Eremanthus arboreus (Gardner) MacLeish (Candeeiro): natural source of α-Bisabolol

Authors

DOI:

https://doi.org/10.33448/rsd-v9i10.9270

Keywords:

Terpenes; Sesquiterpene; Asteraceae; Review; Vanillosmopsis arborea.

Abstract

There is a growing search in the chemical composition of essential oils, as they have biological and pharmacological activities. Among the plants with homogeneous composition in essential oils stands out the species Eremanthus arboreus (Gardner) MacLeish, (Asteraceae) popularly known as the “candeeiro”. This plant species is native to Chapada of Araripe - Ceará, Brazil. The objective was to characterize chemically the constituents of the essential oil (OE) of E. arboreus by means of Gas Chromatography and perform a review of its biological and pharmacological activities. The botanical material was collected in Chapada of Araripe, Barbalha - CE, Brazil, in April 2014, the extraction and collection of OE was done in Clevenger apparatus. The chemical composition of the OE was performed by Gas Chromatography coupled to Mass Spectrometry (CG/MS). As for the review, specialized scientific bases (Scopus, Scielo and Web of Science) were consulted. According to the results, 8 constituents were identified, where α-Bisabolol is mentioned as being the main component of the essential oil of this species. As for the biological and pharmacological activities of the OE, it was demonstrated that the species has the following activities: antimicrobial, larvicide, anti-inflammatory and antinociceptive. Eremanthus arboreus is a species with great pharmaceutical potential and also an alternative for industries that target products based on the constituent α-Bisabolol.

References

Adams, R. P. (2017). Identification of essential oil components by Gas chromatography/mass spectroscopy (5nd ed.). Gruver, TX UDA: Texensis Publishing.

Ahmad, A., Khan, A., Akhtar, F., Yousuf, S., Xess, I., Khan, L. A., & Manzoor, N. (2011). Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candida. European journal of clinical microbiology & infectious diseases, 30(1), 41-50.

Marco, C. A., Santos, H. R., Feitosa, A. S., Feitosa, J. V., & Costa, J. M. (2015). Teor, rendimento e qualidade do óleo essencial de Vanillosmopsis arbórea (Gardner) Baker (candeeiro) e sua ação alelopática. Revista Cubana De Plantas Medicinales, 20(1).

Bezerra, J. W. A., Costa, A. R., da Silva, M. A. P., Rocha, M. I., Boligon, A. A., da Rocha, J. B. T., ... & Kamdem, J. P. (2017). Chemical composition and toxicological evaluation of Hyptis suaveolens (L.) Poiteau (LAMIACEAE) in Drosophila melanogaster and Artemia salina. South African Journal of Botany, 113, 437-442.

Bezerra, S. B., Leal, L. K. A. M., Nogueira, N. A. P., & Campos, A. R. (2009). Bisabolol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide, and K+ ATP channels. Journal of medicinal food, 12(6), 1403-1406.

Bhatia, S. P., McGinty, D., Letizia, C. S., & Api, A. M. (2008). Fragrance material review on α-bisabolol. Food and chemical toxicology, 46(11), S72-S76.

Brehm-Stecher, B. F., & Johnson, E. A. (2003). Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. Antimicrobial agents and chemotherapy, 47(10), 3357-3360.

Cavalcanti, F. S., & Nunes, E. P. (2002). Reflorestamento de clareiras na floresta nacional do Araripe com Vanillosmopsis arborea Baker. Revista Brasileira de Farmacognosia, 12, 94-96.

Cavalieri, E., Mariotto, S., Fabrizi, C., de Prati, A. C., Gottardo, R., Leone, S., ... & Suzuki, H. (2004). α-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Biochemical and biophysical research communications, 315(3), 589-594.

Colares, A. V., Almeida-Souza, F., Taniwaki, N. N., Souza, C. D. S. F., da Costa, J. G. M., Calabrese, K. D. S., & Abreu-Silva, A. L. (2013). In vitro antileishmanial activity of essential oil of Vanillosmopsis arborea (Asteraceae) baker. Evidence-Based Complementary and Alternative Medicine, 2013.

