Effect of exogenous melatonin on the digestive tract of offspring of mice submitted to early weaning: a systematic review





Early Weaning; Stress; Early weaning; Digestive system.


The present study is a systematic review with the objective of characterizing the main findings in the literature, which report the action of exogenous melatonin in the digestive system of mice that suffered early weaning. The bibliographic research was carried out in PubMed, VHL and SCIELO using the following key words: melatonin, stress and digestive tract. A total of 118 articles were found in the 3 databases analyzed. However, after applying the inclusion/exclusion criteria, only 1 article left. The paper found addresses the action of melatonin in the small intestine of mice that were weaned early. Collectively, melatonin supplementation improves body weight gain and intestinal morphology, while exerting little effect on cell proliferation and apoptosis, as well as on goblet cells and Paneth cells in the ileum of weaning mice.

Author Biographies

Marcos Aurélio Santos da Costa, UFPE

Programa de Pós-Graduação em Morfotecnologia

Luiz Henrique da Silva Linhares, Universidade Federal de Pernambuco

Programa de Pós-graduação em Morfotecnologia

Thiago Oliveira Nascimento, Universidade Federal de Pernambuco

Programa de Pós-graduação em Morfotecnologia,

Juliana Pinto de Medeiros, Universidade Federal de Pernambuco

Programa de Pós-graduação em Morfotecnologia

Fernanda Chagas Angelo Mendes Tenorio, Universidade Federal de Pernambuco

Programa de Pós-graduação em Morfotecnologia

Sônia Pereira Leite, Universidade Federal de Pernambuco

Programa de Pós-graduação em Morfotecnologia


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How to Cite

COSTA, M. A. S. da; REGES DOS SANTOS SILVA, R. . . . . . . . . . . . . . . . . . .; SILVA, M. E. da; LINHARES, L. H. da S. .; NASCIMENTO, T. O. .; OLIVEIRA, M. L. F. de .; GOMES, J. A. da S. .; SILVA, T. M. S. da .; SOBREIRA, R. C. B. .; MEDEIROS, J. P. de; TENORIO, F. C. A. M. .; LEITE, S. P. Effect of exogenous melatonin on the digestive tract of offspring of mice submitted to early weaning: a systematic review. Research, Society and Development, [S. l.], v. 9, n. 10, p. e5009108869, 2020. DOI: 10.33448/rsd-v9i10.8869. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/8869. Acesso em: 25 jun. 2022.



Review Article