COVID-19: the historicity of therapies in the first year of the Pandemic

Authors

DOI:

https://doi.org/10.33448/rsd-v11i2.26307

Keywords:

SARS-CoV-2; Therapies; Pandemic; COVID-19.

Abstract

The objective is to know the therapeutic constructs of COVID-19 in its first year of the pandemic. This is a narrative review of the literature, carried out from research in the Biblioteca Virtual de Saúde, Periódicos Capes, PubMed, Cochrane with the standardized descriptors 'Therapy' AND COVID-19, in the first year of the COVID-19 pandemic, after the official declaration of the WHO. As a result, the researched therapeutic targets (in vivo, in vitro, in silico) and published in the first year of this health crisis were described. It was evident that the therapies explored were based on pharmacological and non-pharmacological targets on the host, immune system the virus. The main agents tested in vitro, in vivo, in silico belong to the pharmacological classes of antivirals, antiparasitics, anti-inflammatories, antibiotics as well as monoclonal antibodies, stem cells convalescent plasma. According to the publications, the most cited drugs to treat COVID-19 were hydroxychloroquine, chloroquine, ivermectin, azithromycin, vitamin D, dexamethasone glucocorticoid. It was found that many therapeutic strategies against COVID-19 have been refuted, however, others are being better researched.

References

Alijotas-Reig, J., Esteve-Valverde, E., Belizna, C., Selva-O’Callaghan, A., Pardos-Gea, J., Quintana, A., Mekinian, A., Anunciacion-Llunell, A., & Miró-Mur, F. (2020). Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: A comprehensive review. Autoimmunity Reviews, 19(7), 102569. https://doi.org/10.1016/j.autrev.2020.102569

Alnababteh, M., Hashmi, M., Drescher, G., Vedantam, K., Kohli, A., Hayat, F., Chopra, R., Oweis, E., & Zaaqoq, A. (2020). Extracorporeal Membrane Oxygenation As Rescue Therapy for COVID-19 Induced Hypoxia: Single-Center Study. Chest, 158(4), A2411. https://doi.org/10.1016/j.chest.2020.09.010

Andrade, B. S., Rangel, F. de S., Santos, N. O., Freitas, A. dos S., Soares, W. R. de A., Siqueira, S., Barh, D., Góes-Neto, A., Birbrair, A., & Azevedo, V. A. de C. (2020). Repurposing Approved Drugs for Guiding COVID-19 Prophylaxis: A Systematic Review. Frontiers in Pharmacology, 11(December), 1–12. https://doi.org/10.3389/fphar.2020.590598

Balkhair, A., Al-Zakwani, I., Al Busaidi, M., Al-Khirbash, A., Al Mubaihsi, S., BaTaher, H., Al Aghbari, J., Al Busaidi, I., Al Kindi, M., Baawain, S., Al Alawi, A., Al Lawati, A., Al Rawahi, B., Al-Baimani, K., Al Zidi, K., Elfatih, N., Dawud, B., John, B., Rehman, F., … Balkhair, O. (2021). Anakinra in hospitalized patients with severe COVID-19 pneumonia requiring oxygen therapy: Results of a prospective, open-label, interventional study. International Journal of Infectious Diseases, 103, 288–296. https://doi.org/10.1016/j.ijid.2020.11.149

Bassetti, M., Giacobbe, D. R., Aliberti, S., Barisione, E., Centanni, S., De Rosa, F. G., Di Marco, F., Gori, A., Granata, G., Mikulska, M., Petrosillo, N., Richeldi, L., Santus, P., Tascini, C., Vena, A., Viale, P., & Blasi, F. (2020). Balancing evidence and frontline experience in the early phases of the COVID-19 pandemic: current position of the Italian Society of Anti-infective Therapy (SITA) and the Italian Society of Pulmonology (SIP). Clinical Microbiology and Infection, 26(7), 880–894. https://doi.org/10.1016/j.cmi.2020.04.031

Borba, M. G. S., Val, F. F. A., Sampaio, V. S., Alexandre, M. A. A., Melo, G. C., Brito, M., Mourão, M. P. G., Brito-Sousa, J. D., Baía-da-Silva, D., Guerra, M. V. F., Hajjar, L. A., Pinto, R. C., Balieiro, A. A. S., Pacheco, A. G. F., Santos, J. D. O., Naveca, F. G., Xavier, M. S., Siqueira, A. M., Schwarzbold, A., … Lacerda, M. V. G. (2020). Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial. JAMA Network Open, 3(4), e208857. https://doi.org/10.1001/jamanetworkopen.2020.8857

