Metaplasia and histopathological lesions of the esophageal mucosa

Authors

DOI:

https://doi.org/10.33448/rsd-v11i2.25778

Keywords:

Esophageal mucosa; Metaplasia; Carcinogenesis.

Abstract

Metaplasia is a reversible adaptive process, which occurs in a cell type that, upon a stimulus, undergoes the replacement of another cell type of similar lineage. Objective: to identify the prevalence of metaplasia in esophageal mucosal samples and evaluate the relationship between metaplasia and histopathological lesions. Method: cross-sectional, retrospective study with a sample of 1953 histopathological reports of the esophageal mucosa. Results: from 1953 reports, 548 (28.1%) had metaplasia, 94 (17.1%) of the intestinal type and of these 35 (6.4%) were focal; 133 (6.8%) had Barrett's esophagus, 414 (75.5%) with gastric ectopia, 21 (1.1%) with dysplasia, 12 (57.1%) with low grade and 9 (42.9 %) high degree and 1427 (73.1%) reports presented esophagitis. The median age group of patients with metaplasia was 45 years (IIQ 34-55), with 289 (51.7%) female and 438 (81.4%) from the capital. Of the reports with metaplasia, 46 (8.2%) had Helicobacter pylori, 30 (5.3%) Barrett's esophagus and 14 (2.6%) had gastric atrophy associated with bacteria, however there was no significant association with H. pylori. The association of metaplasia with esophagitis, eosinophilic esophagitis and adenomatous polyp was statistically significant (p<0.001). Together, we observed a lower risk of metaplasia in the presence of esophagitis (RR: 0.44; 95%CI: 0.36-0.55) and higher in the presence of Eosinophils >=15 eos/CGA (RR: 3.27; 95%CI %: 1.70-6.62). Conclusion: We have no evidence of a relationship between esophageal metaplasia and H.pylori. The absence of esophagitis and the presence of Eosinophils >=15 eos/CGA is associated with an increased risk of metaplastic transformation.

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Published

25/01/2022

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MOURA, E. R. .; SOUZA, G. B. V. de .; TRINDADE, Y. T. D. .; SANTANA NETO, D. J. de .; MOREIRA, L. G. .; SILVA, W. S. .; BARRETO, Íkaro D. de C. .; SILVA, D. F. da .; MEURER, L.; TRINDADE, L. M. D. F. . Metaplasia and histopathological lesions of the esophageal mucosa. Research, Society and Development, [S. l.], v. 11, n. 2, p. e29711225778, 2022. DOI: 10.33448/rsd-v11i2.25778. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/25778. Acesso em: 19 apr. 2024.

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Vol. 11 No. 2

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Health Sciences

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Copyright (c) 2022 Elomar Rezende Moura; Gabrielle Barbosa Vasconcelos de Souza; Yasmin Tourinho Delmondes Trindade; Durval José de Santana Neto; Larissa Gonçalves Moreira; Wianne Santos Silva; Íkaro Daniel de Carvalho Barreto; Décio Fragata da Silva; Luíse Meurer; Leda Maria Delmondes Freitas Trindade

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