Relationship between painful manifestations and the use of hydroxyurea in children and adolescents with sickle cell disease
DOI:
https://doi.org/10.33448/rsd-v9i10.9046Keywords:
Pain; Sickle cell disease; Child; Adolescent.Abstract
To analyze the profile of pain, its triggering factors, and the relationship with the use of hydroxyurea in children and adolescents with sickle cell disease. This was an analytical cross-sectional study of 80 patients with sickle cell disease, both male and female, aged 6 to 18 years, seen at the Center for Hematology and Hemotherapy of Pernambuco, Brazil. To assess the pain profile, forms with the adapted visual scale from the “Fear of Dental Pain Questionnaire – Short Form” were used. Fisher's exact test was used to evaluate the association between pain manifestations and the use of hydroxyurea. Pain was reported by 68.7% of the patients and 52.7% of them reported severe pain, which eventually affected their daily routines. Physical triggers presented the highest rate (78.2%). The most frequent sites of pain were the trunk (80%) and lower extremities (54.5%), and constricting (40%) and deep (40%) pain were the most frequent types. Thirty percent of the patients reported being treated with hydroxyurea for prevention of painful events. It is concluded that the patients with sickle cell disease showed a high rate of painful events and physical factors, such as cold temperature, trauma and physical effort, were considered to be the most prevalent. There was no association between the use of hydroxyurea and pain improvement.
References
Anastasi, A. (1982). Psychological Testing. New York: MacMillan Publishing Co, 5th ed.
Araujo, E.M., Alves, R.J.C., Carvalho, E.S.S., Souza, I.M., & Xavier A.S.G. (2013). Atuação de um núcleo de pesquisa e extensão junto à população com doença falciforme na segunda maior cidade do estado da Bahia. Revista Extendere, 1(2), 49-60.
Ballas, S.K. (2007). Current issues in sickle cell pain and its management. Hematology. American Society of Hematology. Education Program, 97-105. DOI: https://doi.org/10.1182/asheducation-2007.1.97
Bandeira, F. M. G. C., Peres, J. C., Carvalho, E. J., Bezerra, I., Araujo A.S., Mello, M. R. B., & Machado, C. (2004). Hidroxiuréia em pacientes com síndromes falciformes acompanhados no Hospital Hemope, Recife, Brasil. Revista Brasileira de Hematologia e Hemoterapia, 26(3), 189-194. DOI: https://doi.org/10.1590/S1516-84842004000300008
Brasil. (2012). Doença falciforme: condutas básicas para tratamento. Brasília, DF: Ministério da Saúde.
Brunetta, D.M., Clé, D.V., Haes, T.M., Roriz-Filho, J.S., & Moriguti J.C. (2010). Manejo das complicações agudas da doença falciforme. Medicina (Ribeirão Preto), 43(3), 231-237. DOI: https://doi.org/10.11606/issn.2176-7262.v43i3p231-237
Campelo, L.M.N., Oliveira, N.F., Magalhães, J.M., Julião, A.M.S., Amorim, F.C.M., & Coelho, M.C.V.S. (2018). The pain of children with sickle cell disease: the nursing approach. Revista Brasileira de Enfermagem, 71, 1463- 1469. DOI: http://dx.doi.org/10.1590/0034-7167-2016-0648
Dias, T.L., Oliveira, C.G.T., Enumo, S.R.F., & Paula, K.M.P. (2013). A dor no cotidiano de cuidadores e crianças com anemia falciforme. Psicologia USP, 24(3), 391-411. DOI: https://doi.org/10.1590/S0103-65642013000300003
Dumaplin, C.A. (2006). Avoiding admission for afebrile pediatric sickle cell pain: pain management methods. Journal of pediatric health care: official publication of National Association of Pediatric Nurse Associates & Practitioners, 20(2), 115-125. DOI: https://doi.org/10.1016/j.pedhc.2005.12.016
Felix, A.A., Souza, H.M., & Ribeiro, S.B.F. (2010). Aspectos epidemiológicos e sociais da doença falciforme. Revista Brasileira de Hematologia e Hemoterapia. 32(3), 203- 208. DOI: http://dx.doi.org/10.1590/S1516-84842010005000072
Ferreira, A.M.B., & Colares, V. (2011). Validação da versão brasileira curta do Fear of Dental Pain Questionnaire - Short Form (S-FDPQ). Pesquisa Brasileira em Odontopediatria e Clínica Integrada. 11(2), 275-279. DOI: https://doi.org/10.4034/PBOCI.2011.112.20
