Case study on the clinical and anatomopathological descriptions of dog with primary uveal lymphoma




Canine; Intraocular lymphosarcoma; Veterinary ophthalmology; Uvea.


Intraocular lymphoma is a malignant neoplasm, which commonly affects the uveal tract of dogs, most of the time, a consequence of the multicentric by the hematogenous spread of neoplastic lymphocytes. The symptoms are varied and the chronicity can cause serious eye problems such as glaucoma and loss of visual acuity. In view of the unusual occurrence of primary ocular lymphoma in dogs, the objective was to discuss the case of a dog with uveal involvement, presenting conjunctival congestion, increased episcleral vessels, hypopyon, hyphema and increased intraocular pressure. After seven days of conservative treatment, symptoms worsened, especially the intraocular pressure. The tutor returned only two months after the consultation with the sonographic report of neoplasia in the uvea. There was an increase in the ocular bulb, vascularization and corneal edema, posterior synechia, discomfort, loss of visual acuity and neoformation in the iris. Was opted for enucleation and the histopathology suggested large cell lymphoma in the uveal tract. Two years after surgery, no metastases were observed. It is concluded that lymphoma can affect the uveal tract primarily in dogs, demonstrating different clinical signs and, in addition, early diagnosis and correctly instituted treatment favor quality of life and survival of the affected.


Aquino, S. M., Hamor, R. E., Valli, V. E., kitchell, B. E., Tuvev, S. S., Bailey, K. L. & Ehrhart, E. J. (2000). Progression of an orbital T-cell rich B-cell lymphoma to a B-cell lymphoma in a dog. Veterinary Ophthalmology, 37(5): 465-469.

Carson, F. L & Hladik, C. (2009). Histotechnology - a self instructional text. (3a ed.), ASCP Press, 400p.

Conceição, L. F., Ribeiro, A. P., Piso, D. Y. T. & Laus, J. L. (2010). Considerations about ocular neoplasia of dogs and cats. Ciência Rural, 40(10):2235-2242.

Cypel, M., Belfort Júnior, R., Moraes, N. & and Muccioli, C. (2007). Linfoma intra-ocular primário de células tipo B: relato de caso. Arquivo Brasileiro de Oftalmologia, 70(4):709-712.

Dubielzig, R. R. (2002). Tumor of the eye. In: Meuten, DJ. Tumors in Domestic Animals, (4a ed.), Ames, p.739-754.

Escanilla, N., Leiva, M., Ordeix, L. & Pena, T. (2012). Uveodermatologic lymphoma in two young related Portuguese water dogs. Veterinary. Ophthalmology, 15(5):345-350.

Gelatt, K. N., Gilger, B. C. & Kem, T. J. (2013). Veterinary Ophthalmology (5a ed.), Wiley-Blackwell, 2260 p.

Grahn, B. H., Peiffer, R. L., Cullen, C. L. & Haines, D. M. (2006). Classification of feline intraocular neoplasms based on morphology, histochemical staining, and immunohistochemical labeling. Veterinary Ophthalmology, 9(6):395-403.

Hesse, K. L., Fredo, G., Guimarães, L. L. B., Reis, M. O., Pigatto, J. A. T., Pavarini, S. P., Driemeier, D. & Sonne, L. (2015). Neoplasmas oculares e de anexos em cães e gatos no Rio Grande do Sul: 265 casos (2009-2014). Pesquisa Veterinária Brasileira, 35(1):49-54.

Labelle, A. L. & Labelle, P. (2013). Canine ocular neoplasia: a review. Veterinary Ophthalmology, 16(1):3-14.

Lanza, M. R., Musciano, A. R., Dubielzig, R. D. & Durham, A. C. (2018). Clinical and pathological classification of canine intraocular lymphoma. Veterinary Ophthalmology, 21(2):167-173.