Botond, L., László, G., Eniko, G., Alexandra, R., Zsuzsa, V., Éva, N., Eszter, M., Gabriella, B., Ilona, B., Péter, R., János, S., János, S., & István, V. N. (2020). Anti-cytokine therapy in novel coronavirus disease (COVID-19) - The first administration of tocilizumab in Hungary at a department of infectology. Orvosi Hetilap, 161(26), 1070–1077. https://doi.org/10.1556/650.2020.31899

Cai, J., Li, H., Zhang, C., Chen, Z., Liu, H., Lei, F., Qin, J. J., Liu, Y. M., Zhou, F., Song, X., Zhou, J., Zhao, Y. C., Wu, B., He, M., Yang, H., Zhu, L., Zhang, P., Ji, Y. X., Zhao, G. N., … Li, H. (2021). The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-19. Cell Metabolism, 33(2), 258-269.e3. https://doi.org/10.1016/j.cmet.2021.01.002

Campbell, C. M., Guha, A., Haque, T., Neilan, T. G., & Addison, D. (2020). Repurposing Immunomodulatory Therapies against Coronavirus Disease 2019 (COVID-19) in the Era of Cardiac Vigilance: A Systematic Review. Journal of Clinical Medicine, 9(9), 2935. https://doi.org/10.3390/jcm9092935

Cantini, F., Niccoli, L., Matarrese, D., Nicastri, E., Stobbione, P., & Goletti, D. (2020). Baricitinib therapy in COVID-19: A pilot study on the safety and clinical impact. Journal of Infection, 81(2), 318–356. https://doi.org/10.1016/j.jinf.2020.04.017

Catteau, L., Dauby, N., Montourcy, M., Bottieau, E., Hautekiet, J., Goetghebeur, E., van Ierssel, S., Duysburgh, E., Van Oyen, H., Wyndham-Thomas, C., Van Beckhoven, D., Bafort, K., Belkhir, L., Bossuyt, N., Caprasse, P., Colombie, V., De Munter, P., Deblonde, J., Delmarcelle, D., … Willems, E. (2020). Low-dose hydroxychloroquine therapy and mortality in hospitalized patients with COVID-19: a nationwide observational study of 8075 participants. International Journal of Antimicrobial Agents, 56(4). https://doi.org/10.1016/j.ijantimicag.2020.106144

Charan, T. R. V., Pederson, J. M., Saravu, K., Gupta, N., Barrett, A., Davis, A. R., Kallmes, K. M., & Evanson, K. W. (2021). Remdesivir therapy in patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials. Annals of Medicine and Surgery, 62(December 2020), 43–48. https://doi.org/10.1016/j.amsu.2020.12.051

Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J., Yu, T., Zhang, X., & Zhang, L. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet, 395(10223), 507–513. https://doi.org/10.1016/S0140-6736(20)30211-7

Choudhary, S., & Silakari, O. (2020). Scaffold morphing of arbidol (umifenovir) in search of multi-targeting therapy halting the interaction of SARS-CoV-2 with ACE2 and other proteases involved in COVID-19. Virus Research, 289(July), 198146. https://doi.org/10.1016/j.virusres.2020.198146

Cueto, M. (2020). Os historiadores e as epidemias na América Latina Nas. História, Ciências, Saúde-Manguinhos, 27(4), 11028–11029. https://doi.org/10.23925/1806-9029.2018v30i2p1-4

Dassarma, B., Tripathy, S., & Matsabisa, M. (2021). Emergence of ancient convalescent plasma (CP) therapy: To manage COVID-19 pandemic. Transfusion Clinique et Biologique, 28(1), 123–127. https://doi.org/10.1016/j.tracli.2020.11.004

Davoodi, L., Abedi, S. M., Salehifar, E., Alizadeh-Navaei, R., Rouhanizadeh, H., Khorasani, G., & Hosseinimehr, S. J. (2020). Febuxostat therapy in outpatients with suspected COVID-19: A clinical trial. International Journal of Clinical Practice, 74(11), 1–8. https://doi.org/10.1111/ijcp.13600

de Simone, G., & Mancusi, C. (2020). Finding the right time for anti-inflammatory therapy in COVID-19. International Journal of Infectious Diseases, 101, 247–248. https://doi.org/10.1016/j.ijid.2020.09.1454

Dixit, S. (2020). Can moderate-intensity aerobic exercise be an effective and valuable therapy in preventing and controlling the pandemic of COVID-19? Medical Hypotheses, 143(April). https://doi.org/10.1016/j.mehy.2020.109854

Drożdżal, S., Rosik, J., Lechowicz, K., Machaj, F., Kotfis, K., Ghavami, S., & Łos, M. J. (2020). FDA-approved drugs with pharmacotherapeutic potential for SARS-CoV-2 (COVID-19) therapy. Drug Resistance Updates, 53(July), 100719. https://doi.org/10.1016/j.drup.2020.100719

