Activity of glucose-6-phosphate dehydrogenase (G6PD) in newborns in a public hospital in the city of Campina Grande, State of Paraíba, Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v9i11.9855

Keywords:

Hematology; Glucosphosphate dehydrogenase deficiency; Health of ethnic minorities.

Abstract

In glucose 6 phosphate dehydrogenase (G6PD) deficient erythrocytes, the decrease in the reduction of NADP in NADPH, leads to a low reducing potential that interferes with the oxidative metabolic capacity of the organism, being vulnerable to hemolysis, with oxidation of the globule membrane, which can lead to the hemolytic crisis. The manifestations of G6PD deficiency are triggered by environmental factors such as drugs, beans, infections. Clinical manifestations consist of hemolytic crisis and neonatal jaundice. Studies indicate that in Brazil the prevalence of G6PD is around 1 to 10%, with the highest rates in populations with African ancestry. The objective was to investigate the G6PD deficiency in newborns in a public maternity hospital in the city of Campina Grande. This is a cross-sectional study, where umbilical cord blood was collected from 147 newborns. The diagnosis of G6PD deficiency will be carried out through the methaemoglobin reduction test (Brewer's test). The city of Campina Grande, as well as the entire Borborema Compartment, does not present any data regarding the prevalence of G6PD deficiency. Through the SUS, the Ministry of Health strengthens the collection of information related to this disease with a view to implementing a health care program for detected patients, promoting improvements in their quality of life.

Author Biography

Evaldo Hipólito de Oliveira, Universidade Federal do Piauí

Possui graduação em Farmácia pela Universidade Federal da Paraíba (1990), graduação em Farmácia e Bioquímica pela Universidade Federal da Paraíba (1991), graduação em Direito pela Universidade Federal do Piauí (1999), Doutorado em Biologia de Agentes Infecciosos e Parasitários (2010), mestrado em Administração pela Universidade Federal da Paraíba (2002), especialização em Vigilância Sanitária e Epidemiológica (1997) e Citologia Clínica (2005). Foi Diretor do Laboratório Central de Saúde Pública do Estado do Piauí-LACEN-PI (2003 a 2007). Atualmente é professor Associado da Universidade Federal do Piauí de microbiologia clínica e imunologia clínica (1994). Tem experiência na área de Farmácia (Interdisciplinaridade), atuando principalmente nos seguintes temas: análises clínicas ( bacteriologia, virologia, imunologia, citologia e hematologia ) e Vírus Linfotrópico de Células T Humanas-1/2-HTLV-1/2, HIV, HBV e HCV (Epidemiologa, Imunologia e Análise Molecular).

References

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Published

28/11/2020

How to Cite

SILVA, K. M. da C. e .; OLIVEIRA, E. H. de .; FERNANDES, S. S. .; LINS, S. P. .; NÓBREGA, R. de A. .; MOREIRA, V. M. .; NOGUEIRA JÚNIOR, F. A. .; NASCIMENTO, M. do S. V. do .; SOARES, L. F. . Activity of glucose-6-phosphate dehydrogenase (G6PD) in newborns in a public hospital in the city of Campina Grande, State of Paraíba, Brazil. Research, Society and Development, [S. l.], v. 9, n. 11, p. e6399119855, 2020. DOI: 10.33448/rsd-v9i11.9855. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/9855. Acesso em: 18 apr. 2024.

Issue

Vol. 9 No. 11

Section

Health Sciences

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Copyright (c) 2020 Keylla Malba da Costa e Silva; Evaldo Hipólito de Oliveira; Suenia Soares Fernandes; Sarah Pereira Lins; Raquel de Almeida Nóbrega; Vandiara Martins Moreira; Francisco Assis Nogueira Júnior; Maria do Socorro Viana do Nascimento; Leonardo Ferreira Soares

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