Essential oils used in the treatment of neuralgia: A systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i5.14606

Keywords:

Phytotherapy; Medicinal plants; Ethnopharmacology.

Abstract

The present work was designed with the objective of characterizing the current studies on the use of essential oils in the treatment of neuralgia in an animal model. It is a systematic review of the literature, where the bibliotegraphic survey was carried out in December 2019, through electronic research, consulting the Medline-PubMed, LILACS, Scopus and Web of Science databases. The present study identified 338 articles. 324 were removed, and 14 articles were selected after the established inclusion and exclusion criteria. All articles selected were in the English language, among them 14 were carried out in Brazil with research using extracts, isolated or complexed essential oils. This systematic review suggests that the natural compounds found have therapeutic potentials for the treatment of neuralgia conditions.

References

Aldred, E. M., Buck, C., & Vall, K. (2009). Pharmacology. Churchill Livingstone, 352p.

Almeida, J. R., Souza, G. R., Silva, J. C., Saraiva, S. R., Júnior, R. G., Quintans, J., Barreto, R., Bonjardim, L. R., Cavalcanti, S. C., & Quintans Júnior, L. J. (2013). Borneol, a bicyclic monoterpene alcohol, reduces nociceptive behavior and inflammatory response in mice. The Scientific World Journal, 2013, 808460.

Amin, B., & Hosseinzadeh, H. (2012). Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. Fitoterapia, 83(5), 888-895.

Batista, P. A., Werner, M. F. P., Oliveira, E. C., Burgos, L., Pereira, P., Brum, L. F. S., Story, G. M., & Santos, A. R. S. (2010). The antinociceptive effect of (-)-linalool in models of chronic inflammatory and neuropathic hypersensitivity in mice. Journal of Pain, 11(11), 1222-1229.

Bi, J., Jiang, B., Zorn, A., Zhao, R. G., Liu, P., & An, L. J. (2013). Catalpol inhibits LPS plus IFN-γ-induced inflammatory response in astrocytes primary cultures. Toxicology in Vitro, 27(2), 543-550.

Carvalho, J. C. T. (2004). Fitoterápicos anti-inflamatórios: aspectos químicos, farmacológicos e aplicações terapêuticas. Tecmedd. Ribeirão Preto: São Paulo, 480p.

Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994). Quantitative assessment of tactile allodynia in the rat paw. Journal of Neuroscience Methods, 53(1), 55-63.

Choudhary, M. I., Azizuddin, S. J., Nawaz, S. A., Khan, K. M., Tareen, R. B.; & Atta-ur-Rahman. (2009). Antiinflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus. Phytotherapy Research, 23(9), 1336-1339.

Chudzik, M., Korzonek-Szlacheta, I., & Król, W. (2015). Triterpenes as potentially cytotoxic compounds. Molecules (Basel, Switzerland), 20(1), 1610–1625.

De-la-Torre-Ugarte-Guanilo, M. C., Takahashi, R. F., & Bertolozzi, M. R. (2011). Systematic review: general notions. Revista da Escola de Enfermagem da USP, 45(5), 1260-1266.

Dellaroza, M. S. G., Pimenta, C. A. M., Lebrão, M. L., & Duarte, Y. A. (2013). Associação de dor crônica com uso de serviços de saúde em idosos residentes em São Paulo. Revista de Saúde Pública, 47(5), 914-922.

Dutra, R. C., Silva, K. A. B. S., Bento, A. F., Marcon, R., Paszcuk, A. F., Meotti, F. C., Pianowski, L. F., & Calixto, J. B. (2012). Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: the involvement of cannabinoid system. Neuropharmacology, 63(4), 593-605.

Dworkin, R. H., Backonja, M., Rowbotham, M. C., Allen, R. R., Argoff, C. R., Bennett, G. J. et al. (2003). Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Archives of Neurology, 60(11), 1524-1534.

Eler, G. J., & Jaques, A. E. (2006). O enfermeiro e as terapias complementares para o alívio da dor. Arquivos de Ciências da Saúde da UNIPAR, 10(3), 185-190.

Elisabetsky, E., Brum, L. F., & Souza, D. O. (1999). Anticonvulsant properties of linalool in glutamate-related seizure models. Phytomedicine, 6(2), 107-113.