Elavarasi, A., Prasad, M., Seth, T., Sahoo, R. K., Madan, K., Nischal, N., Soneja, M., Sharma, A., Maulik, S. K., Shalimar, & Garg, P. (2020). Chloroquine and Hydroxychloroquine for the Treatment of COVID-19: a Systematic Review and Meta-analysis. Journal of General Internal Medicine, 35(11), 3308–3314. https://doi.org/10.1007/s11606-020-06146-w

Elsawah, H. K., Elsokary, M. A., Elrazzaz, M. G., & Elshafie, A. H. (2021). Hydroxychloroquine for treatment of nonsevere COVID-19 patients: Systematic review and meta-analysis of controlled clinical trials. Journal of Medical Virology, 93(3), 1265–1275. https://doi.org/10.1002/jmv.26442

Entrenas Castillo, M., Entrenas Costa, L. M., Vaquero Barrios, J. M., Alcalá Díaz, J. F., López Miranda, J., Bouillon, R., & Quesada Gomez, J. M. (2020). “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study.” Journal of Steroid Biochemistry and Molecular Biology, 203(July). https://doi.org/10.1016/j.jsbmb.2020.105751

ESSALD. (2020). Ozonoterapia para o tratamento de pacientes adultos com COVID-19. Ara Ii, 1–16.

Feldmann, M., Maini, R. N., Woody, J. N., Holgate, S. T., Winter, G., Rowland, M., Richards, D., & Hussell, T. (2020). Trials of anti-tumor necrosis factor therapy for COVID-19 are urgently needed. The Lancet, 395(10234), 1407–1409. https://doi.org/10.1016/S0140-6736(20)30858-8

Ferrando, C., Mellado-Artigas, R., Gea, A., Arruti, E., Aldecoa, C., Adalia, R., Ramasco, F., Monedero, P., Maseda, E., Tamayo, G., Hernández-Sanz, M. L., Mercadal, J., Martín-Grande, A., Kacmarek, R. M., Villar, J., & Suárez-Sipmann, F. (2020). Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: A multicenter, adjusted cohort study. Critical Care, 24(1), 1–11. https://doi.org/10.1186/s13054-020-03314-6

Franzini, M., Valdenassi, L., Ricevuti, G., Chirumbolo, S., Depfenhart, M., Bertossi, D., & Tirelli, U. (2020). Oxygen-ozone (O2-O3) immunochemical therapy for patients with COVID-19. Preliminary evidence was reported. International Immunopharmacology, 88(August), 106879. https://doi.org/10.1016/j.intimp.2020.106879

Garcia, L. P., & Duarte, E. (2020). Intervenções não farmacológicas para o enfrentamento à epidemia da COVID-19 no Brasil. Epidemiologia e Servicos de Saude : Revista Do Sistema Unico de Saude Do Brasil, 29(2), 1–4. https://doi.org/10.5123/S1679-49742020000200009

Gendelman, O., Amital, H., Luigi, N., & Watad, A. (2020). Continuous hydroxychloroquine or colchicine therapy does not prevent infection with SARS-CoV-2: Insights from a large healthcare database analysis. Autoimmunity Reviews Journal, 19(January), 1–4.

Gollob, M. H. (2020). COVID-19, Clinical Trials, and QT-Prolonging Prophylactic Therapy in Healthy Subjects: First, Do No Harm. Journal of the American College of Cardiology, 75(25), 3184–3186. https://doi.org/10.1016/j.jacc.2020.05.008

González-Gay, M. A., Castañeda, S., & Ancochea, J. (2021). Biologic Therapy in COVID-19. Archivos de Bronconeumologia, 57(1), 1–2. https://doi.org/10.1016/j.arbres.2020.06.007

Hamizi, K., Aouidane, S., & Belaaloui, G. (2020). Etoposide-based therapy for severe forms of COVID-19. Medical Hypotheses, 142(April), 109826. https://doi.org/10.1016/j.mehy.2020.109826

Hariyanto, T. I., & Kurniawan, A. (2020). Statin therapy did not improve the in-hospital outcome of coronavirus disease 2019 (COVID-19) infection. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 14(6), 1613–1615. https://doi.org/10.1016/j.dsx.2020.08.023

Homolak, J., & Kodvanj, I. (2020). Widely available lysosome targeting agents should be considered a potential therapy for COVID-19. International Journal of Antimicrobial Agents, 56(2), 106044. https://doi.org/10.1016/j.ijantimicag.2020.106044

