Impact of the uterine microbiota on assisted reproduction: literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i16.38599

Keywords:

Microbiota; IVF; Vaginal Microbiota; Uterine microbiota.

Abstract

Microorganisms present in the female reproductive system, especially in the uterus, may be responsible for infertility in some women, and even for failure on the in vitro fertilization (IVF) cycles. However, this subject is little explored in the clinical area and the literature on this subject is still scarce. Given this problem, the objective of this review was to relate the importance of the uterine microbiota for the success of human reproduction. It is known that the microbiota of the female reproductive tract is inhabited by several microorganisms, including Lactobacillus. The number of species present at the site is related to women's health and various factors such as hormonal fluctuations and age, for example. Depending on the bacterial composition present in the female reproductive system, the woman may have several problems, such as infections, which may even show symptoms and even difficulties in conceiving a pregnancy. Many studies indicate that the balance of the microbiota of the reproductive tract is fundamental to the success of human reproduction, but there is no deep understanding in this regard. Future research should seek to discover in more detail the interactions between the vaginal and uterine microbiota and thus enable meaningful interventions to improve fertility as a result of treatment.

References

Belkaid, Y., & Harrison, O. (2017). Homeostatic Immunity and the Microbiota. Immunity, 46(4), 562–576.

Benner, M., Ferwerda, G., Joosten, I., & Van Der Molen, R. (2018). How uterine microbiota might be responsible for a receptive, fertile endometrium. Human Reproduction Update, 24(4), 393-415: 10.1093/humupd/dmy012.

Bernabeu, A., Lledo, B., Díaz, M., Lozano, M., Ruiz, V., Fuentes, A., Lopez-Pineda, A., Moliner, B., Castillo, J., Ortiz, J., Tem, J., Llacer, J., Carratala-Munuera, C., Orozco-Beltran, D., Quesada, J., & Bernabeu, R. (2019). Effect of the vaginal microbiome on the pregnancy rate in women receiving assisted reproductive treatment. J Assist Reprod Genet, 36(10), 2111-2119. 10.1007/s10815-019-01564-0.

Carlson, B. (2014). Embriologia humana e biologia do desenvolvimento (1 ed.). Rio de Janeiro: Elsevier.

Consolaro, M., & Maria-Engler, S. (2014). Citologia Clínica Cérvico-Vaginal: Texto e Atlas (1ª ed.): Roca.

Fabrini, J., & Capel, L. (2021). O papel da microbiota intestinal na metabolização do Glúten: uma revisão. Brazilian Journal of Development, 7(10), 99008–99035. https://doi.org/10.34117/bjdv7n10-291.

Gonçalves, P., Figueiredo, J., & Gasperin, B. (2021). Biotécnicas aplicadas à Reprodução Animal e à Humana (3º ed.), Reprodução Assistida em Humanos (pp. 376 – 389). Rio de Janeiro: Roca.

Green, K., Zarek, S., & Catherino, W. (2015). Gynecologic health and disease in relation to the microbiome of the female reproductive tract. Fertility and Sterility, 104(6), 1351–1357. 10.1016/j.fertnstert.2015.10.010.

Haahr, T., Jensen, J., Thomsen, L., Duus, L., Rygaard, K., & Humaidan, P. (2016). Abnormal vaginal microbiota may be associated with poor reproductive outcomes: A prospective sudy in IVF patients. Human Reproduction, 31(4), 795– 803. 10.1093/humrep/dew026.

Kindinger, L., Bennett, P., Lee, Y., Marchesi, J., Smith, A., Cacciatore, S., Holmes, E., Nicholson, J., Teoh, T., & MacIntyre, D. (2017). The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk. Microbiome, 5(1), 6. 10.1186/s40168-016-0223-9.

Koedooder, R., Singer, M., Schoenmakers, S., Savelkoul, P., Morré, S., De Jonge, J., Poort, L., Cuypers, W., Beckers, N., Broekmans, F., Cohlen, B., Den Hartog, J., Fleischer, K., Lambalk, C., Smeenk, J., Budding, A., & Laven, J. (2019). The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection: a prospective study. Human Reproduction, 34(6), 1042-1054. 10.1093/humrep/dez065.