Figueiredo, M.S. (2007). Agentes indutores da síntese de hemoglobina fetal. Revista Brasileira de Hematologia e Hemoterapia, 29(3), 313-315. DOI: https://doi.org/10.1590/S1516-84842007000300024
Fixler, J., & Styles L. (2002). Sickle cell disease. Pediatric Clinics of North America, 49(6), 1193- 1210. DOI: https://doi.org/10.1016/S0031-3955(02)00089-5
Freire, M.H.S., Pereira, R.A., Ramos, E.J., Matos, V.F.A., & Migoto, M.T. (2015). O impacto da anemia falciforme na vida de adolescente. Cogitare Enfermagem, 20(3), 548-555. DOI: http://dx.doi.org/10.5380/ce.v20i3.42027
Jesus, J.A. (2010). Doença falciforme no Brasil. Gazeta Médica da Bahia. 80(3), 8-9. DOI: http://dx.doi.org/10.1590/S1516-84842007000300002
Marques, L.N, Souza, A.C.A., & Pereira, A.R. (2015). O viver com a doença falciforme: percepção de adolescentes. Revista de Terapia Ocupacional da Universidade de São Paulo, 26(1), 109-117. DOI: https://doi.org/10.11606/issn.2238-6149.v26i1p109-117
McGann, P.T. (2014). Sickle cell anemia: an underappreciated and unaddressed contributor to global childhood mortality. The Journal of Pediatrics, 165(1), 18-22. DOI: https://doi.org/10.1016/j.jpeds.2014.01.070
National Institutes of Health. (2002). The management of sickle cell disease. Retrieved August 2020 from file:///C:/Users/carol/Downloads/_sites_default_files_publications_04-2117.pdf
Roberti, M.R.F, Moreira, C.L.N.S.O., Tavares, R.S., Borges Filho, H.M., Silva, A.G., Maia, C.H.G., Lima, F.L., Teixeira, D.F., Reciputti, B.P., Silva Filho, C.R., Sado Filho, J., Santos, D.B., & Lemos, I.P. (2010). Avaliação da qualidade de vida em portadores de doença falciforme do Hospital das Clínicas de Goiás, Brasil. Revista Brasileira de Hematologia e Hemoterapia, 32(6), 449-454. DOI: https://doi.org/10.1590/S1516-84842010000600008
Schneider C.M., & Medeiros L.G. (2012). Criança hospitalizada e o impacto emocional gerado nos pais. Unoesc & Ciência, 2(2), 140-155.
Shapiro, B.S. (1989). The management of pain in sickle cell disease. Pediatric Clinics of North America, 36(4), 1029-1045. DOI: https://doi.org/10.1016/S0031-3955(16)36735-9
Silva, M.C, & Shimauti, E.L.T. (2006). Eficácia e toxicidade da hidroxiuréia em crianças com anemia falciforme. Revista Brasileira de Hematologia e Hemoterapia, 28(2), 144-148. DOI: https://doi.org/10.1590/S1516-84842006000200016
Silva-Pinto, A.C, Angulo, I.L., Brunetta, D.M., Neves, F.I.R, Bassi, S.C., Santis, G.C., & Covas, D.M. (2013). Clinical and hematological effects of hydroxyurea therapy in sickle cell patients: a single-center experience in Brazil. Sao Paulo Medical Journal, 131(4), 238-243. DOI: http://dx.doi.org/10.1590/1516-3180.2013.1314467
Sorkin, L.S. (1997) Basic pharmacology and physiology of acute pain processing. Anesthesiology Clinics, 15(2), 235-249. DOI: https://doi.org/10.1016/S0889-8537(05)70331-X
Sousa, G.G.O, Fonseca, F.F., Regis, E.T., Júnior Gomes, L.C.B., & Grunewald, S.T.F. (2015). Crise álgica em crianças portadoras de doença falciforme. Revista Médica de Minas Gerais, 25, 23-27. DOI: https://doi.org/10.5935/2238-3182.20150093
Steinberg, M.H. (1999). Management of sickle cell disease. The New England journal of medicine, 340(13), 1021-1030. DOI: https://doi.org/10.1056/NEJM19990401340307
Taryn, M.A., Lindsay, M.A., Jennifer, A.R., & Melanie, J.B. (2016). Executive functioning and health-related quality of life in pediatric sickle cell disease. Child Neuropsychology, 23(8), 889-906. DOI: https://doi.org/10.1080/09297049.2016.1205011
Tostes, M.A., Braga, J.A.P., Len, C.A., & Hilário, M.O.E. (2008). Avaliação de dor em crianças e adolescentes portadores de doença falciforme. Revista de Ciências Médicas, 17, 141- 147.
Voskaridou, E., Christoulas, D., Bilalis, A., Plata, E., Varvagiannis, K., Stamatopoulos, G., Sinopoulou, K., Balassopoulou, A., Loukopoulos, D. & Terpos, E. (2010). The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS). Blood, 115(12), 2354-2363. DOI: https://doi.org/10.1182/blood-2009-05-221333
Yaster, M., Kost-Byerly, S., & Maxwell, L.G. (2000). The management of pain in sickle cell disease. Pediatric Clinics of North America, 47(3), 699-710. DOI: https://doi.org/10.1016/S0031-3955(05)70233-9
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