Huang, R., Zhu, C., Jian Wang, Xue, L., Li, C., Yan, X., Huang, S., Zhang, B., Zhu, L., Xu, T., Ming, F., Zhao, Y., Cheng, J., Shao, H., Zhao, X. an, Sang, D., Zhao, H., Guan, X., Chen, X., … Wu, C. (2020). Corticosteroid therapy is associated with the delay of SARS-CoV-2 clearance in COVID-19 patients. European Journal of Pharmacology, 889(July), 173556. https://doi.org/10.1016/j.ejphar.2020.173556

Ip, A., Berry, D. A., Hansen, E., Goy, A. H., Pecora, A. L., Sinclaire, B. A., Bednarz, U., Marafelias, M., Berry, S. M., Berry, N. S., Mathura, S., Sawczuk, I. S., Biran, N., Go, R. C., Sperber, S., Piwoz, J. A., Balani, B., Cicogna, C., Sebti, R., … Goldberg, S. L. (2020). Hydroxychloroquine and tocilizumab therapy in COVID-19 patients-An observational study. PLoS ONE, 15(8 August), 1–19. https://doi.org/10.1371/journal.pone.0237693

Izadi, M., Cegolon, L., Javanbakht, M., & Sarafzadeh, A. (2020). Ozone therapy for the treatment of COVID-19 pneumonia: A scoping review. International Immunopharmacology, 92(January).

Jankowska, E. A., Sierpiński, R., Tkaczyszyn, M., Drozd, M., Szachniewicz, J., Duda-Sikuła, M., Knysz, B., Simon, K., Szenborn, L., & Ponikowski, P. (2020). Chloroquine and hydroxychloroquine for the prevention and therapy of coronavirus disease 2019: new hopes and old cardiovascular concerns. Kardiologia Polska, 78(7–8), 811–817. https://doi.org/10.33963/KP.15511

Jha, A. K., Kumar, R., Goenka, M. K., & Dayal, V. M. (2020). Emerging Treatment and Prevention Strategies against COVID-19: A Brief Update. Journal of Digestive Endoscopy, 11(01), 69–72. https://doi.org/10.1055/s-0040-1712547

Ji, F., Liu, W., Hao, D. A., Cheng, J., Tong, X. C., Hao, J. G., Wang, L. P., Li, C. Y., Dai, M. J., & Yan, X. B. (2021). Use of convalescent plasma therapy in eight individuals with mild COVID-19. New Microbes and New Infections, 39, 100814. https://doi.org/10.1016/j.nmni.2020.100814

Kirsch, D. G. (2020). Radiation Therapy as a Treatment for COVID-19? International Journal of Radiation Oncology Biology Physics, 108(5), 1140–1142. https://doi.org/10.1016/j.ijrobp.2020.07.025

Klopfenstein, T., Zayet, S., Lohse, A., Balblanc, J. C., Badie, J., Royer, P. Y., Toko, L., Mezher, C., Kadiane-Oussou, N. J., Bossert, M., Bozgan, A. M., Charpentier, A., Roux, M. F., Contreras, R., Mazurier, I., Dussert, P., Gendrin, V., & Conrozier, T. (2020). Tocilizumab therapy reduced intensive care unit admissions and/or mortality in COVID-19 patients. Medecine et Maladies Infectieuses, 50(5), 397–400. https://doi.org/10.1016/j.medmal.2020.05.001

Lana, R. M., Coelho, F. C., Da Costa Gomes, M. F., Cruz, O. G., Bastos, L. S., Villela, D. A. M., & Codeço, C. T. (2020). The novel coronavirus (SARS-CoV-2) emergency and the role of timely and effective national health surveillance. Cadernos de Saude Publica, 36(3). https://doi.org/10.1590/0102-311x00019620

Langhi, D. M., Santis, G. C. De, & Bordin, J. O. (2020). COVID-19 convalescent plasma transfusion. Hematology, Transfusion and Cell Therapy, 42(2), 113–115. https://doi.org/10.1016/j.htct.2020.04.003

Laurence, J., Mulvey, J. J., Seshadri, M., Racanelli, A., Harp, J., Schenck, E. J., Zappetti, D., Horn, E. M., & Magro, C. M. (2020). Anti-complement C5 therapy with eculizumab in three cases of critical COVID-19. Clinical Immunology, 219(July), 108555. https://doi.org/10.1016/j.clim.2020.108555

Lawlor, M., Gupta, A., Ranard, L. S., Madhavan, M. V., Li, J., Eisenberger, A., Parikh, S. A., Sethi, S. S., & Masoumi, A. (2021). Discordance in activated partial thromboplastin time and anti-factor Xa levels in COVID-19 patients on heparin therapy. Thrombosis Research, 198(June 2020), 79–82. https://doi.org/10.1016/j.thromres.2020.11.030

Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K. S. M., Lau, E. H. Y., Wong, J. Y., Xing, X., Xiang, N., Wu, Y., Li, C., Chen, Q., Li, D., Liu, T., Zhao, J., Liu, M., … Feng, Z. (2020). Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. New England Journal of Medicine, 382(13), 1199–1207. https://doi.org/10.1056/NEJMoa2001316

Li, S., Liu, C., Guo, F., Taleb, S. J., Tong, M., & Shang, D. (2020). Traditional Chinese medicine a potential therapy for COVID-19. American Journal of Chinese Medicine, 48(6), 1263–1277. https://doi.org/10.1142/S0192415X20500627

Li, X., Yang, Y., Liu, L., Yang, X., Zhao, X., Li, Y., Ge, Y., Shi, Y., Lv, P., Zhang, J., Bai, T., Zhou, H., Luo, P., & Huang, S. (2020). Effect of combination antiviral therapy on hematological profiles in 151 adults hospitalized with severe coronavirus disease 2019. Pharmacological Research, 160, 105036. https://doi.org/10.1016/j.phrs.2020.105036

Li, Y., Shi, K., Qi, F., Yu, Z., Chen, C., Pan, J., Wu, G., Chen, Y., Li, J., Chen, Y., Zhou, T., Li, X., & Xia, J. (2021). Thalidomide combined with short-term low-dose glucocorticoid therapy for the treatment of severe COVID-19: A case-series study. International Journal of Infectious Diseases, 103, 507–513. https://doi.org/10.1016/j.ijid.2020.12.023

Lim, Z. J., Subramaniam, A., Reddy, M. P., Blecher, G., Kadam, U., Afroz, A., Billah, B., Ashwin, S., Kubicki, M., Bilotta, F., Curtis, J. R., & Rubulotta, F. (2021). Case Fatality Rates for Patients with COVID-19 Requiring Invasive Mechanical Ventilation. American Journal of Respiratory and Critical Care Medicine, 203(1), 54–66. https://doi.org/10.1164/rccm.202006-2405OC

Liu, W., Zhu, H. L., & Duan, Y. (2020). Virus-, host-, immune-based targets for COVID-19 therapy. Drug Discovery Today, 25(12), 2071–2073. https://doi.org/10.1016/j.drudis.2020.10.001

Liu, X., Long, C., Xiong, Q., Chen, C., Ma, J., Su, Y., & Hong, K. (2020). Association of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with risk of COVID-19, inflammation level, severity, and death in patients with COVID-19: A rapid systematic review and meta-analysis. Clinical Cardiology, July, 1–10. https://doi.org/10.1002/clc.23421

López-Alcalde, J., Yan, Y., Witt, C. M., & Barth, J. (2020). The current State of Research about Chinese Herbal Medicines (CHM) for the Treatment of Coronavirus Disease 2019 (COVID-19): A Scoping Review. Journal of Alternative and Complementary Medicine, 26(7), 557–570. https://doi.org/10.1089/acm.2020.0189

Lovetrue, B. (2020). The AI-discovered etiology of COVID-19 and rationale of the irinotecan+ etoposide combination therapy for critically ill COVID-19 patients. Medical Hypotheses, 144(August), 110180. https://doi.org/10.1016/j.mehy.2020.110180

Mansourabadi, A. H., Sadeghalvad, M., Mohammadi-Motlagh, H. R., & Rezaei, N. (2020). The immune system as a target for therapy of SARS-CoV-2: A systematic review of the current immunotherapies for COVID-19. Life Sciences, 258(June), 118185. https://doi.org/10.1016/j.lfs.2020.118185

Mattos-Silva, P., Felix, N. S., Silva, P. L., Robba, C., Battaglini, D., Pelosi, P., Rocco, P. R. M., & Cruz, F. F. (2020). Pros and cons of corticosteroid therapy for COVID-19 patients. Respiratory Physiology and Neurobiology, 280(June), 103492. https://doi.org/10.1016/j.resp.2020.103492

Muchtaridi, M., Fauzi, M., Ikram, N. K. K., Gazzali, A. M., & Wahab, H. A. (2020). Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2. Molecules, 25(17). https://doi.org/10.3390/molecules25173980

Nadaroglu, H. (2020). Antiviral drugs and plasma therapy used for COVID-19 treatment: a nationwide Turkish algorithm. Drug Metabolism Reviews, 52(4), 531–539. https://doi.org/10.1080/03602532.2020.1803907

