Human saliva as biofluid in the diagnosis of COVID-19

Authors

DOI:

https://doi.org/10.33448/rsd-v9i8.6534

Keywords:

COVID-19; Dentistry; Coronavirus infections; Saliva.

Abstract

The fast and accurate detection of patients infected with COVID-19 is extremely important to obtain control in the population and in hospitals. To review recent literature, presenting human saliva as a biofluid for the detection and diagnosis of COVID-19. A bibliographic search was performed in the PubMed (National Library of Medicine) and Scopus Preview databases through CAPES, with the keywords COVID-19 and dentistry, COVID-19 and saliva, from January 2020 to 11 June 2020. Saliva has been widely used to diagnose various diseases, due to its easy access. Thus, saliva has been presented as one of the viable alternatives for the detection of the new coronavirus, since oral spillage is more significant than viremia. The SARS-CoV-2 virus can be found in human saliva, as well as in the salivary gland, presenting itself as a biofluid to test and diagnose COVID-19 disease.

References

Alizargar, J., S., M. E., Aghamohammadi, M., & Hatefi, S. (2020). Saliva Samples as na Alternative for Novel Coronavirus (COVID-19) Diagnosis. Journal of the Formosan Medical Association. https://doi.org/10.1016/j.jfma.2020.04.030.

Alves, U. E., Neto, Pires, A. C. (2020). Drogas e Medicamentos Investigados para o Tratamento do COVID-19. J. Health Biol Sci. 8(1), 1-7. doi: 10.12662/2317-3206jhbs.v8i1.3284.p1-7.2020.

Azzi, L., Carcano, G., Gianfagna, F., Grossi, P., Gasperina, D. D., Genoni, A., & Fasano, M., et al. (2020). Saliva is a Reliable Tool to Detect SARS-CoV-2. Journal of Infection. 45:50 https://doi.org/10.1016/j.jinf.2020.04.005.

Baghizadeh, F. M. (2020). Oral saliva and COVID-19 [published online ahead of print, 2020 May 27]. Oral Oncol. doi:10.1016/j.oraloncology.2020.104821.

Baghizadeh, F. M. (2020). What dentists need to know about COVID-19. Oral Oncol. 105:104741. doi:10.1016/j.oraloncology.2020.104741.

Eloise, W., Katherine, B., Bowen, Z., Mark, P., & Deborah, A. W. (2020). Saliva as a non-invasive specimen for detection of SARS-CoV-2. Journal of Clinical Microbiology. doi: 10.1128/JCM.00776-20.

Fan, E., Del Sorbo, L., Goligher, E. C. (2017). An official American Thoracic Society/ European Society of Intensive Care Medicine/Society of Critical Care Medicine clinical practice guideline: mechanical ventilation in adult patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 195(9), 1253-1263. doi:10.1164/rccm.201703-0548ST.

Hamid, H., Khurshid, Z., Adanir, N., Zafar, M. S., & Zohaib, S. (2020). COVID-19 Pandemic and Role of Human Saliva as a Testing Biofluid in Point-of-Care Technology [publicado on-line antes da impressão, 2020 Jun 3]. Eur J Dent. doi:10.1055/s-0040-1713020.

Han, P., & Ivanovski, S. (2020). Saliva-Friend and Foe in the COVID-19 Outbreak. Diagnostics (Basel). 10(5). doi:10.3390/diagnostics10050290.

Hurshid, Z., Asiri, F. Y. I., & Al Wadaani, H. (2020). Human Saliva: Non-Invasive Fluid for Detecting Novel Coronavirus (2019-nCoV). Int J Environ Res Public Health. 17(7), 2225. doi:10.3390/ijerph17072225.

Kim, K. H. (2020). COVID-19. Int Neurourol J. 24(1):1. doi:10.5213/inj.2020edi.001.

Nicholson, P. J. (2020). COVID-19: opportunity to learn from necessity. Occup Med (Lond). doi:10.1093/occmed/kqaa054.

Odeh, N. D., Babkair, H., Abu-Hammad, S., Borzangy, S., Abu-Hammad, A., & Abu-Hammad, O. (2020). COVID-19: Present and Future Challenges for Dental Practice. Int J Environ Res Public Health. 17(9), 3151. doi:10.3390/ijerph17093151.

Sabino-Silva, R., Jardim, A. C. G., & Siqueira, W. L. (2020). Coronavirus COVID-19 impacts to dentistry and potential salivary diagnosis. Clin Oral Investig. 24(4), 1619‐1621. doi:10.1007/s00784-020-03248-x.

Sapkota, D., Thapa, S., Hasséus, B., et al. (2020). Teste de saliva para COVID-19 ?. Br Dent J. 228, 658-659. https://doi.org/10.1038/s41415-020-1594-7.

Silva, P. H. B., Pallos, D., Giannecchini, S., & To, K. K. (2020). SARS- CoV-2: What can Saliva Tell US?. Oral Diseases. https://doi.org/10.1111/odi.13365.

Vinayachandran, D., & Balasubramanian, S. (2020). Salivary Diagnostics in COVID-19: Future Research Implications. Journal of Dental Sciences. https://doi.org/10.1016/j.jds.2020.04.006.

Wang, D., Hu, B., & Hu, C. (2020). Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 323(11): 1061-1069.

Xu, R., Cui, B., Duan, X., et al. (2020). Saliva: potential diagnostic value and transmission of 2019-nCoV. Int J Oral. https://doi-org.ez15.periodicos.capes.gov.br/10.1038/s41368-020-0080-z.

Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., et al. (2020). Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a singlecentered, retrospective, observational study. Lancet Respir Med. 8(5), 475-481.

Zhai, P., Ding, Y., Wu, X., Long, J., Zhong, Y., & Li, Y. (2020). The epidemiology, diagnosis and treatment of COVID-19. Int J Antimicrob Agents. 55(5), 105955. doi:10.1016/j.ijantimicag.2020.105955.

Downloads

Published

20/07/2020

How to Cite

FERREIRA FILHO, M. N.; LOPES, I. D. S.; SOUZA, Êmily N. de; PIRES, A. C. Human saliva as biofluid in the diagnosis of COVID-19. Research, Society and Development, [S. l.], v. 9, n. 8, p. e811986534, 2020. DOI: 10.33448/rsd-v9i8.6534. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/6534. Acesso em: 19 apr. 2024.

Issue

Vol. 9 No. 8

Section

Education Sciences

License

Copyright (c) 2020 Mauricy Nascimento Ferreira Filho, Ismael Da Silva Lopes, Êmily Nascimento de Souza, Andressa Cavalcanti Pires

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.