Onde está a abordagem farmacológica no tratamento da obesidade infantil: uma breve revisão

Authors

DOI:

https://doi.org/10.33448/rsd-v9i7.5065

Keywords:

Infância; Obesidade; Farmacologia; Exercício físico.

Abstract

O treinamento físico emergiu como uma ferramenta não farmacológica promissora para a melhoria da composição corporal de uma grande variedade de populações clínicas, incluindo idosos, pacientes com doenças crônicas e crianças com obesidade. É importante destacar a obesidade infantil (CO) como uma preocupação de saúde pública que deve ser atenuada para um melhor crescimento e desenvolvimento da criança. Embora existam vários modelos de treinamento, o ganho particular entre todos é a melhora metabólica que contribui para o aumento da massa muscular e a perda de gordura. Por outro lado, existem vários medicamentos envolvidos no tratamento da obesidade, atuando em caminhos semelhantes relacionados ao treinamento físico para o tratamento da CO. Isso provoca uma questão crucial: considerando o exercício que apenas o exercício e os medicamentos poderiam tratar CO, devemos avaliar a segurança e / ou os efeitos da abordagem farmacológica com o exercício para potencializar o tratamento de CO? Sob essa perspectiva, o objetivo deste estudo foi revisar os efeitos da interação entre medicamentos e treinamento com exercícios no CO e fornecer informações importantes para a adesão dos medicamentos ao exercício nessa população. Trata-se de uma revisão narrativa de caráter descritivo acerca do efeito do exercício e medicamentos na CO. Com base na literatura atual, sugere-se que os medicamentos para exercícios e obesidade apresentem caminhos semelhantes no tratamento de CO. Além disso, recomenda-se que futuros ensaios clínicos randomizados relatem e discutam o efeito do exercício mais medicamentos para obesidade no tratamento ou redução de CO.

References

Christou, G. A., Katsiki, N., & Kiortsis, N. D. (2016). The current role of liraglutide in the pharmacotherapy of obesity. Current vascular pharmacology, 14(2), 201-207.

Anatoliotakis, N., Deftereos, S., Bouras, G., Giannopoulos, G., Tsounis, D., Angelidis, C., Kaoukis, A., & Stefanadis, C. (2013). Myeloperoxidase: expressing inflammation and oxidative stress in cardiovascular disease. Curr Top Med Chem, 13(2), 115-138. doi:10.2174/1568026611313020004

Boland, C. L., Harris, J. B., & Harris, K. B. (2015). Pharmacological management of obesity in pediatric patients. Annals of Pharmacotherapy, 49(2), 220-232.

Borghouts, L., & Keizer, H. (2000). Exercise and insulin sensitivity: a review. International journal of sports medicine, 21(01), 1-12.

Chao, A. M., Wadden, T. A., & Berkowitz, R. I. (2018). The safety of pharmacologic treatment for pediatric obesity. Expert opinion on drug safety, 17(4), 379-385.

Danielsson, P., Janson, A., Norgren, S., & Marcus, C. (2007). Impact sibutramine therapy in children with hypothalamic obesity or obesity with aggravating syndromes. The Journal of Clinical Endocrinology & Metabolism, 92(11), 4101-4106.

Dias, P. C., Henriques, P., Anjos, L. A. D. & Burlandy, L. (2017). Obesidade e políticas públicas: concepções e estratégias adotadas pelo governo brasileiro. Cadernos de Saúde Pública, 33, e00006016.

Dietz, W. H., & Robinson, T. N. (2005). Overweight children and adolescents. New England Journal of Medicine, 352(20), 2100-2109.

Donatsky, O. (1976). Comparison of cellular and humoral immunity against streptococcal and adult human oral mucosa antigens in relation to exacerbation of recurrent aphthous stomatitis. Acta Pathologica Microbiologica Scandinavica Section C Immunology, 84(4), 270-282.

Escrivão, M., Oliveira, F. L. C., Taddei, J., & Lopez, F. A. (2000). Obesidade exógena na infância e na adolescência. J Pediatr, 76(3), 305-310.

Fang, Y., Ma, Y., Mo, D., Zhang, S., Xiang, M., & Zhang, Z. (2019). Methodology of an exercise intervention program using social incentives and gamification for obese children. BMC public health, 19(1), 686.

Fisher-Wellman, K. H., & Bloomer, R. J. (2010). Exacerbated postprandial oxidative stress induced by the acute intake of a lipid meal compared to isoenergetically administered carbohydrate, protein, and mixed meals in young, healthy men. Journal of the American College of Nutrition, 29(4), 373-381.