Fan, W., Huang, F., Wu, Z., Zhu, X., Li, D., & He, H. (2012). The role of nitric oxide in orofacial pain. Nitric Oxide, 12(1), 32-43.

Ferreira, V. F., & Pinto. A. C. (2010). A fitoterapia no mundo atual. Química Nova, 1829p.

Guimarães, A. G., Serafini, M. R., & Quintans-Júnior, L. J. (2014). Terpenes and derivatives as a new perspective for pain treatment: a patent review. Expert Opinion on Therapeutic Patents, 24(3), 243-265.

Holanda Pinto, S. A., Pinto, L. M. S., Guedes, M. A., Cunha, G. M. A., Chaves, M. H., Santos, F. A., & Rao, V. S. (2008). Antinoceptive effect of triterpenoid alpha, beta-amyrin in rats on orofacial pain induced by formalin and capsaicin. Phytomedicine, 15(8), 630-634.

Hosseinzadeh, H., & Talebzadeh, F. (2005). Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. Fitoterapia, 76(7-8), 722-724.

Hosseinzadeh, H., & Younesi, H. M. (2002). Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacology, 2(1), 7-12.

Hosseinzadeh, H., Karimi, G. H., & Niapoor, M. (2004). Antidepressant effects of Crocus sativus stigma extracts and its constituents, crocin and safranal, in mice. Journal of Medicinal Plants, 3(11), 48-58.

Hosseinzadeh, H., Modaghegh, M. H., & Saffari, Z. (2009). Crocus sativus L. (Saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. Evidence-based complementary and alternative medicine: eCAM, 6(3), 343–350.

Jia, Y., Gong, N., Li, T. F., Zhu, B., & Wang, Y. X. (2015). Peptidic exenatide and herbal catalpol mediate neuroprotection via the hippocampal GLP-1 receptor/β-endorphin pathway. Pharmacological Research, 102, 276-285.

Jiang, J., Sehn, Y. Y., Li, J., Lin, Y. H., Luo, C. X., & Zhu, D. Y. (2015). (+)-Borneol alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice. European Journal of Pharmacology, 757, 53-58.

Khalilzadeh, E., Hazrati, R., Sayah, G. V., & Hasannejad, H. (2015). Opioidergic and cholinergic but not nitric oxide pathways are involved in antinociceptive activity of Vitex agnus-castus essential oil in the acute trigeminal model of pain in rat. Asian Journal of Pharmaceutical and Clinical Research, 8(1), 283-286.

Krzyzanowska, A., & Avendaño, C. (2012). Behavioral testing in rodent models of orofacial neuropathic and inflammatory pain. Behavioral and Brain Sciences, 2(5), 678-697.

Kumari, A., Kumar, V., & Yadav, S. K. (2012). Nanotechnology: a tool to enhance values of natural products. Trends in Medical Research, 7, 34-42.

Lappas, C. M., & Lappas, N. T. (2012). D-limonene modulates T lymphocyte activity and viability. Cellular Immunology, 279(1), 30-41.

Lawson, C. (2009). The role of patents in biodiversity conservation. Nature Biotechnology, 27(11), 994-995.

Lima, D. F., Brandão, M. S., Moura, J. B., Leitão, J. M., Carvalho, F. A., Miúra, L. M., Leite, J. R., Sousa, D. P., & Almeida, F. R. (2012). Antinociceptive activity of the monoterpene alpha-phellandrene in rodents: possible mechanisms of action. Journal of Pharmacy and Pharmacology, 64(2), 283-293.

Lima, P. S. S., Lucchese, A. M., Araújo-Filho, H. G., Menezes, P. P., Araújo, A. A. S., Quintans-Júnior, L. J., & Quintans, J. S. S. (2016). Inclusion of terpenes in cyclodextrins: preparation, characterization and pharmacological approaches. Carbohydrate Polymers, 151, 965-987.

Liu, M., Zhou, L., Chen, Z., & Hu, C. (2012). Analgesic effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on spared nerve injury rat model of neuropathic pain. Pharmacology Biochemistry & Behavior, 102(3), 465-470.

Liu, R., Zhang, L., Lan, X., Li, L., Zhang, T. T., Sun, J. H., & Du, G. H. (2011). Protection by borneol on cortical neurons against oxygen-glucose deprivation/reperfusion: involvement of anti-oxidation and anti-inflammation through nuclear transcription factor κappaB signaling pathway. Neuroscience, 176, 408-419.

