidade Federal de Sergipe

Cirurgiã Pediátrica da Maternidade Nossa Senhora de Lourdes, Aracaju-SE, Brasil.

Mestranda da Universidade Federal de Sergipe, Brasil.

Simone Maria de Oliveira, Universidade Federal de Sergipe

Cirurgiã Pediátrica da Materniadade Nossa Senhora de Lourdes, do Hospital Santa Isabel e do Hospital Universitário-UFS localizados em Aracaju-SE, Brasil.

Professora da Universidade Federal de Sergipe, Brasil.

References

Amorim, M. M. R. de, Vilela, P. C., Santos, L. C., Falbo Neto, G. H., Lippo, L. A. M., & Marques, M. (2000). Gastrosquise: Diagnóstico Pré-natal x Prognóstico Neonatal. Revista Brasileira de Ginecologia e Obstetrícia, 22(4). https://doi.org/10.1590/S0100-72032000000400002

Benjamin, B. G., Ethen, M. K., Van Hook, C. L., Myers, C. A., & Canfield, M. A. (2009). Gastroschisis prevalence in Texas 1999–2003. Birth Defects Research Part A: Clinical and Molecular Teratology, NA-NA. https://doi.org/10.1002/bdra.20642

Bhat, V., Moront, M., & Bhandari, V. (2020). Gastroschisis: A State-of-the-Art Review. Children, 7(12), 302. https://doi.org/10.3390/children7120302

Bradnock, T. J., Marven, S., Owen, A., Johnson, P., Kurinczuk, J. J., Spark, P., Draper, E. S., Knight, M., & on behalf of BAPS-CASS. (2011). Gastroschisis: One year outcomes from national cohort study. BMJ, 343(nov15 2), d6749–d6749. https://doi.org/10.1136/bmj.d6749

Calcagnotto, H., Müller, A. L. L., Leite, J. C. L., Sanseverino, M. T. V., Gomes, K. W., & Magalhães, J. A. de A. (2013). Fatores associados à mortalidade em recém-nascidos com gastrosquise. Revista Brasileira de Ginecologia e Obstetrícia, 35(12), 549–553. https://doi.org/10.1590/S0100-72032013001200004

Castilla, E. E., Mastroiacovo, P., & Orioli, I. M. (2008). Gastroschisis: International epidemiology and public health perspectives. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 148C(3), 162–179. https://doi.org/10.1002/ajmg.c.30181

Centofanti, S. F., Francisco, R. P. V., Phillippi, S. T., Galletta, M. A. K., Sousa, A. M. S., Rodrigues, A. S., Curi, R., & Brizot, M. L. (2019). Maternal nutrient intake and fetal gastroschisis: A case-control study. American Journal of Medical Genetics Part A, 179(8), 1535–1542. https://doi.org/10.1002/ajmg.a.61265

Diyaolu, M., Wood, L. S., & Bruzoni, M. (2021). Sutureless closure for the management of gastroschisis. Translational Gastroenterology and Hepatology, 6, 31–31. https://doi.org/10.21037/tgh-20-185

Emil, S. (2018). Surgical strategies in complex gastroschisis. Seminars in Pediatric Surgery, 27(5), 309–315. https://doi.org/10.1053/j.sempedsurg.2018.08.003

Feldkamp, M. L., Reefhuis, J., Kucik, J., Krikov, S., Wilson, A., Moore, C. A., Carey, J. C., & Botto, L. D. (2008). Case-control study of self reported genitourinary infections and risk of gastroschisis: Findings from the national birth defects prevention study, 1997-2003. BMJ, 336(7658), 1420–1423. https://doi.org/10.1136/bmj.39567.509074.25

Guerra, F. A. R., Llerena Jr, J. C., Gama, S. G. N. da, Cunha, C. B. da, & Theme Filha, M. M. (2008). Defeitos congênitos no Município do Rio de Janeiro, Brasil: Uma avaliação através do SINASC (2000-2004). Cadernos de Saúde Pública, 24(1), 140–149. https://doi.org/10.1590/S0102-311X2008000100014

Hunter, A. G. W., & Stevenson, R. E. (2008). Gastroschisis: Clinical presentation and associations. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 148C(3), 219–230. https://doi.org/10.1002/ajmg.c.30178

Jeong, S.-Y., Kim, B.-Y., & Yu, J. E. (2010). De Novo Pericentric Inversion of Chromosome 9 in Congenital Anomaly. Yonsei Medical Journal, 51(5), 775. https://doi.org/10.3349/ymj.2010.51.5.775

