The therapeutic applicability of tyrosol and hydroxytyrosol for Dentistry

Authors

DOI:

https://doi.org/10.33448/rsd-v9i8.6420

Keywords:

Phenylethyl alcohol; Protective agents; Antioxidants; Natural products; Dentistry.

Abstract

Tyrosol (2- (4-hydroxyphenyl) ethanol) and hydroxytyrosol (2- (3,4-dihydroxyphenyl) ethanol) are one of the major representatives of the phenolic compounds found in olives, olive oil and wine. They have high antioxidant, anti-inflammatory, antiviral and anti-tumor properties and are the target of several studies in the medical field. The aim of this work was to evaluate the results of tyrosol and hydroxytyrosol in the published literature with the intention of directing the information about the application of these phenolic compounds in the dental field. An integrative review of the literature published in the last 20 years was carried out, with the purpose of accessing the most recent evidence on the subject, without restriction on the language. It was concluded that, although there are few studies on the therapeutic application of tyrosol and hydroxytyrosol in dentistry, and many of them in vitro, the results shown the potential of these products for their application in dentistry. These compounds can be used in several clinical areas, mainly for anti-inflammatory, antioxidant and anti-tumor activities.

Author Biographies

Adriano Costa Ramos, Universidade Federal de Pernambuco

UNIVERSIDADE FEDERAL DE PERNAMBUCO- UFPECENTRO UNIVERSITÁRIO FACOL- UNIFACOL

Jhony Herick Cavalcanti Nunes Negreiros, Universidade Federal de Pernambuco

Universidade Federal de Pernambuco - UFPECentro Universitário FACOL - UNIFACOL

References

Ammar, S., Oturan, M., Labiadh, L., Guersalli, A., Abdelhédi, R., Oturan, N., & Brillas, E. (2015). Degradation of tyrosol by a novel electro-Fenton process using pyrite as heterogeneous source of iron catalyst. Water research, 74C, 77-87. doi: 10.1016/j.watres.2015.02.006

Arias, L. S., Delbem, A. C., Fernandes, R. A., Barbosa, D. B., & Monteiro, D. R. (2016). Activity of tyrosol against single and mixed-species oral biofilms. J Appl Microbiol, 120(5), 1240-1249. doi:10.1111/jam.13070

Avola, R., Graziano, A., Pannuzzo, G., Bonina, F., & Cardile, V. (2019). Hydroxytyrosol from olive fruits prevents blue-light-induced damage in human keratinocytes and fibroblasts. Journal of cellular physiology, 234(6), 9065–9076. https://doi.org/10.1002/jcp.27584

Bavabeedu, S. S., Mathew, V. B., Fahad, A. N., Al Hutaylah, M. S. H., Al Ahmari, S. A. O., & Al Yami, M. S. A. (2018). Evaluation of the Antibacterial Effect of Virgin Olive oil on Enterococcus Faecalis: An In Vitro Study. Int J Prev Clin Dent Res, 5(2), 1-4.

Bu, Y., Rho, S., Kim, J., Kim, M., Lee, D., Kim, S., & Kim, H. (2007). Neuroprotective effect of tyrosol on transient focal cerebral ischemia in rats. Neuroscience letters, 414, 218-21. 10.1016/j.neulet.2006.08.094

Cano-Carrillo, P., Pons-Fuster, A., & López-Jornet, P. (2014). Efficacy of lycopene-enriched virgin olive oil for treating burning mouth syndrome: a double-blind randomised. Journal of oral rehabilitation, 41(4), 296–305. doi: 10.1111/joor.12147

Carranza Jr., F. A., Newman, M. G., & Takei, H. H. (2016). Periodontia clínica. Rio de Janeiro, Brasil: Guanabara Koogan.

Carvalho, M. B., Lenzi, J., Lehn, C. N., Fava, A. S., Amar, A., Kanda, J. L., ... & Raport, A. (2001). Características clínico-epidemológicas do carcinoma epidermóide de cavidade oral no sexo feminino. Rev. Assoc. Med. Bras., 47(3), 208-214. doi: 10.1590/S0104-42302001000300032

D'Archivio, M., Files,i C., Di Benedetto, R., Gargiulo, R., Giovannini, C., & Masella, R. (2007). Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanita, 43(4), 348-361.

Escudero, C., Virga, C., Aguzzi, A., Hubert, S., & De Leonardi, G. (2016). Estudio Radiográfico de la Asociación de Antioxidantes y Bifosfonatos en Remodelación Ósea Peri-Implantar. Int. J. Odontostomat., 10(3), 531-537.

Brunton, L. L., et al. (2012). Goodman & Gilman: As Bases Farmacológicas da Terapêutica. Rio de Janeiro, Brasil: McGraw-Hill.

Lee, H., Im, S. W., Jung, C. H., Jang, Y. J., Ha, T. Y., & Ahn, J. (2016). Tyrosol, an olive oil polyphenol, inhibits ER stress-induced apoptosis in pancreatic β-cell through JNK signaling. Biochemical and biophysical research communications, 469(3), 748–752. doi: 10.1016/j.bbrc.2015.12.036

Lopes, H. P., & Siqueira Jr., J. F. (2015). Endodontia Biologia e Técnica. Rio de Janeiro, Brasil: Guanabara Koogan.

