Plant species of popular use in pain management: a systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i2.25608

Keywords:

ethno-directed study; validation studies; Pharmacovigilance; Curcuma longa; Mentha x piperita; Zingiber officinale.

Abstract

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage; multifactorial in nature and recognized as a public health problem. Although with synthetic drugs used in therapy, increasing popular use of plants in the treatment and/or relief of pain has been observed; a situation that deserves to be highlighted as it allows selection of plant species for validation studies, but there are risks, as the use of plant-based inputs for therapeutic purposes requires certification of efficacy, safety and quality. Thus, this work aims to carry out a review of ethno-directed studies of plant species used in popular practices for pain treatment. The search was performed in the Scielo, LILACS and Pubmed databases, including articles published from 2011 to 2021, using the descriptors “pain”, “ethnobotany” and “phytotherapy”. 66 articles were selected, with a predominance of publications in Brazil and India, in English; with 70 plant species mentioned, belonging to 40 families, predominantly the Asteraceae family (12.35%). The most mentioned plant species were Curcuma longa L. (7.14%), Zingiber officinale Roscoe (5,71%) and Mentha x piperita L. (4,28%); predominating the use of leaves (54.54%), prepared by decoction (15.15%) and aqueous extraction (13.63%). Although several plant species are popularly used to treat pain, there are still few studies on safety and efficacy certification for therapeutic use. This review indicates species to be selected for continuation with a validation study, aiming to contribute to the offer of new treatment options for pain, but raises the need for Pharmacovigilance actions in Phytotherapy.

References

Abebe, W. (2002). Herbal medication: potential for adverse interactions with analgesic drugs. Journal of Clinical Pharmacy and Therapeutics. 27, 391-401

Aché Laboratórios Farmacêuticos S.A. (2021). Bula do Medicamento Motore® (Curcuma longa). http://www.ache.com.br/Downloads/BulaRapida.aspx?ProductId=445/.

Ahmad, K. S., Hamid, A., Nawaz, F., Hameed, M., Ahmad, F., Deng, J., Akhtar, N., Wazarat, A. & Mahroof, S. (2017). Ethnopharmacological studies of indigenous plants in Kel village, Neelum Valley, Azad Kashmir, Pakistan. Journal of Ethnobiology and Ethnomedicine. 13(68). 10.1186 / s13002-017-0196-1

Albuquerque, U. P., Fonseca-Krueliv, V. S. & Hanazaki, N. (2009). Avanços nas pesquisas etnobotânicas no Brasil. Acta Botanica Brasilica. 23(2), 590–605.

Albuquerque, U. P., Medeiros, P. M., Ramos, M. A., Ferreira Júnior, W. S., Nascimento, A. L. B., Avilez, W. M. T., & Melo, J. G. (2014). Are ethnopharmacological surveys useful for the discovery and development of drugs from medicinal plants? Revista Brasileira de Farmacognosia, 24, 110 -115.

Ali Hussain, H. E. (2002). Hypoglycemic, hypolipidemic and antioxidant properties of combination of Curcumin from Curcuma longa, Linn, and partially purified product from Abroma augusta, Linn. in streptozotocin induced diabetes. Indian Journal of Clinical Biochemistry, 17(2), 33 – 43.

Alm, T. (2013). Ethnobotany of Heracleum persicum Desf. ex Fisch., an invasive species in Norway, or how plant names, uses, and other traditions evolve.Journal of Ethnobiology and Ethnomedicine, 9, 42, 10.1186/1746-4269-9-42.

Amaral, F. M. M., Oliveira, M. A., Coutinho, D. F., Godinho, J. W. L. S., Cartágenes, M. S. S., Neiva, V. A., Neiva Neto, R. R., & Bastos, W. M. (2021). Estudo de validação de espécies vegetais: o elo entre o saber popular e o fitoterápico. In: Trajetória e pesquisa nas ciências farmacêuticas. 1 ed. Ponta Grossa: Atena Editora, 1, 33 – 54.

