Management of patients with Major Depressive Disorder in the context of Primary Health Care: a literature review




Primary Health Care; Depressive Disorder, Major; Therapeutics.


Objective: to investigate, in the national and international literature, the characteristics of the behavior of patients with Major Depressive Disorder in the scope of Primary Health Care. Methods: this is an Integrative Literature Review (IRL), with a sensitive and specific search in the databases. data: Virtual Health Library (VHL), PubMed and Cochrane Library, through the terms and their correlates: “Therapeutics”, “Major Depressive Disorder”, “Primary Health Care” and “Family Doctors”. Results: We identified 518 studies, after applying the eligibility criteria 20 studies included in the qualitative synthesis, which were published in eight different countries from 1995 to 2020, changed total population of 35,590 patients with major depressive disorder. Discussion: evasion studies addressed pharmacological and non-pharmacological measures in intervention, such as psychotherapy and health education, as well as alternative measures, such as care management. Conclusion: the methods used were dissipation in the treatment of depression, but few studies on the subject were used in Brazil.


Culpepper, L., Mathews, M., Ghori, R., & Edwards, J. (2014). Clinical relevance of vilazodone treatment in patients with major depressive disorder: categorical improvement in symptoms. 16(1).

Lin, E. H, et al., (1995). The role of the primary care physician in patients’ adherence to antidepressant therapy. Medical Care, 33(1), 67–74.

Fabian, T. J., Cain, Z. J., Ammerman, D., Eudicone, J. M., Tang, Y., Rollin, L. M., Forbes, R. A., Berman, R. M., & Baker, R. A. (2012). Improvement in functional outcomes with adjunctive Aripiprazole versus placebo in major depressive disorder: a pooled post Hoc analysis of 3 short-term studies. 14(6).

Ruoff, G. (2005). A method that dramatically improves patient adherence to depression treatment. The Journal of Family Practice, 54(10), 846–852.

Gallo, J. J., Bogner, H. R., Morales, K. H., Post, E. P., Lin, J. Y., & Bruce, M. L. (2007). The effect of a primary care practice-based depression intervention on mortality in older adults: a randomized trial. 146(10), 689‐698.

Gidding, L. G., Spigt, M. G., & Dinant, G.-J. (2014). Stepped collaborative depression care: primary care results before and after implementation of a stepped collaborative depression programme. Fam Pract, 31(2), 180–192.

Gensichen, J. et al., (2009). Case management for depression by health care assistants in small primary care practices: a cluster randomized trial. Annals of Internal Medicine, 151(6), 369–378.

Unützer, J. et al., (2002). Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial. JAMA, 288(22), 2836–2845.

Tanner, J. A., et al., (2018). Combinatorial pharmacogenomics and improved patient outcomes in depression: Treatment by primary care physicians or psychiatrists. Journal of Psychiatric Research, 104, 157–162.

Petersen, J. J., et al., (2014). Long-term effects of a collaborative care intervention on process of care in family practices in Germany: a 24-month follow-up study of a cluster randomized controlled trial. General Hospital Psychiatry, 36(6), 570–574.

Katon, W., Von Korff, M., Lin, E., Walker, E., Simon, G. E., Bush, T., Robinson, P., & Russo, J. (1995). Collaborative management to achieve treatment guidelines. Impact on depression in primary care. 273(13), 1026‐1031.

Knight, M. M,, & EA, H. (2008). A collaborative model for the treatment of depression in homebound elders. Issues in Mental Health Nursing, 29(9), 974–991.

Northwood, A. K., Vukovich, M. M., Beckman, A., Walter, J. P., Josiah, N., Hudak, L., O’Donnell Burrows, K., Letts, J. P., & Danner, C. C. (2020). Intensive psychotherapy and case management for Karen refugees with major depression in primary care: a pragmatic randomized control trial. 21(1), 17.

Robinson, P. et al., (1995). Primary care physician use of cognitive behavioral techniques with depressed patients. The Journal of Family Practice, 40(4), 352–357.

Robinson, P., Katon, W., Von Korff, M., Bush, T., Simon, G., Lin, E., & Walker, E. (1997). The education of depressed primary care patients: what do patients think of interactive booklets and a video? 44(6), 562‐571.

Blažeković-Milaković, S. et al., (2011). Comparison of depression treatment among different age groups in primary care setting. Psychiatria Danubina, 23(2), 183–188.

Prasko, S. et al., (2019). Antidepressant treatment outcomes in family medicine. Medicinski Glasnik : Official Publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 16(2).

Zanetidou. S. et al., (2017). Physical Exercise for Late-Life Depression: Customizing an Intervention for Primary Care. Journal of the American Geriatrics Society, 65(2), 348–355.

Malt, U. F. et al., (1999). The Norwegian naturalistic treatment study of depression in general practice (NORDEP)-I: randomised double blind study. BMJ (Clinical Research Ed.), 318(7192), 1180–1184.

Van Gurp, G., Meterissian, G. B., Haiek, L. N., McCusker, J., & Bellavance, F. (2002). St John’s wort or sertraline? Randomized controlled trial in primary care. 48, 905‐912.

Instituto Brasileiro de Geografia e Estatística (2020). Pesquisa Nacional de Saúde. Acervo IBGE.

Guimarães, L. A. et al. (2019). Sintomas depressivos e fatores associados em idosos residentes em instituição de longa permanência. Ciência & Saúde Coletiva [online]. 24(9) 3275-3282. Disponível em: <>.

Motta, C. C. L; Moré, C. L. O. O.; Nunes, C. H. S. S. (2017). O atendimento psicológico ao paciente com diagnóstico de depressão na Atenção Básica. Ciência & Saúde Coletiva, 22(3):911-920.

OPAS (2021). Depressão, Tópicos. Organização Pan-americana de Saúde.

Organização Mundial da Saúde (2021). Depression.

Ouzzani et al (2016). Rayyan — a web and mobile app for systematic reviews. Systematic Reviews 5:210, DOI: 10.1186/s13643-016-0384-4.

Santos, Cristina Mamédio da Costa, Pimenta, Cibele Andrucioli de Mattos e Nobre, Moacyr Roberto Cuce (2007). The PICO strategy for the research question construction and evidence search. Revista Latino-Americana de Enfermagem [online]. 15(3):508-511 Disponível em: <>.

Souza, M. T. de, Silva, M. D. da, & Carvalho, R. de. (2010). Integrative review: what is it? How to do it? Einstein (São Paulo), 8(1), 102–106.



How to Cite

SAMPAIO, R. V.; FIGUEIREDO, P. H. M. de; ROCHA, S. L.; LIMA, L. H. de A. Management of patients with Major Depressive Disorder in the context of Primary Health Care: a literature review. Research, Society and Development, [S. l.], v. 11, n. 2, p. e7211225539, 2022. DOI: 10.33448/rsd-v11i2.25539. Disponível em: Acesso em: 1 mar. 2024.



Review Article