Use of metformin hydrochloride in gestational diabetes: a systematic review
DOI:
https://doi.org/10.33448/rsd-v9i9.6988Keywords:
Gestational Diabetes; Metformin; Pregnant women; Systematic review.Abstract
Gestational Diabetes Mellitus is a condition characterized by an increase in blood glucose levels, which can be initiated or diagnosed during pregnancy. This process occurs due to the production of high levels of hormones by the placenta, most of which are harmful to the action of insulin in the cells increasing the blood sugar level and can affect the growth and well-being of the fetus. Among the drugs used, Metformin Hydrochloride is an oral hypoglycemic drug used to treat Diabetes Mellitus. The present study aimed to elaborate a systematic review on the use of metformin hydrochloride in the treatment of gestational diabetes mellitus. The searches were carried out in the SciElo and Google Acadêmico databases. 763 articles were found in the initial research and after the analysis of the pre-analytical phases, only 6 were selected, since they met the inclusion criteria. After extracting the data, a relationship was made between the use of metformin with the various forms of therapy used in the studies and it was shown that metformin is a drug well applied as monotherapy, being used by 40 % of individuals in one of the studies analyzed and it is also well accepted in combination therapy with insulin in patients who have resistance to it, due to metformin being a drug with easy access and easy dosage. It is concluded that metformin is a safe, effective, low-cost and widely accepted drug for pregnant women who use it in the treatment of gestational Diabetes Mellitus.
References
Amaral, R. A., et al. (2015). Impacto do diabetes gestacional nos desfechos neonatais: uma coorte retrospectiva. Revista Scientia Medica, 25 (1), 1-6.
Forti, A. C., Pires, A. C., & Pittito, B. A. (2019). Diretrizes da Sociedade Brasileira de Diabetes: 2019-2020/ Sociedade Brasileira de Diabetes. São Paulo: Ed Clannada.
Linares-Espinóse, E., et al. (2018). Methodology of a systematic review. Actas Urológicas Españolas (English Edition), 42 (8), 499-506.
Lucena, J. B. S. (2007). Diabetes mellitus tipo 1 e tipo 2. 74 f. TCC (Graduação) - Curso de Farmácia, Centro Universitário das Faculdades Metropolitanas Unidas, São Paulo.
Oliveira, E. C., Melo, S. M. B., & Pereira, S. E. (2016). Diabetes mellitus gestacional: uma revisão da literatura gestational diabetes mellitus: a literature review. Revista Científica FacMais, 5 (1), 129-140.
Oliveira, L. C., et al. (2019). Auditoria de um serviço de tendimento de gestantes portadoras de diabetes mellitus gestacional. Revista Saúde e Pesquisa, 12 (3), 513-520.
Peixoto, C. I. L. S., & Ramalho, C. (2016). The use of metformin during pregnancy. Acta Obstétrica e Ginecológica Portuguesa, 10 (1), 43-49.
Pereira, A. S., et al. (2018). Methodology of cientific research. [e-Book]. Santa Maria City. UAB / NTE / UFSM Editors. Recuperado de https://repositorio.ufsm.br/bitstream/ handle/1/15824/Lic_ Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1.
Pontes, T. C., et al. (2010). Hipoglicemiantes orais no tratamento de diabetes gestacional: analise metodológica da literatura. Revista Brasileira de Ciências da Saúde, 14 (3), 25-32.
Rodrigues, I. M., et al. (2019). Impacto da etnia/raça na diabetes gestacional. Acta Obstétrica e Ginecológica Portuguesa, 13 (2), 72-80.
Silva, A. L., et al. (2016). Neonatal outcomes according to different therapies for gestational diabetes mellitus. Jornal de Pediatria, 93 (1), 87-93.
Silva, J. C., Souza, B. V., & Silva, M. R. (2013). Preditores de Sucesso da Metformina no Tratamento do Diabetes Mellitus Gestacional. Revista Brasileira Saúde Materno Infantil, 13 (2), 129-135.
Silva, R. R., et al. (2019). Desfechos materno-fetais de gestantes com e sem diabetes mellitus gestacional. Arquivos Catarinense de Medicina, 48 (3), 79-92.
Silveira-Filho, L. C., et al. (2018). Impacto do trimestre de diagnóstico no diabetes mellitus gestacional, no tratamento utilizado e na classificação de peso do recém-nascido. Arquivos Catarinense de Medicina, 47 (2), 137-146.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Ellys Cristina Eleonor Pereira Torres, Jéssica Costa de Oliveira, Luanne Eugênia Nunes, Rosueti Diógenes de Oliveira Filho
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