Amorndoljai, P., Taneepanichskul, S., Niempoog, S., & Nimmannit, U. A (2017). Comparative of ginger extract in nanostructure lipid carrier (NLC) and 1% diclofenac gel for treatment of knee osteoartritis (OA). Journal of the Medical Association of Thailand, 100 (4), 447- 456.

Assis, D. B., Aragão Neto, H. C., Fonsêca, D. V., Andrade,H. H. N., Braga, R. M., Badr, N., Maia, M. S., Castro, R. D., Scotti, L., Scotti, M. T., & Almeida, R. N. (2020). Antinociceptive activity of chemical components of essential oils that involves docking studies: a review. Frontiers in Pharmacology, (29). https://doi.org/10.3389/fphar.2020.00777

Batalha Júnior, N. J. P, Amaral, F. M. M., Costa, I. S., Batalha, M. N., Coutinho, D. F., Godinho, J. W. S., Britto, M. H. S. S., & Bezerra, S. A. (2020). FARMACOVIGILÂNCIA EM FITOTERAPIA: uma breve abordagem. In: Ciências da Saúde no Brasil: Impasses e Desafios 2. 1 ed. Ponta Grossa: Atena Editora, 2, 62 -76.

Belda, A., Zaragozí, B., Belda, I., Martínez, J., & Seva, E. (2012). Traditional knowledge of medicinal plants in the Serra de Mariola Natural Park, South-eastern Spain. African Journal of Traditional, Complementary and Alternative Medicines, 10(2), 299 - 309. 10.4314/ajtcam.v10i2.15.

Bettiol, C., Dellaroza, M., Lebrão, M. L., Duarte, Y. A., & Santos, H. (2017). Fatores preditores de dor em idosos do Município de São Paulo, Brasil: Estudo SABE 2006 e 2010. Cadernos de Saúde Pública, 33, (9), e00098416. https://doi.org/10.1590/0102- 311X00098416.

Bhowmick, R., Sarwa, M. S., Dewan, S. M. R., Das, A., Das, B., Uddin, M. M. S., Islam, M. S., & Islam, M. S. (2014). In vivo analgesic, antipyretic, and anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic extract from Litsea glutinosa leaves. Biological Research, 47, 1 - 8.

Brasil. (2015). Monografia da espécie Curcuma longa L. (curcuma). Ministério da Saúde. 158p.

Brasil. (2021). Agência Nacional de Vigilância Sanitária. RDC nº 463, de 27 de janeiro de 2021. 2 ed. Formulário de Fitoterápicos da Farmacopéia Brasileira. Agência Nacional de Vigilância Sanitária. Brasília: Anvisa, 223.

Brasil. (2012). Práticas integrativas e complementares: plantas medicinais e fitoterapia na Atenção Básica. Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Básica Brasília, 156.

Campos, S. C., Silva, C. G., Campana, P. R. V., & Almeida, V. L. (2016). Toxicidade de espécies vegetais. Revista Brasileira de Plantas Medicinais, 18, 373 – 382.

Cardoso, C. M. Z., Silva, C. P., Yamagami, K., Lopes, R. P., Santos, F., Bossani, I., Jesuíno, I., Geres, F., Martorie Junior., T., Graça, M., Kaneko, B., Pavani, E., & Inowe, C. (2009). Elaboração de uma cartilha direcionada aos profissionais da área da saúde, contendo informações sobre interações medicamentosas envolvendo fitoterápicos e alopáticos. Revista Fitos, 4(1), 56 – 69.

Carmona, F., Angelucci, M. A., Sales, D. S., Chiaratti, T. M., Honorato, F. B., Bianchi, R. V., & Pereira, A. M. (2013). Lippia alba (Mill.) N. E. Brown hydroethanolic extract of the leaves is effective in the treatment of migraine in women. Fitomedicina. 20(10), 947-950. 10.1016 / j.phymed.2013.03.017.

Casanova, L. M., & Costa, S. S. (2016). Interações sinérgicas entre plantas medicinais e medicamentos. Revista Saúde e Desenvolvimento, 9(5), 4 -19.

