The neuroendocrine role in the control of hunger and satiety and its relationship with obesity

Authors

DOI:

https://doi.org/10.33448/rsd-v11i2.25621

Keywords:

Obesity; Hunger; Satiety.

Abstract

Obesity is a chronic disorder of multifactorial origin (neuroendocrine, psychic, intestinal and genetic factors) that results from a metabolic-energetic imbalance, whereby a long-term excess of energy intake over expenditure leads to accumulation in the form of fat. The control of the energy balance is carried out by the central nervous system by means of necessary neuroendocrines, in which peripheral circulating hormones, such as leptin and insulin, signal specialized neurons of the hypothalamus over the body's fat stores and induce adequate responses for the maintenance of stocks god stability. Thus, the positive energy balance for a long period, determined by macronutrient intake, energy expenditure and thermogenesis, will result in body weight gain in the form of fat, while the negative energy balance will result in no opposite effect. In this systematic review of works published between 2008 and 2021, neuroendocrine mechanisms that control hunger and satiety, and their relationship with obesity, will be discussed. Thus evidencing that this regulation is carried out by a complex mechanism that needs to be very well understood in order to treat or even prevent obesity.

References

Araújo, T. F. D., Guimarães, D. F., Ferreira, F. R., Luz, J. C. D. M., & Spini, V. B. M. G. (2009). Leptina e o controle neuroendócrino do peso corporal. RBM Revista Brasileira de Medicina, 66(10), 325-30.

Bauer, P. V., Hamr, S. C., & Duca, F. A. (2016). Regulation of energy balance by a gut–brain axis and involvement of the gut microbiota. Cellular and molecular life sciences, 73(4), 737-755. https://doi.org/10.1007/s00018-015-2083-z

Borsato, D., Zanetti, C., Kalegari, M., Zanin, S., & Miguel, M. (2008). O papel do farmacêutico na orientação da obesidade. Visão acadêmica, 9(1). http://dx.doi.org/10.5380/acd.v9i1.14636

Bressan, J., Hermsdorff, H. H., Zulet, M. Á., & Martínez, J. A. (2009). Impacto hormonal e inflamatório de diferentes composições dietéticas: ênfase em padrões alimentares e fatores dietéticos específicos. Arquivos Brasileiros de Endocrinologia & Metabologia, 53, 572-581. https://doi.org/10.1590/S0004-27302009000500010

Brown, R. E. (2008). Could there be a fine-tuning role for brain-derived adipokines in the regulation of bodyweight and prevention of obesity?.McGill Journal of Medicine: MJM, 11(2), 177–184.

Damiani, D., & Damiani, D. (2011). Sinalização cerebral do apetite. Revista da Sociedade Brasileira de Clínica Médica, 9(2), 138-45.

Feijó, F. D. M., Bertoluci, M. C., & Reis, C. (2011). Serotonina e controle hipotalâmico da fome: uma revisão. Revista da Associação Médica Brasileira, 57, 74-77.

Ferreira, A. de S. (2020). Consulta de enfermagem na Estratégia Saúde da Família: Prevenção do sobrepeso e obesidade infantil. Research, Society and Development, 9(5), e17952610. https://doi.org/10.33448/rsd-v9i5.2610

González-munieza, P., Mártinez-gonzález, M.A., Hu, F.B., Després, J.P., Matsuzawa, Y., Loos, R.J.F., Moreno, L.A., Bray, G.A., & Martinez, J.A. (2017). Obesity. Nature reviews. Disease primers, 3, 17034. https://doi.org/10.1038/nrdp.2017.34

Hallschmid, M., Benedict, C., Schultes, B., Born, J., & Kern, W. (2008). Obese men respond to cognitive but not to catabolic brain insulin signaling. International journal of obesity, 32(2), 275-282. https://doi.org/10.1038/sj.ijo.0803722

Jastroch, M., Morin, S., Tschöp, M. H., & Yi, C. X. (2014). The hypothalamic neural–glial network and the metabolic syndrome. Best Practice & Research Clinical Endocrinology & Metabolism, 28(5), 661-671. https://doi.org/10.1016/j.beem.2014.02.002

Landeiro, F. M., & Quarantini, L. de C. (2011). Obesidade: Controle Neural e Hormonal do Comportamento Alimentar. Revista de Ciências Médicas e Biológicas, 10(3), 236–245. https://doi.org/10.9771/cmbio.v10i3.5883

Leite, L. D., & Neto, J. (2009). Integração neuroendócrina na regulação da ingestão alimentar. Neurobiologia, 72(2), 127-143.

Machado, W., Monteiro, E. R., & Salerno, V. (2016). Leptina e exercício físico: mecanismos para controle do peso corporal. Revista Brasileira de Prescrição e Fisiologia do Exercício, 9(54), 471-480.

Madsbad S. (2014). The role of glucagon-like peptide-1 impairment in obesity and potential therapeutic implications. Diabetes, Obesity & Metabolism, 16(1), 9–21. https://doi.org/10.1111/dom.12119

Mishra, A. K., Dubey, V., & Ghosh, A. R. (2016). Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota. Metabolism: clinical and experimental, 65(1), 48–65. https://doi.org/10.1016/j.metabol.2015.10.008

Morales Clavijo, M., & Carvajal Garcés, C. F. (2010). Obesidad y resistencia a la leptina. Gaceta médica boliviana, 33(1), 63-68.

Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014). Neurobiology of food intake in health and disease. Nature reviews. Neuroscience, 15(6), 367–378. https://doi.org/10.1038/nrn3745

Perelló, M., & Zigman, J. M. (2012). The role of ghrelin in reward-based eating. Biological psychiatry, 72(5), 347–353. https://doi.org/10.1016/j.biopsych.2012.02.016

Prado, E. S., Almeida, R. D. D., & Melo, L. A. D. (2008). Controle do apetite e exercício físico: uma atualização. Revista Brasileira de Ciência e Movimento, 16(2): 109-116

Ribeiro, E. B. (2009). Studying the central control of food intake and obesity in rats. Revista de Nutrição, 22 (1), 163-171. https://doi.org/10.1590/S1415-52732009000100015

Rodrigues, G. B. de O., Lima, G. P., Sampaio, H. A. de C., Pinto, F. J. M., Carneiro, C., Cordeiro, M. D., & Carioca, A. A. F. (2021). A Escala de Analogia Visual do Apetite como ferramenta de apoio na detecção do risco de fracasso da persistência de perda de peso de pacientes com obesidade submetidos à gastroplastia. Research, Society and Development, 10(7), e50410716568. https://doi.org/10.33448/rsd-v10i7.16568

Saltiel, A. R., & Olefsky, J. M. (2017). Inflammatory mechanisms linking obesity and metabolic disease. The Journal of Clinical Investigation, 127(1), 1–4. https://doi.org/10.1172/JCI92035

Santanna, S., Caiado, N. M., & Silva, L. D. (2014). Neuromodulação Hipotalâmica: uma proposta terapêutica para obesidade. Revista Medicina e Saúde de Brasília, 3(2), 192-204.

Schneeberger, M., Gomis, R., & Claret, M. (2014). Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance. The Journal Of Endocrinology, 220(2), T25–T46. https://doi.org/10.1530/JOE-13-0398

Stoeckel, L. E., Birch, L. L., Heatherton, T., Mann, T., Hunter, C., Czajkowski, S., Onken, L., Berger, P. K., & Savage, C. R. (2017). Psychological and neural contributions to appetite self-regulation. Obesity (Silver Spring, Md.), 25 Suppl 1(Suppl 1), S17–S25. https://doi.org/10.1002/oby.21789

Valassi, E., Scacchi, M., & Cavagnini, F. (2008). Neuroendocrine control of food intake. Nutrition, metabolism, and cardiovascular diseases. NMCD, 18(2), 158–168. https://doi.org/10.1016/j.numecd.2007.06.004

Van de Sande-Lee, S., & Velloso, L. A. (2012). Disfunção hipotalâmica na obesidade. Arquivos Brasileiros de Endocrinologia & Metabologia, 56 (6), 341-350. https://doi.org/10.1590/S0004-27302012000600001

Veiga, L. (2016). Obesidade: regulação hormonal. Saúde & Tecnologia, (16), 5-15. http://dx.doi.org/10.25758/set.1421

Velloso, L. A., & Schwartz, M. W. (2011). Altered hypothalamic function in diet-induced obesity. International Journal Of Obesity, 35(12), 1455–1465. https://doi.org/10.1038/ijo.2011.56

Wanderley, E. N., & Ferreira, V. A. (2010). Obesidade: uma perspectiva plural. Ciência & Saúde Coletiva, 15(1), 185-194. https://doi.org/10.1590/S1413-81232010000100024

World Healthy Organization (WHO). (2021). Obesity and overweight. Genebra. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight

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Published

26/01/2022

How to Cite

SILVA, S. S. da; SILVA, S. H.; AGUIAR, G. A. .; BATISTA, S. O. .; SANTOS , A. C. M.; BANDEIRA, F. L. C. .; ALVES, M. T.; SILVA, Áthila G. F. da; SOUSA, V. A. de; RODRIGUES, C. N. da S.; SILVA, N. C. da; SOUZA, L. A. de; OLIVEIRA , T. R. J. .; CARDOSO, B. S. .; GONÇALVES, J. B. da S. The neuroendocrine role in the control of hunger and satiety and its relationship with obesity. Research, Society and Development, [S. l.], v. 11, n. 2, p. e33311225621, 2022. DOI: 10.33448/rsd-v11i2.25621. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/25621. Acesso em: 19 apr. 2024.

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Vol. 11 No. 2

Section

Review Article

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Copyright (c) 2022 Saray Sallin da Silva; Shara Hozana Silva; Géssica Adorno Aguiar; Stefane Oliveira Batista; Ana Clara Marinho Santos ; Fernanda Láuria Chaves Bandeira; Maryana Teixeira Alves; Áthila Gabriele Ferreira da Silva; Vanessa Alves de Sousa; Cicera Natália da Silva Rodrigues; Nibsyan Cristina da Silva; Letícia Aparecida de Souza; Thaysa Renata Jorge Oliveira ; Bianca Silva Cardoso; Josyane Borges da Silva Gonçalves

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