Machado, F. S., Iles, B., Sá, R. E., Araújo, D. D., Andrade, G. L., Arantes, A. R., Sousa, G. C., Monteiro, L. D., Oliveira, A. C. P., Santos, L. B. P & Franco, M. S. C. R. (2021). Prospecção científica e tecnológica do uso de nanopartículas com alendronato de sódio no tratamento de câncer. Reserach, Society and Development, 10(12):1-10.

Maggs, D. J., Miller, P. E., Ofri, R. (2013). Slatter´s Fundamentals of Veterinary Ophthalmology. (5a ed.), Elsevier, 506p.

Malho, P., Dunn, K., Donaldson, D., Dubielzig, R. R., Birand, Z. & Starkey, M. (2013). Investigation of prognostic indicators for human uveal melanoma as biomarkers of canine uveal melanoma metastasis. Journal of Small Animal Practice, 54(11):584-593.

Martin, L. F. T., Rocha, E. M., Garcia, S. B. & Paula, J. S. (2013). Topical Brazilian propolis improves corneal wound healing and inflammation in rats following alkali burns. BMC Complementary Alternative and Medicine, 13(1):1-7.

Moreira, M. V. L., Teixeira Neto, R. LAL., Langohr, I. M. & Ecco, R. (2018). Prospective study of ocular and periocular diseases in animals: 188 cases. Pesquisa Veterinária Brasileira, 38(3):502-510.

Mota, L. P., Carvalho, M. R. R. A., Carvalho Neto, A. L., Ferreira, F. A. A., Poty, J. A. C., Pompeu, J. G. F., Rocha, M. M. L., Fé, R. C. M., Silva, L. E. B., Carvalho Neto, E. A., Silva, F. M. S., Oliveira, C. P. C., Rabelo, M. N., Marques, L. B. L. L & Oliveira, G. M. S. (2121). Neoplasia de cabeça e pescoço: Principais causas e tratamentos. Research, Society and Development, 10(5):1-11, 2021.

Oliveira, M. C., Faleiro, R. D., Santos, C. C. A., Oliveira, G. F., Daoualibi, Y., Sonne, L., Brito, M. F. & Ubiali, D. G. (2016). Linfoma de células T multicêntrico e ocular em equino. Revista Brasileira de Medicina Veterinária, 38(2):149-153.

Oriá, A. P., Estrela-Lima, A., Dórea Neto, F. A., Raposo, A. C. S., Bono, E. T. & Monção-Silva, R. M. (2015). Principais neoplasias intraoculares em cães e gatos. Revista Investigação, 14(2):33-39.

Ota-Kuroki, J., Ragsdale, J. M., Bawa, B., Wakamatsu, N. & Kuroki, K. (2013). Intraocular and periocular lymphoma in dogs and cats: a retrospective review of 21 cases (2001-2012). Veterinary Ophthalmology, 17(6):389-96.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da Pesquisa Científica. Universidade Federal de Santa Maria. UFSM. Pesquisa-Cientifica.pdf?sequence=1.

Rodriguez, E. A. K., Perlmann, E., Abranches, L. S., Pecora, R., Suhett, L. & Goes, A. C. A. (2017). Linfoma intravascular uveal em um cão. Revista Científica de Medicina Veterinária - Pequenos Animais e Animais de Estimação, 15(46):34-37.

Wiggans, K. T., Skorupski, K. A., Reilly, C. M. & Allstadt, S. D. (2014). Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985-2013). Journal of the American Veterinary, 244(4):460-470.




How to Cite

DIAS, F. G. G.; MAGALHÃES, L. F.; PEREIRA, L. de F. .; HONSHO, C. dos S. .; COSTA, M. L. .; OLIVEIRA, A. R. de .; BELMIRO, D. do N. .; RAMOS, V. M. R.; JORGE, A. T. . Case study on the clinical and anatomopathological descriptions of dog with primary uveal lymphoma. Research, Society and Development, [S. l.], v. 11, n. 2, p. e47111226019, 2022. DOI: 10.33448/rsd-v11i2.26019. Disponível em: Acesso em: 25 apr. 2024.



Agrarian and Biological Sciences