Chekole, G. (2017). Ethnobotanical study of medicinal plants used against human ailments in Gubalafto District, Northern Ethiopia. Journal of Ethnobiology and Ethnomedicine, 13(55). 10.1186/s13002-017-0182-7.

Chen, W. Y., Yang, T., Yang, J., Qiu, Z. C., Ding, X. Y., Wang, Y. H., & Wang, Y. H. (2021). Wild plants used by the Lhoba people in Douyu Village, characterized by high mountains and valleys, in southeastern Tibet, China. Journal of Ethnobiology and Ethnomedicine, 17, (46). 10.1186/s13002-021-00472-x.

Clement, Y. N., Baksh-Comeau, Y. S., & Seaforth, C. E. (2015). An ethnobotanical survey of medicinal plants in Trinidad. Journal of Ethnobiology and Ethnomedicine, 11(67). 10.1186/s13002-015-0052-0.

Conde, R., Corrêa, V. S., Carmona, F., Contini, S. H., & Pereira, A. M. (2011). Chemical composition and therapeutic effects of Lippia alba (Mill.) N. E. Brown leaves hydro-alcoholic extract in patients with migraine. Fitomedicina, 18(14), 1197 - 1201. 10.1016 / j.phymed.2011.06.016.

Coutinho, D. F., Amaral, F. M. M., Luz, T. R. S. A., Brito, M. C. A., Almeida, J. S., Pimentel, K. B. A., Silva, M. V. S. (2020). Prescrição em fitoterapia: orientações para profissionais da área de saúde visando o uso racional de plantas medicinais e fitoterápicos, In: Ciências da Saúde: Avanços Recentes e Necessidades Sociais 2. 2 ed. Ponta Grossa: Atena Editora, 2020, 219 - 252.

Desantana, J. M., & Perissinotti, D. M. N. (2020). Definição de dor revisada após quatro décadas. Brazilian Journal of Pain, 3(3), 197 – 198.

Dias, E. C. M., Trevisan, D. D., Nagai, S. C., Ramos, N. A., & Silva, E. M. (2017). Uso de fitoterápicos e potenciais riscos de interações medicamentosas: reflexões para prática segura. Revista Baiana de Saúde Pública, 41(2), 297 – 307.

Dresch, R. R., Libório, Y. B., Czermainski, S., & Costa, B. (2021). Compilação de levantamentos de uso de plantas medicinais no Rio Grande do Sul. Physis: Revista de Saúde Coletiva, 31(2), 1 -14.

Galvão, T. F., & Pereira, M. G. (2014). Revisões sistemáticas da literatura: passos para sua elaboração. Epidemiologia e Serviços de Saúde, 23, 183-184.

Ghavipour, M., Sotoudeh, G., Tavakoli, E., Mowla, K., Hasanzadeh, J., & Mazloom, Z. (2017). Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in Rheumatoid Arthritis patients. European Journal of Clinical Nutrition, 71(1), 92 – 96. 10.1038 / ejcn.2016.151.

Godinho, J. W. L. S. (2014). Atenção Farmacêutica em Fitoterapia: avaliação da comercialização e controle de qualidade de amostras de Passiflora edulis Sims. adquiridas em farmácias e drogarias no município de São Luís, estado do Maranhão. 31f. Monografia (Graduação em Farmácia Bioquímica) - Universidade Federal do Maranhão, São Luís, 2014.

Griz, S. A. S., Matos-Rocha, T. J., Santos, A. F., Costa, J. G., & Mousinho, K. C. (2017). Medicinal plants profile used by the 3rd District population of Maceió-AL. Brazilian Journal of Biology, 77(4),794 - 802. 10.1590 / 1519-6984.01116.

Hasenclever, L., Paranhos, J., Costa, C. R., Cunha, G., & Vieira, D. (2017). A indústria de fitoterápicos brasileira: desafios e oportunidades. Ciência & Saúde Coletiva, 22(8), 2559 - 2569.

Hashempur, M. H., Sadrneshin, S., Mosavat, S. H., & Ashraf, A. (2016). Green tea (Camellia sinensis) for patients with knee osteoarthritis: A randomized open-label active-controlled clinical trial. Clinical Nutrition, 37(1), 85 - 90. 10.1016 / j.clnu.2016.12.004.