Marković, K. A., Torić, J., Barbarić, M., & Brala, J. C. (2019). Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health. Molecules, 24(10), 2001. doi: 10.3390/molecules24102001

Mazzotti, F., Benabdelkamel, H., Di Donna, L., Maiuolo, L., Napoli, A., & Sindona, G. (2012). Assay of tyrosol and hydroxytyrosol in olive oil by tandem mass spectrometry and isotope dilution method. Food chemistry, 135(3), 1006–1010. doi: 10.1016/j.foodchem.2012.05.005

Ramalho, M. A. S., Santos, B., Ramalho, D. F., Cunha, S. M. D., Anjos, R. M, Oliveira, H. M. B. F., & & Oliveira Filho, A. A. (2020). Antiadherent activity of essencial oils of Eucalyptus globulus and Eucalyptus citriodora against Klebsiella pneumoniae strains. Res., Soc. Dev., 9(7), 1-15. doi: 10.33448/rsd-v9i7.4245

Rôças, I. N., & Siqueira, J. F., Jr (2011). Comparison of the in vivo antimicrobial effectiveness of sodium hypochlorite and chlorhexidine used as root canal irrigants: a molecular microbiology study. Journal of endodontics, 37(2), 143–150. doi: 10.1016/j.joen.2010.11.006

Rocas, I., Siqueira Jr, J., & Santos, K. (2004). Association of Enterococcus faecalis With Different Forms of Periradicular Diseases. Journal of Endodontics, 30(5), 315–320. doi:10.1097/00004770-200405000-00004

Rodrigues, C. F., & Černáková, L. (2020). Farnesol and Tyrosol: Secondary Metabolites with a Crucial quorum-sensing Role in Candida Biofilm Development. Genes, 11(4), 444. doi: 10.3390/genes11040444

Sebaa, S., Boucherit-Otmani, Z., & Courtois, P. (2019). Effects of tyrosol and farnesol on Candida albicans biofilm. Molecular medicine reports, 19(4), 3201–3209. doi: 10.3892/mmr.2019.9981

Silva, S. A. M., Michniak-Kohn, B., & Leonardi, G. R. (2017). An overview about oxidation in clinical practice of skin aging. An. Bras. Dermatol, 92(3), 367-374. doi: 10.1590/abd1806-4841.20175481

Simões, A. C. M. (2016). Da planta ao medicamento. Rio de Janeiro, Brasil: Guanabara Koogan.

Souza, J. A. S., Barbosa, D. B., Amaral, J. G., Monteiro, D., Gorup, L., Neto, F., & Delbem, A. (2019). Antimicrobial Activity of Compounds Containing Silver Nanoparticles and Calcium Glycerophosphate in Combination with Tyrosol. Indian Journal of Microbiology, 59. doi: 10.1007/s12088-019-00797-y

Salucci, S., Burattini, S., Battistelli, M., Buontempo, F., Canonico, B., Martelli, A. M., & Falcieri, E. (2015). Tyrosol prevents apoptosis in irradiated keratinocytes. Journal of dermatological science, 80(1), 61–68. doi: 10.1016/j.jdermsci.2015.07.002

Sun, Y., Zhou, D., & Shahidi, F. (2017). Antioxidant properties of tyrosol and hydroxytyrosol saturated fatty acid esters. Food Chemistry, 245. doi: 10.1016/j.foodchem.2017.11.051

Tedesco, A. (2019). Harmonização Facial: A nova face da Odontologia. São Paulo, Brasil: Napoleão-Quintessence.

Tsikopoulos, K., Bidossi, A., Drago, L., Petrenyov, D. R., Givissis, P., Mavridis, D., & Papaioannidou, P. (2019). Is Implant Coating With Tyrosol- and Antibiotic-loaded Hydrogel Effective in Reducing Cutibacterium (Propionibacterium) acnes Biofilm Formation? A Preliminary In Vitro Study. Clinical orthopaedics and related research, 477(7), 1736–1746. doi: 10.1097/CORR.0000000000000663

Vale, L., Delbem, A., Arias, L., Fernandes Scappaticci, R., Vieira, A., Barros Barbosa, D., & Monteiro, D. (2017). Differential effects of the combination of tyrosol with chlorhexidine gluconate on oral biofilms. Oral diseases, 23. doi: 10.1111/odi.12648

Published

31/07/2020

How to Cite

RAMOS, A. C.; NEGREIROS, J. H. C. N.; LIMA, A. K. M. de; CORDEIRO, M. de A.; GODOY, G. P. The therapeutic applicability of tyrosol and hydroxytyrosol for Dentistry. Research, Society and Development, [S. l.], v. 9, n. 8, p. e830986420, 2020. DOI: 10.33448/rsd-v9i8.6420. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/6420. Acesso em: 19 apr. 2024.

Issue

Section

Health Sciences