Friedman, K. E., Reichmann, S. K., Costanzo, P. R., & Musante, G. J. (2002). Body image partially mediates the relationship between obesity and psychological distress. Obesity research, 10(1), 33-41.

García-Hermoso, A., Ceballos-Ceballos, R., Poblete-Aro, C., Hackney, A., Mota, J., & Ramírez-Vélez, R.(2017). Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials. International journal of obesity, 41(4), 475-482.

Gilligan, D. M., Panza, J. A., Kilcoyne, C. M., Waclawiw, M. A., Casino, P. R., & Quyyumi, A. A. (1994). Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation, 90(6), 2853-2858.

Gray, J., Yeo, G. S., Cox, J. J., Morton, J., Adlam, A. L. R., Keogh, J. M., Yanovski, J. A., El Gharbawy, A., Han, J. C., & Tung, Y. L. (2006). Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes, 55(12), 3366-3371.

Gurnani, M., Birken, C., & Hamilton, J. (2015). Childhood obesity: causes, consequences, and management. Pediatric Clinics, 62(4), 821-840.

Hansen, D. L., Toubro, S., Stock, M.J., Macdonald, I. A., & Astrup, A. (1998). Thermogenic effects of sibutramine in humans. The American journal of clinical nutrition, 68(6), 1180-1186.

Hutchinson, J., Emerick, J., & Saxena, H. (2016). The future of pediatric obesity. Primary Care: Clinics in Office Practice, 43(1), 1-17.

Ip, P., Ho, F. K-W., Louie, L. H-T., Chung, T. W-H., Cheung, Y-F., Lee, S-L., Hui, S. S-C., Ho, W. K-Y., Ho, D. S-Y., & Wong, W. H-S. (2017). Childhood obesity and physical activity-friendly school environments. The Journal of pediatrics, 191, 110-116.

Kelsey, M. M., Zaepfel, A., Bjornstad, P., & Nadeau, K.J. (2014). Age-related consequences of childhood obesity. Gerontology, 60(3), 222-228.

Khera, R., Murad, M. H., Chandar, A. K., Dulai, P. S., Wang, Z., Prokop, L. J., Loomba, R., Camilleri, M., & Singh, S. (2016). Association of pharmacological treatments for obesity with weight loss and adverse events: a systematic review and meta-analysis. Jama, 315(22), 2424-2434.

Loeffler, I., & Wolf, G. (2014). Transforming growth factor-β and the progression of renal disease. Nephrology Dialysis Transplantation, 29(suppl_1), i37-i45.

McCambridge, T.M., Bernhardt, D. T., Brenner, J. S., Congeni, J. A., Gomez, J. E., Gregory, A. J., Gregory, D. B., Griesemer, B. A., Reed, F. E., & Rice, S. G. (2006). Active healthy living: prevention of childhood obesity through increased physical activity. Pediatrics, 117(5), 1834-1842.

McManus, A. M., & Mellecker, R. R. (2012). Physical activity and obese children. Journal of Sport and Health Science, 1(3), 141-148.

Mogul, A., Irby, M. B., & Skelton, J. A. (2014). A systematic review of pediatric obesity and family communication through the lens of addiction literature. Childhood Obesity, 10(3), 197-206.

Molina-Garcia, P., Migueles, J. H., Cadenas-Sanchez, C., Esteban-Cornejo, I., Mora-Gonzalez, J., Rodriguez-Ayllon, M., Plaza-Florido, A., Molina-Molina, A., Garcia-Delgado, G., & D’Hondt, E. (2019). Fatness and fitness in relation to functional movement quality in overweight and obese children. Journal of sports sciences, 37(8), 878-885.

Monteiro, P. A., Chen, K. Y., Lira, F. S., Saraiva, B. T. C., Antunes, B. M. M., Campos, E. Z., & Freitas, I. F. (2015). Concurrent and aerobic exercise training promote similar benefits in body composition and metabolic profiles in obese adolescents. Lipids in health and disease, 14(1), 153.

Mortensen, S. P., & Saltin, B. (2014). Regulation of the skeletal muscle blood flow in humans. Experimental physiology, 99(12), 1552-1558.

Nakayama, H., Nishida, K., & Otsu, K. (2016). Macromolecular degradation systems and cardiovascular aging. Circulation research, 118(10), 1577-1592.

Nicolaidis, S. (2019). Environment and obesity. Metabolism, 100, 153942.

Noland, R. C. (2015). Exercise and regulation of lipid metabolism. In Progress in molecular biology and translational science (Vol. 135, pp. 39-74): Elsevier.

Ogden, C. L., Flegal, K. M., Carroll. M. D., & Johnson, C. L. (2002). Prevalence and trends in overweight among US children and adolescents, 1999-2000. Jama, 288(14), 1728-1732.

