Aphthous lesions of the oral cavity: clinical presentation, diagnosis and treatment





Etiology; Treatment; Aphthoid lesions; Diagnosis.


Aphthoid lesions comprise a group of diseases characterized by single or multiple, painful, superficial ulcerations located on the oral mucosa. A typical aphthoid lesion is small, round or ovoid, with circumscribed margins, erythematous halo, and a pale or yellowish background. This study aimed to review the literature on aphthoid lesions of the oral mucosa, highlighting their clinical presentation, diagnosis and treatment, as well as the importance of a correct clinical management in patients who have such lesions in the oral cavity. For the construction of this work, a bibliographic survey was carried out in the databases SciVerse Scopus, Scientific Electronic Library Online (Scielo), U.S. National Library of Medicine (PUBMED) and ScienceDirect, using the Mendeley reference manager. Scientific studies available in the literature report that there are various aphthoid lesions that affect the oral cavity. These cases involve recurrent aphthous stomatitis, Behçet's disease, systemic lupus erythematosus, mucosite and chemical burn. These injuries can harm the quality of life of patients who present complaints of discomfort from these injuries. Therefore, it becomes essential that health professionals are familiar with these disorders, once these oral lesions can serve as fundamental indicators of early diagnosis of disease.


Abida, R., Yeoh, S.-A., & Isenberg, D. A. (2022). Advances in systemic lupus erythematosus. Medicine, 50(1), 7–17. https://doi.org/https://doi.org/10.1016/j.mpmed.2021.10.003

Bhat, A., Naguwa, S., Cheema, G., & Gershwin, M. E. (2010). The epidemiology of transverse myelitis. Autoimmunity Reviews, 9(5), A395–A399. https://doi.org/https://doi.org/10.1016/j.autrev.2009.12.007

Binda, N. C., Binda, A. L. C., Rodrigues, S. de A., Loures, L. L. da S., Sá, A. C. S. F. de, Silva, J. V. L., Franco, A. G., Borba, T. O. da S., Magalhães, P. Í. B. M. de A., Araújo, E. L. da S. F. de, Souza, H. Y. M. S. de, Barbosa, R. L. S., Savi, F. da R., Reis, J. L., Ramalho, M. A., Fernandes, C. da S., & Sátiro, V. D. de S. (2021). Manifestações orais decorrentes da radioterapia de cabeça e pescoço. In Research, Society and Development. 10(12), e411101220519. https://doi.org/10.33448/rsd-v10i12.20519

Boss, M.-K., Ke, Y., Bian, L., Harrison, L. G., Lee, B.-I., Prebble, A., Martin, T., Trageser, E., Hall, S., Wang, D. D., Wang, S., Chow, L., Holwerda, B., Raben, D., Regan, D., Karam, S. D., Dow, S., Young, C. D., & Wang, X.-J. (2021). Therapeutic Intervention Using a Smad7-Based Tat Protein to Treat Radiation-Induced Oral Mucositis. International Journal of Radiation Oncology*Biology*Physics. https://doi.org/https://doi.org/10.1016/j.ijrobp.2021.09.039

Campos, L., Carvalho, D. L. C., Castro, J. R., & Simões, A. (2013). Laserterapia no tratamento da mucosite oral induzida por quimioterapia: relato de caso. Revista Da Associacao Paulista de Cirurgioes Dentistas, 67(2), 102–106.

Carrión-Barberà, I., Salman-Monte, T. C., Vílchez-Oya, F., & Monfort, J. (2021). Neuropsychiatric involvement in systemic lupus erythematosus: A review. Autoimmunity Reviews, 20(4), 102780. https://doi.org/https://doi.org/10.1016/j.autrev.2021.102780

Cui, R. Z., Bruce, A. J., & Rogers, R. S. 3rd. (2016). Recurrent aphthous stomatitis. Clinics in Dermatology, 34(4), 475–481. https://doi.org/10.1016/j.clindermatol.2016.02.020

Da Costa, G. B. F., & Castro, J. F. L. (2013). Etiologia e tratamento da estomatite aftosa recorrente - Revisão de literatura. Medicina (Brazil), 46(1), 3–9. https://doi.org/10.11606/issn.2176-7262.v46i1p1-7

Gorsky, M., Epstein, J., Rabenstein, S., Elishoov, H., & Yarom, N. (2007). Topical minocycline and tetracycline rinses in treatment of recurrent aphthous stomatitis: a randomized cross-over study. Dermatology Online Journal, 13(2), 1.