Kirby, R. S., Marshall, J., Tanner, J. P., Salemi, J. L., Feldkamp, M. L., Marengo, L., Meyer, R. E., Druschel, C. M., Rickard, R., & Kucik, J. E. (2013). Prevalence and Correlates of Gastroschisis in 15 States, 1995 to 2005. Obstetrics & Gynecology, 122(2), 275–281. https://doi.org/10.1097/AOG.0b013e31829cbbb4

Lap, C. C. M. M., Brizot, M. L., Pistorius, L. R., Kramer, W. L. M., Teeuwen, I. B., Eijkemans, M. J., Brouwers, H. A. A., Pajkrt, E., van Kaam, A. H., van Scheltema, P. N. A., Eggink, A. J., van Heijst, A. F., Haak, M. C., van Weissenbruch, M. M., Sleeboom, C., Willekes, C., van der Hoeven, M. A., van Heurn, E. L., Bilardo, C. M., … Manten, G. T. R. (2016). Outcome of isolated gastroschisis; an international study, systematic review and meta-analysis. Early Human Development, 103, 209–218. https://doi.org/10.1016/j.earlhumdev.2016.10.002

Luquetti, D. V., & Koifman, R. J. (2011). Surveillance of birth defects: Brazil and the US. Ciência & Saúde Coletiva, 16(suppl 1), 777–785. https://doi.org/10.1590/S1413-81232011000700008

Merks, J. H. M., van Karnebeek, C. D. M., Caron, H. N., & Hennekam, R. C. M. (2003). Phenotypic abnormalities: Terminology and classification. American Journal of Medical Genetics, 123A(3), 211–230. https://doi.org/10.1002/ajmg.a.20249

Nazer Herrera, J., Karachon Essedin, L., Cifuentes Ovalle, L., & Assar Cuevas, R. (2016). Gastrosquisis: ¿una pandemia con tasas en aumento? Experiencia del estudio colaborativo latino americano de malformaciones congénitas (ECLAMC) en Chile. Período 1982-2014. Revista Chilena de Pediatría, 87(5), 380–386. https://doi.org/10.1016/j.rchipe.2016.06.003

Poulain, P., Milon, J., Frémont, B., Proudhon, J.-F., Odent, S., Babut, J.-M., Le Marec, B., Grall, J.-Y., & Giraud, J.-R. (1994). Remarks about the prognosis in case of antenatal diagnosis of gastroschisis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 54(3), 185–190. https://doi.org/10.1016/0028-2243(94)90280-1

Sbragia Neto, L., Melo Filho, A. A., Barini, R., Huguet, P. R., Marba, S., & Bustorff-Silva, J. M. (1999). Importância do diagnóstico pré-natal de gastrosquise. Revista Brasileira de Ginecologia e Obstetrícia, 21(8). https://doi.org/10.1590/S0100-72031999000800008

Severino, A. J. (2017). METODOLOGIA DO TRABALHO CIENTIFICO. CORTEZ EDITORA.

Vilela, P. C., Amorim, M. M. R. de, Falbo Neto, G. H., Santos, L. C., Santos, R. V. H., & Correia, C. (2002). Fatores prognósticos para óbito em recém-nascidos com gastrosquise. Acta Cirurgica Brasileira, 17(suppl 1), 17–20. https://doi.org/10.1590/S0102-86502002000700005

Vu, L. T., Nobuhara, K. K., Laurent, C., & Shaw, G. M. (2008). Increasing Prevalence of Gastroschisis: Population-based Study in California. The Journal of Pediatrics, 152(6), 807–811. https://doi.org/10.1016/j.jpeds.2007.11.037

West, K. W., Rescorla, F. J., Scherer, L. R., & Grosfeld, J. L. (1995). Diagnosis and treatment of symptomatic breast masses in the pediatric population. Journal of Pediatric Surgery, 30(2), 182–187. https://doi.org/10.1016/0022-3468(95)90557-X

Published

15/12/2022

How to Cite

SILVA, F. L. C. .; MONTALVÃO , M. V. P. .; OLIVEIRA, S. M. de . Management and prognosis of gastroschisis in a public maternity hospital in the state of Sergipe. Research, Society and Development, [S. l.], v. 11, n. 16, p. e460111638455, 2022. DOI: 10.33448/rsd-v11i16.38455. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/38455. Acesso em: 16 apr. 2024.

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Section

Health Sciences