Padwal, R. S., & Majumdar, S. R. (2007). Drug treatments for obesity: orlistat, sibutramine, and rimonabant. The Lancet, 369(9555), 71-77.

Pasquali, R., Patton, L., & Gambineri, A. (2007). Obesity and infertility. Current Opinion in Endocrinology, Diabetes and Obesity, 14(6), 482-487.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Methodology of cientific research. [e-Book]. Santa Maria City. UAB / NTE / UFSM Editors. Accessed on: July, 1st, 2020.Available at: https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1.

Potter, V. R. (1946). The assay of animal tissues for respiratory enzymes. 5. The malic dehydrogenase system. Journal of Biological Chemistry, 165, 311-324.

Prado, W. L., Balagopal, P. B., Lofrano-Prado, M. C., Oyama, L. M., Botero, J. P., & Hill, J. O. (2014). Effect of aerobic exercise on hunger feelings and satiety regulating hormones in obese teenage girls. Pediatric exercise science, 26(4), 463-469.

Raj, D. S., Pecoits-Filho, R., & Kimmel, P. L. (2020). Inflammation in chronic kidney disease. In Chronic Renal Disease (pp. 355-373): Elsevier.

Romano, A. D., Serviddio G, De Matthaeis, A., Bellanti, F., & Vendemiale, G. (2010). Oxidative stress and aging. Journal of nephrology, 23, S29-36.

Rybczyńska, A., Marchwińska, A., Dyś, A., Boblewski, K., Lehmann, A., & Lewko, B. (2017). Activity of the calcium-sensing receptor influences blood glucose and insulin levels in rats. Pharmacological Reports, 69(4), 709-713.

Shukla, A. P., Kumar, R. B., & Aronne, L. J. (2015). Lorcaserin Hcl for the treatment of obesity. Expert opinion on pharmacotherapy, 16(16), 2531-2538.

Skouteris, H., Cox, R., Huang, T., Rutherford, L., Edwards, S., & Cutter-Mackenzie, A. (2014). Promoting obesity prevention together with environmental sustainability. Health promotion international, 29(3), 454-462.

Srivastava, G., & Apovian, C. (2018). Future pharmacotherapy for obesity: new anti-obesity drugs on the horizon. Current obesity reports, 7(2), 147-161.

Steinbeck, K. (2001). Obesity in children-the importance of physical activity. Australian Journal of Nutrition and Dietetics, 58, S28-S32.

Steinbeck, K. S. (2001). The importance of physical activity in the prevention of overweight and obesity in childhood: a review and an opinion. Obesity reviews, 2(2), 117-130.

Wolf, A. M., & Colditz, G. A. (1994). The cost of obesity. Pharmacoeconomics, 5(1), 34-37.

Wright, D. C., Han, D-H., Garcia-Roves, P. M., Geiger, P. C., Jones, T. E., & Holloszy, J. O. (2007). Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1α expression. Journal of Biological Chemistry, 282(1), 194-199.

Xia, L., Wang, Z., Zhang, Y., Yang, X., Zhan, Y., Cheng, R., & Zhang, J. (2015). Reciprocal regulation of insulin and plasma 5'-AMP in glucose homeostasis in mice. The Journal of endocrinology, 224(3), 225-234.

Yanovski, J. A. (2001). Pediatric obesity. Reviews in Endocrine and Metabolic Disorders, 2(4), 371-383.

Yanovski, J. A. (2015). Pediatric obesity. An introduction. Appetite, 93, 3-12.

Zhao, Y., Banerjee, S., Dey, N., LeJeune, W. S., Sarkar, P. S., Brobey, R., Rosenblatt, K. P., Tilton, R. G., & Choudhary, S. (2011). Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine) 536 phosphorylation. Diabetes, 60(7), 1907-1916.

Zieliński, J., Slominska, E. M., Król-Zielińska, M., Krasiński, Z., & Kusy, K. (2019). Purine metabolism in sprint-vs endurance-trained athletes aged 20‒90 years. Scientific reports, 9(1), 1-10.

Downloads

Published

16/06/2020

How to Cite

CORRÊA, H. L.; SILVA, S. L. da; FURTESNAU, S. C.; SILVA, C. H. da; ROCHA, Y. R. de L.; CAMPBELL, C. S. G.; NEVES, R. P.; ROSA, T. S. Onde está a abordagem farmacológica no tratamento da obesidade infantil: uma breve revisão. Research, Society and Development, [S. l.], v. 9, n. 7, p. e871975065, 2020. DOI: 10.33448/rsd-v9i7.5065. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/5065. Acesso em: 18 apr. 2024.

Issue

Section

Review Article