Factors related to the occurrence of acute renal insufficiency in the intensive care unit: an integrative review





Acute kidney injury; Renal insufficiency; Critical care.


This study aimed to describe the clinical conditions, diagnostic and therapeutic interventions related to the occurrence of acute renal insufficiency in the intensive care unit. This is an integrative literature review study on articles published in the PubMed and LILACS databases. As for the results, 22 articles were selected and from them the ARI in the ICU was related to: sepsis, electrolyte disturbances, prematurity, obstetric complications and ARDS (clinical conditions); use of contrast to perform exams (diagnostic intervention) and nephrotoxic drugs, invasive mechanical ventilation, fluid overload (after surgery with the use of cardiopulmonary bypass (CPB) and surgical patient after pediatric surgery for myocardial revascularization and use of CPB (therapeutic interventions). Acute renal insufficiency in the ICU is related to the patient's profile and the interventions inherent to this sector. The physiological mechanisms involved in this complication can be triggered by the interventions that are necessary with the critical patient. This requires the adoption of protective conduct for renal function and the adoption of parameters for its monitoring.

Author Biography

Sarah Glícia Medeiros Dantas, Universidade do Estado do Rio Grande do Norte

Departamento de Enfermagem

Estudante de Graduação



Ávila, M. O .N., Rocha, P. N., Zanetta, D. M. T., Yu, L. & Burdmann, E. A. (2014). Balanço hídrico, injúria renal aguda e mortalidade de pacientes em unidade de terapia intensiva. Jornal Brasileiro de Nefrologia, 36 (3), 379-388.

Awdishu, L. (2017). Drug-induced kidney disease in the ICU: mechanisms, susceptibility, diagnosis and management strategies. Current Opinion in Critical Care, 23(6), 484-490.

Benichel, C. R., & Meneguin, S. (2020). Fatores de risco para lesão renal aguda em pacientes clínicos intensivos. Acta Paulista de Enfermagem, 33, e-APE20190064.

dos Santos, L.L. & Magro, M.S.C. (2015). Ventilação mecânica e a lesão renal aguda em pacientes na unidade de terapia intensiva. Acta Paulista de Enfermagem, 28(2), 146-151.

Ganong LH. (1987). Integrative reviews of nursing research. Research in Nursing & Health, 10(1), 1-11.

Gopal, G. (2014). Acute kidney injury (AKI) in perinatal asphyxia. Indian Journal of Pharmaceutical and Biological Research, 2(2), 60-65.

Guerci, P., Ergin, B. & Ince, C. (2017). The macro-and microcirculation of the kidney. Best Practice & Research Clinical Anaesthesiology, 31, 315-329.

Guyton, A. C. & Hall, J.E. (2017). Guyton e Hall tratado de fisiologia médica (13a ed.). São Paulo: Elsevier Brasil.

Koralkar, R., Ambalavanan, N., Levitan, E., McGwin, G., Goldstein, S. & Askenaz, D. (2011) Acute kidney injury reduces survival in very low birth weight infants. Pediatric Research, 69,


Kuiper, J. W., Vaschetto, R., Corte, F. D., Plötz, F. B. & Groeneveld, A. B. J. (2011) Bench-to-bedside review: Ventilation-induced renal injury through systemic mediator release-just theory or a causal relationship? Critical Care, 15(4), 228.

Mendes, K. D. S., Silveira, P. & Galvão, C. M. (2008). Revisão Integrativa: Método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto - Enfermagem, 17, (4), 758-764.

Moore, P. K., Hsu, R. K. & Liu, K. D. (2018). Management of Acute Kidney Injury: Core Curriculum 2018. American Journal of Kidney Diseases, 72, 136 - 148.

Neyra, J. A., Canepa-Escaro, F., Li, X., Manllo, J., Adams-Huet, B., Yee, J. & Yessayan, L. (2015). Association of hyperchloremia with hospital mortality in critically ill septic patients. Critical Care Medicine, 43 (9), 1938-1944.

Pedreira, A. B., Caliman, A. O., Ribeiro, B. D. C., Fernandes, C. A. B., Diniz, M. P. & Pinel, R. L. T. ( 2017). Prevenção da nefrotoxicidade induzida por contraste - revisão da literatura. Revista Esfera Acadêmica Saúde, 2 (2), 55-68.

Peres, L. A. B., Wandeur, V. & Matsuo, T. (2015). Preditores de injúria renal aguda e de mortalidade em uma unidade de terapia intensiva. Jornal Brasileiro de Nefrologia, 37, 38-46.

Prakash, J. (2012). The kidney in pregnancy: A journey of three decades. Indian Journal of Pharmaceutical and Biological Research, 22 (3), 159–167.

Rezende, J. M. & Barbosa, C. A. (2017). Rezende obstetrícia fundamental (14a ed). São Paulo: Guanabara Koogan.

Salis, S., Mazzanti, V. V., Merli, G., Salvi, L., Tedesco, C. C., Veglia, F. & Sisillo, E. (2008). Cardiopulmonary bypass duration is an independent predictor of morbidity and mortality after cardiac surgery. Journal of Cardiothoracic and Vascular Anesthesia, 22(6), 814-822.

Scharnweber, T., Alhilali, L. & Fakhran, S. (2017). Contrast-induced acute kidney injury: Pathophysiology, manifestations, prevention, and management. Magnetic Resonance Imaging Clinics of North America, 25(4), 743-753.

Selewski, D. T., Charlton, J. R., Jetton, J. G., Guillet, R., Mhanna, M. J., Askenazi, D. J. & Kent, A. L. (2015). Neonatal acute kidney injury. Pediatrics, 136 (2), 463-473.

Sharkey, R. A., Mulloy, E. M., Long, M. & O'Neill, S. J. (1999). The effect of continuous positive airway pressure (CPAP) on renal vascular resistance: the influence of renal denervation. Critical Care, 3 (1), 33-37.

Slater, M. B., Gruneir, A., Rochon, P. A., Howard, A. W., Koren, G. & Parshuaram, C.S. (2016). Identifying high-risk medications associated with acute kidney injury in critically ill patients: a pharmacoepidemiologic evaluation. Pediatric Drugs, 19, 59-67.

Thongprayoon, C., Cheungpasitporn, W., Srivali, N., Ungprasert, P., Kittanamongkolchai, W. & Kashani, K. (2016). The impact of fluid balance on diagnosis, staging and prediction of mortality in critically ill patients with acute kidney injury. Journal of Nephrology, 29, 221–227.

Toto R. (2001). Angiotensin II subtype 1 receptor blockers and renal function. Arch Intern Med, 161(12), 1492-1499.

Xu, J., Bo, S., Fang, Y., Liu, Z., Zou, J., Liu, L., . . . Teng, J. (2015) Postoperative fluid overload is a useful predictor of the short-term outcome of renal replacement therapy for acute kidney injury after cardiac surgery. Medicine (Baltimore), 94 (33), 1-5.



How to Cite

DANTAS, S. G. M.; VIEIRA, A. N. .; FERNANDES, N. T.; PAULA, E. G. de; SOMBRA, M. P. P.; CARVALHO, A. C. B. de; MAXIMIANO, L. C. de S.; DANTAS, L. A. L. Factors related to the occurrence of acute renal insufficiency in the intensive care unit: an integrative review. Research, Society and Development, [S. l.], v. 9, n. 10, p. e1089108330, 2020. DOI: 10.33448/rsd-v9i10.8330. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/8330. Acesso em: 8 jun. 2023.



Health Sciences