Use of Bauhinia forficata Link infusion in the treatment of diabetes mellitus

Authors

DOI:

https://doi.org/10.33448/rsd-v9i10.8574

Keywords:

Chronic disease; Hypoglycemic; Medicinal plants.

Abstract

Diabetes mellitus is a chronic disease that affects millions of people around the world. One of the medicinal plants used by the Brazilian population in the treatment of diabetes mellitus is Bauhinia forficata Link. The objective of this work was to conduct a review of clinical case studies in order to analyze the hypoglycemic effect of B. forficata infusion in diabetic and pre-diabetic individuals. A direct search for articles of clinical cases was carried out in the databases LILACS, PubMed, SciELO, and Scopus. Were searched works in Spanish, English and Portuguese, published in the last 10 years and that only used the infusion of leaves of the plant species in the treatment of mens and womens, over the age of 18, with pre-diabetes or diabetes mellitus. Were used the keywords "Bauhinia forficata" and "diabetes", and the boolean operator “AND”. Five studies were found, of which three of them presented positive results in relation to the use of B. forficata infusion as an effective hypoglycemic agent in diabetic and pre-diabetic individuals, while two studies did not present positive results. It was concluded that the infusion of B. forficata is able to assist in the treatment of diabetes mellitus, despite the need for more scientific evidence on the subject.

Author Biographies

Daniela da Costa de Oliveira, Universidade Federal de Lavras

Nutritionist graduated from the Universidade Federal de Lavras.

Samuel Vitor Assis Machado de Lima, Universidade Federal de Alfenas

Biologist graduated from the Universidade Federal de Lavras, master's student in the graduate program in Environmental Sciences at the Universidade Federal de Alfenas.

João Paulo Lima de Oliveira, Universidade Federal de Lavras

Nutritionist graduated from the Universidade Federal de Lavras, Master in Nutrition and Health from the same institution, PhD student in the postgraduate program in Medicinal, Aromatic and Spice Plants also from the Universidade Federal de Lavras.

References

American Diabetes Association. (2020). Introduction: Standards of medical care in diabetes - 2020. Diabetes care, 43(1), S1 – S2.

Brasil. Portaria interministerial nº 2.960, de 09 de dezembro de 2008. (2008). Aprova o Programa Nacional de Plantas Medicinais e Fitoterápicos e cria o Comitê Nacional de Plantas Medicinais e Fitoterápicos. Brasília – DF. Retrieved September 16, 2020, from https://bvsms.saude.gov.br/bvs/saudelegis/gm/2008/pri2960_09_12_2008.html

Chiang, J. L., Kirkman, M. S., Laffel, L. B. M., & Peters, A. L. (2014). Type 1 diabetes through the life span: a position statement of the American Diabetes Association. Diabetes care, 37(7), 2034 – 2054.

Cunha, A. M. da., Menon, S., Menon, R., Couto, A. G., Bürger, C., & Biavatti, M. W. (2010). Hypoglycemic activity of dried extracts of Bauhinia forficata (Link). Phytomedicine, 17(1), 37 – 41.

Curcio, S. A. F., Stefan, L. F. B., Randi, B. A., Dias, M. A., Silva, R. E., & Caldeira, E. J. (2012). Hypoglycemic effects of an aqueous extract of Bauhinia forficata on the salivary glands of diabetic mice. Pakistan Journal of Pharmaceutical Sciences, 25(3), 493 – 499.

De-Fronzo, R. A. (2009). From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes, 58(4), 773 – 795.

Fabro, M., Ramos, F. A., Israel, A. P., & Souza, P. A. (2020). Identificação das plantas medicinais utilizadas pelos moradores da região da AMURES (Associação dos Municípios da Região Serrana). Research, Society and Development, 9(7), 1 – 10.

Fontana-Pereira, D., Cazarolli, L. H., Lavado, C., Mengatto, V., Figueiredo, M. S. R. B., Guedes, A., Pizzolatti, M. G, & Silva, F. R. M. B. (2011). Effects of flavonoids on α-glucosidase activity: Potential targets for glucose homeostasis. Nutrition, 27(11-12): 1161 – 1167.