Corpas-López, V., Merino-Espinosa, G., Acedo-Sánchez, C., Díaz-Sáez, V., Navarro-Moll, M. C., Morillas-Márquez, F., & Martín-Sánchez, J. (2018). Effectiveness of the sesquiterpene (-)-α-bisabolol in dogs with naturally acquired canine leishmaniosis: An exploratory clinical trial. Veterinary research communications, 42(2), 121-130.

Costa, J. G. M., Campos, A. R., Brito, S. A., Pereira, C. K. B., Souza, E. O., & Rodrigues, F. F. G. (2010). Biological screening of araripe basin medicinal plants using Artemia salina Leach and pathogenic bacteria. Pharmacognosy Magazine, 6(24), 331-334.

Forrer, M., Kulik, E. M., Filippi, A., & Waltimo, T. (2013). The antimicrobial activity of alpha-bisabolol and tea tree oil against Solobacterium moorei, a Gram-positive bacterium associated with halitosis. Archives of oral biology, 58(1), 10-16.

Furtado, R. F., Lima, M. G., Andrade Neto, M., Bezerra, J. N. S., & Silva, M. D. V. (2005). Larvicidal activity of essential oils against Aedes aegypti L.(Diptera: Culicidae). Neotropical Entomology, 34(5), 843-847.

Gerdakaneh, M., Mohammadi, N., & Arji, I. (2018). Study of Seasonal Variation on Essential Oil Content and Constituents of Eucalyptus (Eucalyptus globulus) in Three Zones of Kermanshah Province. Journal of Medicinal Plants, 2(66), 50-62.

Gonçalves, O., Pereira, R., Gonçalves, F., Mendo, S., Coimbra, M. A., & Rocha, S. M. (2011). Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 723(1), 18-25.

Leite, L. H. I., Leite, G. D. O., Coutinho, T. S., Sousa, S. D. G., Sampaio, R. S., Costa, J. G. M., ... & Campos, A. R. (2014). Topical antinociceptive effect of Vanillosmopsis arborea Baker on acute corneal pain in mice. Evidence-Based Complementary and Alternative Medicine, 2014, 1-6.

Leite, G. O., Leite, L. H. I., Sampaio, R. S., Araruna, M. K. A., Rodrigues, F. F. G., de Menezes, I. R. A., ... & Campos, A. R. (2011a). Modulation of topical inflammation and visceral nociception by Vanillosmopsis arborea essential oil in mice. Biomedicine & Preventive Nutrition, 1(3), 216-222.

Leite, G. O., Leite, L. H. I., Sampaio, R. S., Araruna, M. K. A., de Menezes, I. R. A., da Costa, J. G. M., & Campos, A. R. (2011b). (−)-α-Bisabolol attenuates visceral nociception and inflammation in mice. Fitoterapia, 82(2), 208-211.

Leite, G. O., Penha, A. R., Fernandes, C. N., Souza, H. H. F., Costa, J. G. M., & Campos, A. R. (2009). Gastroprotective mechanism of Vanillosmopsis arborea bark essential oil. Fitoterapia, 80(1), 77-80.

Massada, Y. (1995). Analysis of essential oil by chromatography and spectrometry. New York: John Wiley & Sons.

Matos, F. J. A. (2009). Introdução à Fitoquímica Experimental. Fortaleza: UFC.

Matos, M. E. O., Sousa, M. P., Matos, F. J. A., & Craveiro, A. A. (1988). Sesquiterpenes from Vanillosmopsis arborea. Journal of natural products, 51(4), 780-782.

Morales-Yuste, M., Morillas-Márquez, F., Martín-Sánchez, J., Valero-López, A., & Navarro-Moll, M. C. (2010). Activity of (-) α-bisabolol against Leishmania infantum promastigotes. Phytomedicine, 17(3-4), 279-281.

Mota, M. L., Lobo, L. T. C., da Costa, J. M. G., Costa, L. S., Rocha, H. A., e Silva, L. F. R., ... & de Andrade Neto, V. F. (2012). In vitro and in vivo antimalarial activity of essential oils and chemical components from three medicinal plants found in northeastern Brazil. Planta medica, 78(07), 658-664.

Oliveira, F. S., de Freitas, T. S., da Cruz, R. P., do Socorro Costa, M., Pereira, R. L. S., Quintans-Júnior, L. J., ... & Serafini, M. R. (2017). Evaluation of the antibacterial and modulatory potential of α-bisabolol, β-cyclodextrin and α-bisabolol/β-cyclodextrin complex. Biomedicine & Pharmacotherapy, 92, 1111-1118.

