Intestinal bacterial agent with biotechnological potential against metabolic disorders: An integrative review of Akkermansia muciniphila




Akkermansia muciniphila; Obesity; Gut microbiota; Probiotic.


Some chronic metabolic diseases are caused by eating disorders. In this aspect, the intestinal microbiota participates effectively, directly and indirectly, in various processes carried out in this environment, contributing to the homeostasis of the organism and in the regularization of these nutritional disorders. Recently, studies published in recent years have increasingly demonstrated the role of these microorganisms in the gastrointestinal tract and how they can act as probiotics, such as the bacteria Akkermansia muciniphila, which is interconnected with various biochemical and physiological processes. Thus, this work aimed to carry out an integrative review to compile information regarding the action of the A. muciniphila bacteria against metabolic dysfunctions. For this purpose, a scientific survey was carried out using a digital database, namely: PubMed (, ScienceDirect ( and Google Scholar ( From the prospection, 14 articles on the subject were selected. Despite it, according to the scientific literature, the efficiency of A. muciniphila acting on behalf of the organism was evidenced in order to prevent and/or treat metabolic disorders resulting from diets rich, mainly in fat - a factor that can lead to obesity and, consequently, diabetes.


Ahlawat, S., Asha, & Sharma, K. K. (2021). Gut-organ axis: a microbial outreach and networking. Letters in applied microbiology, 72(6), 636–668.

Adak, A., & Khan, M. R. (2019). An insight into gut microbiota and its functionalities. Cellular and molecular life sciences : CMLS, 76(3), 473–493.

Bian, X., Wu, W., Yang, L., Lv, L., Wang, Q., Li, Y., Ye, J., Fang, D., Wu, J., Jiang, X., Shi, D., & Li, L. (2019). Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice. Frontiers in microbiology, 10, 2259.

Chatterjee, S., Khunti, K., & Davies, M. J. (2017). Type 2 diabetes. Lancet, 389(10085), 2239–2251.

Devine, P. L., & McKenzie, I. F. (1992). Mucins: structure, function, and associations with malignancy. BioEssays : news and reviews in molecular, cellular and developmental biology, 14(9), 619–625.

Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004). Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. International journal of systematic and evolutionary microbiology, 54(5), 1469–1476.

Derrien, M., Van Baarlen, P., Hooiveld, G., Norin, E., Müller, M., & de Vos, W. M. (2011). Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila. Frontiers in microbiology, 2, 166.

Depommier, C., Van Hul, M., Everard, A., Delzenne, N. M., De Vos, W. M., & Cani, P. D. (2020). Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice. Gut microbes, 11(5), 1231–1245.

Dao, M. C., Everard, A., Aron-Wisnewsky, J., Sokolovska, N., Prifti, E., Verger, E. O., Kayser, B. D., Levenez, F., Chilloux, J., Hoyles, L., MICRO-Obes Consortium, Dumas, M. E., Rizkalla, S. W., Doré, J., Cani, P. D., & Clément, K. (2016). Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut, 65(3), 426–436.

Deng, L., Ou, Z., Huang, D., Li, C., Lu, Z., Liu, W., Wu, F., Nong, C., Gao, J., & Peng, Y. (2020). Diverse effects of different Akkermansia muciniphila genotypes on Brown adipose tissue inflammation and whitening in a high-fat-diet murine model. Microbial pathogenesis, 147.

De la Cuesta-Zuluaga, J., Mueller, N. T., Corrales-Agudelo, V., Velásquez-Mejía, E. P., Carmona, J. A., Abad, J. M., & Escobar, J. S. (2017). Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid-Producing Microbiota in the Gut. Diabetes care, 40(1), 54–62.

Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., de Vos, W. M., & Cani, P. D. (2013). Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proceedings of the National Academy of Sciences of the United States of America, 110(22), 9066–9071.

Ferreira, S. R. G & Pititto, B. A. (2021). Aspectos Epidemiológicos do Diabetes Mellitus e seu Impacto no Indivíduo e na Sociedade.

Fletcher, B., Gulanick, M., & Lamendola, C. (2002). Risk factors for type 2 diabetes mellitus. The Journal of cardiovascular nursing, 16(2), 17–23.

Golay, A., & Ybarra, J. (2005). Link between obesity and type 2 diabetes. Best practice & research. Clinical endocrinology & metabolism, 19(4), 649–663.

Guthrie, R. A., & Guthrie, D. W. (2004). Pathophysiology of diabetes mellitus. Critical care nursing quarterly, 27(2), 113–125.

Gibson, G. R., & Roberfroid, M. B. (1995). Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. The Journal of nutrition, 125(6), 1401–1412.