Ma, Y., Zhou, L. L., Yan, H. Y., & Liu, M. (2009). Effects of extracts from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on MSU crystal-induced rats gouty arthritis. American Journal of Chinese Medicine, 37(4), 669-683.

Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., The Prisma Group. (2015). Principais itens para relatar Revisões sistemáticas e Meta-análises: A recomendação PRISMA. Epidemiologia e Serviços de Saúde, 24(2), 335-342.

Nanjundaiah, S. M., Venkatesha, S. H., Yu, H., Tong, L., Stains, J. P., & Moudgil, K. D. (2012). Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk. The Journal of Biological Chemistry, 287(26), 22216–22226.

Nascimento, S. S., Araújo, A. A., Brito, R. G., Serafini, M. R., Menezes, P. P., DeSantana, J. M., Lucca, W., Jr, Alves, P. B., Blank, A. F., Oliveira, R. C., Oliveira, A. P., Albuquerque, R. L., Jr, Almeida, J. R., & Quintans Júnior, L. J. (2014). Cyclodextrin-complexed Ocimum basilicum leaves essential oil increases Fos protein expression in the central nervous system and produce an antihyperalgesic effect in animal models for fibromyalgia. International Journal of Molecular Sciences, 16(1), 547–563.

Nishijima, C. M., Ganev, E. G., Mazzardo-Martins, L., Martins, D. F., Rocha, L. R., Santos, A. R., & Hiruma-Lima, C. A. (2014). Citral: A monoterpene with prophylactic and therapeutic antinociceptive effects in experimental models of acute and chronic pain. European Journal of Pharmacology, 736, 16-25.

Nucci, C., Mazzardo-Martins, L., Stramosk, J., Brethanha, L. C., Pizzolatti, M. G., Santos, A. R., & Martins, D. F. (2012). Oleaginous extract from the fruits Pterodon pubescens Benth induces antinociception in animal models of acute and chronic pain. Journal of Ethnopharmacology, 143(1), 170-178.

Nucci-Martins, C., Martins, D. F., Nascimento, L. F., Venzke, D., Oliveira, A. S., Frederico, M. J., Silva, F. R., Brighente, I. M., Pizzolatti, M. G., & Santos, A. R. (2015). Ameliorative potential of standardized fruit extract of Pterodon pubescens Benth on neuropathic pain in mice: evidence for the mechanisms of action. Journal of Ethnopharmacology, 175, 273-286.

Oliveira, M. A., Guimarães, A. G., Araújo, A. A. S., Quintans-Júnior, L. J., & Quintans, J. S. S. (2017). New drugs or alternative therapy to blurring the symptoms of fibromyalgia-a patent review. Expert Opinion on Therapeutic Patents, 27(10), 1147-1157.

Oliveira, S. G. D., Moura, F. R. R., Demarco, F. F., Nascente, P. S., Del Pino, F. A. B., & Lund, R. G. (2012). An ethnomedicinal survey on phytotherapy with professionals and patients from Basic Care Units in the Brazilian Unified Health System. Journal of Ethnopharmacology, 140(2), 428-437.

Oliveira, T. V. C., Meneses, D. C. S., Santana, I. C. J., Ferreira, M. E. R., Leite, R. N. O., Carvalho Neto, J. N., Pereyra, B. B. S., Cândido, J. F., Dantas, C. G., Gomes, M. Z., & Cândido, E. A. F. (2018). Correlation of spasticity with functionality of spastic individuals after physiotherapy treatment associated with herbal medicine derived from Alpinia zerumbet. International Journal of Development Research, 8(1), 18443-18447.

Orhan, I., Küpeli, E., Aslan, M., Kartal, M., & Yesilada, E. (2006). Bioassay-guided evaluation of anti-inflammatory and antinociceptive activities of pistachio, Pistacia vera L. Journal of Ethnopharmacology, 105(1-2), 235-240.

Otuki, M. F., Ferreira, J., Lima, F. V., Meyre-Silva, C., Malheiros, A., Muller, L. A., Cani, G. S., Santos, A. R., Yunes, R. A., & Calixto, J. B. (2005). Antinociceptive properties of a mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways. Journal of Pharmacology and Experimental Therapeutics, 313(1), 310-318.

