Effect of the gel based on Moringa oleifera lam. as a phytotherapy in wound healing
DOI:
https://doi.org/10.33448/rsd-v9i11.9957Keywords:
Rats, Wistar; Wound Healing; Surgical Wound; Moringa oleífera.Abstract
Objective: To evaluate the healing effects of Moringa oleifera in rats (Rattus norvegicus). Methodology: Moringa leaves were collected, dried, crushed, mixed with hexane solvent and filtered. After removing the solvent and moisture, he combined the resulting concentrate with the natrosol gel, reaching concentrations of 5% and 10%. 60 male rats were divided into 4 groups: negative control (without treatment), positive control (treated with AGE), Moringa 5% (treated with Moringa gel at 5%) and Moringa 10% (treated with Moringa gel at 10 %). It was subdivided into three groups of 5 animals according to the evaluation period (7, 14 and 21 days). A longitudinal incision (3.0 cm) was made in the cervical region; in the dorsal region an area of 2 cm² was demarcated and resected with a punch. Result: In the analysis of healing resistance, after 7 days, the 5% and 10% moringa groups showed a significant regression; after 14 and 21 days, the Moringa 10% group showed statistical significance when compared to the other groups. In the microscopic analysis, after 7 days, collagen fibers more evident in the Moringa groups 5% and 10%; after 14 and 21 days, few blood vessels, low intensity inflammatory reaction and more organized and intense collagen deposition in the Moringa 10% group. Conclusion: Moringa, especially at a concentration of 10%, proved to be beneficial in the repair process of surgically induced skin wounds in rats.
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Copyright (c) 2020 Walkyria Pereira Ferreira Moura; Amanda Fonseca Costa Assunção; Karolinny dos Santos Silva; Laryssa Roque da Silva; Arthur Antônio Cavalcante de Morais; Danniel Cabral Leão Ferreira; José Figueredo-Silva; Rosemarie Brandim Marques; Antonio Luiz Martins Maia Filho
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