Vitamin D supplementation in asthma control – integrative review




Respiratory Tract Diseases; Calciferols ; Database.


Currently, vitamin D deficiency has been recognized as a pandemic caused by multiple factors. An increasing number of academics have focused their efforts on research related to the adverse effects of vitamin D deficiency and its possible association with pathologies, such as asthma. Few studies have been published with direct assessments of the role of vitamin D in asthma, but there is research that indirectly links this vitamin with disease mechanisms. This manuscript is an integrative review that used the PICO method (population, intervention, comparison, result) for the following question: “Does vitamin D supplementation help with asthma control?” Included in the study population were asthmatics, without other comorbidities; the intervention was supplementation with vitamin D and the comparison with non-supplemented individuals, the result analyzed was whether or not there was improvement in asthma control. In conclusion, high doses of vitamin D supplementation, associated with standard asthma treatment, can improve disease control parameters, although more studies are needed on the subject.


Alansari, K., Davidson, B. L., Yousef, K. I., Mohamed, A. N. H., & Alattar, I. (2017). Rapid vs maintenance vitamin D supplementation in deficient children with asthma to prevent exacerbations. Chest, 152(3), 527-536.

Ali, A. M., Selim, S., Abbassi, M. M., & Sabry, N. A. (2017). Effect of alfacalcidol on the pulmonary function of adult asthmatic patients: A randomized trial. Annals of Allergy, Asthma & Immunology, 118(5), 557-563.

Arshi, S., Fallahpour, M., Nabavi, M., Bemanian, M. H., Javad-Mousavi, S. A., Nojomi, M., ... & Akbarpour, N. (2014). The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma. Annals of Allergy, Asthma & Immunology, 113(4), 404-409.

Castro, M., King, T. S., Kunselman, S. J., Cabana, M. D., Denlinger, L., Holguin, F., ... & National Heart, Lung, and Blood Institute. (2014). Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. Jama, 311(20), 2083-2091.

Chambers, E. S., & Hawrylowicz, C. M. (2011). The impact of vitamin D on regulatory T cells. Current allergy and asthma reports, 11(1), 29-36.

Chandrashekara, S., & Patted, A. (2017). Role of vitamin D supplementation in improving disease activity in rheumatoid arthritis: An exploratory study. International journal of rheumatic diseases, 20(7), 825-831.

Chesné, J., Braza, F., Mahay, G., Brouard, S., Aronica, M., & Magnan, A. (2014). IL-17 in severe asthma. Where do we stand? American journal of respiratory and critical care medicine, 190(10), 1094-1101.

Dall'Ara, F., Cutolo, M., Andreoli, L., Tincani, A., & Paolino, S. (2017). Vitamin D and systemic lupus erythematous: a review of immunological and clinical aspects. Clinical and experimental rheumatology, 36(1), 153-162.

de Groot, J. C., van Roon, E. N., Storm, H., Veeger, N. J., Zwinderman, A. H., Hiemstra, P. S., ... & Ten Brinke, A. (2015). Vitamin D reduces eosinophilic airway inflammation in nonatopic asthma. Journal of Allergy and Clinical Immunology, 135(3), 670-675.

Fares, M. M., Alkhaled, L. H., Mroueh, S. M., & Akl, E. A. (2015). Vitamin D supplementation in children with asthma: a systematic review and meta-analysis. BMC research notes, 8(1), 1-10.

Hamzaoui, A., Berraïes, A., Hamdi, B., Kaabachi, W., Ammar, J., & Hamzaoui, K. (2014). Vitamin D reduces the differentiation and expansion of Th17 cells in young asthmatic children. Immunobiology, 219(11), 873-879.

Kerley, C. P., Hutchinson, K., Cormican, L., Faul, J., Greally, P., Coghlan, D., & Elnazir, B. (2016). Vitamin D3 for uncontrolled childhood asthma: A pilot study. Pediatric Allergy and Immunology, 27(4), 404-412.

Kerley, C. P., Elnazir, B., Faul, J., & Cormican, L. (2015). Vitamin D as an adjunctive therapy in asthma. Part 2: a review of human studies. Pulmonary pharmacology & therapeutics, 32, 75-92.

Lewis, E., Fernandez, C., Nella, A., Hopp, R., Gallagher, J. C., & Casale, T. B. (2012). Relationship of 25-hydroxyvitamin D and asthma control in children. Annals of Allergy, Asthma, & Immunology, 108(4), 281-282.