Oussalah, M., Caillet, S., Saucier, L., & Lacroix, M. (2007). Inhibitory effects of selected plant essential oils on the growth of four pathogenic bacteria: E. coli O157:H7, Salmonella Typhimurium, Staphylococcus aureus and Listeria monocytogenes. Food Control, 18(5), 414-420.

Paris, D., Ganey, N. J., Laporte, V., Patel, N. S., Beaulieu-Abdelahad, D., Bachmeier, C., March, A., Ait-Ghezala, G., & Mullan, M. J. (2010). Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease. Journal of Neuroinflammation, 7, 17.

Parmar, S. K., Sharma, T. P., Airao, V. B., Bhatt, R., Aghara, R., Chavda, S., Rabadiya, S. O., & Gangwal, A. P. (2013). Neuropharmacological effects of triterpenoids. Phytopharmacology, 4(2), 354-372.

Paula-Freire, L. I., Andersen, M. L., Molska, G. R., Köhn, D. O., & Carlini, E. L. (2013). Evaluation of the antinociceptive activity of Ocimum gratissimum L. essential oil and its isolated active principles in mice. Phytotherapy Research, 27(8), 1220-1224.

Paula-Freire, L. I., Molska, G. R., Andersen, M. L., & Carlini, E. L. (2016). Ocimum gratissimum essential oil and its isolated compounds (eugenol and myrcene) reduce neuropathic pain in mice. Planta Medica, 82(3), 211-216.

Piccinelli, A. C., Santos, J. A., Konkiewitz, E. C., Oesterreich, S. A., Formagio, A. S., Croda, J., Ziff, E. B., & Kassuya, C. A. (2015). Antihyperalgesic and antidepressive actions of (R)-(+)-limonene, α-phellandrene, and essential oil from Schinus terebinthifolius fruits in a neuropathic pain model. Nutritional Neuroscience, 18(5), 217-224.

Pina, L. T. S., Gouveia, D. N., Costa, J. S., Quintans, J. S. S., Quintans-Júnior, L. J., Barreto, R. S. S., & Guimarães, A. G. (2017). New perspectives for chronic pain treatment: a patent review (2010-2016). Expert Opinion on Therapeutic Patents, 27(7), 787-796.

Quintans-Júnior, L. J., Araújo, A. A. S., Brito, R. G., Santos, P. L., Quintans, J. S. S., Menezes, P. P., Serafini, M. R., Silva, G. F., Carvalho, F. M. S., Brogden, N. K., & Sluka, K. A. (2016). β-caryophyllene, a dietary cannabinoid, complexed with β-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of Fos expression in superficial dorsal horn. Life Sciences, 149, 34-41.

Quintans-Júnior, L. J., Barreto, R. S. S., Menezes, P. P., Almeida, J. R. G. S., Viana, A. F. S. C., Oliveira, R. C. M., Oliveira, A. P., Gelain, D. P., Lucca Júnior, W., & Araújo, A. A. S. (2013). β-Cyclodextrin-complexed (-)-linalool produces antinociceptive effect superior to that of (-)-linalool in experimental pain protocols. Basic & Clinical Pharmacology & Toxicology, 113(3), 167-172.

Quintão, N. L. M., Silva, G. F., Antonialli, C. S., Rocha, L. W., Filho, V. C., & Cicció, J. F. (2010). Chemical composition and evaluation of the antihypernociceptive effect of the essential oil extracted from the leaves of Ugni myricoides on inflammatory and neuropathic models of pain in mice. Planta Medica, 76(13), 1411-1418.

Saberi, M., Rezvanizadeh, A., & Bakhtiarian, A. (2008). The antiepileptic activity of Vitex agnus-castus extract on amygdala kindled seizures in male rats. Neuroscience Letters, 441(2), 193-196.

Santos, O. J., Barros-Filho, A. K. D., Malafaia, O., Ribas-Filho, J. M., Santos, R. H. P., & Santos, R. A. P. (2012). Schinus terebinthifolius raddi (anacardiaceae) in the healing process of gastrorraphy in rats. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), 25(3), 140-146.