Heydari, M., Homayouni, K., Hashempur, M. H., & Shams, M. (2016). Topical Citrullus colocynthis (bitter apple) extract oil in painful diabetic neuropathy: A double-blind randomized placebo-controlled clinical trial. Journal of Diabetes, 8(2), 246 - 252. 10.1111 / 1753-0407.12287.

Hosseini, S. H, Bibak, H. Ghara, A. R, Sahebkar, A, & Shakeri, A. (2021). Ethnobotany of the medicinal plants used by the ethnic communities of Kerman province, Southeast Iran. Journal of Ethnobiology and Ethnomedicine, 17(1), 31. 10.1186 / s13002-021-00438-z.

IASP. Defending the IASP definition of pain. Monist 2017, 100, 439–464.

Islam, A. T. M. R, Hasan, M, Islam, T., Rahman, A., Mitra, S., & Das, S. K. (2020). Ethnobotany of Medicinal Plants Used by Rakhine Indigenous Communities in Patuakhali and Barguna District of Southern Bangladesh. Journal of Evidence-based Integrative Medicine, 25, 2515690X20971586. 10.1177 / 2515690X20971586.

Jorim, R. Y., Korape, S., Legu, W., Koch, M., Barrows, L. R., Matainaho, T. K., & Rai, P. P. (2012). An ethnobotanical survey of medicinal plants used in the eastern highlands of Papua New Guinea. Journal of Ethnobiology and Ethnomedicine, 8 (47). 10.1186 / 1746-4269-8-47.

Kazanci, C., Oruç, S., & Mosulishvili, M. (2020). Medicinal ethnobotany of wild plants: a cross-cultural comparison around Georgia-Turkey border, the Western Lesser Caucasus. Journal of Ethnobiology and Ethnomedicine, 16 (1) 71. 10.1186 / s13002-020-00415-y.

Kuptniratsaikul, V., Dajpratham, P., Taechaarpornkul, W., Buntragulpoontawee, M., Lukkanapichonchut, P., Chootip, C., Saengsuwan, J., Tantayakom, K., & Laongpech, S. (2014). Eficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clinical Interventions in Aging, 9, 451 - 458. 10.2147 / CIA.S58535.

Kutal, D. H., Kunwar, R. M., Uprety, Y., Adhikari, Y. P., Bhattarai, S., Adhikari, B., Kunwar, L. M., Bhatt, M. D., & Bussmann, R. W. (2021). Selection of medicinal plants for traditional medicines in Nepal. Journal of Ethnobiology and Ethnomedicine, 17, (1) 59. 10.1186 / s13002-021-00486-5.

Lauche, R., Gräf, N., Cramer, H., Al-Abtah, J., Dobos, G., & Saha, F. J. (2016). Efficacy of Cabbage Leaf Wraps in the Treatment of Symptomatic Osteoarthritis of the Knee: A Randomized Controlled Trial. The Clinical Journal of Pain, 32, (11), 961 - 971. 10.1097 / AJP.0000000000000352.

Lucena, C. M., Lucena, R. F., Costa, G. M., Carvalho, T. K., Costa, G. G., Alves, R. R., Pereira, D. D., Ribeiro, J. E., Alves, C. A., Quirino, Z. G. & Nunes, E. N. (2013). Use and knowledge of Cactaceae in Northeastern Brazil. Journal of Ethnobiology and Ethnomedicine, 9, (62). 10.1186 / 1746-4269-9-62.

Maema, L. P, Potgieter, M, & Mahlo, S. M. (2016). Nvasive Alien Plant Species Used For The Treatment Of Various Diseases In Limpopo Province, South Africa. African Journal of Traditional, Complementary, and Alternative Medicines, 13, (4), 223 – 231. 10.21010 / ajtcam.v13i4.29.