Nagoba, B., Gavkare, A., Jamadar, N., Mumbre, S., & Selkar, S. (2020). Positive aspects, negative aspects, and limitations of plasma therapy with special reference to COVID-19. Journal of Infection and Public Health, 13(12), 1818–1822. https://doi.org/10.1016/j.jiph.2020.08.011

Najar Nobari, N., Seirafianpour, F., Mashayekhi, F., & Goodarzi, A. (2020). A systematic review on treatment-related mucocutaneous reactions in COVID-19 patients. Dermatologic Therapy, October 2020, 1–16. https://doi.org/10.1111/dth.14662

Nasonov, E., & Samsonov, M. (2020). The role of Interleukin 6 inhibitors in therapy of severe COVID-19. Biomedicine and Pharmacotherapy, 131, 110698. https://doi.org/10.1016/j.biopha.2020.110698

Oladele, J. O., Ajayi, E. I., Oyeleke, O. M., Oladele, O. T., Olowookere, B. D., Adeniyi, B. M., Oyewole, O. I., & Oladiji, A. T. (2020). A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria-based medicinal plants. Heliyon, 6(9), e04897. https://doi.org/10.1016/j.heliyon.2020.e04897

OMS. (2020). Therapeutics and COVID-19. Living Guideline, November, 58.

Parasher, A. (2020). COVID-19: Current understanding of its pathophysiology, clinical presentation, and treatment. Postgraduate Medical Journal, 1(1), 1–9. https://doi.org/10.1136/postgradmedj-2020-138577

Patel, M., Gangemi, A., Marron, R., Chowdhury, J., Yousef, I., Zheng, M., Mills, N., Tragesser, L., Giurintano, J., Gupta, R., Gordon, M., Rali, P., D’Alonso, G., Fleece, D., Zhao, H., Patlakh, N., & Criner, G. (2020). Retrospective analysis of high flow nasal therapy in COVID-19-related moderate-to-severe hypoxaemic respiratory failure. BMJ Open Respiratory Research, 7(1), 1–11. https://doi.org/10.1136/bmjresp-2020-000650

Poor, H. D., Ventetuolo, C. E., Tolbert, T., Chun, G., Serrao, G., Zeidman, A., Dangayach, N. S., Olin, J., Kohli‐Seth, R., & Powell, C. A. (2020). COVID‐19 critical illness pathophysiology drove by diffuse pulmonary thrombi and pulmonary endothelial dysfunction responsive to thrombolysis. Clinical and Translational Medicine, 10(2), 3–7. https://doi.org/10.1002/ctm2.44

Procter, B. C., Ross, C., Pickard, V., Smith, E., Hanson, C., & McCullough, P. A. (2021). Clinical outcomes after early ambulatory multidrug therapy for high-risk SARS-CoV-2 (COVID-19) infection. Reviews in Cardiovascular Medicine, 21(4), 611–614. https://doi.org/10.31083/J.RCM.2020.04.260

Rafiee, F., Keshavarz, P., Katal, S., Assadi, M., Nejati, S. F., Ebrahimian Sadabad, F., & Gholamrezanezhad, A. (2021). Coronavirus Disease 2019 (COVID-19) in Molecular Imaging: A Systematic Review of Incidental Detection of SARS-CoV-2 Pneumonia on PET Studies. Seminars in Nuclear Medicine, 51(2), 178–191. https://doi.org/10.1053/j.semnuclmed.2020.10.002

Razmi, M., Hashemi, F., Gheytanchi, E., Dehghan Manshadi, M., Ghods, R., & Madjd, Z. (2020). Immunomodulatory-based therapy as potentially promising treatment strategy against severe COVID-19 patients: A systematic review. International Immunopharmacology, 88(June), 106942. https://doi.org/10.1016/j.intimp.2020.106942

Rodríguez-Molinero, A., Pérez-López, C., Gálvez-Barrón, C., Miñarro, A., Rodríguez Gullello, E. A., Collado Pérez, I., Milà Ràfols, N., Mónaco, E. E., Hidalgo García, A., Añaños Carrasco, G., & Chamero Pastilla, A. (2021). Association between high-dose steroid therapy, respiratory function, and time to discharge in patients with COVID-19: Cohort study. Medicina Clinica, 156(1), 7–12. https://doi.org/10.1016/j.medcli.2020.08.003

Russo, V., Di Maio, M., Attena, E., Silverio, A., Scudiero, F., Celentani, D., Lodigiani, C., & Di Micco, P. (2020). Clinical impact of pre-admission antithrombotic therapy in hospitalized patients with COVID-19: A multicenter observational study. Pharmacological Research, 159, 104965. https://doi.org/10.1016/j.phrs.2020.104965