Santos-Júnior, L., Oliveira, T. V. C., Cândido, J. F., Santana, D. S., Pereira Filho, R. N., Pereyra, B. B. S., Gomes, M. Z., Lima, S. O., Albuquerque-Júnior, R. L. C., & Cândido, E. A. F. (2017). Effects of the essential oil of Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm. on healing and tissue repair after partial Achilles tenotomy in rats. Acta Cirúrgica Brasileira, 32(6), 449-458.

Schestatsky, P. (2008). Definição, diagnóstico e tratamento da dor neuropática. Revista do Hospital das Clínicas de Porto Alegre, 28(3), 177-187.

Silva, K. A. B. S., Paszcuk, A. F., Passos, G. F., Silva, E. S., Bento, A. F., Meotti, F. C., & Calixto, J. B. (2011). Activation of cannabinoid receptors by the pentacyclic triterpene α, β-amyrin inhibits inflammatory and neuropathic persistent pain in mice. Pain, 152(8), 1872-1887.

Siqueira-Lima, P. S., Silva, J. C., Quintans, J. S.S., Antoniolli, A. R., Shanmugam, S., Barreto, R. S. S., Santos, M. R. V., Almeida, J. R. G. S., Bonjardim, L. R., Menezes, I. R.A., & Quintans-Júnior, L. J. (2017). Natural products assessed in animal models for orofacial pain – a systematic review. Revista Brasileira de Farmacognosia, 27(1), 124-134.

Sousa, D. G., Sousa, S. D. G., Silva, R. E. R., Silva-Alves, K. S., Ferreira-da-Silva, F. W., Kerntopf, M. R., Menezes, I. R. A., Leal-Cardoso, J. H., & Barbosa, R. (2015). Essential oil of Lippia alba and its main constituent citral block the excitability of rat sciatic nerves. Brazilian Journal of Medical and Biological Research, 48(8), 697-702.

Stojković, D., Soković, M., Glamočlija, J., Džamić, A., Ćirić, A., Ristić, M., & Grubišić, D. (2011). Chemical composition and antimicrobial activity of Vitex agnus-castus L. fruits and leaves essential oils. Food Chemistry, 128(1), 1017-1022.

Upton, R. (2001). Chaste Tree Fruit, Vitex Agnus-Castus: Standards of Analysis, Quality Control, and Therapeutics, Santa Cruz, CA. American Herbal Pharmacopoeia: Santa Cruz, CA.

Venkatesha, S. H., Yu, H., Rajaiah, R., Tong, L., & Moudgil, K. D. (2011). Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses. The Journal of Biological Chemistry, 286(17), 15138–15146.

Wang, S., Zhang, D., Hu, J., Jia, Q., Xu, W., Su, D., Song, H., Xu, Z., Cui, J., Zhou, M., Yang, J., & Xiao, J. (2017). A clinical and mechanistic study of topical borneol-induced analgesia. EMBO Molecular Medicine, 9(6), 802–815.

Wang, W., Ha, C., Lin, T., Wang, D., Wang, Y., & Gong, M. (2018). Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats. Journal of Pharmacy and Pharmacology, 70(1), 81-88.

Wang, Y., Zhang, R., Xie, J., Lu, J., & Yue, Z. (2014). Analgesic activity of catalpol in rodent models of neuropathic pain, and Its spinal mechanism. Cell Biochemistry and Biophysics, 70(3), 1565-1571.

Yang, L., Li, Y., Ren, J., Zhu, C., Fu, J., Lin, D., & Qiu, Y. (2014). Celastrol attenuates inflammatory and neuropathic pain mediated by cannabinoid receptor type 2. International Journal of Molecular Sciences, 15(8), 13637–13648.

Published

27/04/2021

How to Cite

SANTOS, I. V. .; CAVALCANTI, M. S. da S. .; CABRAL, A. B. .; RAMOS, K. M. .; OLIVEIRA JÚNIOR, R. G. de .; SARAIVA, S. R. G. de L. .; CALUMBY, R. J. N. .; MENEZES, P. dos P. .; QUINTANS JÚNIOR, L. J.; ALMEIDA, J. R. G. da S. .; CABRAL SILVA, J. Essential oils used in the treatment of neuralgia: A systematic review. Research, Society and Development, [S. l.], v. 10, n. 5, p. e6710514606, 2021. DOI: 10.33448/rsd-v10i5.14606. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/14606. Acesso em: 26 apr. 2024.

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Health Sciences