Magalhães, P. K. A, Araujo, E. N, Santos, A. M, Vanderlei, M. B, Souza, C. C. L, Correia, M. S, Fonseca, S. A, Pavão, J. M. J. S, Souza, M. A, Costa, J. G, Santos, A. F, & Matos-Rocha, T. J. (2021). Ethnobotanical and ethnopharmacological study of medicinal plants used by a traditional community in Brazil's northeastern. Brazilian Journal of Biology, 82, e2376424. 10.1590 / 1519-6984.237642.

Malik, K., Ahmad, M., Zafar, M, Ullah, R., Mahmood, H. M., Parveen, B., Rashid, N., Sultana, S., Shah, S. N., & Lubna. (2019). An ethnobotanical study of medicinal plants used to treat skin diseases in northern Pakistan. BMC Complementary and Alternative Medicine, 19, (1), 210. 10.1186 / s12906-019-2605-6.

Marchi, J. P., Tedesco, L., Melo, A. Da C., Frasson, A. C., França, V. F., Sato, S. W., & Lovato, E. C. W. (2016). Curcuma longa L.:o açafrão da terra, e seus benefícios medicinais. Arquivos de Ciências da Saúde da UNIPAR, 20, (3), 189-194.

Marques, M. A. A., Lima, D. A., Andreotti, C. E., Gasparotto Junior, A., & Lourenço, E. L. B. (2016). Caracterização das plantas medicinais e medicamentos fitoterápicos para tratamento da osteoporose utilizados no Brasil. Arquivos de Ciências da Saúde, 20(3), 183 - 188.

Medeiros, M. F., & De Albuquerque, U. P. (2012). The pharmacy of the Benedictine monks: the use of medicinal plants in Northeast Brazil during the nineteenth century (1823-1829). Journal of Ethnopharmacology, 139(1), 280 - 286. 10.1016 / j.jep.2011.11.014.

Medeiros, P. M., Figueiredo, K. F., Gonçalves, P. H. S., Caetano, R. A., Santos, É. M. D. C., Dos Santos, G. M. C., Barbosa, D. M., De Paula, M., & Mapeli, A. M. (2021). Wild plants and the food-medicine continuum-an ethnobotanical survey in Chapada Diamantina (Northeastern Brazil). Journal of Ethnobiology and Ethnomedicine, 17, (1), 37. 10.1186 / s13002-021-00463-y.

Miguéis, G. D. S., Da Silva, R. H., Damasceno Júnior, G. A., & Guarim-Neto, G. (2019). Plants used by the rural community of Bananal, Mato Grosso, Brazil: Aspects of popular knowledge. Plos One, 14, 1, e0210488. 10.1371 / journal.pone.0210488.

Mongalo, N. I., & Makhafola, T. J. (2018). Ethnobotanical knowledge of the lay people of Blouberg area (Pedi tribe), Limpopo Province, South Africa. Journal of Ethnobiology and Ethnomedicine, 14(1), 46. 10.1186 / s13002-018-0245-4.

Montesano, V. Negro, D., Sarli, G., De Lisi, A., Laghetti, G., & Hammer, K. (2012). Notes about the uses of plants by one of the last healers in the Basilicata region (South Italy). Journal of Ethnobiology and Ethnomedicine, 8, 15. 10.1186 / 1746-4269-8-15.

Mozaffari-Khosravi, H., Naderi, Z., Dehghan, A., Nadjarzadeh, A., & Fallah Huseini, H. (2016). Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial. Journal of Nutrition in Gerontology and Geriatrics, 35(3), p. 209 - 218. 10.1080 / 21551197.2016.1206762.

Musharraf, M. U., Ahmad, Z., & Yaqub, Z. (2017). Comparison of topical capsaicin and topical turpentine Oil for treatment of painful diabetic neuropathy. Journal of Ayub Medical College, Abbottabad: JAMC, 29, (3), 384 - 387.

Nash, R. J., Azantsa, B. K., Sharp, H., & Shanmugham, V. (2018). Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial. Clinical Interventions in Aging, 13, 2119 - 2126. 10.2147 / CIA.S173227.

