Use of in natura and ozonated essential oils in the in vitro control of Trichophyton mentagrophytes




Dermatophyte; Ozone; Medicinal plants; Natural antifungal.


Some species of fungi are capable of causing mycotic infections. One of these infections is dermatophytosis, caused by a group of fungi, called dermatophytes, which comprises the genera Trichophyton, Microsporum and Epidermophyton. The treatment of the disease is carried out using conventional antifungals. The emergence of resistant strains has stimulated the development of natural medicines and the use of ozone gas. The objective of this research was to evaluate the antifungal activity of essential oils in natura and ozonized against the Trichophyton mentagrophytes ATTC 9533. Essential oils in natura and ozonated from Cinnamomum cassia, (L.) Presl), Eugenia caryphollata L. Merr. & L. M. Perry, Cymbopogon winterianus Jowitt, Eucalyptus globulus Labill, Eucalyptus staigeriana F. Muell. ex F. M. Bailey e Mentha piperita L. evaluated for antifungal activity. The oils were ozonized in corona equipment. The microdilution technique was used to assess the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC). The fungicidal kinetics of essential oils were determined. C. winterianus C. cassia and E. caryphollata ozonated oils proved to be able to cancel Trichophyton mentagrophytes with exposure for 5-10 minutes, proving to be more efficient than those of eucalyptus and mint. In general, the results showed the antifungal activity of essential oils, pointing to the possibility of use in antifungal therapy against the dermatophyte evaluated. However, there is a need for studies on the safety in use and the effectiveness of essential oils.

Author Biographies

Joelma Evelin Pereira Kume, Universidade Brasil

Mestre em Ciências Ambientais

Universidade Brasil (UB)

Roberto Andreani Junior, Universidade Brasil

Professor Titular do Mestrado em Ciências Ambientais

Universidade Brasil

Marilisa Flavia Pereira Di-Tanno, Estadual de Educação Tecnológica Paula Souza

Doutora em Engenharia Biomédica

Professora do Centro Estadual de Educação Tecnológica Paula Souza 


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How to Cite

KUME, J. E. P.; ANDREANI JUNIOR, R. .; DI-TANNO, M. F. P. .; KOZUSNY-ANDREANI, D. I. Use of in natura and ozonated essential oils in the in vitro control of Trichophyton mentagrophytes. Research, Society and Development, [S. l.], v. 10, n. 1, p. e4710111233, 2021. DOI: 10.33448/rsd-v10i1.11233. Disponível em: Acesso em: 2 feb. 2023.



Health Sciences