Saeedi Saravi, S. S., & Beer, J. H. (2020). Apelin-potential therapy for COVID-19? Journal of Molecular and Cellular Cardiology, 145(June), 84–87. https://doi.org/10.1016/j.yjmcc.2020.06.007

Samaddar, A., Grover, M., & Nag, V. L. (2020). Pathophysiology and Potential Therapeutic Candidates for COVID-19: A Poorly Understood Arena. Frontiers in Pharmacology, 11(585888), 1–23. https://doi.org/10.3389/fphar.2020.585888

Sauñe, P. M., Bryce-Alberti, M., Portmann-Baracco, A. S., & Accinelli, R. A. (2020). Methylprednisolone pulse therapy: An alternative management of severe COVID-19. Respiratory Medicine Case Reports, 31(June), 12–14. https://doi.org/10.1016/j.rmcr.2020.101221

Seyedpour, S., Khodaei, B., Loghman, A. H., Seyedpour, N., Kisomi, M. F., Balibegloo, M., Nezamabadi, S. S., Gholami, B., Saghazadeh, A., & Rezaei, N. (2020). Targeted therapy strategies against SARS-CoV-2 cell entry mechanisms: A systematic review of in vitro and in vivo studies. Journal of Cellular Physiology, June. https://doi.org/10.1002/jcp.30032

Seyhan, A. U., Doganay, F., Yilmaz, E., Topal, N. P., & Ak, R. (2020). Investigation of QT prolongation with hydroxychloroquine and azithromycin for the treatment of COVID‐19. Journal of the College of Physicians and Surgeons Pakistan, 30(10), S153–S157. https://doi.org/10.29271/jcpsp.2020.Supp2.S153

Shah, M., Captain, J., Vaidya, V., Kulkarni, A., Valsangkar, K., Nair, P. M. K., & Ganu, G. (2021). Safety and efficacy of ozone therapy in mild to moderate COVID-19 patients: A phase 1/11 randomized control trial (SEOT study). International Immunopharmacology, 91(October 2020), 107301. https://doi.org/10.1016/j.intimp.2020.107301

Shereen, M. A., Khan, S., Kazmi, A., Bashir, N., & Siddique, R. (2020). COVID-19 infection: Emergence, transmission, and characteristics of human coronaviruses. Journal of Advanced Research, 24, 91–98. https://doi.org/10.1016/j.jare.2020.03.005

Shi, C., Tingting, W., Li, J. P., Sullivan, M. A., Wang, C., Wang, H., Deng, B., & Zhang, Y. (2021). Comprehensive Landscape of Heparin Therapy for COVID-19. Carbohydrate Polymers, 254(August), 117232. https://doi.org/10.1016/j.carbpol.2020.117232

Stremmel, C., Kellnar, A., Massberg, S., & Kääb, S. (2020). Hydroxychloroquine in COVID-19 Therapy: Protection Versus Proarrhythmia. Journal of Cardiovascular Pharmacology and Therapeutics, 25(6), 497–502. https://doi.org/10.1177/1074248420935740

Sun, M., Xu, Y., He, H., Zhang, L., Wang, X., Qiu, Q., Sun, C., Guo, Y., Qiu, S., & Ma, K. (2020). A potentially effective treatment for COVID-19: A systematic review and meta-analysis of convalescent plasma therapy in treating severe infectious disease. International Journal of Infectious Diseases, 98, 334–346. https://doi.org/10.1016/j.ijid.2020.06.107.

Taha, M., Sharma, A., & Soubani, A. (2020). Clinical deterioration during neutropenia recovery after G-CSF therapy inpatient with COVID-19. Respiratory Medicine Case Reports, 31, 101231. https://doi.org/10.1016/j.rmcr.2020.101231.

Takahashi, W., Yoneda, T., Koba, H., Ueda, T., Tsuji, N., Ogawa, H., & Asakura, H. (2021). Potential mechanisms of nafamostat therapy for severe COVID-19 pneumonia with disseminated intravascular coagulation. International Journal of Infectious Diseases, 102, 529–531. https://doi.org/10.1016/j.ijid.2020.10.093.

Tong, S., Su, Y., Yu, Y., Wu, C., Chen, J., Wang, S., & Jiang, J. (2020). Ribavirin therapy for severe COVID-19: a retrospective cohort study. International Journal of Antimicrobial Agents, 56(3), 1–5. https://doi.org/10.1016/j.ijantimicag.2020.106114.

Trivedi, N., Verma, A., & Kumar, D. (2020). Possible treatment and strategies for COVID-19: review and assessment. European Review for Medical and Pharmacological Sciences, 24(23), 12593–12608. https://doi.org/10.26355/eurrev_202012_24057.