Nasiri, A., Mahmodi, M. A., & Nobakht, Z. (2016). Effect of aromatherapy massage with lavender essential oil on pain in patients with osteoarthritis of the knee: A randomized controlled clinical trial. Complementary Therapies in Clinical Practice, 25, 75 - 80. 10.1016 / j.ctcp.2016.08.002.

Nicoletti, M. A., Carvalho, K. C., Oliveira Jr, M. A., Bertasso, C. C., Caporossi, P. Y., & Tavares, A. P. L. (2010). Popular use of medicines containing drugs from vegetal source and/or medicinal plants: main interactions resulting from that. Revista Saúde, 4(1), 25 – 39.

Nicoletti, M. A., Oliveira-Júnior, M. A., Bertasso, C.C., Caporossi, P. Y., & Tavares, A. P. L. (2007).Principais interações no uso de medicamentos fitoterápicos. Infarma, 19, (1/2), 32 – 40.

Niempoog, S., Pawa, K. K., & Amatyakul, C. (2012). The Efficacy of Powdered Ginger in Osteoarthritis of The Knee. The Journal of Medical Association of Thailand, 95(1), 59. http://jmatonline.com/index.php/jmat/article/view/1904/0.

Novotna, B., Polesny, Z., Pinto-Basto, M. F., Van Damme, P., Pudil, P., Mazancova, J., & Duarte, M. C. (2020). Medicinal plants used by 'root doctors', local traditional healers in Bie province, Angola. Journal of Ethnopharmacology, 26. https://doi.org/10.1016/j.jep.2020.112662.

Oliveira, F. C., Silveira, P. F., Bandeira, M. A. M., & Arrais, P. S. D. (2008). Farmacovigilância e reações adversas às plantas medicinais e fitoterápicos: uma realidade. Revista Brasileira de Farmacognosia, 18, 618 - 626.

Oliveira, F. C., Albuquerque, U. P., Fonseca-Krueliv, V. S., & Hanazaki, N. (2009). Avanços nas pesquisas etnobotânicas no Brasil. Acta Botanica Brasilica, 23(2), 590 – 605.

Pedrollo, C. T, Kinupp, V. F, Shepard, G. Jr, & Heinrich, M. (2016). Medicinal plants at Rio Jauaperi, Brazilian Amazon: Ethnobotanical survey and environmental conservation. Journal of Ethnopharmacology, 186, 111-124. 10.1016 / j.jep.2016.03.055.

Pereira, J. B. A., Rodrigues, M. M., Morais, I. R., Vieira, C. R. S., Sampaio, J. P. M., Moura, M. G., Damasceno, M. F. M., Silva, J. N., Calou, I. B. F., Deus, F. A., Peron, A. P, Abreu, M. C., Militão, G. C. G., & Ferreira, P. M. P. (2015). O papel terapêutico do Programa Farmácia Viva e das plantas medicinais. Revista Brasileira de Plantas Medicinais, 17(4), 550 - 561.

Posso, I. P., Palmeira, C. C. A., & Vieira, E. B. M. (2016). Epidemiology of neuropathic pain. Revista Dor, 17, S11-14.

Quintans, J.S., Antoniolli, Â.R., Almeida, J.R., Santana-Filho, V. J., & Quintans-Júnior, L.J. (2014). Natural Products Evaluated in Neuropathic Pain Models - A Systematic Review. Basic & Clinical Pharmacology & Toxicology, 114, 442 - 450.

Quiroga, R, Meneses, L, & Bussmann, R. W. (2012). Etnobotânica medicinal em Huacareta (Chuquisaca, Bolívia). Journal of Ethnobiology and Ethnomedicine,8(29). 10.1186 / 1746-4269-8-29.

Rahmatullah, M., Khatun, Z., Hasan, A., Parvin, W., Moniruzzaman, M., Khatun, A., Mahal, M. J., Bhuiyan, M. S., Mou, S. M., & Jahan, R. (2012). Survey and scientific evaluation of medicinal plants used by the Pahan and Teli tribal communities of Natore district, Bangladesh. African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM, 9(3) 366 - 373. 10.4314 / ajtcam.v9i3.10.

