Relationship between uncontrolled use of alcoholic beverages and memory loss




Alcohol abuse; Central Nervous System Disease; Memory loss.


The consumption of alcoholic beverages is related as a cause of more than 200 types of diseases, mainly liver cirrhosis, cardiovascular diseases and several types of cancer. The light-moderate use of alcoholic beverages, unlike heavy consumption, does not have clear influencing factors for the main diseases mentioned. This article aimed to elucidate the relationship between uncontrolled consumption of alcoholic substances and memory loss, based on highly credible research. It was an integrative exploratory literature review based on the analysis of eleven selected articles, which addressed the consequences of alcohol consumption in sufficient quantities capable of promoting changes in the homeostasis of the central nervous system. Through this review of human neuropathology related to alcohol, it was possible to identify some main factors that justify the pathologies caused by the consumption of alcoholic beverages. The results showed that excessive alcohol consumption negatively affects verbal episodic memory processes, i.e. storage and recall, as well as monitoring of verbal learning tasks. In addition to memory loss, other pathologies stood out in all studies, including metabolic damage to the central nervous system, damage to the hippocampus and frontal cortex, loss of cognitive flexibility and accelerated aging. It is concluded that there is a negative relationship between excessive consumption of alcoholic substances and memory loss.


Abrahao, K. P., Salinas, A. G., & Lovinger, D. M. (2017). Alcohol and the Brain: Neuronal Molecular Targets, Synapses, and Circuits. Neuron, v. 96 (6), 1223–1238. 10.1016/j.neuron.2017.10.032.

Bø, R., Aker, M., Billieux, J., & Landrø, N. I. (2016). Binge Drinkers Are Fast, Able to Stop – but They Fail to Adjust. J. Int. Neuropsychol. Soc. 22, 38–46. 10.1017/S1355617715001204

Carbia, C., Cadaveira, F., Caamaño-Isorna, F., Rodríguez-Holguín, S., & Corral, M. (2017). Binge drinking during adolescence and young adulthood is associated with deficits in verbal episodic memory. PloS one, 12(2), 01–08. 10.1371/journal.pone.0171393

Carbia, C., López-Caneda, E., Corral, M., & Cadaveira, F. (2018). A systematic review of neuropsychological studies involving young binge drinkers. Neuroscience and biobehavioral reviews, 90, 332–349. 10.1016/j.neubiorev.2018.04.013

Cheetham, A., Allen, N. B., Whittle, S., Simmons, J., Yücel, M., & Lubman, D. I. (2014). Volumetric differences in the anterior cingulate cortex prospectively predict alcohol-related problems in adolescence. Psychopharmacology, 231(8), 1731–1742.

Clapp, P., Wackernah, R., & Minnick, M. (2014). Alcohol use disorder: pathophysiology, effects, and pharmacologic options for treatment. Substance Abuse and Rehabilitation, 1–. 10.2147/SAR.S37907

Cservenka, A. & Brumback, T. (2017). The burden of binge and heavy drinking on the brain: effects on adolescent and young adult neural structure and function. Front Psychol. 8, 1111. 0.3389/fpsyg.2017.01111

De la Monte, S. M. & Kril, J. J. (2014). Human alcohol-related neuropathology. Acta neuropathologica, 127(1), 71-90. 10.1007/s00401-013-1233-3

Gierski, F., Stefaniak, N., Benzerouk, F., Gobin, P., Schmid, F., Henry, A., Kaladjian, A., & Naassila, M. (2020). Component process analysis of verbal memory in a sample of students with a binge drinking pattern. Addictive behaviors reports, 12, 100323. 10.1016/j.abrep.2020.100323

Kojima, G., Liljas, A. Iliffe, S., Jivraj, S., & Walters, K. (2017). A systematic review and meta-analysisof prospective associations betweenalcohol consumption and incident frailty. Oxford University Press on behalf of the British Geriatrics Society, 47, 26–34. 10.1093/ageing/afx086

Nunes, P. T., Kipp, B. T., Reitz, N. L., & Savage, L. M. (2019). Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction. International review of neurobiology, 148, 101–168. 10.1016/bs.irn.2019.09.002

Roberto, M. & Varodayan, F. P. (2017). Synaptic targets: Chronic alcohol actions. Neuropharmacology, 122, 85–99. 10.1016/j.neuropharm.2017.01

Salas-Gomez, D., Fernandez-Gorgojo, M., Pozueta, A., Diaz-Ceballos, I., Lamarain, M., Perez, C., & Sanchez-Juan, P. (2016). Binge drinking in young university students is associated with alterations in executive functions related to their starting age. PLoS ONE, 11(11), 1-12.

Sanchez, Z. M. (2017). A prática de binge drinking entre jovens e o papel das promoções de bebidas alcoólicas: uma questão de saúde pública. Epidemiol. Serv. Saúde, 26(1), 195–219.

Santos, C. M. da C., Pimenta, C. A. de M., & Nobre, M. R. C. (2007). A estratégia PICO para a construção da pergunta de pesquisa e busca de evidências. Rev Latino-am Enfermagem 15(3), 01-04.

Savage, L. M., Nunes, P. T., Gursky, Z. H., Milbocker, K. A., & Klintsova, A. Y. Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function. Neuropsychology review, 31(3), 447–471. 10.1007/s11065-020-09450-8

Silveri, M. M., dager, A. D., Cohen-Gilbert, J. E., & Sneider, J. T. (2016). Neurobiological signatures associated with alcohol and drug use in the human adolescent brain. Neuroscience Biobehavior, 70, 244–259. 10.1016/j.neubiorev.2016.06.042

Souza, M. T. de, Silva, M. D. da, & Carvalho, R. de (2010). Revisão integrativa: o que é e como fazer. Einstein, 8(11), 102-6.

Sullivan, E. V., & Pfefferbaum, A. (2019). Brain-behavior relations and effects of aging and common comorbidities in alcohol use disorder: a review. Neuropsychology, 33(6), 760–780. 10.1037/neu0000557

WOrld Health Organization. WHO. (2016). Management of substance abuse. Retrieved October 5, 2021, from

Zahr, N. M., Pohl, K. M., Saranathan, M., Sullivan, E.V., & Pfefferbaum, A. (2019). Hippocampal subfield CA2+3 exhibits accelerated aging in Alcohol Use Disorder: A preliminary study. NeuroImage. Clinical, 22, 1-8. 10.1016/j.nicl.2019.101764



How to Cite

MELO, I. M. .; MESQUITA, J. V. .; MACIEL, T. Relationship between uncontrolled use of alcoholic beverages and memory loss. Research, Society and Development, [S. l.], v. 11, n. 2, p. e46411225836, 2022. DOI: 10.33448/rsd-v11i2.25836. Disponível em: Acesso em: 21 jun. 2024.



Review Article