Hansen, C. H., Krych, L., Nielsen, D. S., Vogensen, F. K., Hansen, L. H., Sørensen, S. J., Buschard, K., & Hansen, A. K. (2012). Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse. Diabetologia, 55(8), 2285–2294.

Kim, S., Lee, Y., Kim, Y., Seo, Y., Lee, H., Ha, J., Lee, J., Choi, Y., Oh, H., & Yoon, Y. (2020). Akkermansia muciniphila Prevents Fatty Liver Disease, Decreases Serum Triglycerides, and Maintains Gut Homeostasis. Applied and environmental microbiology, 86(7), e03004-19.

Leles, M. B. L. (2018). Influência da Diabetes Mellitus nas doenças crônicas e agudas. Pebmed.

Lawenius, L., Scheffler, J. M., Gustafsson, K. L., Henning, P., Nilsson, K. H., Colldén, H., Islander, U., Plovier, H., Cani, P. D., de Vos, W. M., Ohlsson, C., & Sjögren, K. (2020). Pasteurized Akkermansia muciniphila protects from fat mass gain but not from bone loss. American journal of physiology, Endocrinology and metabolism, 318(4), E480–E491.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica. UFSM.

Roopchand, D. E., Carmody, R. N., Kuhn, P., Moskal, K., Rojas-Silva, P., Turnbaugh, P. J., & Raskin, I. (2015). Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet-Induced Metabolic Syndrome. Diabetes, 64(8), 2847–2858.

Saboya, P. P., Bodanese, L. C., Zimmermann, P. R., Gustavo, A. D., Macagnan, F. E., Feoli, A. P., & Oliveira, M. D. (2017). Lifestyle Intervention on Metabolic Syndrome and its Impact on Quality of Life: A Randomized Controlled Trial. Arquivos brasileiros de cardiologia, 108(1), 60–69.

Samson, S. L., & Garber, A. J. (2014). Metabolic syndrome. Endocrinology and metabolism clinics of North America, 43(1), 1–23.

Saklayen, M. G. (2018). The Global Epidemic of the Metabolic Syndrome. Current hypertension reports, 20(2), 12.

Sociedade Brasileira de Endocrinologia e Metabologia. (2020). A Obesidade é uma doença crônica.

Souza, M. T., Silva, M. D., Carvalho, R. (2010). Revisão integrativa: o que é e como fazer?. Einstein, 8(1).

Shen, W., Shen, M., Zhao, X., Zhu, H., Yang, Y., Lu, S., Tan, Y., Li, G., Li, M., Wang, J., Hu, F., & Le, S. (2017). Anti-obesity Effect of Capsaicin in Mice Fed with High-Fat Diet Is Associated with an Increase in Population of the Gut Bacterium Akkermansia muciniphila. Frontiers in microbiology, 8, 272.

Schneeberger, M., Everard, A., Gómez-Valadés, A. G., Matamoros, S., Ramírez, S., Delzenne, N. M., Gomis, R., Claret, M., & Cani, P. D. (2015). Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice. Scientific reports, 5, 16643.

Sheng, L., Jena, P. K., Liu, H. X., Hu, Y., Nagar, N., Bronner, D. N., Settles, M. L., Bäumler, A. J., & Wan, Y. Y. (2018). Obesity treatment by epigallocatechin-3-gallate-regulated bile acid signaling and its enriched Akkermansia muciniphila. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(12), fj201800370R.

World Health organization. (2021). Diabetes.

World Health Organization. (2020). Obesity and overweight.

Yang, M., Bose, S., Lim, S., Seo, J., Shin, J., Lee, D., Chung, W. H., Song, E. J., Nam, Y. D., & Kim, H. (2020). Beneficial Effects of Newly Isolated Akkermansia muciniphila Strains from the Human Gut on Obesity and Metabolic Dysregulation. Microorganisms, 8(9), 1413.

Zhao, S., Liu, W., Wang, J., Shi, J., Sun, Y., Wang, W., Ning, G., Liu, R., & Hong, J. (2017). Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice. Journal of molecular endocrinology, 58(1), 1–14.



How to Cite

SILVA, P. H. .; FREITAS , L. de B. R. de .; SANTOS, S. M. dos .; CARMO, T. L. do .; PORTO, A. L. F. .; OLIVEIRA, V. de M. .; CALAÇA, P. R. de A. .; SOARES, M. T. C. V. . Intestinal bacterial agent with biotechnological potential against metabolic disorders: An integrative review of Akkermansia muciniphila. Research, Society and Development, [S. l.], v. 10, n. 8, p. e45510817454, 2021. DOI: 10.33448/rsd-v10i8.17454. Disponível em: Acesso em: 1 mar. 2024.



Health Sciences