Raja, S.N., Carr, D.B., Cohen, M., Finnerup, N. B., Flor, H., Gibson, S., Keefeh, F. J., Mogili , J. S., Ringkampj , M., Slukak , K. A., Songl , X., Stevensm, B., Sullivann , M. D., Tutelmano , P. R., Ushidap , T., & Vaderq, K. (2020). The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. https://drmichaelstafford.com/wp- content/uploads/2020/07/The_revised_International_Association_for_the.98346.pdf.

Rakotoarivelo, N. H., Rakotoarivony, F., Ramarosandratana, A. V. Jeannoda, V. H., Kuhlman, A. R., Randrianasolo, A., & Bussmann, R. W. (2015). Medicinal plants used to treat the most frequent diseases encountered in Ambalabe rural community, Eastern Madagascar. Journal of Ethnobiology and Ethnomedicine, 11(68). 10.1186 / s13002-015-0050-2.

Rudrappa, G. H., Chakravarthi, P. T., & Benny, I. R. (2020). Efficacy of high-dissolution turmeric-sesame formulation for pain relief in adult subjects with acute musculoskeletal pain compared to acetaminophen: A randomized controlled study. Medicine, 99(28), e20373. 10.1097 / MD.0000000000020373.

Santos, M. R. A., Lima, M. R., & Oliveira, C. L. L. G. (2014). Medicinal plants used in Rondônia, Western Amazon, Brazil / Plantas medicinais usadas em Rondônia, Amazônia Ocidental, Brasil. Revista Brasileira de Plantas Medicinais, 16(3) 707 – 720.

Shep, D., Khanwelkar, C., Gade, P., & Karad, S. (2020). Efficacy and safety of combination of curcuminoid complex and diclofenac versus diclofenac in knee osteoarthritis: A randomized trial. Medicine, 99(16), e19723. 10.1097 / MD.0000000000019723.

Shoara R, Hashempur Mh, Ashraf A, Salehi A, Dehshahri S, & Habibagahi Z. (2015). Efficacy and safety of topical Matricaria chamomilla L. (chamomile) oil for knee osteoarthritis: A randomized controlled clinical trial. Complementary Therapies in Clinical Practice, 21(3), 181 - 187. 10.1016 / j.ctcp.2015.06.003.

Silva, A. G., Machado, E. R., Almeida, L. M., Nunes, R. M., Giesbrecht, P. C., Costa, R. M., Costa, H. B., Romão, W., & Kuster, R. M. A (2015). Clinical Trial with Brazilian Arnica (Solidago chilensis Meyen) Glycolic Extract in the Treatment of Tendonitis of Flexor and Extensor Tendons of Wrist and Hand. Phytotherapy Research: PTR, 29(6), 864 - 869. 10.1002 / ptr.5323.

Silva, O. N., Amaral, F. M. M., Godinho, J. W. L.S., Ferreira, T. T. D., Coutinho, D. F., Neiva, V. A., Neiva Neto, R. R., & Bastos, W. M. (2021). Toxicidade de plantas de uso medicinal: desmitificando o “se natural, não faz mal”. In: Trajetória e pesquisa nas ciências farmacêuticas. 1 ed. Ponta Grossa: Atena Editora, 1, 11 - 32.

Simões, C. O. M., Schenkel, E. P., Mello, J. C. P., Mentz, L. A., & Petrovick, P. R. (2017). Farmacognosia: do produto natural ao medicamento. 1. ed. Porto Alegre: Artmed, 486.

Singh, A. G., Kumar, A., & Tewari, D. D. (2012). An ethnobotanical survey of medicinal plants used in Terai forest of western Nepal. Journal of Ethnobiology and Ethnomedicine, 8, 19. 10.1186 / 1746 - 4269-8-19.

Singla, R. K., Guimarães, A. G., Zengin, G. (2021). Application of plant secondary metabolites to pain neuromodulation. Frontiers in Pharmacology, 14. https://doi.org/10.3389/fphar.2020.623399.

Silveira, P. F., Bandeira, M. A. M., & Arrais, P. S. D. (2008). Farmacovigilância e reações adversas às plantas medicinais e fitoterápicos: uma realidade. Revista Brasileira de Farmacognosia, 18, 618 – 626.