Rocha, N. F. M., de Oliveira, G. V., de Araújo, F. Y. R., Rios, E. R. V., Carvalho, A. M. R., Vasconcelos, L. F., ... & de Sousa, F. C. F. (2011). (−)-α-Bisabolol-induced gastroprotection is associated with reduction in lipid peroxidation, superoxide dismutase activity and neutrophil migration. European Journal of Pharmaceutical Sciences, 44(4), 455-461.

Rodrigues, F. F. G., Colares, A. V., Nonato, C. D. F. A., Galvão-Rodrigues, F. F., Mota, M. L., Braga, M. F. B. M., & da Costa, J. G. M. (2018). In vitro antimicrobial activity of the essential oil from Vanillosmopsis arborea Barker (Asteraceae) and its major constituent, α-bisabolol. Microbial pathogenesis, 125, 144-149.

Saltão, R., & Veiga, F. (2001). Ciclodextrinas em novos sistemas terapêuticos. Brazilian Journal of Pharmaceutical Sciences, 37(1), 1-17.

Santos, N. K. A., Coutinho, H. D. M., Viana, G. S. B., Rodrigues, F. F., & Costa, J. G. (2011). Chemical characterization and synergistic antibiotic activity of volatile compounds from the essential oil of Vanillosmopsis arborea. Medicinal chemistry research, 20(5), 637-641.

Santos, N. K., Rodrigues, F. F., Coutinho, H. D., Viana, G. S., & Costa, J. G. (2013). Isolation of alpha-bisabolol from the essential oil of Vanillosmopsis arborea baker and modulation of antibiotic activity using gaseous contact. Journal of Essential Oil Bearing Plants, 16(6), 826-831.

Santos, N. K., Viana, G. S., Cunha, W., Campos, A., & Costa, J. G. M. (2015). The essential oil from Vanillosmopsis arborea Baker (Asteraceae) presents antinociceptive, anti‐inflammatory, and sedative effects. International Journal of Green Pharmacy (IJGP), 9(2), 138-142.

Silva, T. I., Alves, A. C. L., Azevedo, F. R., Marco, C. A., Santos, H. R., & Azevedo, R. (2017). Actividad larvicida de aceites esenciales en Aedes aegypti L. (Diptera: Culicidae). Idesia (Arica), 35(2), 63-70.

Teixeira, A. M. R., Lima, I. K. C., Xavier, M. R., Pereira, R. L. S., Gonçalves, B. G., de Sena Junior, D. M., ... & de Faria, J. L. B. (2018). Vibrational spectroscopy study of essential oils from Plectranthus amboinicus Lour. Spreng and Vanillosmopsis arborea Baker. Vibrational Spectroscopy, 98, 22-29.

Van Zyl, R. L., Seatlholo, S. T., Van Vuuren, S. F., & Viljoen, A. M. (2006). The biological activities of 20 nature identical essential oil constituents. Journal of Essential Oil Research, 18(sup1), 129-133.

Zappi, D. C., Filardi, F. L. R., Leitman, P., Souza, V. C., Walter, B. M., Pirani, J. R., ... & Forzza, R. C. (2015). Growing knowledge: an overview of seed plant diversity in Brazil. Rodriguésia, 66 (4), 1085-1113.

Downloads

Published

29/10/2020

How to Cite

MACEDO, G. F. .; ALMEIDA-BEZERRA, J. W.; SILVA, V. B. da .; LIMA, E. E. .; MENEZES, S. A. de .; PORTELA, B. Y. M. .; BRAGA, B. L. P. .; BEZERRA , J. de S. .; OLIVEIRA , M. G. de .; ALENCAR , D. R. .; COSTA, A. R. . .; SOUZA , M. A. de .; CRUZ NETO , J. .; PEREIRA, T. da C. .; SILVA, F. S. H. da . Eremanthus arboreus (Gardner) MacLeish (Candeeiro): natural source of α-Bisabolol. Research, Society and Development, [S. l.], v. 9, n. 10, p. e9599109270, 2020. DOI: 10.33448/rsd-v9i10.9270. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/9270. Acesso em: 23 apr. 2024.

Issue

Section

Agrarian and Biological Sciences