Miziara, I. D., Costa, K. C., Mahmoud, A., Weber, R., Wilhelmsen, N. S. W., & Imamura, R. (2009). Laryngeal manifestations in atypical Recurrent Aphthous Stomatitis. Brazilian Journal of Otorhinolaryngology, 75(5), 660–664. https://doi.org/10.1590/s1808-86942009000500008

Neville, B. W. D. D. C. A. J. B. (2009). Oral and Maxillofacial Pathology. (3rd ed.).

Pereira, A., Shitsuka, D., Parreira, F., & Shitsuka, R. (2018). Método Qualitativo, Quantitativo ou Quali-Quanti. In Metodologia da Pesquisa Científica. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1. Acesso em: 28 março 2020.

Scully, C, & Felix, D. H. (2005). Oral medicine--update for the dental practitioner. Aphthous and other common ulcers. British Dental Journal, 199(5), 259–264. https://doi.org/10.1038/sj.bdj.4812649

Scully, Crispian, Gorsky, M., & Lozada-Nur, F. (2003). The diagnosis and management of recurrent aphthous stomatitis: a consensus approach. Journal of the American Dental Association (1939), 134(2), 200–207. https://doi.org/10.14219/jada.archive.2003.0134

Sonis, S. T. (2013). Oral Mucositis in Head and Neck Cancer: Risk, Biology, and Management. American Society of Clinical Oncology Educational Book, 33, e236–e240. https://doi.org/10.14694/EdBook_AM.2013.33.e236

Suharyani, I., Fouad Abdelwahab Mohammed, A., Muchtaridi, M., Wathoni, N., & Abdassah, M. (2021). Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis. Drug Design, Development and Therapy, 15, 4071–4089. https://doi.org/10.2147/DDDT.S328371

Vincent, S. D., & Lilly, G. E. (1992). Clinical, historic, and therapeutic features of aphthous stomatitis. Literature review and open clinical trial employing steroids. Oral Surgery, Oral Medicine, and Oral Pathology, 74(1), 79–86. https://doi.org/10.1016/0030-4220(92)90219-g

Wang, M., Wang, Z., Zhang, S., Zhang, L., Zhao, J., Wang, Q., Tian, X., Li, M., Chiganer, E. H., & Zeng, X. (2021). Relapse rates and risk factors for unfavorable neurological prognosis of transverse myelitis in systemic lupus erythematosus: A systematic review and meta-analysis. Autoimmunity Reviews, 102996. https://doi.org/https://doi.org/10.1016/j.autrev.2021.102996



How to Cite

AFONSO , Áquila de O. .; CAPELARIO, E. de F. S. .; SILVA, F. A. B. da; SANTOS, M. de L.; CORREA, L. F. A. .; MACIEL , B. T.; LOPES, G. M. .; FREITAS, D. da P. .; ALBUQUERQUE, I. F. de S. A. .; SILVA, R. B. .; SÁTIRO, V. D. de S.; DAMIÃO, R. P. .; FRANCO, A. G. .; PEREIRA, L. D. .; SILVA, L. G. T. da .; SOUZA, T. P. P. de; SÁ, A. C. S. F. de .; MELO , H. C. . Aphthous lesions of the oral cavity: clinical presentation, diagnosis and treatment . Research, Society and Development, [S. l.], v. 11, n. 2, p. e52111226056, 2022. DOI: 10.33448/rsd-v11i2.26056. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/26056. Acesso em: 28 feb. 2024.



Health Sciences