Franco, M. J., Caetano, I. C. S., Caetano, J., & Dragunski, D. C. (2011). Determinação de metais em plantas medicinais comercializadas na região de Umuarama-PR. Arquivos de Ciência da Saúde da UNIPAR, 15(2), 121-127.

Heller, M., Bosco, S. M. D., Rempel, C., & Moreira, T. R. (2013). Variações metabólicas em indivíduos em utilização de Bauhinia forficata. ConScientiae saúde, 12(3), 419 -425.

Hu, J., Yu, X., Wang, Z., Wang, F., Wang, L., Gao, H., Chen, Y., Zhao, W., Jia, Z., Yan, S., & Wang, Y. (2013). Long term effects of the implantation of Wharton's jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus. Endocrine Journal, 60(3), 347 – 357.

Insel, R. A., Dunne, J. L., Atkinson, M. A., Chiang, J. L., Dabelea, D., Gottlieb, P. A., Greenbaum, C. J., Herold, K. C., Krischer, J. P., Lernmark, A., Ratner, R. E., Rewers, M. J., Schatz, D. A., Skyler, J. S., Sosenko, J. M., & Ziegler, A. G. (2015). Staging pre symptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes care, 38(10), 1964 – 1974.

International Diabetes Federation. (2019). IDF Diabetes Atlas. Retrived August 09, 2020, from https://www.diabetesatlas.org/upload/resources/2019/IDF_Atlas_9th_Edition_2019.pdf.

Kappel, V. D., Cazarolli, L. H., Pereira, D. F., Postal, B. G., Zamoner, A., Reginatto, F. H., & Silva, F. R. M. B. (2013). Involvement of GLUT-4 in the stimulatory effect of rutin on glucose uptake in rat soleus muscle. Journal of Pharmacy Pharmacology, 65(8), 1179 – 1186.

Mariángel, P. C., Lorca, M. A., Leon, F. M., Rocca, P. F., Zapata, L. V., & Navarrete, E. P. (2019). Effects of Bauhinia forficata (Link) tea on lipid profile in diabetic patients. Journal of Medicinal Food, 22(3) 321 – 323.

Marques, G. S., Rolim, L. A., Alves, L. D. S., Silva, C. C. A. R., Soares, L. A. L., & Rolim-Neto, P. J. (2013). Estado da arte de Bauhinia forficata Link (Fabaceae) como alternativa terapêutica para o tratamento do Diabetes mellitus. Revista de Ciências Farmaceuticas Básica e Aplicada, 34(3), 313 – 320.

Ministério da Saúde / Secretaria de Vigilância em Saúde. (2020, April). Vigitel Brasil 2019: principais resultados. Boletim Epidemiológico, 51(16), p. 21.

Ministério da Saúde. (2009). RENISUS – Relação Nacional de Plantas Medicinais de Interesse ao SUS. Retrieved April 21, 2020, from http://portal.saude.gov.br/portal/arquivos/ pdf/RENISUS.pdf.

Miyake, E. T., Akisue, G., & Akisue, M. K. (1986). Pharmacognostic characterization of Bauhinia forficata (Link). Revista Brasileira de Farmacognosia, 1(1), 58 – 68.

Moraes, E. A. de., Rempel, C., Périco, E., & Strohschoen, A. A. G. (2010). Avaliação do perfil glicêmico de portadores de Diabetes Mellitus tipo II em UBSs que utilizam infusão de folhas de Bauhinia forficata. ConScientiae Saúde, 9(4), 569 – 574.

Moraes, J. S., Santos, D. L., Fecury, A. A., Dendasck, C. V., Dias, C. A. G. de M., Pinheiro, M. da C. N., Souza, K. O. da, Silva, I. R. da, & Oliveira, E. de. (2020). O uso da planta Cissus verticillata (Insulina) no tratamento do Diabetes mellitus, em uma comunidade costeira do Pará, Amazônia, Brasil. Research, Society and Development, 9(7), 1 – 23.

Odeyemi, S., & Bradley, G. (2018). Medicinal plants used for the traditional management of diabetes in the Eastern Cape, South Africa: pharmacology and toxicology. Molecules 23(11), 1 – 19.