Koedooder, R., Mackens, S., Budding, A., Fares, D., Blockeel, C., Laven, J., & Schoenmakers, S. (2019). Identification and evaluation of the microbiome in the female and male reproductive tracts. Human Reproduction Update, 25(3), 298–325. 10.1093/humupd/dmy048.

Kroon, S., Ravel, J., & Huston, W. (2018). Cervicovaginal microbiota, women’s health, and reproductive outcomes. Fertility and Sterility. 110(3), 327–336. 10.1016/j.fertnstert.2018.06.036.

Lloyd-Price, J., Abu-Ali, G., & Huttenhower, C. (2016). The healthy human microbiome. Genome Medicine, 8(1), 1–11. 10.1016/j.fertnstert.2018.06.036.

Moreno, I., Codoner, F., Vilella, F., Valbuena, D., Martinez-Blanch, J., Jimenez-Almazán, J., Alonso, R., Alamá, P., Remohí, J., Pellicer, A., Ramon, D., & Simon, C. (2016). Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol, 215(6), 684-703. 10.1016/j.ajog.2016.09.075.

Moreno, I., & Franasiak, J. (2017). Endometrial microbiota-new player in town. Fertil Steril, 108(1), 32-39. 10.1016/j.fertnstert.2017.05.034.

Moreno, I. & Simon, C. (2018). Relevance of assessing the uterine microbiota in infertility. Fertil Steril, 110(3), 337-343. 10.1016/j.fertnstert.2018.04.041.

Nasiri, N., & Eftekhari-Yazdi, P. (2015). An overview of the available methods for morphological scoring of pre-implantation embryos in vitro fertilization. Cell Journal (Yakhteh), 16(4), 392. 10.22074/cellj.2015.486.

Ortiz, M., Karin, J., & Carmen, V. (2022). Impact of bacterial vaginosis on the reproductive outcomes of IVF: meta-analysis. Obstetrics & Gynecology International Journal, 13(4), 191 – 202.

Schoenmakers, S., & Laven, J. (2020). The vaginal microbiome as a tool to predict IVF success. Current Opinion Obstet Gynecol, 32(3), 169–178. 10.1097/GCO.0000000000000626.

Simopoulou, M., Giannelou, P., Bakas, P., Gkoles, L., Kalampokas, T., Pantos, K., & Koutsilieris, M. (2016). Making ICSI safer and more effective: A review of the human oocyte and ICSI practice. In Vivo, 30(4), 387-400.

Sinha, S., & Agrawal, N. (2015). Endorphin alone is a better drug for ovarian stimulation than in combination with compeer in intrauterine insemination. The Journal of obstetrics and Gynecology of India, 66(5), 333-8.

Souza, M., Silva, M., & Carvalho R. (2010). Integrative review: what is it? How to do it? Einstein, 8(1), 102-106. https://doi.org/10.1590/S1679-45082010RW1134.

Turnbaugh, P., Ley, R., Hamady, M., Fraser-Liggett, C., Knight, R., & Gordon, J. (2007). The Human Microbiome Project. Nature, 449, 804–810.

Valenti, P., Rosa, L., Capobianco, D., Lepanto, M., Schiavi, E., Cutone, A., Paesano, R., & Mastromarino, P. (2018). Role of Lactobacilli and Lactoferrin in the Mucosal Cervicovaginal Defense. Front Immunol, 9(376). 10.3389/fimmu.2018.00376.

Vinturache, A., Gyamfi-Bannerman, C., Hwang, J., Mysorekar, I., & Jacobsson, B., Preterm Birth International Collaborative (PREBIC) (2016). Maternal microbiome - A pathway to preterm birth. Semin Fetal Neonatal Med, 21(2), 94-99. 10.1016/j.siny.2016.02.004.

Whittemore, R., Chao, A., Jang, M., Minges, K., & Park, C. (2014). Methods for knowledge synthesis: an overview. Heart Lung, 43(5), 453-61. 10.1016/j.hrtlng.2014.05.014.

Published

14/12/2022

How to Cite

SILVA, S. M. B. da; DUTRA, P. D. S. de S. .; SALES, A. I. L.; PADILHA , D. de M. M. Impact of the uterine microbiota on assisted reproduction: literature review. Research, Society and Development, [S. l.], v. 11, n. 16, p. e441111638599, 2022. DOI: 10.33448/rsd-v11i16.38599. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/38599. Acesso em: 25 apr. 2024.

Issue

Section

Review Article