Valizadeh, H., Abdolmohammadi-vahid, S., Danshina, S., Ziya Gencer, M., Ammari, A., Sadeghi, A., Roshangar, L., Aslani, S., Esmaeilzadeh, A., Ghaebi, M., Valizadeh, S., & Ahmadi, M. (2020). Nano-curcumin therapy is a promising method in modulating inflammatory cytokines in COVID-19 patients. International Immunopharmacology, 89(June), 107088. https://doi.org/10.1016/j.intimp.2020.107088.

Veenstra, J., Buechler, C. R., Robinson, G., Chapman, S., Adelman, M., Tisack, A., Dimitrion, P., Todter, E., Kohen, L., & Lim, H. W. (2020). Antecedent immunosuppressive therapy for immune-mediated inflammatory diseases in the setting of a COVID-19 outbreak. Journal of the American Academy of Dermatology, 83(6), 1696–1703. https://doi.org/10.1016/j.jaad.2020.07.089.

Vegivinti, C. T. R., Pederson, J. M., Saravu, K., Gupta, N., Evanson, K. W., Kamrowski, S., Schmidt, M., Barrett, A., Trent, H., Dibas, M., Reierson, N. L., Mikoff, N., Pisipati, S., Joseph, B. A., Selvan, P. T., Dmytriw, A. A., Pulakurthi, Y. S., Keesari, P. R., Sriram, V., … Hassan, A. E. (2021). Efficacy of convalescent plasma therapy for COVID-19: A systematic review and meta-analysis. Journal of Clinical Apheresis, November 2020, 1–13. https://doi.org/10.1002/jca.21881

Vianello, A., Arcaro, G., Molena, B., Turato, C., Sukthi, A., Guarnieri, G., Lugato, F., Senna, G., & Navalesi, P. (2020). High-flow nasal cannula oxygen therapy to treat patients with hypoxemic acute respiratory failure consequent to SARS-CoV-2 infection. Thorax, 75(11), 998–1000. https://doi.org/10.1136/thoraxjnl-2020-214993

Wang, N., Zhan, Y., Zhu, L., Hou, Z., Liu, F., Song, P., Qiu, F., Wang, X., Zou, X., Wan, D., Qian, X., Wang, S., Guo, Y., Yu, H., Cui, M., Tong, G., Xu, Y., Zheng, Z., Lu, Y., & Hong, P. (2020). Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients. Cell Host and Microbe, 28(3), 455-464.e2. https://doi.org/10.1016/j.chom.2020.07.005

Wiersinga, W. J., Rhodes, A., Cheng, A. C., Peacock, S. J., Prescott, H. C., & Joost Wiersinga, W. (2020). Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) AReview. JAMA, 324(8), 782–793. https://doi.org/10.1001/jama.2020.12839

Xu, P., Huang, J., Fan, Z., Huang, W., Qi, M., Lin, X., Song, W., & Yi, L. (2020). Arbidol/IFN-α2b therapy for patients with coronavirus disease 2019: a retrospective multicenter cohort study. Microbes and Infection, 22(4–5), 200–205. https://doi.org/10.1016/j.micinf.2020.05.012

Yao, T. T., Qian, J. D., Zhu, W. Y., Wang, Y., & Wang, G. Q. (2020). A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus—A possible reference for coronavirus disease-19 treatment option. Journal of Medical Virology, 92(6), 556–563. https://doi.org/10.1002/jmv.25729

Yousefifard, M., Zali, A., Mohamed Ali, K., Madani Neishaboori, A., Zarghi, A., Hosseini, M., Safari, S., Ali, M. K., & Neishaboori, M. A. (2020). Antiviral Therapy in Management ofCOVID-19: a Systematic Review on Current Evidence. Archives of Academic Emergency Medicine, 8(1), 45.

Zhao, M. (2020). Cytokine storm and immunomodulatory therapy in COVID-19: Role of chloroquine and anti-IL-6 monoclonal antibodies. International Journal of Antimicrobial Agents, 55(6), 105982. https://doi.org/10.1016/j.ijantimicag.2020.105982

Zhaori, G., Lu, L., Liu, C., & Guo, Y. (2020). Progresses in clinical studies on antiviral therapies for COVID-19—Experience and lessons in the design of clinical trials. Pediatric Investigation, 4(4), 263–274. https://doi.org/10.1002/ped4.12227.

Published

06/02/2022

How to Cite

ANDOLFATTO, D.; ZANATTA, L.; FERRAZ, L. COVID-19: the historicity of therapies in the first year of the Pandemic. Research, Society and Development, [S. l.], v. 11, n. 2, p. e60011226307, 2022. DOI: 10.33448/rsd-v11i2.26307. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/26307. Acesso em: 21 jul. 2024.

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Section

Health Sciences