Pashikanti, S., Alba, D. R., Boissonneault, G. A., & Laurean, D. C. (2010). Rutin metabolites: Novel inhibitors of nonoxidative advanced glycation end products. Free radical biology & medicine, 48(5), 656 – 663.

Pozzobon, A., Hoerlle, J., Carreno, I., Strohschoen, A. G., Bosco, S. M. D, & Rempel, C. (2014). Verificação do efeito hipoglicemiante da planta medicinal Bauhinia forficata em indivíduos com diabetes mellitus tipo 2. ConScientiae Saúde, 13(1), 69 – 75.

Rosa, R., Nita, A. E., Rached, R., Donato, B., & Rahal, E. (2014). Estimated hospitalizations attributable to diabetes mellitus within the public healthcare system in Brazil from 2008 to 2010: study DIAPS 79. Revista da Associação Médica Brasileira, 60(3), 222 – 230.

Santos, M. M., Nunes, M. G. S., Martins, R. D. (2012). Uso empírico de plantas medicinais para tratamento de diabetes. Revista Brasileira de Plantas Medicinais, 14(2), 327 – 334.

Shane-McWhorter, L. (2001). Biological complementary therapies: a focus on botanical products in diabetes. Diabetes spectrum 14(4): 199 – 208.

Sharma, S., Ali, A., Ali, J., Sahni, J. K., & Baboota, S. (2013). Rutin: Therapeutic potential and recent advances in drug delivery. Expert Opinion on Investigational Drugs, 22(8), 1063 – 1079.

Sixel, P. J., & Pecinalli, N. R. (2005). Características farmacológicas gerais das plantas medicinais. Infarma - Ciências Farmacêuticas 16(13-14), 74 – 77.

Skyler, J. S., Bakris, G. L., Bonifacio, E., Darsow, T., Eckel, R. H., Groop, L., Groop P. H., Handelsman, Y., Insel, R. A., Mathieu, C., McElvaine, A. T., Palmer, J. P., Pugliese, A., Schatz, D. A., Sosenko, J. M., Wilding, J. P. H., & Ratner, R. E. (2017). Differentiation of diabetes by pathophysiology, natural history, and prognosis. Diabetes, 66(2), 241 – 255.

Sociedade Brasileira de Diabetes. (2019). Diretrizes sociedade brasileira de diabetes 2019-2020. São Paulo: Clannad Editora Científica.

Toloza-Zambrano, P., Avello, M., & Fernández, P. (2015). Determinación de rutina y trigonelina en extractos de hojas de Bauhinia forficata subsp. pruinosa y evaluación del efecto hipoglicemiante en humanos. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 14(1), 21 – 32.

Trojan-Rodrigues, M., Alves, T. L. S., Soares, G. L. G., & Ritter, M. R. (2012). Plants used as antidiabetics in popular medicine in Rio Grande do Sul, southern Brazil. Journal of Ethnopharmacology, 139(1), 155 – 163.

World Health Organization. (2013). WHO traditional medicine strategy: 2014-2023. Geneva: Author.

Zaccaron, C., Rempel, C., Strohschoen, A. A. G., Bosco, S. M. D., & Moreschi, C. (2014). Efeito da planta medicinal Bauhinia forficata (Link) nos indivíduos diabéticos tipo 2. ConScientiae Saúde, 13(2), 171-178.

Zhou, J. Y., & Zhou, S. W. (2012). Protection of trigonelline on experimental diabetic peripheral neuropathy. Evidence-Based Complementary and Alternative Medicine, 2012, pp.8.

Downloads

Published

27/09/2020

How to Cite

OLIVEIRA, D. da C. de .; LIMA, S. V. A. M. de .; OLIVEIRA, J. P. L. de. Use of Bauhinia forficata Link infusion in the treatment of diabetes mellitus . Research, Society and Development, [S. l.], v. 9, n. 10, p. e3159108574, 2020. DOI: 10.33448/rsd-v9i10.8574. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/8574. Acesso em: 24 apr. 2024.

Issue

Section

Review Article