Soo-May, L., Sanip, Z., Ahmed-Shokri, A., Abdul-Kadir, A. M. D., & Lazin, M. R. (2018). The effects of Momordica charantia (bitter melon) supplementation in patients with primary knee osteoarthritis: A single-blinded, randomized controlled trial. Complementary Therapies in Clinical Practice, 32, 181 - 186. 10.1016 / j.ctcp.2018.06.012 .

Souza, G. R., Silva, J. C, Oliveira Júnior, R. G, Lima-Saraiva, S. R. G., Guimarães, A. L., Oliveira, A. P, & Almeida, J. R. G. S. (2015). Atividade antinociceptiva do extrato etanólico das folhas de Morus nigra L. (Moraceae). Revista de Ciências Farmacêuticas Básica e Aplicada, 36(1), 137 - 142.

Tabuti, J. R., Kukunda, C. B., Kaweesi, D., & Kasilo, O. M. (2012). Herbal medicine use in the districts of Nakapiripirit, Pallisa, Kanungu, and Mukono in Uganda. Journal of Ethnobiology and Ethnomedicine, 8(35). 10.1186 / 1746-4269-8-35.

Tovar, R. T., & Petzel, R. M. (2009). Herbal toxicity. Disease-a-month: DM, 55(10), 592 - 641. doi.org/10.1016/j.disamonth.2009.05.001.

Tugume, P., Kakudidi, E. K., Buyinza, M., Namaalwa, J., Kamatenesi, M., Mucunguzi, P., & Kalema, J. (2016). Ethnobotanical survey of medicinal plant species used by communities around Mabira Central Forest Reserve, Uganda. Journal of Ethnobiology ond Ethnomedicine, 12, (5). 10.1186 / s13002-015-0077-4.

Tugume, P., & Nyakoojo, C. (2019). Ethno-pharmacological survey of herbal remedies used in the treatment of pediatric diseases in Buhunga parish, Rukungiri District, Uganda. BMC Complementary and Alternative Medicine, 19(1), 353. doi.org/10.1186/s12906-019-2763-6.

Uddin, M. S., Mamun, A. A., Sumsuzzman, D. M., Ashraf, G. M., Perveen, A., Bungau, S. G., Mousa, S. A., El-Seedi, H. R., Bin-Jumah, M. N., & Abdel-Daim, M. M. (2020). Emerging promise of cannabinoids for the management of pain and associated neuropathological alterations in Alzheimer's disease. Frontiers in Pharmacology, 11, 1097. https://doi.org/10.3389/fphar.2020.01097.

Vasconcelos, F. H., & Araújo, G. C. (2018). Prevalência de dor crônica no Brasil: estudo descritivo. Brazilian Journal of Pain, 1(2), 176 -179.

Wang, Z., Jones, G., Winzenberg, T., Cai., G, Laslett, L. L., Aitken, D., Hopper, I., Singh, A., Jones, R., Fripp, J., Ding, C., & Antony, B. (2020). Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis: A Randomized Trial. Annals of Internal Medicin,, 173(11), 861-869. 10.7326/M20-0990. Epub 2020 Sep 15. PMID: 32926799

World Health Organization. WHO (1999). Monographs on selected medicinal plants. Geneva: World Health Organization. 1, 295.

World Health Organization. WHO. (2002). Traditional Medicine: Growing Needs and Potential. 2, 357.

Published

23/01/2022

How to Cite

OLIVEIRA, A. C. da S. de .; BATALHA JUNIOR, N. de J. P. .; SEREJO, A. P. M.; COSTA, I. S.; OLIVEIRA NETO, A. C. de; GODINHO, J. W. L. da S. .; KZAM, P. M.; AMARAL, F. M. M. do. Plant species of popular use in pain management: a systematic review. Research, Society and Development, [S. l.], v. 11, n. 2, p. e22511225608, 2022. DOI: 10.33448/rsd-v11i2.25608. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/25608. Acesso em: 29 feb. 2024.

Issue

Section

Health Sciences