Luo, J., Liu, D., & Liu, C. T. (2015). Can vitamin D supplementation in addition to asthma controllers improve clinical outcomes in patients with asthma?: a meta-analysis. Medicine, 94(50).

Majak, P., Olszowiec-Chlebna, M., Smejda, K., & Stelmach, I. (2011). Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. Journal of Allergy and Clinical Immunology, 127(5), 1294.

Marinho, A., Carvalho, C., Boleixa, D., Bettencourt, A., Leal, B., Guimarães, J., ... & Silva, B. M. (2017). Vitamin D supplementation effects on FoxP3 expression in T cells and FoxP3+/IL-17A ratio and clinical course in systemic lupus erythematosus patients: a study in a Portuguese cohort. Immunologic research, 65(1), 197-206.

Martineau, A. R., Cates, C. J., Urashima, M., Jensen, M., Griffiths, A. P., Nurmatov, U., ... & Griffiths, C. J. (2016). Vitamin D for the management of asthma. Cochrane Database of Systematic Reviews, (9).

Martineau, A. R., MacLaughlin, B. D., Hooper, R. L., Barnes, N. C., Jolliffe, D. A., Greiller, C. L., ... & Griffiths, C. J. (2015). Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs). Thorax, 70(5), 451-457.

Mateussi, M. V., Latorraca, C. D. O. C., Daou, J. P., Martimbianco, A. L. C., Riera, R., Pacheco, R. L., & Pachito, D. V. (2017). What do Cochrane systematic reviews say about interventions for vitamin D supplementation? Sao Paulo Medical Journal, 135, 497-507.

Ministério da Saúde. DATASUS. Acesso: 23/10/2018.

Moghaddassi, M., Pazoki, M., Salimzadeh, A., Ramim, T., & Alipour, Z. (2018). Association of serum level of 25-hydroxy Vitamin D deficiency and pulmonary function in healthy individuals. The Scientific World Journal, 2018.

Mudambi, K., & Bass, D. (2018). Vitamin D: a brief overview of its importance and role in inflammatory bowel disease. Translational gastroenterology and hepatology, 3.

Pojsupap, S., Iliriani, K., Sampaio, T. Z. A. L., O’Hearn, K., Kovesi, T., Menon, K., & McNally, J. D. (2015). Efficacy of high-dose vitamin D in pediatric asthma: a systematic review and meta-analysis. Journal of Asthma, 52(4), 382-390.

Ribeiro, C., Tavares, B., & Luís, A. S. (2013). Vitamina D e asma brônquica. Revista Portuguesa de Imunoalergologia, 21(2), 81-89.

SOCIEDADE BRASILEIRA DE PNEUMOLOGIA E TISIOLOGIA (2012). Diretrizes da Sociedade Brasileira de Pneumologia e Tisiologia para o Manejo da Asma. Brasília: Editora Cubo.

Solidoro, P., Bellocchia, M., Aredano, I., Mattei, A., Pivetta, E., Patrucco, F., ... & Bucca, C. (2017). Asthmatic patients with vitamin D deficiency have decreased exacerbations after vitamin replacement. Nutrients, 9(11), 1234.

Tachimoto, H., Mezawa, H., Segawa, T., Akiyama, N., Ida, H., & Urashima, M. (2016). Improved control of childhood asthma with low‐dose, short‐term vitamin D supplementation: a randomized, double‐blind, placebo‐controlled trial. Allergy, 71(7), 1001-1009.

Xystrakis, E., Kusumakar, S., Boswell, S., Peek, E., Urry, Z., Richards, D. F., ... & Hawrylowicz, C. M. (2006). Reversing the defective induction of IL-10–secreting regulatory T cells in glucocorticoid-resistant asthma patients. The Journal of clinical investigation, 116(1), 146-155.

Yadav, M., & Mittal, K. (2014). Effect of vitamin D supplementation on moderate to severe bronchial asthma. The Indian Journal of Pediatrics, 81(7), 650-654.



How to Cite

TROMBIM , L. C.; COSTA, S. M.; SUTER , L. M. da C.; LEME, J. G. C. P.; DANTAS , D. A. R.; SILVA, D. T. de R. e; SALGE, A. K. M. .; MEDEIROS, M. F. C. de .; CAVALCANTE, J. R. A. .; COSTA, G. B. . C.; BLANCO, G. R.; ROSSI, R. C. Vitamin D supplementation in asthma control – integrative review. Research, Society and Development, [S. l.], v. 11, n. 2, p. e49911225862, 2022. DOI: 10.33448/rsd-v11i2.25862. Disponível em: Acesso em: 30 may. 2024.



Review Article